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The map label for this gene is lpxD [H]

Identifier: 77457338

GI number: 77457338

Start: 1285546

End: 1286601

Strand: Direct

Name: lpxD [H]

Synonym: Pfl01_1111

Alternate gene names: 77457338

Gene position: 1285546-1286601 (Clockwise)

Preceding gene: 77457337

Following gene: 77457339

Centisome position: 19.97

GC content: 61.27

Gene sequence:

>1056_bases
ATGACCGTGACTATCAAGCTCGGCCAGTTGGCCGAGTTCCTCGGCGCCACCCTGAGTGGCGACCCCGAGAAGCAAATCAC
TGGGCTAGCCACCTTGCAGGAGGCTGGCCCAGCTCAGTTGAGCTTTCTGGCAAACCCCCAATACCGTAAATACCTGGCTG
GCACGCAAGCCGCAGCCCTGTTGCTCAAGGCTGCCGACGCGGAAGGTTATGCCGGTAATGCGCTGGTGGTGCCGGATCCT
TATCTGGCTTACGCACGCATTTCCCATCTATTCGATCCGAAGCCCAAGGCCACTGCCGGCATTCATCCGACGGCGGTGAT
TGCCGAGGATGCCGTGGTCGATCCGAGCGCCAGTGTCGGTCCCTTCGTTGTGATCGAAGCCGGTGCTCGAATCGGCGCAG
ATGTGACACTCGGCGCGCATTGCGTTGTCGGAGCCCGCAGCGAAATCGGCGAGGGCGGCTGGCTGGCCCCGCGAGTCACG
CTGTATCACGATGTGCGGATCGGCAAGCGGGTGGTGATCCAGTCCGGCGCCGTGCTCGGCGGTGAAGGCTTCGGTTTTGC
CAACGAGAAGGGTGTTTGGCAGAAGATCGCCCAGATCGGCGGCGTGACCATCGGTGACGATGTGGAGATTGGCGTGAACA
CTGCCATCGACCGCGGTGCGCTGGCCGATACCGTGATCGGCAATGGTGTGAAGCTCGACAACCAGATTCAGATCGCCCAC
AACGTGCAGGTCGGTGACCACACCGCCATGGCCGCGTGCGTGGGGATTTCCGGCAGCACCAAAATCGGCAAGCACTGCAT
GCTCGCCGGGGGTGTTGGCCTGGTAGGGCACATCGATATTTGCGACAACGTATTCCTGACCGGGATGACCATGGTGACCC
ACTCGATTACCGAGCCGGGTGCCTATTCTTCCGGCACAGCTATGCAACCTGCGGCCGAATGGCGCAAAAGCGCGGCCCGT
ATTCGTCAGCTCGATGACATCGCGCGACGTTTGAAACAGCTGGAAAAGCGGTCCGGGGAAGTGACCCCCGACGGTAATGC
TTCATCTGAAGGCTGA

Upstream 100 bases:

>100_bases
TTTTGACCTGGTGTTCGAGCGTGGCGCAGTGATCGATGTCAAACCTCAGTACGACATCACGCGCCAGGTTATCGAGCGCA
TGAATCAGCTGAAGTAACCC

Downstream 100 bases:

>100_bases
TACCATTTCCATATCAAGTGTGCACAGCCTCTGGACTGCCTCCTTGATTTGCTAGAGGAGTGCGCGTCAGTCGCGCTCCC
AATCTTTACATAGGCTTCCC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MTVTIKLGQLAEFLGATLSGDPEKQITGLATLQEAGPAQLSFLANPQYRKYLAGTQAAALLLKAADAEGYAGNALVVPDP
YLAYARISHLFDPKPKATAGIHPTAVIAEDAVVDPSASVGPFVVIEAGARIGADVTLGAHCVVGARSEIGEGGWLAPRVT
LYHDVRIGKRVVIQSGAVLGGEGFGFANEKGVWQKIAQIGGVTIGDDVEIGVNTAIDRGALADTVIGNGVKLDNQIQIAH
NVQVGDHTAMAACVGISGSTKIGKHCMLAGGVGLVGHIDICDNVFLTGMTMVTHSITEPGAYSSGTAMQPAAEWRKSAAR
IRQLDDIARRLKQLEKRSGEVTPDGNASSEG

Sequences:

>Translated_351_residues
MTVTIKLGQLAEFLGATLSGDPEKQITGLATLQEAGPAQLSFLANPQYRKYLAGTQAAALLLKAADAEGYAGNALVVPDP
YLAYARISHLFDPKPKATAGIHPTAVIAEDAVVDPSASVGPFVVIEAGARIGADVTLGAHCVVGARSEIGEGGWLAPRVT
LYHDVRIGKRVVIQSGAVLGGEGFGFANEKGVWQKIAQIGGVTIGDDVEIGVNTAIDRGALADTVIGNGVKLDNQIQIAH
NVQVGDHTAMAACVGISGSTKIGKHCMLAGGVGLVGHIDICDNVFLTGMTMVTHSITEPGAYSSGTAMQPAAEWRKSAAR
IRQLDDIARRLKQLEKRSGEVTPDGNASSEG
>Mature_350_residues
TVTIKLGQLAEFLGATLSGDPEKQITGLATLQEAGPAQLSFLANPQYRKYLAGTQAAALLLKAADAEGYAGNALVVPDPY
LAYARISHLFDPKPKATAGIHPTAVIAEDAVVDPSASVGPFVVIEAGARIGADVTLGAHCVVGARSEIGEGGWLAPRVTL
YHDVRIGKRVVIQSGAVLGGEGFGFANEKGVWQKIAQIGGVTIGDDVEIGVNTAIDRGALADTVIGNGVKLDNQIQIAHN
VQVGDHTAMAACVGISGSTKIGKHCMLAGGVGLVGHIDICDNVFLTGMTMVTHSITEPGAYSSGTAMQPAAEWRKSAARI
RQLDDIARRLKQLEKRSGEVTPDGNASSEG

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=337, Percent_Identity=48.6646884272997, Blast_Score=331, Evalue=4e-92,
Organism=Escherichia coli, GI1786378, Length=194, Percent_Identity=30.9278350515464, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36307; Mature: 36176

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTIKLGQLAEFLGATLSGDPEKQITGLATLQEAGPAQLSFLANPQYRKYLAGTQAAAL
CEEEEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCHHHHHH
LLKAADAEGYAGNALVVPDPYLAYARISHLFDPKPKATAGIHPTAVIAEDAVVDPSASVG
HHHHCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEECCCCCCC
PFVVIEAGARIGADVTLGAHCVVGARSEIGEGGWLAPRVTLYHDVRIGKRVVIQSGAVLG
CEEEEECCCCCCCCEEECCEEEEECHHHCCCCCCCCCEEEEEEECCCCCEEEEECCCEEC
GEGFGFANEKGVWQKIAQIGGVTIGDDVEIGVNTAIDRGALADTVIGNGVKLDNQIQIAH
CCCCCCCCCCHHHHHHHHHCCEEECCCCEECCCCCCCCCCHHHHHHCCCEEECCEEEEEE
NVQVGDHTAMAACVGISGSTKIGKHCMLAGGVGLVGHIDICDNVFLTGMTMVTHSITEPG
ECCCCCCCEEHEEECCCCCCCCCCEEEEECCCCEEEEEEHHCCHHHHHHHHHHHCCCCCC
AYSSGTAMQPAAEWRKSAARIRQLDDIARRLKQLEKRSGEVTPDGNASSEG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TVTIKLGQLAEFLGATLSGDPEKQITGLATLQEAGPAQLSFLANPQYRKYLAGTQAAAL
EEEEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCHHHHHH
LLKAADAEGYAGNALVVPDPYLAYARISHLFDPKPKATAGIHPTAVIAEDAVVDPSASVG
HHHHCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEECCCCCCC
PFVVIEAGARIGADVTLGAHCVVGARSEIGEGGWLAPRVTLYHDVRIGKRVVIQSGAVLG
CEEEEECCCCCCCCEEECCEEEEECHHHCCCCCCCCCEEEEEEECCCCCEEEEECCCEEC
GEGFGFANEKGVWQKIAQIGGVTIGDDVEIGVNTAIDRGALADTVIGNGVKLDNQIQIAH
CCCCCCCCCCHHHHHHHHHCCEEECCCCEECCCCCCCCCCHHHHHHCCCEEECCEEEEEE
NVQVGDHTAMAACVGISGSTKIGKHCMLAGGVGLVGHIDICDNVFLTGMTMVTHSITEPG
ECCCCCCCEEHEEECCCCCCCCCCEEEEECCCCEEEEEEHHCCHHHHHHHHHHHCCCCCC
AYSSGTAMQPAAEWRKSAARIRQLDDIARRLKQLEKRSGEVTPDGNASSEG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA