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The map label for this gene is degS [H]

Identifier: 77457102

GI number: 77457102

Start: 1021691

End: 1022848

Strand: Reverse

Name: degS [H]

Synonym: Pfl01_0875

Alternate gene names: 77457102

Gene position: 1022848-1021691 (Counterclockwise)

Preceding gene: 77457106

Following gene: 77457101

Centisome position: 15.89

GC content: 61.92

Gene sequence:

>1158_bases
ATGCTCAAGGCGCTGCGTTTTTTCGGCTGGCCGCTGTTGGCCGGCGTGCTTATCGCTCTGTTGATTATTCAGCGTTACCC
GCAGTGGGTCGGGCTTCCGAGCCTCGACGTCAACTTGCAACAGGCCCCGCAGACCACCAGCGTGCAGCAGGGGCCAGTGT
CGTATGCGGACGCGGTGACCATCGCCGCGCCGTCGGTGGTCAACCTCTACACCACCAAAGTCATCAACAAGCCGAGCCAT
CCGCTGTTCGAAGACCCGCAGTTCCGCCGCTTCTTCGGTGACAATTCGCCGAAGCAGAAGCGCATGGAATCAAGCCTCGG
CTCCGGCGTGATCATGAGCCCGGAAGGCTACATCCTGACCAACAACCACGTCACCAGCGGCGCCGACCAGATCGTCGTGG
CGCTCAAGGACGGTCGCGAAACCCTGGCCCGAGTGATCGGCAGCGATCCGGAAACCGACCTCGCCGTCCTGAAGATCGAC
CTGAAGAACCTGCCGGCGATCACCGTCGGACGCTCCGACAATATCCGCATTGGCGACGTCGCACTGGCGATCGGCAACCC
GTTCGGGGTCGGCCAGACCGTGACCATGGGCATCATCAGCGCCACCGGCCGCAACCAGTTGGGCCTGAACAACTACGAAG
ACTTCATCCAGACCGACGCGGCGATCAATCCGGGCAACTCCGGTGGTGCGCTGGTCGACGCCAACGGCAACCTCACCGGC
ATCAACACTGCGATTTTCTCCAAGTCCGGCGGCTCGCAAGGCATCGGCTTCGCGATCCCGGTGAAACTGGCGATGGAAGT
GATGAAGTCGATCATCGAGCACGGTCAGGTGATTCGCGGCTGGCTGGGCATTGAAGTACAACCGCTGACCCAGGAACTGG
CCGAGTCGTTTGGCCTGTCCGGGCGTCCGGGAATTGTAGTGGCGGGGATTTTCCGCGATGGCCCGGCCCAGAAGGCCGGC
CTGCAACTGGGTGACGTGATTCTCAGCATCGACGGCGAACCGGCCGGTGATGGCCGCAAGTCGATGAACCAAGTGGCGCG
GATCAAGCCGACCGACAAGGTCACGATTCAGGTGATGCGCAACGGCAAGGAATTGAAGCTGACCGCTGAAATCGGTCTGC
GTCCACCGCCGGCGCCGGTGAAGGAAAAAGAAGAGTAA

Upstream 100 bases:

>100_bases
AGACTCCTAAATATCCCGTTCAGAGGCGCGCGCGGCCTCGTATAATGCGCGACATTATGGGCGGTCTGACCCCGCCTGCA
ACTTTTCCAGGACGTGCTTA

Downstream 100 bases:

>100_bases
GACTTTGTTCGCGTCACTGACGCGAATAACAGACATTCTCAACAGGCATGTTATATTGTTTCAATTAGCACATTGGAACA
ACATAACATGTCGTCTCGAA

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MLKALRFFGWPLLAGVLIALLIIQRYPQWVGLPSLDVNLQQAPQTTSVQQGPVSYADAVTIAAPSVVNLYTTKVINKPSH
PLFEDPQFRRFFGDNSPKQKRMESSLGSGVIMSPEGYILTNNHVTSGADQIVVALKDGRETLARVIGSDPETDLAVLKID
LKNLPAITVGRSDNIRIGDVALAIGNPFGVGQTVTMGIISATGRNQLGLNNYEDFIQTDAAINPGNSGGALVDANGNLTG
INTAIFSKSGGSQGIGFAIPVKLAMEVMKSIIEHGQVIRGWLGIEVQPLTQELAESFGLSGRPGIVVAGIFRDGPAQKAG
LQLGDVILSIDGEPAGDGRKSMNQVARIKPTDKVTIQVMRNGKELKLTAEIGLRPPPAPVKEKEE

Sequences:

>Translated_385_residues
MLKALRFFGWPLLAGVLIALLIIQRYPQWVGLPSLDVNLQQAPQTTSVQQGPVSYADAVTIAAPSVVNLYTTKVINKPSH
PLFEDPQFRRFFGDNSPKQKRMESSLGSGVIMSPEGYILTNNHVTSGADQIVVALKDGRETLARVIGSDPETDLAVLKID
LKNLPAITVGRSDNIRIGDVALAIGNPFGVGQTVTMGIISATGRNQLGLNNYEDFIQTDAAINPGNSGGALVDANGNLTG
INTAIFSKSGGSQGIGFAIPVKLAMEVMKSIIEHGQVIRGWLGIEVQPLTQELAESFGLSGRPGIVVAGIFRDGPAQKAG
LQLGDVILSIDGEPAGDGRKSMNQVARIKPTDKVTIQVMRNGKELKLTAEIGLRPPPAPVKEKEE
>Mature_385_residues
MLKALRFFGWPLLAGVLIALLIIQRYPQWVGLPSLDVNLQQAPQTTSVQQGPVSYADAVTIAAPSVVNLYTTKVINKPSH
PLFEDPQFRRFFGDNSPKQKRMESSLGSGVIMSPEGYILTNNHVTSGADQIVVALKDGRETLARVIGSDPETDLAVLKID
LKNLPAITVGRSDNIRIGDVALAIGNPFGVGQTVTMGIISATGRNQLGLNNYEDFIQTDAAINPGNSGGALVDANGNLTG
INTAIFSKSGGSQGIGFAIPVKLAMEVMKSIIEHGQVIRGWLGIEVQPLTQELAESFGLSGRPGIVVAGIFRDGPAQKAG
LQLGDVILSIDGEPAGDGRKSMNQVARIKPTDKVTIQVMRNGKELKLTAEIGLRPPPAPVKEKEE

Specific function: Senses the OMP signal triggered by the accumulation of unassembled porins in the envelope and then initiates rseA degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by rseP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=328, Percent_Identity=34.4512195121951, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI22129776, Length=330, Percent_Identity=33.9393939393939, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI24308541, Length=277, Percent_Identity=33.5740072202166, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI7019477, Length=334, Percent_Identity=32.0359281437126, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1789630, Length=383, Percent_Identity=44.1253263707572, Blast_Score=259, Evalue=1e-70,
Organism=Escherichia coli, GI1786356, Length=364, Percent_Identity=41.4835164835165, Blast_Score=248, Evalue=6e-67,
Organism=Escherichia coli, GI1789629, Length=284, Percent_Identity=45.4225352112676, Blast_Score=242, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24646839, Length=389, Percent_Identity=30.0771208226221, Blast_Score=124, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011783
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 40942; Mature: 40942

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKALRFFGWPLLAGVLIALLIIQRYPQWVGLPSLDVNLQQAPQTTSVQQGPVSYADAVT
CCCHHHHHCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHCCCCCCCCCCCCCCHHCEEE
IAAPSVVNLYTTKVINKPSHPLFEDPQFRRFFGDNSPKQKRMESSLGSGVIMSPEGYILT
ECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCEEECCCCEEEE
NNHVTSGADQIVVALKDGRETLARVIGSDPETDLAVLKIDLKNLPAITVGRSDNIRIGDV
CCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCCEEEEEE
ALAIGNPFGVGQTVTMGIISATGRNQLGLNNYEDFIQTDAAINPGNSGGALVDANGNLTG
EEEECCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEECCCCEEE
INTAIFSKSGGSQGIGFAIPVKLAMEVMKSIIEHGQVIRGWLGIEVQPLTQELAESFGLS
EEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHCCCEEEHHHCCEEEHHHHHHHHHCCCC
GRPGIVVAGIFRDGPAQKAGLQLGDVILSIDGEPAGDGRKSMNQVARIKPTDKVTIQVMR
CCCCEEEEEEECCCCCHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEEE
NGKELKLTAEIGLRPPPAPVKEKEE
CCCEEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MLKALRFFGWPLLAGVLIALLIIQRYPQWVGLPSLDVNLQQAPQTTSVQQGPVSYADAVT
CCCHHHHHCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHCCCCCCCCCCCCCCHHCEEE
IAAPSVVNLYTTKVINKPSHPLFEDPQFRRFFGDNSPKQKRMESSLGSGVIMSPEGYILT
ECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCEEECCCCEEEE
NNHVTSGADQIVVALKDGRETLARVIGSDPETDLAVLKIDLKNLPAITVGRSDNIRIGDV
CCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCCEEEEEE
ALAIGNPFGVGQTVTMGIISATGRNQLGLNNYEDFIQTDAAINPGNSGGALVDANGNLTG
EEEECCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEECCCCEEE
INTAIFSKSGGSQGIGFAIPVKLAMEVMKSIIEHGQVIRGWLGIEVQPLTQELAESFGLS
EEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHCCCEEEHHHCCEEEHHHHHHHHHCCCC
GRPGIVVAGIFRDGPAQKAGLQLGDVILSIDGEPAGDGRKSMNQVARIKPTDKVTIQVMR
CCCCEEEEEEECCCCCHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEEE
NGKELKLTAEIGLRPPPAPVKEKEE
CCCEEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]