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The map label for this gene is adhB [H]

Identifier: 77454824

GI number: 77454824

Start: 231159

End: 232265

Strand: Direct

Name: adhB [H]

Synonym: pREL1_0257

Alternate gene names: 77454824

Gene position: 231159-232265 (Clockwise)

Preceding gene: 77454823

Following gene: 77454825

Centisome position: 85.12

GC content: 61.61

Gene sequence:

>1107_bases
ATGAAGACACGCGCTGCTGTTCTCTGGGGCCTGGGAGAGAAGTGGGAGGTAGAGGAAGTCGAGCTTGATCCGCCCGGCCC
CAACGAGGTGCTCGTCAGGCTGACCGCGAGTGGGTTGTGCCATTCCGATGAACATCTCGTGACCGGTGACTTGCCCTTCC
CTCTACCCGTAGTCGGCGGTCACGAAGGCGCCGGCACCGTGGTGGAAATCGGCGCGGGAGTCGAGGATATCGCCGAGGGC
GATTCGGTCATCCTCACCTTCCTTCCGTCGTGCGGGCACTGTTCCTACTGCGCACGCGGTATAGGGAACCTGTGCGACGC
AGGCGCGGCCGTCATGATGGGACCCCAGCTCGATGGCACCTACCGCTTCCATGCACGCGGCGAGGACATCGGCCAGATGT
GCTTGCTGGGCACCTTCTCGGAGTACACGGTCGTGCCGAGGGCGTCGCTGGTTAAGATCGATACAGGAACACCGCTGGAT
AAGGCGGCGTTGATCGGCTGCGGCGTCACCACCGGTTACGGGTCGGCGGTGCGCACAGGCGAAGTGCGCGCCGGGGACAC
AGTGGTCGTAATCGGAGCCGGCGGTATCGGCATGAACGCGATTCAAGGCGCACGGATCGCCGGCGCGTTGAACATCATCG
CCGTCGACCCCGTGGAATTCAAAAGGGAGCAATCCAGCGTGTTCGGCGCGACGCATGCCGTTGCCTCGATCGACGAAGCG
TGGGCGCTGGTCAGTGACATTACTCGCGGCAAACTCGCCGACGTCTGCATCTTGACCACGGATGTCGCCGAAGGGTCCTA
TACTTCCGAGGCGCTATCACTCGTTGGCAAACGTGGGCGAGTGGTTGTCACCGCGATCGGGCATCCCGAGGAGACCACTA
TGTCGGGCTCTTTGTTGGAGTTGACACTCTACGAAAAGCAGATCCGCGGTTCCCTGTACGGCTCGTCGAACGCTGCGCAT
GACGTCCCTCGCCTCGTCGAACTGTACAACGGCGGAAACCTCAAGCTCGATGAGCTGATCACCCGTGAGTACACTCTCGA
TCAGATTAACGAGGGCTATGAGGACATGCGATCAGGCCGCAACATCCGAGGGCTCATTCGATTCTGA

Upstream 100 bases:

>100_bases
GAAGAAGTTGCGGCGCCAATACGCCGACGGTGACTTCATTGTTGAGACGCTCGACTGAATCGGCCTTCACGGCAACCGAA
TTATTGATCTAAGGAGAATC

Downstream 100 bases:

>100_bases
CGCCACCGCGGGGACAAATTCCCGCAGTCAGTGGTGAATGTCGGGTGGCGGAGCCCAAATAACGGCGAGGTTTGCAGATC
GAGTACTGCGCCGTGGAGCC

Product: putative zinc-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKTRAAVLWGLGEKWEVEEVELDPPGPNEVLVRLTASGLCHSDEHLVTGDLPFPLPVVGGHEGAGTVVEIGAGVEDIAEG
DSVILTFLPSCGHCSYCARGIGNLCDAGAAVMMGPQLDGTYRFHARGEDIGQMCLLGTFSEYTVVPRASLVKIDTGTPLD
KAALIGCGVTTGYGSAVRTGEVRAGDTVVVIGAGGIGMNAIQGARIAGALNIIAVDPVEFKREQSSVFGATHAVASIDEA
WALVSDITRGKLADVCILTTDVAEGSYTSEALSLVGKRGRVVVTAIGHPEETTMSGSLLELTLYEKQIRGSLYGSSNAAH
DVPRLVELYNGGNLKLDELITREYTLDQINEGYEDMRSGRNIRGLIRF

Sequences:

>Translated_368_residues
MKTRAAVLWGLGEKWEVEEVELDPPGPNEVLVRLTASGLCHSDEHLVTGDLPFPLPVVGGHEGAGTVVEIGAGVEDIAEG
DSVILTFLPSCGHCSYCARGIGNLCDAGAAVMMGPQLDGTYRFHARGEDIGQMCLLGTFSEYTVVPRASLVKIDTGTPLD
KAALIGCGVTTGYGSAVRTGEVRAGDTVVVIGAGGIGMNAIQGARIAGALNIIAVDPVEFKREQSSVFGATHAVASIDEA
WALVSDITRGKLADVCILTTDVAEGSYTSEALSLVGKRGRVVVTAIGHPEETTMSGSLLELTLYEKQIRGSLYGSSNAAH
DVPRLVELYNGGNLKLDELITREYTLDQINEGYEDMRSGRNIRGLIRF
>Mature_368_residues
MKTRAAVLWGLGEKWEVEEVELDPPGPNEVLVRLTASGLCHSDEHLVTGDLPFPLPVVGGHEGAGTVVEIGAGVEDIAEG
DSVILTFLPSCGHCSYCARGIGNLCDAGAAVMMGPQLDGTYRFHARGEDIGQMCLLGTFSEYTVVPRASLVKIDTGTPLD
KAALIGCGVTTGYGSAVRTGEVRAGDTVVVIGAGGIGMNAIQGARIAGALNIIAVDPVEFKREQSSVFGATHAVASIDEA
WALVSDITRGKLADVCILTTDVAEGSYTSEALSLVGKRGRVVVTAIGHPEETTMSGSLLELTLYEKQIRGSLYGSSNAAH
DVPRLVELYNGGNLKLDELITREYTLDQINEGYEDMRSGRNIRGLIRF

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=378, Percent_Identity=37.3015873015873, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=35.7723577235772, Blast_Score=231, Evalue=6e-61,
Organism=Homo sapiens, GI34577061, Length=378, Percent_Identity=36.5079365079365, Blast_Score=231, Evalue=6e-61,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=35.7723577235772, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI4501929, Length=376, Percent_Identity=36.1702127659575, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI156523966, Length=375, Percent_Identity=35.2, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI71565154, Length=375, Percent_Identity=35.2, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4501939, Length=369, Percent_Identity=35.230352303523, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI71565152, Length=378, Percent_Identity=32.2751322751323, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI156627571, Length=357, Percent_Identity=24.6498599439776, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1786552, Length=375, Percent_Identity=35.4666666666667, Blast_Score=184, Evalue=7e-48,
Organism=Escherichia coli, GI87082125, Length=383, Percent_Identity=27.9373368146214, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787863, Length=338, Percent_Identity=27.2189349112426, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790045, Length=349, Percent_Identity=26.9340974212034, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788073, Length=378, Percent_Identity=24.3386243386243, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786518, Length=378, Percent_Identity=28.8359788359788, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788407, Length=337, Percent_Identity=26.1127596439169, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI226510992, Length=359, Percent_Identity=26.4623955431755, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786825, Length=354, Percent_Identity=25.4237288135593, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788075, Length=357, Percent_Identity=25.2100840336134, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87081918, Length=337, Percent_Identity=28.1899109792285, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=385, Percent_Identity=32.2077922077922, Blast_Score=200, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI71997431, Length=387, Percent_Identity=32.0413436692506, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17565904, Length=349, Percent_Identity=32.9512893982808, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI71988145, Length=371, Percent_Identity=28.5714285714286, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17562584, Length=366, Percent_Identity=30.6010928961749, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562582, Length=372, Percent_Identity=29.0322580645161, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=372, Percent_Identity=25.8064516129032, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=371, Percent_Identity=25.6064690026954, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=382, Percent_Identity=35.8638743455497, Blast_Score=209, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6323729, Length=369, Percent_Identity=27.9132791327913, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319621, Length=226, Percent_Identity=35.8407079646018, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323961, Length=230, Percent_Identity=32.6086956521739, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=214, Percent_Identity=33.6448598130841, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=348, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=353, Percent_Identity=25.2124645892351, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=341, Percent_Identity=26.3929618768328, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=341, Percent_Identity=26.3929618768328, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=381, Percent_Identity=24.1469816272966, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17737895, Length=380, Percent_Identity=36.5789473684211, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI17737897, Length=362, Percent_Identity=25.9668508287293, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17137530, Length=367, Percent_Identity=25.3405994550409, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 38806; Mature: 38806

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRAAVLWGLGEKWEVEEVELDPPGPNEVLVRLTASGLCHSDEHLVTGDLPFPLPVVGG
CCCCEEEEECCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCEEECC
HEGAGTVVEIGAGVEDIAEGDSVILTFLPSCGHCSYCARGIGNLCDAGAAVMMGPQLDGT
CCCCCCEEEECCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCE
YRFHARGEDIGQMCLLGTFSEYTVVPRASLVKIDTGTPLDKAALIGCGVTTGYGSAVRTG
EEEEECCCCHHCEEEEECCCCEEECCCCEEEEEECCCCCCHHEEEECCCCCCCCCCEECC
EVRAGDTVVVIGAGGIGMNAIQGARIAGALNIIAVDPVEFKREQSSVFGATHAVASIDEA
CCCCCCEEEEEECCCCCCHHHCCCEEECEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
WALVSDITRGKLADVCILTTDVAEGSYTSEALSLVGKRGRVVVTAIGHPEETTMSGSLLE
HHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEE
LTLYEKQIRGSLYGSSNAAHDVPRLVELYNGGNLKLDELITREYTLDQINEGYEDMRSGR
EEEEHHHHCCEECCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHCCHHHHHCCHHHHHCCC
NIRGLIRF
CCEEEECC
>Mature Secondary Structure
MKTRAAVLWGLGEKWEVEEVELDPPGPNEVLVRLTASGLCHSDEHLVTGDLPFPLPVVGG
CCCCEEEEECCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCEEECC
HEGAGTVVEIGAGVEDIAEGDSVILTFLPSCGHCSYCARGIGNLCDAGAAVMMGPQLDGT
CCCCCCEEEECCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCE
YRFHARGEDIGQMCLLGTFSEYTVVPRASLVKIDTGTPLDKAALIGCGVTTGYGSAVRTG
EEEEECCCCHHCEEEEECCCCEEECCCCEEEEEECCCCCCHHEEEECCCCCCCCCCEECC
EVRAGDTVVVIGAGGIGMNAIQGARIAGALNIIAVDPVEFKREQSSVFGATHAVASIDEA
CCCCCCEEEEEECCCCCCHHHCCCEEECEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
WALVSDITRGKLADVCILTTDVAEGSYTSEALSLVGKRGRVVVTAIGHPEETTMSGSLLE
HHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEE
LTLYEKQIRGSLYGSSNAAHDVPRLVELYNGGNLKLDELITREYTLDQINEGYEDMRSGR
EEEEHHHHCCEECCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHCCHHHHHCCHHHHHCCC
NIRGLIRF
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]