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The map label for this gene is cmcT [H]

Identifier: 77454670

GI number: 77454670

Start: 99891

End: 101312

Strand: Direct

Name: cmcT [H]

Synonym: pREL1_0103

Alternate gene names: 77454670

Gene position: 99891-101312 (Clockwise)

Preceding gene: 77454668

Following gene: 77454671

Centisome position: 36.78

GC content: 59.0

Gene sequence:

>1422_bases
ATGCCTCGAAGTCCGATGAACACCACGCTCGTCGAGGAAAACCGACATCGCTCCGCGAGCATCGCACTCGCAGTGGTGTG
TGCCGCGCAGTTCATGGTTGTTCTTGATATCTCGGTGGTGAATGTTGCTCTGCCGTCCATCCGCGAGAGTCTTGGGTTCG
ACGCTGGCGGATTGGCATGGGTAGTGAATGCCTACGCATTGACCTTTGCGGGCTTCCTGCTGCTCGGTGGCCGTCTGGCG
GATCTTCTGGGGCGCCGACGGGTCTTTTTGATCGGCTTGGCAGTGTTTTCCGGAGCAAGCCTCGCCGGTGGCCTCGTAAA
TTCGGCGTCTCTTCTCGTCGTGGCCAGGGCGGTTCAAGGCTTGGGTGCTGCGATCCTCGCGCCAGCGACGCTAACTGTTT
TGACCGCCACTTTCCCCGAAGGCCCTCGTCGCACTCGTGCACTGGCCACTTGGACGGCGGTGGGCATCGCAGGCGGTACA
GCAGGAAATTTGGTGGGAGGTATCCTCACCGAATATCTGACATGGCGGTCGACGCTGCTGATCAATGTGCCGATCGGGAT
GGCTGCAGTGCTGCTGGCTGTTCGCTATATTGCCGCTGATCGTCCCTCTGGGCCGCGTCCACGACTGGACTTCGCTGGAG
CAGTCTTGGCGACAGCAGGTCTCGGATCCTTGGCTTACGGTATCGCCCAGGCTGCAGATGATGGTTGGTCGGCAAACTCG
ACCATCTCTGGCATTGCGATTGGCGTATCGCTCCTGATCGCCTTCGTCGTCGTCGAAAAATGGGTGACATCGTCACCTCT
GATACCGCTGCATATCTTTCGGAACAGGGCAGTCTCCATCGGCAATGTGATCATGCTGCTGGCTGGAGCATGCCTGAACC
CGATGTGGTACTTCCTGACTCTGTCCATGCAGAATGTACTCGGCTACAGCCCCGTACAAACAGGTCTGGCCTTTCTGCCT
CATACCATTGTCGCGATAGCTATCGGGGTGGGGCTGACTCCCTGGATGATGGGCAGAATTGACGGCCGCTTTCTCATTGC
ATCCGGATCGATCGTGGCTGCTGCAGGATTCTGGGTACAAGCCCAACTCGATACCGACAGCGGTTATGTGCAGGGAATCC
TTCTGCCCGCCATCATCTTCAGCGTCGGGAGTGGAATACTGAACACTCCCATCACTGCTGCTGTCACCTCAGGGATCCCC
GCCGCCGACGCGGGTGCTGCCTCAGGGCTGATGAATACCACCAAACAGATCGGTGGCGCGCTCGGGCTCTCCGTCCTGGT
CACTTATGCAGCTACGAGCAGTCTCGACAAGGACGACCTCCTGGCCTCGTACAACGGTGCGTTCTACGCCATTGCGGCAA
TCATGATCGTGACGGCACTCTGTGCGCTGGCCTTACCGGCGCACAGGGACCACGCAGAATGA

Upstream 100 bases:

>100_bases
CTCCCTGTGTCGGAGGTAGAGCCGGAACTCGACATCTGCAAAAACTCACCTTGGTACGTTTGTATAAGATACAGATGTAC
CAAGTTTTGGGGAGTGGCCT

Downstream 100 bases:

>100_bases
AACCTCTACCCCGCCAAAGATATACAGCTGAGGTCGAGAACTGATCGCGTGCTGTCCGGTTTTGTGAGATATGACGTGCT
GGCCTTGGGAGGCACCGTCA

Product: putative drug resistance efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MPRSPMNTTLVEENRHRSASIALAVVCAAQFMVVLDISVVNVALPSIRESLGFDAGGLAWVVNAYALTFAGFLLLGGRLA
DLLGRRRVFLIGLAVFSGASLAGGLVNSASLLVVARAVQGLGAAILAPATLTVLTATFPEGPRRTRALATWTAVGIAGGT
AGNLVGGILTEYLTWRSTLLINVPIGMAAVLLAVRYIAADRPSGPRPRLDFAGAVLATAGLGSLAYGIAQAADDGWSANS
TISGIAIGVSLLIAFVVVEKWVTSSPLIPLHIFRNRAVSIGNVIMLLAGACLNPMWYFLTLSMQNVLGYSPVQTGLAFLP
HTIVAIAIGVGLTPWMMGRIDGRFLIASGSIVAAAGFWVQAQLDTDSGYVQGILLPAIIFSVGSGILNTPITAAVTSGIP
AADAGAASGLMNTTKQIGGALGLSVLVTYAATSSLDKDDLLASYNGAFYAIAAIMIVTALCALALPAHRDHAE

Sequences:

>Translated_473_residues
MPRSPMNTTLVEENRHRSASIALAVVCAAQFMVVLDISVVNVALPSIRESLGFDAGGLAWVVNAYALTFAGFLLLGGRLA
DLLGRRRVFLIGLAVFSGASLAGGLVNSASLLVVARAVQGLGAAILAPATLTVLTATFPEGPRRTRALATWTAVGIAGGT
AGNLVGGILTEYLTWRSTLLINVPIGMAAVLLAVRYIAADRPSGPRPRLDFAGAVLATAGLGSLAYGIAQAADDGWSANS
TISGIAIGVSLLIAFVVVEKWVTSSPLIPLHIFRNRAVSIGNVIMLLAGACLNPMWYFLTLSMQNVLGYSPVQTGLAFLP
HTIVAIAIGVGLTPWMMGRIDGRFLIASGSIVAAAGFWVQAQLDTDSGYVQGILLPAIIFSVGSGILNTPITAAVTSGIP
AADAGAASGLMNTTKQIGGALGLSVLVTYAATSSLDKDDLLASYNGAFYAIAAIMIVTALCALALPAHRDHAE
>Mature_472_residues
PRSPMNTTLVEENRHRSASIALAVVCAAQFMVVLDISVVNVALPSIRESLGFDAGGLAWVVNAYALTFAGFLLLGGRLAD
LLGRRRVFLIGLAVFSGASLAGGLVNSASLLVVARAVQGLGAAILAPATLTVLTATFPEGPRRTRALATWTAVGIAGGTA
GNLVGGILTEYLTWRSTLLINVPIGMAAVLLAVRYIAADRPSGPRPRLDFAGAVLATAGLGSLAYGIAQAADDGWSANST
ISGIAIGVSLLIAFVVVEKWVTSSPLIPLHIFRNRAVSIGNVIMLLAGACLNPMWYFLTLSMQNVLGYSPVQTGLAFLPH
TIVAIAIGVGLTPWMMGRIDGRFLIASGSIVAAAGFWVQAQLDTDSGYVQGILLPAIIFSVGSGILNTPITAAVTSGIPA
ADAGAASGLMNTTKQIGGALGLSVLVTYAATSSLDKDDLLASYNGAFYAIAAIMIVTALCALALPAHRDHAE

Specific function: Involved in cephamycin export [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=427, Percent_Identity=29.03981264637, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788710, Length=445, Percent_Identity=27.8651685393258, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI87081983, Length=394, Percent_Identity=27.1573604060914, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1790195, Length=421, Percent_Identity=26.603325415677, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1788392, Length=306, Percent_Identity=31.0457516339869, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324954, Length=327, Percent_Identity=26.605504587156, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325455, Length=238, Percent_Identity=28.9915966386555, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323520, Length=431, Percent_Identity=25.2900232018561, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323935, Length=448, Percent_Identity=24.5535714285714, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322958, Length=361, Percent_Identity=23.8227146814404, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321663, Length=151, Percent_Identity=27.1523178807947, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48605; Mature: 48474

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRSPMNTTLVEENRHRSASIALAVVCAAQFMVVLDISVVNVALPSIRESLGFDAGGLAW
CCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VVNAYALTFAGFLLLGGRLADLLGRRRVFLIGLAVFSGASLAGGLVNSASLLVVARAVQG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHCCCHHHCHHHCHHHHHHHHHHHHH
LGAAILAPATLTVLTATFPEGPRRTRALATWTAVGIAGGTAGNLVGGILTEYLTWRSTLL
CCHHHHCCHHEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCEEE
INVPIGMAAVLLAVRYIAADRPSGPRPRLDFAGAVLATAGLGSLAYGIAQAADDGWSANS
EECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCC
TISGIAIGVSLLIAFVVVEKWVTSSPLIPLHIFRNRAVSIGNVIMLLAGACLNPMWYFLT
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LSMQNVLGYSPVQTGLAFLPHTIVAIAIGVGLTPWMMGRIDGRFLIASGSIVAAAGFWVQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCEEEEECEEEE
AQLDTDSGYVQGILLPAIIFSVGSGILNTPITAAVTSGIPAADAGAASGLMNTTKQIGGA
EEECCCCCHHHHHHHHHHHHHHCCCHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LGLSVLVTYAATSSLDKDDLLASYNGAFYAIAAIMIVTALCALALPAHRDHAE
HHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PRSPMNTTLVEENRHRSASIALAVVCAAQFMVVLDISVVNVALPSIRESLGFDAGGLAW
CCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VVNAYALTFAGFLLLGGRLADLLGRRRVFLIGLAVFSGASLAGGLVNSASLLVVARAVQG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHCCCHHHCHHHCHHHHHHHHHHHHH
LGAAILAPATLTVLTATFPEGPRRTRALATWTAVGIAGGTAGNLVGGILTEYLTWRSTLL
CCHHHHCCHHEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCEEE
INVPIGMAAVLLAVRYIAADRPSGPRPRLDFAGAVLATAGLGSLAYGIAQAADDGWSANS
EECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCC
TISGIAIGVSLLIAFVVVEKWVTSSPLIPLHIFRNRAVSIGNVIMLLAGACLNPMWYFLT
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LSMQNVLGYSPVQTGLAFLPHTIVAIAIGVGLTPWMMGRIDGRFLIASGSIVAAAGFWVQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCEEEEECEEEE
AQLDTDSGYVQGILLPAIIFSVGSGILNTPITAAVTSGIPAADAGAASGLMNTTKQIGGA
EEECCCCCHHHHHHHHHHHHHHCCCHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LGLSVLVTYAATSSLDKDDLLASYNGAFYAIAAIMIVTALCALALPAHRDHAE
HHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]