Click here to switch to the map view.

The map label for this gene is frzE [H]

Identifier: 77457283

GI number: 77457283

Start: 1223280

End: 1225574

Strand: Direct

Name: frzE [H]

Synonym: Pfl01_1056

Alternate gene names: 77457283

Gene position: 1223280-1225574 (Clockwise)

Preceding gene: 77457282

Following gene: 77457284

Centisome position: 19.0

GC content: 65.05

Gene sequence:

>2295_bases
ATGACCCCCGAGCAAATGCGCGACGCCTCCTTGCTCGAGCTGTTCAGCCTCGAAGCCGAAGCCCAGACCCAGGTGCTCAG
CGCCGGGCTGCTGGCGCTGGAGCGCAATCCGACCCAGGCCGATCAGCTCGAATCGTGCATGCGCGCGGCGCACTCGTTGA
AAGGCGCGGCGCGGATCGTCGGCATCGACAGCGGCGTCAGCGTCGCCCACGTGATGGAAGATTGCCTGGTCAGTGCGCAG
GAGGGGCGGTTGTTCCTGCGTCCGGAGCATATCGACGCGTTGTTGCAGGGCACCGATTTGCTGATGCGCATCGCCACCCC
GGCCAACGGCCCGCAACCGGCGGACATCGAGGCTTATGTGGCGTTGATGGGCGGTTTGCTCGACCCGGCGGCACCGGCCG
TGGTGCCCGCCGCTCAGAGCGCACCGCCGATGGCCGAGTTTCAGCTTCAGCCACTGCCGGTGGTTGAGCCAGCGCCGGTT
GAAGTCTCGGTCGAGGTGACCGAGCCGGAGCCCGCGCCGCGCAAGAGCAAACGCACCACTGAAGGTGGCGAGCGGGTGCT
GCGGGTCACCGCCGAACGCCTGAACAGCCTGCTCGACCTGTCGAGCAAATCCCTGGTGGAAACCCAGCGCCTCAAGCCGC
ACCTGGCCACCATGCAGCGCCTCAAACGCATGCAGAACAACGGCCTGCGGGCGCTGGAAAGTCTTAACGTTCATCTCAAG
GAACACGCCCTGAGCCTTGAAGCTCAAGAGGCGCTGGAAGACGCGCGACGTTTGCTCGCCGAATCCCAGCAGTTGCTGGC
AGAGAAAAACGCCGAACTCGACGAGTTTGCCTGGCAGGCGAGTCAGCGTGCGCAAGTGCTCTATGACACCGCGCTGGCCT
GCCGCATGCGGCCGTTCGCCGATGTGCTGTCGGGTCAGGTGCGGATGGTGCGCGACCTCGGCCGCAGCCTCGGCAAGCAG
GTGCGGCTGGAGATCGAGGGCGAGAAGACTCAGGTCGACCGCGATGTACTGGAAAAACTCGAAGCACCGCTGACGCACCT
GCTGCGCAACGCGGTCGATCACGGCATCGAAACCCCACAGGAACGCCTGCTCAAGGGCAAGCCCGAGGAAGGCCTGATCC
GTCTGCGCGCCTCGCATCAGGCCGGTCTGCTGGTGCTGGAACTGAGCGACGACGGCAATGGTGTGGATCTGGAAAAAGTC
CGCCGCAGCATCGTCGAACGCCAGTTGTCGCCCGCGGAAACCGCCGCCCAGTTGAGTGAAGAGGAACTGCTGACCTTCCT
GTTTCTGCCGGGTTTCAGTCTGCGCGACAAGGTCACCGAAGTGTCGGGTCGTGGCGTCGGTCTCGATGCTGTTCAGCACA
TGGTCCGCCAGTTGCGCGGTGCGGTGGTGCTGGAGCAGACGGCGGGCGAGGGCAGTCGTTTCTATCTCGAAGTGCCGCTG
ACCCTGTCGGTGGTGCGCAGCCTGGTGGTGGAGGTCGGCGACGAGGCCTATGCCTTCCCGCTGGCGCACATCGAGCGCAT
GTGCGACCTGGCGCCGGAGGACATCGTGCAGGTCGAAGGGCGCCAGCATTTCTGGCACGAAGGCCGGCACGTCGGGCTGG
TGGCGGCCAGTCAGTTGTTGCAACGCCCGGCCAGCCAGAACAGCGGCGAGACCCTGAAGGTCGTGGTGATCCGCGAGCGT
GATGCGATCTACGGCGTGGCGGTCGAGCGCTTCATCGGCGAGCGCACGCTGGTGGTGCTGCCACTGGACGAACGGCTGGG
CAAGGTGCAGGACATTTCCGCCGGGGCCTTGCTCGACGATGGCTCGGTGGTGCTGATCGTCGATGTTGAAGACATGCTGC
GTTCGGTGGACAAACTGCTCAATACCGGGCGTCTGGAGCGCATTGCCCGCCACGGTAATCAGGCCGCGGAAGCCGCGCGC
AAACGGATTCTGGTGGTCGACGACTCGCTGACCGTGCGCGAGCTGCAACGCAAGCTGCTGCTCAATCGCGGCTACGACGT
GGCCGTTGCGGTGGACGGCATGGACGGCTGGAACGCCCTGCGCTCCGAGGACTTCGATCTGCTGATCACCGACATTGACA
TGCCGCGCATGGACGGCATCGAACTGGTCTCGCTGCTGCGCCGCGACAACCGTCTGCAATCGTTGCCGGTGATGGTGGTG
TCCTACAAGGATCGCGAGGAAGATCGCCGCCGTGGACTGGACGCCGGCGCCGACTATTATCTGGCCAAGGCCAGTTTTCA
TGACGACGCCCTGCTCGACGCGGTGGTTGAGCTCATCGGAGGAGCGCGGGCATGA

Upstream 100 bases:

>100_bases
CCAGTGCCAAATACACCCGAGGCGTGTTGCCTTTCAAAGGTCGCAGCCTGCGTTGGCTGGATGAAGAACAGCTGTTGTCC
GCCGTGTCCCGGAGCCTCAC

Downstream 100 bases:

>100_bases
AGATCGCAATCGTCAATGACATGCCTCTGGCGGTGGAAGCCCTGCGTCGTGCGCTGGCCTTCGAGCCGGCGCATCAGGTG
GTGTGGGTCGCCAGCAACGG

Product: CheA Signal transduction histidine kinase (STHK)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 764; Mature: 763

Protein sequence:

>764_residues
MTPEQMRDASLLELFSLEAEAQTQVLSAGLLALERNPTQADQLESCMRAAHSLKGAARIVGIDSGVSVAHVMEDCLVSAQ
EGRLFLRPEHIDALLQGTDLLMRIATPANGPQPADIEAYVALMGGLLDPAAPAVVPAAQSAPPMAEFQLQPLPVVEPAPV
EVSVEVTEPEPAPRKSKRTTEGGERVLRVTAERLNSLLDLSSKSLVETQRLKPHLATMQRLKRMQNNGLRALESLNVHLK
EHALSLEAQEALEDARRLLAESQQLLAEKNAELDEFAWQASQRAQVLYDTALACRMRPFADVLSGQVRMVRDLGRSLGKQ
VRLEIEGEKTQVDRDVLEKLEAPLTHLLRNAVDHGIETPQERLLKGKPEEGLIRLRASHQAGLLVLELSDDGNGVDLEKV
RRSIVERQLSPAETAAQLSEEELLTFLFLPGFSLRDKVTEVSGRGVGLDAVQHMVRQLRGAVVLEQTAGEGSRFYLEVPL
TLSVVRSLVVEVGDEAYAFPLAHIERMCDLAPEDIVQVEGRQHFWHEGRHVGLVAASQLLQRPASQNSGETLKVVVIRER
DAIYGVAVERFIGERTLVVLPLDERLGKVQDISAGALLDDGSVVLIVDVEDMLRSVDKLLNTGRLERIARHGNQAAEAAR
KRILVVDDSLTVRELQRKLLLNRGYDVAVAVDGMDGWNALRSEDFDLLITDIDMPRMDGIELVSLLRRDNRLQSLPVMVV
SYKDREEDRRRGLDAGADYYLAKASFHDDALLDAVVELIGGARA

Sequences:

>Translated_764_residues
MTPEQMRDASLLELFSLEAEAQTQVLSAGLLALERNPTQADQLESCMRAAHSLKGAARIVGIDSGVSVAHVMEDCLVSAQ
EGRLFLRPEHIDALLQGTDLLMRIATPANGPQPADIEAYVALMGGLLDPAAPAVVPAAQSAPPMAEFQLQPLPVVEPAPV
EVSVEVTEPEPAPRKSKRTTEGGERVLRVTAERLNSLLDLSSKSLVETQRLKPHLATMQRLKRMQNNGLRALESLNVHLK
EHALSLEAQEALEDARRLLAESQQLLAEKNAELDEFAWQASQRAQVLYDTALACRMRPFADVLSGQVRMVRDLGRSLGKQ
VRLEIEGEKTQVDRDVLEKLEAPLTHLLRNAVDHGIETPQERLLKGKPEEGLIRLRASHQAGLLVLELSDDGNGVDLEKV
RRSIVERQLSPAETAAQLSEEELLTFLFLPGFSLRDKVTEVSGRGVGLDAVQHMVRQLRGAVVLEQTAGEGSRFYLEVPL
TLSVVRSLVVEVGDEAYAFPLAHIERMCDLAPEDIVQVEGRQHFWHEGRHVGLVAASQLLQRPASQNSGETLKVVVIRER
DAIYGVAVERFIGERTLVVLPLDERLGKVQDISAGALLDDGSVVLIVDVEDMLRSVDKLLNTGRLERIARHGNQAAEAAR
KRILVVDDSLTVRELQRKLLLNRGYDVAVAVDGMDGWNALRSEDFDLLITDIDMPRMDGIELVSLLRRDNRLQSLPVMVV
SYKDREEDRRRGLDAGADYYLAKASFHDDALLDAVVELIGGARA
>Mature_763_residues
TPEQMRDASLLELFSLEAEAQTQVLSAGLLALERNPTQADQLESCMRAAHSLKGAARIVGIDSGVSVAHVMEDCLVSAQE
GRLFLRPEHIDALLQGTDLLMRIATPANGPQPADIEAYVALMGGLLDPAAPAVVPAAQSAPPMAEFQLQPLPVVEPAPVE
VSVEVTEPEPAPRKSKRTTEGGERVLRVTAERLNSLLDLSSKSLVETQRLKPHLATMQRLKRMQNNGLRALESLNVHLKE
HALSLEAQEALEDARRLLAESQQLLAEKNAELDEFAWQASQRAQVLYDTALACRMRPFADVLSGQVRMVRDLGRSLGKQV
RLEIEGEKTQVDRDVLEKLEAPLTHLLRNAVDHGIETPQERLLKGKPEEGLIRLRASHQAGLLVLELSDDGNGVDLEKVR
RSIVERQLSPAETAAQLSEEELLTFLFLPGFSLRDKVTEVSGRGVGLDAVQHMVRQLRGAVVLEQTAGEGSRFYLEVPLT
LSVVRSLVVEVGDEAYAFPLAHIERMCDLAPEDIVQVEGRQHFWHEGRHVGLVAASQLLQRPASQNSGETLKVVVIRERD
AIYGVAVERFIGERTLVVLPLDERLGKVQDISAGALLDDGSVVLIVDVEDMLRSVDKLLNTGRLERIARHGNQAAEAARK
RILVVDDSLTVRELQRKLLLNRGYDVAVAVDGMDGWNALRSEDFDLLITDIDMPRMDGIELVSLLRRDNRLQSLPVMVVS
YKDREEDRRRGLDAGADYYLAKASFHDDALLDAVVELIGGARA

Specific function: FrzE is involved in a sensory transduction pathway that controls the frequency at which cells reverse their gliding direction. FrzE seems to be capable of autophosphorylating itself on an histidine residue and then to transfer that group to an aspartate r

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=361, Percent_Identity=34.0720221606648, Blast_Score=205, Evalue=7e-54,
Organism=Escherichia coli, GI1788191, Length=103, Percent_Identity=37.8640776699029, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=101, Percent_Identity=39.6039603960396, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786599, Length=103, Percent_Identity=34.9514563106796, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF01584 CheW; PF02518 HATPase_c; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 84222; Mature: 84090

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEQMRDASLLELFSLEAEAQTQVLSAGLLALERNPTQADQLESCMRAAHSLKGAARIV
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEE
GIDSGVSVAHVMEDCLVSAQEGRLFLRPEHIDALLQGTDLLMRIATPANGPQPADIEAYV
ECCCCCHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHH
ALMGGLLDPAAPAVVPAAQSAPPMAEFQLQPLPVVEPAPVEVSVEVTEPEPAPRKSKRTT
HHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
EGGERVLRVTAERLNSLLDLSSKSLVETQRLKPHLATMQRLKRMQNNGLRALESLNVHLK
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EHALSLEAQEALEDARRLLAESQQLLAEKNAELDEFAWQASQRAQVLYDTALACRMRPFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
DVLSGQVRMVRDLGRSLGKQVRLEIEGEKTQVDRDVLEKLEAPLTHLLRNAVDHGIETPQ
HHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
ERLLKGKPEEGLIRLRASHQAGLLVLELSDDGNGVDLEKVRRSIVERQLSPAETAAQLSE
HHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCH
EELLTFLFLPGFSLRDKVTEVSGRGVGLDAVQHMVRQLRGAVVLEQTAGEGSRFYLEVPL
HHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECH
TLSVVRSLVVEVGDEAYAFPLAHIERMCDLAPEDIVQVEGRQHFWHEGRHVGLVAASQLL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHCCCEEHHHHHHHHH
QRPASQNSGETLKVVVIRERDAIYGVAVERFIGERTLVVLPLDERLGKVQDISAGALLDD
HCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEEEECHHHCCCHHCCCCCCEECC
GSVVLIVDVEDMLRSVDKLLNTGRLERIARHGNQAAEAARKRILVVDDSLTVRELQRKLL
CCEEEEEEHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCEEEEECCCCHHHHHHHHHH
LNRGYDVAVAVDGMDGWNALRSEDFDLLITDIDMPRMDGIELVSLLRRDNRLQSLPVMVV
HCCCCEEEEEEECCCCHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHCCEEEE
SYKDREEDRRRGLDAGADYYLAKASFHDDALLDAVVELIGGARA
EECCCHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TPEQMRDASLLELFSLEAEAQTQVLSAGLLALERNPTQADQLESCMRAAHSLKGAARIV
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEE
GIDSGVSVAHVMEDCLVSAQEGRLFLRPEHIDALLQGTDLLMRIATPANGPQPADIEAYV
ECCCCCHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHH
ALMGGLLDPAAPAVVPAAQSAPPMAEFQLQPLPVVEPAPVEVSVEVTEPEPAPRKSKRTT
HHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
EGGERVLRVTAERLNSLLDLSSKSLVETQRLKPHLATMQRLKRMQNNGLRALESLNVHLK
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EHALSLEAQEALEDARRLLAESQQLLAEKNAELDEFAWQASQRAQVLYDTALACRMRPFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
DVLSGQVRMVRDLGRSLGKQVRLEIEGEKTQVDRDVLEKLEAPLTHLLRNAVDHGIETPQ
HHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
ERLLKGKPEEGLIRLRASHQAGLLVLELSDDGNGVDLEKVRRSIVERQLSPAETAAQLSE
HHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCH
EELLTFLFLPGFSLRDKVTEVSGRGVGLDAVQHMVRQLRGAVVLEQTAGEGSRFYLEVPL
HHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECH
TLSVVRSLVVEVGDEAYAFPLAHIERMCDLAPEDIVQVEGRQHFWHEGRHVGLVAASQLL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHCCCEEHHHHHHHHH
QRPASQNSGETLKVVVIRERDAIYGVAVERFIGERTLVVLPLDERLGKVQDISAGALLDD
HCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEEEECHHHCCCHHCCCCCCEECC
GSVVLIVDVEDMLRSVDKLLNTGRLERIARHGNQAAEAARKRILVVDDSLTVRELQRKLL
CCEEEEEEHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCEEEEECCCCHHHHHHHHHH
LNRGYDVAVAVDGMDGWNALRSEDFDLLITDIDMPRMDGIELVSLLRRDNRLQSLPVMVV
HCCCCEEEEEEECCCCHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHCCEEEE
SYKDREEDRRRGLDAGADYYLAKASFHDDALLDAVVELIGGARA
EECCCHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2165608; 2123853 [H]