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The map label for this gene is dxr

Identifier: 77457334

GI number: 77457334

Start: 1279932

End: 1281122

Strand: Direct

Name: dxr

Synonym: Pfl01_1107

Alternate gene names: 77457334

Gene position: 1279932-1281122 (Clockwise)

Preceding gene: 77457333

Following gene: 77457335

Centisome position: 19.88

GC content: 61.8

Gene sequence:

>1191_bases
GTGAGTCGCCCACAGCAGATTACCGTCCTGGGCGCGACCGGATCGATCGGTCTGAGTACGCTGGACGTTATCGCCCGGCA
TCCGGATCGTTATCAGGCTTTCGCCCTGAGCGGTTTTACCCGTCTGAGCGAACTGTTTGCCCTGTGTGTCCGTCATCTTC
CTGAATATGCGGTAGTGCCGGAGGCCGGTGCTGCTCGCAACCTGCAGGACGATTTACGAGCCGCTGGCCTGTCGACGCAG
GTGCTGGTTGGCGAGGAAGGCTTGTGTCAGGTCGCTGCTGCGCCTGAGGTGGATGCCGTCATGGCGGCCATTGTCGGCGC
GGCGGGTTTGCGCCCGACTCTGGCGGCTGTCGAGGCGGGCAAGAAGATTCTTCTGGCCAACAAGGAAGCGCTGGTCATGT
CCGGCGCCTTGTTCATGCAGGCGGTGCGCAAGAGCGGTTCGGTCCTGTTGCCGATCGACAGCGAGCACAACGCGATTTTC
CAGTGTATGCCGCAGGACTTTGCTCGCGGGTTGAGCAATGTCGGGGTCCGTCGGATTTTGCTGACGGCCTCCGGTGGCCC
TTTCCGGCAGACGCCAATGGCCGAACTGGCGCATGTTTCACCGGACCAGGCCTGTGCCCACCCGAACTGGTCGATGGGCC
GCAAGATCTCCGTGGATTCGGCCAGCATGATGAACAAAGGGCTCGAATTGATCGAAGCCTGCTGGTTGTTCGATGCCAAG
CCTTCGCAAGTCGAAGTGGTGATTCATCCACAAAGCGTGATTCATTCGCTGGTCGATTATGTGGACGGTTCGGTGCTGGC
GCAGTTGGGCAATCCCGACATGCGCACGCCGATTGCCAATGCCCTGGCCTGGCCTGAGCGCATTGACTCGGGCGTGGCGC
CGCTGGATCTATTCGCTGTAGCACGCCTGGATTTCGAAGCGCCCGACGAAGAGCGCTTCCCGTGCCTTCGGCTTGCGCGG
CAGGCGGCCGAGGCGGGAAACAGCGCCCCGGCCATGCTCAATGCGGCGAATGAAGTGGCGGTGGCCGCGTTTCTCGACGG
ACGGGTTCGCTACCTGGAAATCGCGAGTATCATCGAGGAAGTCTTGAATCTCGAGCCTGTGGTGGCCCTGGACAATCTCG
ATGCGGTATTCGCCGCTGACGCGACTGCCCGGACATTGGCCGGGCAGTGGTTGAGTCGTAACGGCCGATAG

Upstream 100 bases:

>100_bases
GCAGTAATCTGCTGCCGGGGCATGGTGGCGTGCTGGATCGCATCGACAGTCTGACGGCGGCGATCCCGGTCTTTGCGGTG
CTGTTGTGGATGGCGGCATC

Downstream 100 bases:

>100_bases
GTCTTGCAATACATGGCTTCACGCGGCACTGGACAGGATTGCGGAGAAAGTAGATGAGCGCGCTCTATATGATTGCCGGC
ACCCTGATCGCTCTGGGTGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSRPQQITVLGATGSIGLSTLDVIARHPDRYQAFALSGFTRLSELFALCVRHLPEYAVVPEAGAARNLQDDLRAAGLSTQ
VLVGEEGLCQVAAAPEVDAVMAAIVGAAGLRPTLAAVEAGKKILLANKEALVMSGALFMQAVRKSGSVLLPIDSEHNAIF
QCMPQDFARGLSNVGVRRILLTASGGPFRQTPMAELAHVSPDQACAHPNWSMGRKISVDSASMMNKGLELIEACWLFDAK
PSQVEVVIHPQSVIHSLVDYVDGSVLAQLGNPDMRTPIANALAWPERIDSGVAPLDLFAVARLDFEAPDEERFPCLRLAR
QAAEAGNSAPAMLNAANEVAVAAFLDGRVRYLEIASIIEEVLNLEPVVALDNLDAVFAADATARTLAGQWLSRNGR

Sequences:

>Translated_396_residues
MSRPQQITVLGATGSIGLSTLDVIARHPDRYQAFALSGFTRLSELFALCVRHLPEYAVVPEAGAARNLQDDLRAAGLSTQ
VLVGEEGLCQVAAAPEVDAVMAAIVGAAGLRPTLAAVEAGKKILLANKEALVMSGALFMQAVRKSGSVLLPIDSEHNAIF
QCMPQDFARGLSNVGVRRILLTASGGPFRQTPMAELAHVSPDQACAHPNWSMGRKISVDSASMMNKGLELIEACWLFDAK
PSQVEVVIHPQSVIHSLVDYVDGSVLAQLGNPDMRTPIANALAWPERIDSGVAPLDLFAVARLDFEAPDEERFPCLRLAR
QAAEAGNSAPAMLNAANEVAVAAFLDGRVRYLEIASIIEEVLNLEPVVALDNLDAVFAADATARTLAGQWLSRNGR
>Mature_395_residues
SRPQQITVLGATGSIGLSTLDVIARHPDRYQAFALSGFTRLSELFALCVRHLPEYAVVPEAGAARNLQDDLRAAGLSTQV
LVGEEGLCQVAAAPEVDAVMAAIVGAAGLRPTLAAVEAGKKILLANKEALVMSGALFMQAVRKSGSVLLPIDSEHNAIFQ
CMPQDFARGLSNVGVRRILLTASGGPFRQTPMAELAHVSPDQACAHPNWSMGRKISVDSASMMNKGLELIEACWLFDAKP
SQVEVVIHPQSVIHSLVDYVDGSVLAQLGNPDMRTPIANALAWPERIDSGVAPLDLFAVARLDFEAPDEERFPCLRLARQ
AAEAGNSAPAMLNAANEVAVAAFLDGRVRYLEIASIIEEVLNLEPVVALDNLDAVFAADATARTLAGQWLSRNGR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=394, Percent_Identity=54.8223350253807, Blast_Score=416, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_PSEPF (Q3KHA6)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_346839.1
- ProteinModelPortal:   Q3KHA6
- SMR:   Q3KHA6
- STRING:   Q3KHA6
- GeneID:   3716512
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_1107
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   PFLU205922:PFL_1107-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42173; Mature: 42042

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: BINDING 128-128 BINDING 155-155 BINDING 184-184 BINDING 207-207 BINDING 229-229

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPQQITVLGATGSIGLSTLDVIARHPDRYQAFALSGFTRLSELFALCVRHLPEYAVVP
CCCCCEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
EAGAARNLQDDLRAAGLSTQVLVGEEGLCQVAAAPEVDAVMAAIVGAAGLRPTLAAVEAG
CCCCCCCCHHHHHHCCCCEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHCC
KKILLANKEALVMSGALFMQAVRKSGSVLLPIDSEHNAIFQCMPQDFARGLSNVGVRRIL
CEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHEEECCHHHHHHHHHCCEEEEE
LTASGGPFRQTPMAELAHVSPDQACAHPNWSMGRKISVDSASMMNKGLELIEACWLFDAK
EEECCCCCCCCCHHHHHCCCCCHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCC
PSQVEVVIHPQSVIHSLVDYVDGSVLAQLGNPDMRTPIANALAWPERIDSGVAPLDLFAV
CCEEEEEECCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHCHHHHCCCCCHHHHHHH
ARLDFEAPDEERFPCLRLARQAAEAGNSAPAMLNAANEVAVAAFLDGRVRYLEIASIIEE
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCHHEEEEHHCCCHHHHHHHHHHHH
VLNLEPVVALDNLDAVFAADATARTLAGQWLSRNGR
HHCCCCEEEECCCCEEEECCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SRPQQITVLGATGSIGLSTLDVIARHPDRYQAFALSGFTRLSELFALCVRHLPEYAVVP
CCCCEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
EAGAARNLQDDLRAAGLSTQVLVGEEGLCQVAAAPEVDAVMAAIVGAAGLRPTLAAVEAG
CCCCCCCCHHHHHHCCCCEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHCC
KKILLANKEALVMSGALFMQAVRKSGSVLLPIDSEHNAIFQCMPQDFARGLSNVGVRRIL
CEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHEEECCHHHHHHHHHCCEEEEE
LTASGGPFRQTPMAELAHVSPDQACAHPNWSMGRKISVDSASMMNKGLELIEACWLFDAK
EEECCCCCCCCCHHHHHCCCCCHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCC
PSQVEVVIHPQSVIHSLVDYVDGSVLAQLGNPDMRTPIANALAWPERIDSGVAPLDLFAV
CCEEEEEECCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHCHHHHCCCCCHHHHHHH
ARLDFEAPDEERFPCLRLARQAAEAGNSAPAMLNAANEVAVAAFLDGRVRYLEIASIIEE
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCHHEEEEHHCCCHHHHHHHHHHHH
VLNLEPVVALDNLDAVFAADATARTLAGQWLSRNGR
HHCCCCEEEECCCCEEEECCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA