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The map label for this gene is ggt [H]

Identifier: 75674360

GI number: 75674360

Start: 187584

End: 189338

Strand: Direct

Name: ggt [H]

Synonym: Nwi_0161

Alternate gene names: 75674360

Gene position: 187584-189338 (Clockwise)

Preceding gene: 75674358

Following gene: 75674361

Centisome position: 5.51

GC content: 66.67

Gene sequence:

>1755_bases
ATGATCCGCCGCGAGATACGCCGGTACGTATTTTTCCTGTTTGCGATGAGTGTAATCGTCGCATGGACGCCGTTGTCGTC
GCTCGCCTTCGCGCAGGATGCGCGCGGCGCGGTCCCGGCGGTGACCTCCGACGCGATTCGTCCGGTCGCCGCCAAACACG
GCATGGTGGTGGCGCAGGAGCGGCTCGCGGCCAGGATCGGCGCTGACGTACTCGCGCAGGGCGGCAATGCCGTCGATGCG
GCGGTCGCGACCGGTTTCGCCCTGGCGGTCACCTATCCGCGCGCCGGAAACATCGGCGGCGGCGGGTTCATGCTGATTCA
CCTGGCCGATTCCAGCCGTGACATCGCCATCGATTATCGCGAGACCGCGCCAGGCGCGACCGGACGCGACATCTTCCTCG
GCGCCGACGGCAAGCCCGACCCGGCGAAGTCGCGTGATTCCGCGCTCGGCATCGGCGTGCCCGGCACCGTCGCGGGACTG
GCGCTGGCGCTCGACAGATACGGCTCCGGCAGGTTCACGCTTGCCCGCCTTCTTCAGCCCGCGATCACGCTGGCGCGCGA
GGGGATCACGGTAGCCGACGACAGCGCCGACACGTTGTCGGGGTCGCATGACCGTCTTGCGCGCTGGCCGTCCTCGATGA
AGATTTTCGCGCGTCCCGACGGCGCCGCCTTGCGCGAGGGCGATCGGCTGGTCCAGACCGATCTGGCCGCGACCCTGACC
GCGATCGCCGGGCAGGGGCCGCAAGGTTTTTATGAAGGTCCGGTGGCTTCGAAGCTGGTGAAGGGGATCGGCGCGGCCGG
CGGAATCATGACGCTTGAGGACCTCAAGTCCTATCGGCCGCTGATCCGGGAGCCGGTGCGGGGCAGGTATCGGGGCTATG
ACATCATCTCGATGCCGCTATCATCGTCCGGCGGCACCGTGCTCCTCGAATCGCTGAACATCCTCGAAGGCTTCCCGATG
CGCGACCTGCATCAGGGATCGCCGGATTCGCTGCATGTGCTGGTCGAGGCGATGAAGCGCGCCTATGCGGATCGCGCGCG
CCATCTCGGCGATCCCGCTTTCGTCAACGCTCCGGTTACGACCCTGCTTGCGAAAGACTACGCCGCGAAACAGCGCGCCT
CGATCGACATGATGAACGCGACGCCGGCCGACGCCGTGCTCGCGTCGCCCCGCGAAGGAGACAACACCACGCATTTCTCC
GTGGCCGACGCCTTCGGCAATGTCGTCAGCAACACCTACACGCTGAACTTCAGCTATGGCGTCGGACTGGTGGCGGAGGG
CACCGGCGTCCTGCTCAACAACGAGCTTGACGATTTTACCGCAGCACCCGGCGCGGCGAACGCCTTCGGTCTGGTCGGGT
TCGAGGCCAACCTGCCCGGTCCCGGCAAGCGGCCGCTGTCCTCGATGACGCCGACCATCGTTCTGAAGGACGGCAAGCCG
GTGCTGGCGACGGGATCGCCCGGCGGCAGCCGCATCGTCTCCACGGTGCTTCAGGTGATCGTCAACGTGCTCGATTACGA
TATGAACATCGCCGCCGCCGTTCAGGCGCCGCGGCTGCATCATCAGTGGCTGCCGGATGAAGTCCGCGCCGAAGAAGGAT
TTCCCGATGGCGTCATCGCGGAATTGAGGGCGCGAGGCCACACCGTCGTTGTCCCGATGGGACAGACCTCGGCCAACTCC
ATCGCCATCACCCCGGATGGCTTGTTCGGCGCGCCGGATCCGCGGACCCGCGGGTCAAGCGCCGCCGGATATTGA

Upstream 100 bases:

>100_bases
ATGTTCCGTCGAATCGCGTGAGGCGTCTGACCCTGCGCCTCAATTCCTATAGCATCGTTCCTGTTAACGACAACGAATCC
TCCAGATACGGGACCAATGG

Downstream 100 bases:

>100_bases
GGTGATGACCTGCGCGGGCGCTGAGCCTCCACAAGGATTCGATCATGATGACCACGCAACCGCTGTGGCGGGCGTATGTC
CTCTTCCTGATGCCGATGAT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MIRREIRRYVFFLFAMSVIVAWTPLSSLAFAQDARGAVPAVTSDAIRPVAAKHGMVVAQERLAARIGADVLAQGGNAVDA
AVATGFALAVTYPRAGNIGGGGFMLIHLADSSRDIAIDYRETAPGATGRDIFLGADGKPDPAKSRDSALGIGVPGTVAGL
ALALDRYGSGRFTLARLLQPAITLAREGITVADDSADTLSGSHDRLARWPSSMKIFARPDGAALREGDRLVQTDLAATLT
AIAGQGPQGFYEGPVASKLVKGIGAAGGIMTLEDLKSYRPLIREPVRGRYRGYDIISMPLSSSGGTVLLESLNILEGFPM
RDLHQGSPDSLHVLVEAMKRAYADRARHLGDPAFVNAPVTTLLAKDYAAKQRASIDMMNATPADAVLASPREGDNTTHFS
VADAFGNVVSNTYTLNFSYGVGLVAEGTGVLLNNELDDFTAAPGAANAFGLVGFEANLPGPGKRPLSSMTPTIVLKDGKP
VLATGSPGGSRIVSTVLQVIVNVLDYDMNIAAAVQAPRLHHQWLPDEVRAEEGFPDGVIAELRARGHTVVVPMGQTSANS
IAITPDGLFGAPDPRTRGSSAAGY

Sequences:

>Translated_584_residues
MIRREIRRYVFFLFAMSVIVAWTPLSSLAFAQDARGAVPAVTSDAIRPVAAKHGMVVAQERLAARIGADVLAQGGNAVDA
AVATGFALAVTYPRAGNIGGGGFMLIHLADSSRDIAIDYRETAPGATGRDIFLGADGKPDPAKSRDSALGIGVPGTVAGL
ALALDRYGSGRFTLARLLQPAITLAREGITVADDSADTLSGSHDRLARWPSSMKIFARPDGAALREGDRLVQTDLAATLT
AIAGQGPQGFYEGPVASKLVKGIGAAGGIMTLEDLKSYRPLIREPVRGRYRGYDIISMPLSSSGGTVLLESLNILEGFPM
RDLHQGSPDSLHVLVEAMKRAYADRARHLGDPAFVNAPVTTLLAKDYAAKQRASIDMMNATPADAVLASPREGDNTTHFS
VADAFGNVVSNTYTLNFSYGVGLVAEGTGVLLNNELDDFTAAPGAANAFGLVGFEANLPGPGKRPLSSMTPTIVLKDGKP
VLATGSPGGSRIVSTVLQVIVNVLDYDMNIAAAVQAPRLHHQWLPDEVRAEEGFPDGVIAELRARGHTVVVPMGQTSANS
IAITPDGLFGAPDPRTRGSSAAGY
>Mature_584_residues
MIRREIRRYVFFLFAMSVIVAWTPLSSLAFAQDARGAVPAVTSDAIRPVAAKHGMVVAQERLAARIGADVLAQGGNAVDA
AVATGFALAVTYPRAGNIGGGGFMLIHLADSSRDIAIDYRETAPGATGRDIFLGADGKPDPAKSRDSALGIGVPGTVAGL
ALALDRYGSGRFTLARLLQPAITLAREGITVADDSADTLSGSHDRLARWPSSMKIFARPDGAALREGDRLVQTDLAATLT
AIAGQGPQGFYEGPVASKLVKGIGAAGGIMTLEDLKSYRPLIREPVRGRYRGYDIISMPLSSSGGTVLLESLNILEGFPM
RDLHQGSPDSLHVLVEAMKRAYADRARHLGDPAFVNAPVTTLLAKDYAAKQRASIDMMNATPADAVLASPREGDNTTHFS
VADAFGNVVSNTYTLNFSYGVGLVAEGTGVLLNNELDDFTAAPGAANAFGLVGFEANLPGPGKRPLSSMTPTIVLKDGKP
VLATGSPGGSRIVSTVLQVIVNVLDYDMNIAAAVQAPRLHHQWLPDEVRAEEGFPDGVIAELRARGHTVVVPMGQTSANS
IAITPDGLFGAPDPRTRGSSAAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=541, Percent_Identity=35.4898336414048, Blast_Score=269, Evalue=6e-72,
Organism=Homo sapiens, GI73915090, Length=541, Percent_Identity=35.4898336414048, Blast_Score=269, Evalue=6e-72,
Organism=Homo sapiens, GI73915096, Length=541, Percent_Identity=35.4898336414048, Blast_Score=269, Evalue=6e-72,
Organism=Homo sapiens, GI73915094, Length=541, Percent_Identity=35.4898336414048, Blast_Score=269, Evalue=6e-72,
Organism=Homo sapiens, GI113429324, Length=542, Percent_Identity=34.3173431734317, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI113429326, Length=546, Percent_Identity=33.5164835164835, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI109148539, Length=520, Percent_Identity=32.8846153846154, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI153266885, Length=557, Percent_Identity=28.9048473967684, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI153266901, Length=558, Percent_Identity=29.0322580645161, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI153266907, Length=557, Percent_Identity=28.0071813285458, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI30581157, Length=192, Percent_Identity=37.5, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI30581155, Length=192, Percent_Identity=37.5, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI218505805, Length=229, Percent_Identity=33.1877729257642, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI310124095, Length=228, Percent_Identity=31.140350877193, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1789856, Length=549, Percent_Identity=49.3624772313297, Blast_Score=518, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17506189, Length=551, Percent_Identity=32.6678765880218, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI212646519, Length=499, Percent_Identity=35.2705410821643, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI72000294, Length=499, Percent_Identity=35.2705410821643, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI193208245, Length=530, Percent_Identity=31.6981132075472, Blast_Score=225, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI193208247, Length=530, Percent_Identity=31.6981132075472, Blast_Score=224, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI17542894, Length=617, Percent_Identity=29.3354943273906, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17564448, Length=423, Percent_Identity=26.7139479905437, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI72001497, Length=234, Percent_Identity=25.2136752136752, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI72001495, Length=234, Percent_Identity=25.2136752136752, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323330, Length=560, Percent_Identity=30.7142857142857, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI161077496, Length=499, Percent_Identity=33.8677354709419, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI18859893, Length=541, Percent_Identity=33.641404805915, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI45551474, Length=546, Percent_Identity=29.4871794871795, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI161077878, Length=546, Percent_Identity=29.4871794871795, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI161077880, Length=546, Percent_Identity=29.4871794871795, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24642670, Length=546, Percent_Identity=29.4871794871795, Blast_Score=195, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24642666, Length=546, Percent_Identity=29.4871794871795, Blast_Score=195, Evalue=8e-50,
Organism=Drosophila melanogaster, GI18859741, Length=508, Percent_Identity=29.3307086614173, Blast_Score=172, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61102; Mature: 61102

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRREIRRYVFFLFAMSVIVAWTPLSSLAFAQDARGAVPAVTSDAIRPVAAKHGMVVAQE
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEEHHHH
RLAARIGADVLAQGGNAVDAAVATGFALAVTYPRAGNIGGGGFMLIHLADSSRDIAIDYR
HHHHHHCHHHHHCCCCCHHHHHHCCEEEEEECCCCCCCCCCCEEEEEEECCCCEEEEEEC
ETAPGATGRDIFLGADGKPDPAKSRDSALGIGVPGTVAGLALALDRYGSGRFTLARLLQP
CCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
AITLAREGITVADDSADTLSGSHDRLARWPSSMKIFARPDGAALREGDRLVQTDLAATLT
HHHHHHCCCEEECCCCHHCCCCHHHHHHCCCCCEEEECCCCCHHHCCCHHHHHHHHHHHH
AIAGQGPQGFYEGPVASKLVKGIGAAGGIMTLEDLKSYRPLIREPVRGRYRGYDIISMPL
HHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCEEEEECC
SSSGGTVLLESLNILEGFPMRDLHQGSPDSLHVLVEAMKRAYADRARHLGDPAFVNAPVT
CCCCCEEEEEHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHH
TLLAKDYAAKQRASIDMMNATPADAVLASPREGDNTTHFSVADAFGNVVSNTYTLNFSYG
HHHHHHHHHHHHCCEEECCCCCCHHHEECCCCCCCCEEEEHHHHHHHHHCCEEEEEEECC
VGLVAEGTGVLLNNELDDFTAAPGAANAFGLVGFEANLPGPGKRPLSSMTPTIVLKDGKP
CEEEECCCEEEECCCCCHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCE
VLATGSPGGSRIVSTVLQVIVNVLDYDMNIAAAVQAPRLHHQWLPDEVRAEEGFPDGVIA
EEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCCCHHHHHCCCCCCHHHH
ELRARGHTVVVPMGQTSANSIAITPDGLFGAPDPRTRGSSAAGY
HHHHCCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIRREIRRYVFFLFAMSVIVAWTPLSSLAFAQDARGAVPAVTSDAIRPVAAKHGMVVAQE
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEEHHHH
RLAARIGADVLAQGGNAVDAAVATGFALAVTYPRAGNIGGGGFMLIHLADSSRDIAIDYR
HHHHHHCHHHHHCCCCCHHHHHHCCEEEEEECCCCCCCCCCCEEEEEEECCCCEEEEEEC
ETAPGATGRDIFLGADGKPDPAKSRDSALGIGVPGTVAGLALALDRYGSGRFTLARLLQP
CCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
AITLAREGITVADDSADTLSGSHDRLARWPSSMKIFARPDGAALREGDRLVQTDLAATLT
HHHHHHCCCEEECCCCHHCCCCHHHHHHCCCCCEEEECCCCCHHHCCCHHHHHHHHHHHH
AIAGQGPQGFYEGPVASKLVKGIGAAGGIMTLEDLKSYRPLIREPVRGRYRGYDIISMPL
HHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCEEEEECC
SSSGGTVLLESLNILEGFPMRDLHQGSPDSLHVLVEAMKRAYADRARHLGDPAFVNAPVT
CCCCCEEEEEHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHH
TLLAKDYAAKQRASIDMMNATPADAVLASPREGDNTTHFSVADAFGNVVSNTYTLNFSYG
HHHHHHHHHHHHCCEEECCCCCCHHHEECCCCCCCCEEEEHHHHHHHHHCCEEEEEEECC
VGLVAEGTGVLLNNELDDFTAAPGAANAFGLVGFEANLPGPGKRPLSSMTPTIVLKDGKP
CEEEECCCEEEECCCCCHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCE
VLATGSPGGSRIVSTVLQVIVNVLDYDMNIAAAVQAPRLHHQWLPDEVRAEEGFPDGVIA
EEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCCCHHHHHCCCCCCHHHH
ELRARGHTVVVPMGQTSANSIAITPDGLFGAPDPRTRGSSAAGY
HHHHCCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]