Click here to switch to the map view.

The map label for this gene is merR1 [H]

Identifier: 77454715

GI number: 77454715

Start: 145314

End: 145736

Strand: Direct

Name: merR1 [H]

Synonym: pREL1_0148

Alternate gene names: 77454715

Gene position: 145314-145736 (Clockwise)

Preceding gene: 77454710

Following gene: 77454722

Centisome position: 53.51

GC content: 60.28

Gene sequence:

>423_bases
GTGAAAATTGGTGAACTGGCCGCTCGGAGTGGCGTTGCCCCGAAGACGCTGCGTTTCTACGAGGACAGTGGGGTGATTCC
CGTCCCGGTCCGAAAGTCCAACGGCTACCGGGATTTCGGTCCGGAATCTCTTTCGCGTTTGCGGTTCGTCCGCAGCGCCC
AGTCTGCAGGTCTCACCTTGCGAGAGATCCGCCAGATCCTCACCACCCATGACCGCGGGGCGGCTCCTTGTGAGCAGGTC
GTGGAGATGCTCTCGGAGCATCTCTCCCAGGTTCGTGGCAAGATCCGCGAACTTGCCACCCTCGAAACAAACCTTGTTGC
GCTGCTGGGTCGAGCGGAAAGTGGGATTCCGCCGGAAACCGACGATGTCGGTGTGTGCTGGATCCTGGAATCTGAGCCTC
AGGACGGTGTTGCTGAATCGTGA

Upstream 100 bases:

>100_bases
GCGTTCGCCGTCAGCGCGACGACGAGCGGTCCGAGTCACCTGCGGTTCCCGAACGTCATCCATAATGGACATTCCAGTGC
GATGGAAGGTCAAGGATCTC

Downstream 100 bases:

>100_bases
AATCGATTGCGGGTGCACCCCCCTGTTTCAGCAGGTTCGGCGCTCAGCAATGTGATGAGGTGAGCGAAGCGGTTGTAGCG
GTGTTGCCGGTGTGTTGATC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MKIGELAARSGVAPKTLRFYEDSGVIPVPVRKSNGYRDFGPESLSRLRFVRSAQSAGLTLREIRQILTTHDRGAAPCEQV
VEMLSEHLSQVRGKIRELATLETNLVALLGRAESGIPPETDDVGVCWILESEPQDGVAES

Sequences:

>Translated_140_residues
MKIGELAARSGVAPKTLRFYEDSGVIPVPVRKSNGYRDFGPESLSRLRFVRSAQSAGLTLREIRQILTTHDRGAAPCEQV
VEMLSEHLSQVRGKIRELATLETNLVALLGRAESGIPPETDDVGVCWILESEPQDGVAES
>Mature_140_residues
MKIGELAARSGVAPKTLRFYEDSGVIPVPVRKSNGYRDFGPESLSRLRFVRSAQSAGLTLREIRQILTTHDRGAAPCEQV
VEMLSEHLSQVRGKIRELATLETNLVALLGRAESGIPPETDDVGVCWILESEPQDGVAES

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=138, Percent_Identity=31.8840579710145, Blast_Score=70, Evalue=6e-14,
Organism=Escherichia coli, GI1786695, Length=131, Percent_Identity=28.2442748091603, Blast_Score=64, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15301; Mature: 15301

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGELAARSGVAPKTLRFYEDSGVIPVPVRKSNGYRDFGPESLSRLRFVRSAQSAGLTL
CCCHHHHHHCCCCCHHEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCH
REIRQILTTHDRGAAPCEQVVEMLSEHLSQVRGKIRELATLETNLVALLGRAESGIPPET
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DDVGVCWILESEPQDGVAES
CCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKIGELAARSGVAPKTLRFYEDSGVIPVPVRKSNGYRDFGPESLSRLRFVRSAQSAGLTL
CCCHHHHHHCCCCCHHEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCH
REIRQILTTHDRGAAPCEQVVEMLSEHLSQVRGKIRELATLETNLVALLGRAESGIPPET
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DDVGVCWILESEPQDGVAES
CCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]