Click here to switch to the map view.

The map label for this gene is fadD [H]

Identifier: 77454823

GI number: 77454823

Start: 229488

End: 231116

Strand: Direct

Name: fadD [H]

Synonym: pREL1_0256

Alternate gene names: 77454823

Gene position: 229488-231116 (Clockwise)

Preceding gene: 77454822

Following gene: 77454824

Centisome position: 84.5

GC content: 61.51

Gene sequence:

>1629_bases
ATGAAAAGCACCATGCAGGACGTTCCGCTGACCGTGTCGTCGATAGTGCGGCATGCCTCCAGGATTCATGGCGAGCGTGC
GGTGTTGACCGCGCGTGGACCCGGGCAGATCTCCCGGGTGTCGTACCGAGAGCTGGGCGAACGTGCGGCTCAGTTGGCTA
ATGCATTGCGCGCGATCGGGATTCGTGGAGATGAGCGCGTCGCGACCCTCCAATGGAGTAACCAGGAGCATCTGGAATGC
TATTCGGCGGTGCCATCGATGGGCGCGGTGCTGCACACGTTGAATCTGCGACTGCCGACTGAACAGCTGACGTGGATCGC
AAACCATGCCGACGATCGGGTGGTCATCGTCGACGGAACGGTCCTTCCTCTCCTGGCGTCGGCTCTTCCCTCGATGACCT
CGGTTCGCACGGTGCTCGTCACCGGTACTGGCGACCTTGCCGCTGTTGAGGGGTGTGGAAAGGACGTCCTTCGGTACGAC
GATGTGGTCGCCGCCCAGCCGAGCTCATTCGACTGGCCAGACGTCGACGAACGGTCGGCCGCTGCGATGTGCTACACCAG
CGGCACCACCGGCCATCCGAAAGGCGTTATCTACAGCCATCGTTCGACGTGGCTGCATTCTCAGGCAGCGTGCGCCTCGA
ATGCGCTGGGCATCGGTCATGACGACACGGTATTGACGATCGTGCCGATGTTCCATGCCAATGCGTGGGGACTGCCGTAC
GCGGCGATGATGGCAGGCGCGCAGATGCTGCTGCCCGACCGCTTTTTACAGGCTGAGCCGTTGGTGGAGATGATCGAGGC
AGCGCGACCGACGATGGCGGGAGCGGTCCCGACGATCTGGACCGACGTCTTGCACTACCTGCGTGACAATCCAGGCCATG
ACGTCAGTTCGCTGAAGATGGTGGCCTGCGGGGGTTCAGCCGTTCCGCGGTCGTTGATAACCGCTTACGACGAGCTGGGT
ATCCGCATCGTACAGGCATGGGGAATGACCGAGACCTCGCCGCTTGCTGCAGTCGCGCTCCCGCGGGACACCGACTCACC
GGAGAGGTCCCTTCAGGTACGCGGAACCCAGGGCAGGGTGGTGGCCGGTGTGGAGGCCCGCATCGTCGACGACTCTGATG
CTGAGCAGCCCTGGGACGGAAAGTCGGTGGGCGAGATTCAGATTCGCGGCCCATGGATCACCGGGTCGTACTACCAGCAT
GACAGTGCGGCGGTGACGCCGGATGGATGGTTGTGTACCGGAGATGTTGGCGTGATCAGCGCAGATGCGTTCATCACTCT
GACCGACCGTTCCAAGGATGTCATCAAGTCGGGAGGTGAATGGATCTCGTCAGTCGAACTGGAGAATGAATTGGCCGCTC
ATCCTGCGGTGCGCACCGCCACTGTGATCGGTGTGCCAGACGATAAGTGGCAGGAACGACCGCTGGCAGTGGTCGTCCTC
GATACCGGACGCACCGTTACGGCTAGGGAGCTGTCGGGATTCTTGCGCGACCGTGTGGCCAAGTGGTGGCTACCTGAACG
ATGGGCATTCGTTACTGAAGTTCCACTGACCTCGACAGGCAAGTTTGACAAGAAGAAGTTGCGGCGCCAATACGCCGACG
GTGACTTCATTGTTGAGACGCTCGACTGA

Upstream 100 bases:

>100_bases
GTCGATGTTGCAGAGCGAGAATCGACAGGATCTCATCGATGCGTGACTACCGATCGATGCGTGACTTCCGCTTGACCGCT
GACCGCAGGACGGTGGCGCG

Downstream 100 bases:

>100_bases
ATCGGCCTTCACGGCAACCGAATTATTGATCTAAGGAGAATCATGAAGACACGCGCTGCTGTTCTCTGGGGCCTGGGAGA
GAAGTGGGAGGTAGAGGAAG

Product: long-chain-fatty-acid--CoA ligase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MKSTMQDVPLTVSSIVRHASRIHGERAVLTARGPGQISRVSYRELGERAAQLANALRAIGIRGDERVATLQWSNQEHLEC
YSAVPSMGAVLHTLNLRLPTEQLTWIANHADDRVVIVDGTVLPLLASALPSMTSVRTVLVTGTGDLAAVEGCGKDVLRYD
DVVAAQPSSFDWPDVDERSAAAMCYTSGTTGHPKGVIYSHRSTWLHSQAACASNALGIGHDDTVLTIVPMFHANAWGLPY
AAMMAGAQMLLPDRFLQAEPLVEMIEAARPTMAGAVPTIWTDVLHYLRDNPGHDVSSLKMVACGGSAVPRSLITAYDELG
IRIVQAWGMTETSPLAAVALPRDTDSPERSLQVRGTQGRVVAGVEARIVDDSDAEQPWDGKSVGEIQIRGPWITGSYYQH
DSAAVTPDGWLCTGDVGVISADAFITLTDRSKDVIKSGGEWISSVELENELAAHPAVRTATVIGVPDDKWQERPLAVVVL
DTGRTVTARELSGFLRDRVAKWWLPERWAFVTEVPLTSTGKFDKKKLRRQYADGDFIVETLD

Sequences:

>Translated_542_residues
MKSTMQDVPLTVSSIVRHASRIHGERAVLTARGPGQISRVSYRELGERAAQLANALRAIGIRGDERVATLQWSNQEHLEC
YSAVPSMGAVLHTLNLRLPTEQLTWIANHADDRVVIVDGTVLPLLASALPSMTSVRTVLVTGTGDLAAVEGCGKDVLRYD
DVVAAQPSSFDWPDVDERSAAAMCYTSGTTGHPKGVIYSHRSTWLHSQAACASNALGIGHDDTVLTIVPMFHANAWGLPY
AAMMAGAQMLLPDRFLQAEPLVEMIEAARPTMAGAVPTIWTDVLHYLRDNPGHDVSSLKMVACGGSAVPRSLITAYDELG
IRIVQAWGMTETSPLAAVALPRDTDSPERSLQVRGTQGRVVAGVEARIVDDSDAEQPWDGKSVGEIQIRGPWITGSYYQH
DSAAVTPDGWLCTGDVGVISADAFITLTDRSKDVIKSGGEWISSVELENELAAHPAVRTATVIGVPDDKWQERPLAVVVL
DTGRTVTARELSGFLRDRVAKWWLPERWAFVTEVPLTSTGKFDKKKLRRQYADGDFIVETLD
>Mature_542_residues
MKSTMQDVPLTVSSIVRHASRIHGERAVLTARGPGQISRVSYRELGERAAQLANALRAIGIRGDERVATLQWSNQEHLEC
YSAVPSMGAVLHTLNLRLPTEQLTWIANHADDRVVIVDGTVLPLLASALPSMTSVRTVLVTGTGDLAAVEGCGKDVLRYD
DVVAAQPSSFDWPDVDERSAAAMCYTSGTTGHPKGVIYSHRSTWLHSQAACASNALGIGHDDTVLTIVPMFHANAWGLPY
AAMMAGAQMLLPDRFLQAEPLVEMIEAARPTMAGAVPTIWTDVLHYLRDNPGHDVSSLKMVACGGSAVPRSLITAYDELG
IRIVQAWGMTETSPLAAVALPRDTDSPERSLQVRGTQGRVVAGVEARIVDDSDAEQPWDGKSVGEIQIRGPWITGSYYQH
DSAAVTPDGWLCTGDVGVISADAFITLTDRSKDVIKSGGEWISSVELENELAAHPAVRTATVIGVPDDKWQERPLAVVVL
DTGRTVTARELSGFLRDRVAKWWLPERWAFVTEVPLTSTGKFDKKKLRRQYADGDFIVETLD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=519, Percent_Identity=26.3969171483622, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI187761345, Length=540, Percent_Identity=27.037037037037, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI187761343, Length=540, Percent_Identity=27.037037037037, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI58082049, Length=529, Percent_Identity=24.5746691871456, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI38505220, Length=521, Percent_Identity=23.6084452975048, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI122937307, Length=529, Percent_Identity=23.062381852552, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI157311624, Length=525, Percent_Identity=23.6190476190476, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI157311622, Length=525, Percent_Identity=23.6190476190476, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI28416953, Length=533, Percent_Identity=24.765478424015, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI42544132, Length=514, Percent_Identity=21.4007782101167, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI13375727, Length=569, Percent_Identity=22.4956063268893, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI115511026, Length=364, Percent_Identity=24.4505494505494, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI145693145, Length=500, Percent_Identity=29.6, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI221142682, Length=520, Percent_Identity=26.7307692307692, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI1786810, Length=552, Percent_Identity=27.8985507246377, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788107, Length=515, Percent_Identity=25.8252427184466, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1788595, Length=496, Percent_Identity=25.4032258064516, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789201, Length=367, Percent_Identity=25.0681198910082, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790505, Length=557, Percent_Identity=22.9802513464991, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17559526, Length=539, Percent_Identity=26.530612244898, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17538037, Length=547, Percent_Identity=25.5941499085923, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17531443, Length=550, Percent_Identity=22.5454545454545, Blast_Score=138, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17558820, Length=505, Percent_Identity=24.950495049505, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17557194, Length=558, Percent_Identity=24.3727598566308, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71994703, Length=538, Percent_Identity=24.3494423791822, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71994694, Length=538, Percent_Identity=24.3494423791822, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71994690, Length=538, Percent_Identity=24.3494423791822, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=512, Percent_Identity=25.78125, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17560308, Length=527, Percent_Identity=26.5654648956357, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17560140, Length=508, Percent_Identity=21.6535433070866, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71996755, Length=354, Percent_Identity=24.5762711864407, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71985884, Length=366, Percent_Identity=25.1366120218579, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115534440, Length=520, Percent_Identity=21.3461538461538, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319699, Length=362, Percent_Identity=29.0055248618785, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6323903, Length=520, Percent_Identity=21.5384615384615, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320852, Length=416, Percent_Identity=25, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324893, Length=380, Percent_Identity=22.3684210526316, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI18859661, Length=418, Percent_Identity=28.9473684210526, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24581924, Length=586, Percent_Identity=23.8907849829352, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI21355181, Length=540, Percent_Identity=24.0740740740741, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24656500, Length=510, Percent_Identity=23.1372549019608, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19922652, Length=546, Percent_Identity=21.2454212454212, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24648260, Length=365, Percent_Identity=24.1095890410959, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648257, Length=508, Percent_Identity=23.4251968503937, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356441, Length=520, Percent_Identity=22.6923076923077, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356947, Length=461, Percent_Identity=23.2104121475054, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653035, Length=378, Percent_Identity=22.4867724867725, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI20130357, Length=502, Percent_Identity=20.7171314741036, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281365686, Length=220, Percent_Identity=28.1818181818182, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 58802; Mature: 58802

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTMQDVPLTVSSIVRHASRIHGERAVLTARGPGQISRVSYRELGERAAQLANALRAIG
CCCCCHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHC
IRGDERVATLQWSNQEHLECYSAVPSMGAVLHTLNLRLPTEQLTWIANHADDRVVIVDGT
CCCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHEECCCCHHHHHEEECCCCCEEEEECCC
VLPLLASALPSMTSVRTVLVTGTGDLAAVEGCGKDVLRYDDVVAAQPSSFDWPDVDERSA
HHHHHHHHCCCCCCEEEEEEECCCCEEEHHHCCHHHHHHCCEEECCCCCCCCCCCCCCCC
AAMCYTSGTTGHPKGVIYSHRSTWLHSQAACASNALGIGHDDTVLTIVPMFHANAWGLPY
EEEEEECCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCH
AAMMAGAQMLLPDRFLQAEPLVEMIEAARPTMAGAVPTIWTDVLHYLRDNPGHDVSSLKM
HHHHCCCHHHCCHHHHCCCHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCEEE
VACGGSAVPRSLITAYDELGIRIVQAWGMTETSPLAAVALPRDTDSPERSLQVRGTQGRV
EEECCCHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCE
VAGVEARIVDDSDAEQPWDGKSVGEIQIRGPWITGSYYQHDSAAVTPDGWLCTGDVGVIS
EECEEEEEECCCCCCCCCCCCCCCEEEEECCEEECCCEECCCCEECCCCEEEECCCCEEE
ADAFITLTDRSKDVIKSGGEWISSVELENELAAHPAVRTATVIGVPDDKWQERPLAVVVL
CCEEEEEECCCHHHHHCCCHHHHHEEHHHHHHCCCCEEEEEEEECCCCCCCCCCEEEEEE
DTGRTVTARELSGFLRDRVAKWWLPERWAFVTEVPLTSTGKFDKKKLRRQYADGDFIVET
CCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEE
LD
CC
>Mature Secondary Structure
MKSTMQDVPLTVSSIVRHASRIHGERAVLTARGPGQISRVSYRELGERAAQLANALRAIG
CCCCCHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHC
IRGDERVATLQWSNQEHLECYSAVPSMGAVLHTLNLRLPTEQLTWIANHADDRVVIVDGT
CCCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHEECCCCHHHHHEEECCCCCEEEEECCC
VLPLLASALPSMTSVRTVLVTGTGDLAAVEGCGKDVLRYDDVVAAQPSSFDWPDVDERSA
HHHHHHHHCCCCCCEEEEEEECCCCEEEHHHCCHHHHHHCCEEECCCCCCCCCCCCCCCC
AAMCYTSGTTGHPKGVIYSHRSTWLHSQAACASNALGIGHDDTVLTIVPMFHANAWGLPY
EEEEEECCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCH
AAMMAGAQMLLPDRFLQAEPLVEMIEAARPTMAGAVPTIWTDVLHYLRDNPGHDVSSLKM
HHHHCCCHHHCCHHHHCCCHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCEEE
VACGGSAVPRSLITAYDELGIRIVQAWGMTETSPLAAVALPRDTDSPERSLQVRGTQGRV
EEECCCHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCE
VAGVEARIVDDSDAEQPWDGKSVGEIQIRGPWITGSYYQHDSAAVTPDGWLCTGDVGVIS
EECEEEEEECCCCCCCCCCCCCCCEEEEECCEEECCCEECCCCEECCCCEEEECCCCEEE
ADAFITLTDRSKDVIKSGGEWISSVELENELAAHPAVRTATVIGVPDDKWQERPLAVVVL
CCEEEEEECCCHHHHHCCCHHHHHEEHHHHHHCCCCEEEEEEEECCCCCCCCCCEEEEEE
DTGRTVTARELSGFLRDRVAKWWLPERWAFVTEVPLTSTGKFDKKKLRRQYADGDFIVET
CCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEE
LD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]