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The map label for this gene is ghrB [H]

Identifier: 77457163

GI number: 77457163

Start: 1086874

End: 1087854

Strand: Reverse

Name: ghrB [H]

Synonym: Pfl01_0936

Alternate gene names: 77457163

Gene position: 1087854-1086874 (Counterclockwise)

Preceding gene: 77457164

Following gene: 77457162

Centisome position: 16.9

GC content: 62.28

Gene sequence:

>981_bases
ATGCCAATGAAAAAAACAGTCCTGGCCTTCAGCCGCATCACCCCGCCCATGATCGAACGCCTGCAACAGGACTTCGACGT
CATCGTCCCCAACCCGAAAAACGGCGACATCAACGCCCAGTTCAACGAAGCCCTGCCCCACGCCCACGGCCTGATCGGCG
TCGGTCGCAAACTCGGCAAGGCCCAACTGGAAAACGCCGCGAAACTCGAAGTGGTCTCCAGCGTCTCCGTCGGCTACGAC
AACTACGACCTCGCCTACTTCAACGAACGCGGGATCATGCTCACCAACACCCCGGACGTCCTGACCGAAAGCACCGCTGA
CCTGGCCTTCGCCCTGATCATGAGCAGCGCCCGCCGCGTCGCCGAACTGGACGCCTGGACCAAGGCCGGCCAATGGCAGG
CCAGCGTCGGCGCACCACTGTTCGGTTGCGACGTACACGGCAAGACCCTGGGCATCGTCGGCATGGGCAACATCGGCGCC
GCCGTCGCCCGTCGCGGACGTTTCGGTTTCAACATGCCGATTATCTACAGCGGCAACAGCCGCAAGACCGAACTGGAACA
GGAACTCGGCGCGCAATTTCGCAGCCTTGACCAACTGCTGGCCGAAGCCGATTTCGTCTGCCTGGTGGTGCCGCTCAGCG
ACAAGACCCGCCACCTGATCAGCCATCGCGAACTGGCGCTGATGAAACCTGACGCGATTCTGGTGAACATCTCCCGTGGC
CCGGTAGTCGACGAGCCGGCACTGATCGAAGCCCTGCAAAACAACCGCATTCGCGGTGCCGGCCTCGACGTCTACGAGAA
AGAACCGCTGGCCGAGTCGCCGCTGTTTCAGTTGAAAAACGCTGTCACCCTGCCACACATCGGCTCGGCGACGAATGAAA
CCCGCGAAGCCATGGCCAACCGCGCACTGACCAACCTGCGCAGCGCGCTGCTCGGCGAACGGCCGCAGGATCTGGTCAAT
CCACAAGTCTGGCGCGGATAA

Upstream 100 bases:

>100_bases
AAACCCCAAGAGCCTGGTCGGCCCAGAGGCCGCCAAGACAACCTCAAACAGAAAATGTTAGCTTGCTTGGCAATCACATC
AGCCGCCAAGCCCGAGCCCA

Downstream 100 bases:

>100_bases
AAAAGTACGGGCAAGTGCATGACTGCACTTGCCCGTTAGTTACGCCATACACAAATTGAAATTGAACAGCAAACCAATTC
AAACAACAGCATTATAAGCT

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MPMKKTVLAFSRITPPMIERLQQDFDVIVPNPKNGDINAQFNEALPHAHGLIGVGRKLGKAQLENAAKLEVVSSVSVGYD
NYDLAYFNERGIMLTNTPDVLTESTADLAFALIMSSARRVAELDAWTKAGQWQASVGAPLFGCDVHGKTLGIVGMGNIGA
AVARRGRFGFNMPIIYSGNSRKTELEQELGAQFRSLDQLLAEADFVCLVVPLSDKTRHLISHRELALMKPDAILVNISRG
PVVDEPALIEALQNNRIRGAGLDVYEKEPLAESPLFQLKNAVTLPHIGSATNETREAMANRALTNLRSALLGERPQDLVN
PQVWRG

Sequences:

>Translated_326_residues
MPMKKTVLAFSRITPPMIERLQQDFDVIVPNPKNGDINAQFNEALPHAHGLIGVGRKLGKAQLENAAKLEVVSSVSVGYD
NYDLAYFNERGIMLTNTPDVLTESTADLAFALIMSSARRVAELDAWTKAGQWQASVGAPLFGCDVHGKTLGIVGMGNIGA
AVARRGRFGFNMPIIYSGNSRKTELEQELGAQFRSLDQLLAEADFVCLVVPLSDKTRHLISHRELALMKPDAILVNISRG
PVVDEPALIEALQNNRIRGAGLDVYEKEPLAESPLFQLKNAVTLPHIGSATNETREAMANRALTNLRSALLGERPQDLVN
PQVWRG
>Mature_325_residues
PMKKTVLAFSRITPPMIERLQQDFDVIVPNPKNGDINAQFNEALPHAHGLIGVGRKLGKAQLENAAKLEVVSSVSVGYDN
YDLAYFNERGIMLTNTPDVLTESTADLAFALIMSSARRVAELDAWTKAGQWQASVGAPLFGCDVHGKTLGIVGMGNIGAA
VARRGRFGFNMPIIYSGNSRKTELEQELGAQFRSLDQLLAEADFVCLVVPLSDKTRHLISHRELALMKPDAILVNISRGP
VVDEPALIEALQNNRIRGAGLDVYEKEPLAESPLFQLKNAVTLPHIGSATNETREAMANRALTNLRSALLGERPQDLVNP
QVWRG

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=270, Percent_Identity=40.7407407407407, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI23308577, Length=308, Percent_Identity=31.8181818181818, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI145580578, Length=275, Percent_Identity=35.2727272727273, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI4557499, Length=275, Percent_Identity=35.2727272727273, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI145580575, Length=275, Percent_Identity=35.2727272727273, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4557497, Length=275, Percent_Identity=33.8181818181818, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI61743967, Length=275, Percent_Identity=33.8181818181818, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=48.3076923076923, Blast_Score=300, Evalue=7e-83,
Organism=Escherichia coli, GI1789279, Length=264, Percent_Identity=32.1969696969697, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787645, Length=257, Percent_Identity=29.1828793774319, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081824, Length=192, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=242, Percent_Identity=31.8181818181818, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=276, Percent_Identity=29.3478260869565, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=244, Percent_Identity=34.4262295081967, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=273, Percent_Identity=33.6996336996337, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=273, Percent_Identity=32.967032967033, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6321253, Length=282, Percent_Identity=29.0780141843972, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6325144, Length=150, Percent_Identity=32, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324964, Length=287, Percent_Identity=24.390243902439, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574286, Length=317, Percent_Identity=35.9621451104101, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24585514, Length=280, Percent_Identity=37.5, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI28574282, Length=280, Percent_Identity=37.5, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI45552429, Length=280, Percent_Identity=37.5, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI28574284, Length=280, Percent_Identity=37.5, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI45551003, Length=280, Percent_Identity=37.5, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI28571528, Length=262, Percent_Identity=37.4045801526718, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24585516, Length=248, Percent_Identity=35.0806451612903, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI62472511, Length=271, Percent_Identity=33.5793357933579, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646446, Length=271, Percent_Identity=33.5793357933579, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646448, Length=271, Percent_Identity=33.5793357933579, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646452, Length=271, Percent_Identity=33.5793357933579, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646450, Length=271, Percent_Identity=33.5793357933579, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19921140, Length=234, Percent_Identity=32.4786324786325, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 35586; Mature: 35455

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMKKTVLAFSRITPPMIERLQQDFDVIVPNPKNGDINAQFNEALPHAHGLIGVGRKLGK
CCCHHHHHHHHHCCHHHHHHHHCCCCEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHH
AQLENAAKLEVVSSVSVGYDNYDLAYFNERGIMLTNTPDVLTESTADLAFALIMSSARRV
HHHCCCHHEEEEHHHCCCCCCCEEEEECCCCEEEECCCHHHHCCHHHHHHHHHHHHHHHH
AELDAWTKAGQWQASVGAPLFGCDVHGKTLGIVGMGNIGAAVARRGRFGFNMPIIYSGNS
HHHHHHHCCCCCCCCCCCCEEEECCCCCEEEEEEECCHHHHHHHCCCCCCCCCEEECCCC
RKTELEQELGAQFRSLDQLLAEADFVCLVVPLSDKTRHLISHRELALMKPDAILVNISRG
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCHHEEECCCEEEEECCCC
PVVDEPALIEALQNNRIRGAGLDVYEKEPLAESPLFQLKNAVTLPHIGSATNETREAMAN
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHH
RALTNLRSALLGERPQDLVNPQVWRG
HHHHHHHHHHHCCCCHHHCCCCCCCC
>Mature Secondary Structure 
PMKKTVLAFSRITPPMIERLQQDFDVIVPNPKNGDINAQFNEALPHAHGLIGVGRKLGK
CCHHHHHHHHHCCHHHHHHHHCCCCEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHH
AQLENAAKLEVVSSVSVGYDNYDLAYFNERGIMLTNTPDVLTESTADLAFALIMSSARRV
HHHCCCHHEEEEHHHCCCCCCCEEEEECCCCEEEECCCHHHHCCHHHHHHHHHHHHHHHH
AELDAWTKAGQWQASVGAPLFGCDVHGKTLGIVGMGNIGAAVARRGRFGFNMPIIYSGNS
HHHHHHHCCCCCCCCCCCCEEEECCCCCEEEEEEECCHHHHHHHCCCCCCCCCEEECCCC
RKTELEQELGAQFRSLDQLLAEADFVCLVVPLSDKTRHLISHRELALMKPDAILVNISRG
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCHHEEECCCEEEEECCCC
PVVDEPALIEALQNNRIRGAGLDVYEKEPLAESPLFQLKNAVTLPHIGSATNETREAMAN
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHH
RALTNLRSALLGERPQDLVNPQVWRG
HHHHHHHHHHHCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA