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The map label for this gene is uppS [H]

Identifier: 77457332

GI number: 77457332

Start: 1278374

End: 1279129

Strand: Direct

Name: uppS [H]

Synonym: Pfl01_1105

Alternate gene names: 77457332

Gene position: 1278374-1279129 (Clockwise)

Preceding gene: 77457331

Following gene: 77457333

Centisome position: 19.86

GC content: 60.19

Gene sequence:

>756_bases
ATGGACAAGACCAAGCAGACTGCGCCGTCCACGGTGCCGCGCCATGTCGCGATCATCATGGATGGCAATAATCGCTGGGC
GAAAAAACGCTTTATGCCGGGTGTCGCCGGGCATAAGGCTGGCGTGGATGCTGTGCGGGCGGTGATCGAGGTGTGTGCCG
AGGCCAAGGTCGAAGTGCTCACCCTGTTCGCCTTTTCCAGTGAAAACTGGCAGCGTCCGGCTGACGAGGTCAGCGCCTTG
ATGGACCTGTTCTTCAAGGCGCTGCGTCGTGAAGCCAAGCGCCTGAACGACAACAACATCAGTCTGCGCATCATCGGCGA
CCGTACGCGGTTTCATCCCGAGCTTCAGGCAGCCATGCGTGAAGCAGAAGCGATGACCGCTGGTGCCAACCGCTTCATTC
TGCAGATCGCCGCCAATTACGGCGGTCAGTGGGACATTGCGCAAGCGGCGCAGCGTCTGGCGCGTGAAGTTCAGGCGGGT
CATCTGCGACCGGAAGACATCACGCCGGATCTGCTGCAGACCTGTCTGGTCACTGGTGATCTGCCGTTGCCCGACCTGTG
CATCCGCACCGGCGGCGAGCATCGCATCAGCAACTTCCTCTTGTGGCAGTTGGCTTACGCCGAGTTGTACTTCTCCGACC
TGTTCTGGCCGGACTTCAAACACGAAGCCATGCGCAATGCGCTGGTCGATTTCGCTTTGCGCCAGCGTCGCTTCGGTAAA
ACGAGCGAGCAGGTCGAAGCTGGAGCCCGGGTTTAA

Upstream 100 bases:

>100_bases
GCGAGATCGACGATCTGACCAAGAAGTTCGTGGCTGAAATCGACGCCAAGCTGGCCGAGAAAGAAAAAGACCTGATGGCC
GTATAAGGGTCGAGTTTTAA

Downstream 100 bases:

>100_bases
TGCTTAAACAACGCATCATCACTGCACTGATTCTGTTGCCGATCGCTCTGGGCGGATTTTTCCTGCTCGAGGGTTCCGGT
TTTGCCCTGTTCATCGGTCT

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MDKTKQTAPSTVPRHVAIIMDGNNRWAKKRFMPGVAGHKAGVDAVRAVIEVCAEAKVEVLTLFAFSSENWQRPADEVSAL
MDLFFKALRREAKRLNDNNISLRIIGDRTRFHPELQAAMREAEAMTAGANRFILQIAANYGGQWDIAQAAQRLAREVQAG
HLRPEDITPDLLQTCLVTGDLPLPDLCIRTGGEHRISNFLLWQLAYAELYFSDLFWPDFKHEAMRNALVDFALRQRRFGK
TSEQVEAGARV

Sequences:

>Translated_251_residues
MDKTKQTAPSTVPRHVAIIMDGNNRWAKKRFMPGVAGHKAGVDAVRAVIEVCAEAKVEVLTLFAFSSENWQRPADEVSAL
MDLFFKALRREAKRLNDNNISLRIIGDRTRFHPELQAAMREAEAMTAGANRFILQIAANYGGQWDIAQAAQRLAREVQAG
HLRPEDITPDLLQTCLVTGDLPLPDLCIRTGGEHRISNFLLWQLAYAELYFSDLFWPDFKHEAMRNALVDFALRQRRFGK
TSEQVEAGARV
>Mature_251_residues
MDKTKQTAPSTVPRHVAIIMDGNNRWAKKRFMPGVAGHKAGVDAVRAVIEVCAEAKVEVLTLFAFSSENWQRPADEVSAL
MDLFFKALRREAKRLNDNNISLRIIGDRTRFHPELQAAMREAEAMTAGANRFILQIAANYGGQWDIAQAAQRLAREVQAG
HLRPEDITPDLLQTCLVTGDLPLPDLCIRTGGEHRISNFLLWQLAYAELYFSDLFWPDFKHEAMRNALVDFALRQRRFGK
TSEQVEAGARV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=34.6666666666667, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=34.6666666666667, Blast_Score=151, Evalue=7e-37,
Organism=Escherichia coli, GI1786371, Length=233, Percent_Identity=55.793991416309, Blast_Score=263, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI71993029, Length=229, Percent_Identity=32.7510917030568, Blast_Score=147, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6319474, Length=238, Percent_Identity=34.0336134453782, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=225, Percent_Identity=34.2222222222222, Blast_Score=119, Evalue=3e-28,
Organism=Drosophila melanogaster, GI18857969, Length=213, Percent_Identity=36.150234741784, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28304; Mature: 28304

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKTKQTAPSTVPRHVAIIMDGNNRWAKKRFMPGVAGHKAGVDAVRAVIEVCAEAKVEVL
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHH
TLFAFSSENWQRPADEVSALMDLFFKALRREAKRLNDNNISLRIIGDRTRFHPELQAAMR
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHCCHHHHHHHH
EAEAMTAGANRFILQIAANYGGQWDIAQAAQRLAREVQAGHLRPEDITPDLLQTCLVTGD
HHHHHHCCCHHEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
LPLPDLCIRTGGEHRISNFLLWQLAYAELYFSDLFWPDFKHEAMRNALVDFALRQRRFGK
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
TSEQVEAGARV
CHHHHHCCCCC
>Mature Secondary Structure
MDKTKQTAPSTVPRHVAIIMDGNNRWAKKRFMPGVAGHKAGVDAVRAVIEVCAEAKVEVL
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHH
TLFAFSSENWQRPADEVSALMDLFFKALRREAKRLNDNNISLRIIGDRTRFHPELQAAMR
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHCCHHHHHHHH
EAEAMTAGANRFILQIAANYGGQWDIAQAAQRLAREVQAGHLRPEDITPDLLQTCLVTGD
HHHHHHCCCHHEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
LPLPDLCIRTGGEHRISNFLLWQLAYAELYFSDLFWPDFKHEAMRNALVDFALRQRRFGK
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
TSEQVEAGARV
CHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]