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The map label for this gene is yrkH [H]

Identifier: 77454710

GI number: 77454710

Start: 139746

End: 141113

Strand: Direct

Name: yrkH [H]

Synonym: pREL1_0143

Alternate gene names: 77454710

Gene position: 139746-141113 (Clockwise)

Preceding gene: 77454709

Following gene: 77454715

Centisome position: 51.46

GC content: 63.3

Gene sequence:

>1368_bases
ATGAGCACGACCGACCCGGACATCGCCATCATTGAAACTTCCAGCCTCGGCGACCGCAGCTATCTGATCAGCCACGACGG
TATCGCCGTGGTGATCGATCCACAACGCGACATCGACCGCGTCCGGGCGCTGGCAGCAGAAAAGAACGCTGTCATCACCC
ACGTGCTGGAAACTCACATCCACAACGACTACGTCACTGGCGGCCTGGAACTTGCGCGCGCCACGGGTGCCGAATACGTC
GTCCCGGACGGCGATCCGGTCGAATACGAGCGCCGAGCAGTCGTCGACGGCGATGTCGTCGACGCGGGATCGACGACGTT
CGAGGTCATGCACACCCCAGGGCATACTCATCACCACGTCAGTTACGTTCTGCACCGGCGCGGCGAGCCGATCGCAATCT
TCACCGGCGGCTCCATGCTCTACGGGTCCACCGGGCGCACTGACCTGCTCGGCTCCGAGCACACTGATGAACTGACCCAC
GCGCAGTACCATTCGGTCCGCCGTATCGCGGCCGAACTGGCCGCTGAGGTGGAGGTCTACCCCACACATGGGTTCGGTAG
CTTCTGTGCCGCAACTCCGACCAGCGGGGACTCATCCACCATCGGTGAACAGCAGCAGTCCAACCCCGCACTGACTCAGG
ACGAACACACCTATGTCGACGAGCTGATCGCGGGCCTGTCTGCATATCCCGCGTACTACGCCCATATGGGCGTCATCAAC
ACCAAAGGGCCGGCCCCGATCGACCTGTCCATGCCCGAGCCCGTCGATCCAGACGAACTACGTCGCCGCATCGACGCCGG
GCAATGGGTCGTTGACCTACGAGCACGCACCGCTTTCGCCGCCGGCCACGTCGATGGCTCTCTCGGGTTCGAACTGTCGA
CCAGCTTCGTCACCTATCTCGGATGGCTTTATCAGTGGGGCGTGCCGTTGACGCTGATCGGTGAAACAACCGACCAGATC
GCCGAGGCGACCCGCGAGCTGGCTCGGATCGGCATCGACAGTCCCTCCGGATCCGCCGTCGGTGAGATTCACTCGCTCGT
CGGCGACGGAAAGGTCCGCTCCTACGATGTATCCGACTTCGCCGGACTCGCGGCGGCCACCGGCGAACGTGAGATAAGCG
TCCTCGATGCGCGTCAACAGTCCGAGTACGCGGACAGCCACCTTCCTGGTGCCGTGAACATCCCCCTCCACGAGCTACCA
CACCGACTCGAGGAAGTTTCCGCGGCCGAAGTGTGGGTGCACTGCGCATCCGGTTACCGCGCATCGATCGCCGCTTCACT
TCTCGACCGCGAACACCGCACAGTGGTCCTCATCGACGATGACTACGAGCATGCCGTGCAGCTCGGCCTCCACACATCGC
CCGCCTGA

Upstream 100 bases:

>100_bases
CCATGACCGAAGCAGAACTGGAAAAGCTCTTCCTGGCGCTGGCCTGAACGCCCGCTTCACATCAGGAACGAGGCCGACCG
ACAACATGTAGGAGCTCCCC

Downstream 100 bases:

>100_bases
CGAATGCGCCGCCGCTGCGCAAGCCGCACGATGCGAGTGGTTCACGGGGCTGATCTCCCCGATTTCAGCAAACGGCCATC
GGATAATTCCGACAGAGGGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSTTDPDIAIIETSSLGDRSYLISHDGIAVVIDPQRDIDRVRALAAEKNAVITHVLETHIHNDYVTGGLELARATGAEYV
VPDGDPVEYERRAVVDGDVVDAGSTTFEVMHTPGHTHHHVSYVLHRRGEPIAIFTGGSMLYGSTGRTDLLGSEHTDELTH
AQYHSVRRIAAELAAEVEVYPTHGFGSFCAATPTSGDSSTIGEQQQSNPALTQDEHTYVDELIAGLSAYPAYYAHMGVIN
TKGPAPIDLSMPEPVDPDELRRRIDAGQWVVDLRARTAFAAGHVDGSLGFELSTSFVTYLGWLYQWGVPLTLIGETTDQI
AEATRELARIGIDSPSGSAVGEIHSLVGDGKVRSYDVSDFAGLAAATGEREISVLDARQQSEYADSHLPGAVNIPLHELP
HRLEEVSAAEVWVHCASGYRASIAASLLDREHRTVVLIDDDYEHAVQLGLHTSPA

Sequences:

>Translated_455_residues
MSTTDPDIAIIETSSLGDRSYLISHDGIAVVIDPQRDIDRVRALAAEKNAVITHVLETHIHNDYVTGGLELARATGAEYV
VPDGDPVEYERRAVVDGDVVDAGSTTFEVMHTPGHTHHHVSYVLHRRGEPIAIFTGGSMLYGSTGRTDLLGSEHTDELTH
AQYHSVRRIAAELAAEVEVYPTHGFGSFCAATPTSGDSSTIGEQQQSNPALTQDEHTYVDELIAGLSAYPAYYAHMGVIN
TKGPAPIDLSMPEPVDPDELRRRIDAGQWVVDLRARTAFAAGHVDGSLGFELSTSFVTYLGWLYQWGVPLTLIGETTDQI
AEATRELARIGIDSPSGSAVGEIHSLVGDGKVRSYDVSDFAGLAAATGEREISVLDARQQSEYADSHLPGAVNIPLHELP
HRLEEVSAAEVWVHCASGYRASIAASLLDREHRTVVLIDDDYEHAVQLGLHTSPA
>Mature_454_residues
STTDPDIAIIETSSLGDRSYLISHDGIAVVIDPQRDIDRVRALAAEKNAVITHVLETHIHNDYVTGGLELARATGAEYVV
PDGDPVEYERRAVVDGDVVDAGSTTFEVMHTPGHTHHHVSYVLHRRGEPIAIFTGGSMLYGSTGRTDLLGSEHTDELTHA
QYHSVRRIAAELAAEVEVYPTHGFGSFCAATPTSGDSSTIGEQQQSNPALTQDEHTYVDELIAGLSAYPAYYAHMGVINT
KGPAPIDLSMPEPVDPDELRRRIDAGQWVVDLRARTAFAAGHVDGSLGFELSTSFVTYLGWLYQWGVPLTLIGETTDQIA
EATRELARIGIDSPSGSAVGEIHSLVGDGKVRSYDVSDFAGLAAATGEREISVLDARQQSEYADSHLPGAVNIPLHELPH
RLEEVSAAEVWVHCASGYRASIAASLLDREHRTVVLIDDDYEHAVQLGLHTSPA

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=247, Percent_Identity=27.5303643724696, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538952, Length=211, Percent_Identity=28.436018957346, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330176, Length=240, Percent_Identity=27.5, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR001763 [H]

Pfam domain/function: PF00753 Lactamase_B; PF00581 Rhodanese [H]

EC number: NA

Molecular weight: Translated: 49138; Mature: 49007

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00380 RHODANESE_1 ; PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTDPDIAIIETSSLGDRSYLISHDGIAVVIDPQRDIDRVRALAAEKNAVITHVLETHI
CCCCCCCEEEEEECCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHH
HNDYVTGGLELARATGAEYVVPDGDPVEYERRAVVDGDVVDAGSTTFEVMHTPGHTHHHV
CCCEECCCHHHHHHCCCCEECCCCCCCCCCCEEEECCCEECCCCCEEEEEECCCCCHHHH
SYVLHRRGEPIAIFTGGSMLYGSTGRTDLLGSEHTDELTHAQYHSVRRIAAELAAEVEVY
HHHHHCCCCEEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEE
PTHGFGSFCAATPTSGDSSTIGEQQQSNPALTQDEHTYVDELIAGLSAYPAYYAHMGVIN
ECCCCCCHHCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCEEE
TKGPAPIDLSMPEPVDPDELRRRIDAGQWVVDLRARTAFAAGHVDGSLGFELSTSFVTYL
CCCCCCEECCCCCCCCHHHHHHHHCCCCEEEEEHHHHEEEECCCCCCCCCCHHHHHHHHH
GWLYQWGVPLTLIGETTDQIAEATRELARIGIDSPSGSAVGEIHSLVGDGKVRSYDVSDF
HHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEECCHHH
AGLAAATGEREISVLDARQQSEYADSHLPGAVNIPLHELPHRLEEVSAAEVWVHCASGYR
HHHHHCCCCCEEEEECCHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCH
ASIAASLLDREHRTVVLIDDDYEHAVQLGLHTSPA
HHHHHHHHCCCCCEEEEEECCHHHHHEECCCCCCC
>Mature Secondary Structure 
STTDPDIAIIETSSLGDRSYLISHDGIAVVIDPQRDIDRVRALAAEKNAVITHVLETHI
CCCCCCEEEEEECCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHH
HNDYVTGGLELARATGAEYVVPDGDPVEYERRAVVDGDVVDAGSTTFEVMHTPGHTHHHV
CCCEECCCHHHHHHCCCCEECCCCCCCCCCCEEEECCCEECCCCCEEEEEECCCCCHHHH
SYVLHRRGEPIAIFTGGSMLYGSTGRTDLLGSEHTDELTHAQYHSVRRIAAELAAEVEVY
HHHHHCCCCEEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEE
PTHGFGSFCAATPTSGDSSTIGEQQQSNPALTQDEHTYVDELIAGLSAYPAYYAHMGVIN
ECCCCCCHHCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCEEE
TKGPAPIDLSMPEPVDPDELRRRIDAGQWVVDLRARTAFAAGHVDGSLGFELSTSFVTYL
CCCCCCEECCCCCCCCHHHHHHHHCCCCEEEEEHHHHEEEECCCCCCCCCCHHHHHHHHH
GWLYQWGVPLTLIGETTDQIAEATRELARIGIDSPSGSAVGEIHSLVGDGKVRSYDVSDF
HHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEECCHHH
AGLAAATGEREISVLDARQQSEYADSHLPGAVNIPLHELPHRLEEVSAAEVWVHCASGYR
HHHHHCCCCCEEEEECCHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCH
ASIAASLLDREHRTVVLIDDDYEHAVQLGLHTSPA
HHHHHHHHCCCCCEEEEEECCHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]