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The map label for this gene is pcaK [H]

Identifier: 77457140

GI number: 77457140

Start: 1063616

End: 1065013

Strand: Direct

Name: pcaK [H]

Synonym: Pfl01_0913

Alternate gene names: 77457140

Gene position: 1063616-1065013 (Clockwise)

Preceding gene: 77457139

Following gene: 77457142

Centisome position: 16.52

GC content: 62.23

Gene sequence:

>1398_bases
ATGCATAACCAGATTGCCAGCTTTCGGGCGGCACTCGACGCCCGTCCTGTGTCCCGCTTTCAGTGGTTGCTCCTGATTCT
TCTCGCCTTGCTGCTGGTCACCGACGGCTATGACGCCCAGGTGCTCGGTTACGTGGTGCCGGCACTGGCGCAGGACTGGG
GCCTGGAAAAATCCGCATTCGGTCCGGTATTCAGCGCCAACCTTCTGGGCCTGACCCTCGGTTCGCTCGCCGTGACGCCG
CTGGCCGATCGCTTCGGCGTTCGACGGATTCTGCTCGCCTGCGTGCTGATCTACGCCAGCCTCACCGTGCTGATGGTGTT
CGCCGATTCCCTGAATACCCTGATGATCGCGCGTTTCATCTGCGGCATCGGCATGGGCGGCGCGATGCCCAGCGCCATGG
CGTTGATGTCGGAATATTCACCGCCACGCCTGCGTACGCTGATGGTGACGCTGGCGGCCTGCGGTTTTTCTTTCGGCGGT
GCGGCGGGTGGTTTTGTCGCGGCCGGTTTCATTGACCGTTTCGGTTGGCAAGCGGTGTTCCTCGCCGGCGGTGTCACGCC
GTTGCTGTTGTTCCCGTTTCTCTGGTGGATGCTGCCGGAATCCTTGCCACGACTGCTGCGTGACGCACCACCCTATGCGC
GCCTGCGCAAAGTCACCGCGCGAATGCTGCCAGACTGGCAACCGCCCGCCGCATCGGTTGAGCAGAATGAGCGCGAGCAG
GGCAGCAAACTGACCGTGGTGGAGTTGTTCCGCAATGGTTACGCCCGTCCGACCTTGCTGATCTGGGCGACGTTTTTCGT
CAGCCTGATCCTGCTGTATTTCATGATCAGCTGGCTGCCGTCGCTGCTGCTCGAAAGCGGGCTGAAACTCAATGAAGCGA
ACCTGGTGACGTCGATGTTCCTGTTCGCCGGCACGCTCGGCGCGATCTGCATGGCGTGGTTCGCCGACCGCTTGAAAAGC
AAGGTGCGACTGCTGTCCGGCGTGTTGGCCGGCGCGGCGGTGTGCACGATCCTGCTGGGCCTGAACCACGACAATCCGCG
TTATCTGGTGGCCTGTGTGTTTACGGCGGGGTTTTGCATCATTGGCGGGCAACTGACGCTCAATGCGTTCGCCAGCAATT
TCTATCCGGCCCACGTGCGCGCTACCGGCACCGGCTGGGCATTGGGAGTAGGGCGGTTCGGCTCGATTCTCGGGCCGCTG
TTCGGCAGCCTGTTGCTGGCAACGCACATTCCGGTGGAGCAGATTTTCTTCTTCTGCGCGATTCCGGCGGTGATTGCGGC
GTTGCTGATCATTCAGGTGCGTTCGCCAGCCACTGCGCTGTTCAGTGGACAACCGCGTTCGGTGGCAGATGGCCCAGCCG
TTCCGTCAGGCGAAGTCGCTGAATCGGGTCGTCGCTGA

Upstream 100 bases:

>100_bases
GCCGGACACGCCGAAGTAGCATTTGATGGCTCCCGTGCAGCGCACGGGAGCCATTACGGTTACCCGCAAAAAATCATAAA
AACAAAACAGGTACCTTGCG

Downstream 100 bases:

>100_bases
GCAATAGCGCATGCTCCAGATCGAAACGCTCGGCGTTCGGGCAATCGAGACGCTGGTACAGACTGGCCCGCGCCAGGTAG
TCGGCGGCGCTGGCGTTGCC

Product: general substrate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MHNQIASFRAALDARPVSRFQWLLLILLALLLVTDGYDAQVLGYVVPALAQDWGLEKSAFGPVFSANLLGLTLGSLAVTP
LADRFGVRRILLACVLIYASLTVLMVFADSLNTLMIARFICGIGMGGAMPSAMALMSEYSPPRLRTLMVTLAACGFSFGG
AAGGFVAAGFIDRFGWQAVFLAGGVTPLLLFPFLWWMLPESLPRLLRDAPPYARLRKVTARMLPDWQPPAASVEQNEREQ
GSKLTVVELFRNGYARPTLLIWATFFVSLILLYFMISWLPSLLLESGLKLNEANLVTSMFLFAGTLGAICMAWFADRLKS
KVRLLSGVLAGAAVCTILLGLNHDNPRYLVACVFTAGFCIIGGQLTLNAFASNFYPAHVRATGTGWALGVGRFGSILGPL
FGSLLLATHIPVEQIFFFCAIPAVIAALLIIQVRSPATALFSGQPRSVADGPAVPSGEVAESGRR

Sequences:

>Translated_465_residues
MHNQIASFRAALDARPVSRFQWLLLILLALLLVTDGYDAQVLGYVVPALAQDWGLEKSAFGPVFSANLLGLTLGSLAVTP
LADRFGVRRILLACVLIYASLTVLMVFADSLNTLMIARFICGIGMGGAMPSAMALMSEYSPPRLRTLMVTLAACGFSFGG
AAGGFVAAGFIDRFGWQAVFLAGGVTPLLLFPFLWWMLPESLPRLLRDAPPYARLRKVTARMLPDWQPPAASVEQNEREQ
GSKLTVVELFRNGYARPTLLIWATFFVSLILLYFMISWLPSLLLESGLKLNEANLVTSMFLFAGTLGAICMAWFADRLKS
KVRLLSGVLAGAAVCTILLGLNHDNPRYLVACVFTAGFCIIGGQLTLNAFASNFYPAHVRATGTGWALGVGRFGSILGPL
FGSLLLATHIPVEQIFFFCAIPAVIAALLIIQVRSPATALFSGQPRSVADGPAVPSGEVAESGRR
>Mature_465_residues
MHNQIASFRAALDARPVSRFQWLLLILLALLLVTDGYDAQVLGYVVPALAQDWGLEKSAFGPVFSANLLGLTLGSLAVTP
LADRFGVRRILLACVLIYASLTVLMVFADSLNTLMIARFICGIGMGGAMPSAMALMSEYSPPRLRTLMVTLAACGFSFGG
AAGGFVAAGFIDRFGWQAVFLAGGVTPLLLFPFLWWMLPESLPRLLRDAPPYARLRKVTARMLPDWQPPAASVEQNEREQ
GSKLTVVELFRNGYARPTLLIWATFFVSLILLYFMISWLPSLLLESGLKLNEANLVTSMFLFAGTLGAICMAWFADRLKS
KVRLLSGVLAGAAVCTILLGLNHDNPRYLVACVFTAGFCIIGGQLTLNAFASNFYPAHVRATGTGWALGVGRFGSILGPL
FGSLLLATHIPVEQIFFFCAIPAVIAALLIIQVRSPATALFSGQPRSVADGPAVPSGEVAESGRR

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI166064021, Length=454, Percent_Identity=25.3303964757709, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI24308167, Length=451, Percent_Identity=23.5033259423503, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI7662270, Length=170, Percent_Identity=28.8235294117647, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI8923870, Length=384, Percent_Identity=25.78125, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI24497490, Length=344, Percent_Identity=25, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081723, Length=384, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788068, Length=444, Percent_Identity=24.3243243243243, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI87082404, Length=383, Percent_Identity=23.4986945169713, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786229, Length=368, Percent_Identity=24.4565217391304, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082231, Length=415, Percent_Identity=22.6506024096386, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87082159, Length=391, Percent_Identity=25.3196930946292, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788074, Length=413, Percent_Identity=20.8232445520581, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082320, Length=363, Percent_Identity=21.763085399449, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787880, Length=157, Percent_Identity=27.3885350318471, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=418, Percent_Identity=23.6842105263158, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560496, Length=403, Percent_Identity=22.5806451612903, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24640198, Length=477, Percent_Identity=21.5932914046122, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640196, Length=477, Percent_Identity=21.5932914046122, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640200, Length=477, Percent_Identity=21.5932914046122, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19922616, Length=349, Percent_Identity=23.7822349570201, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50055; Mature: 50055

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCHHHCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]