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The map label for this gene is coaE

Identifier: 75674303

GI number: 75674303

Start: 124101

End: 124700

Strand: Direct

Name: coaE

Synonym: Nwi_0104

Alternate gene names: 75674303

Gene position: 124101-124700 (Clockwise)

Preceding gene: 75674302

Following gene: 75674304

Centisome position: 3.65

GC content: 60.67

Gene sequence:

>600_bases
ATGCTGGTGATTGGGCTGACCGGCTCGATCGGAATGGGGAAATCGACCACCGCCCGACTTTTCTCGGAAGCGGGAGTTCC
GGTTTACGACGCGGACGCGACCGTTCACGCCATCTACGAAGGAGAGGCGGCTTTCCTGGTCGAGGCCGCGTTTCCGGGAA
CAACCGTCAACGGCAAGGTCGACCGTGAAAAATTGTCGGCGAAGGTCGTGCACGACGCCGCAGCCATGAAGCGGCTCGAG
CAGATCGTACATCCCCTGCTCTACGATTACCGTCAGGCGTTTCTTCAGCAGGCCGAACGATCAGGTGCCGCGGTGGCGGT
GATCGACGTGCCGTTGCTGTTTGAAACCGGGGGCGAACGGTCAGTCGATGCCGTTGTTGTCGTCACGACAACGCCTGAAA
TTCAGCGTGAACGCATTCTGGCGCGCGGCAATATGACGAGCGAAAAGCTGAAGGCTATCCAGGCCCGCCAGTTGCCGGAC
GCCGAAAAGCGCAAGCGGGCGGATTTCGTAGTGGATACCTCGCACGGTGTCGATGCTGTGCGCACGCAAATCCGCGAAAT
TCTGGCAGCGGCTGCTAAGATGCCGCGACGGCGGTCCTGA

Upstream 100 bases:

>100_bases
GAGGGAGACCATTTCACGATCCTGGGCTTGCCGCTGTTGCCGTTGCTTGCTTATCTGCGTTCTCAGTGGCTGCTATCGTT
GTGACAGCGGACGTTCGAAT

Downstream 100 bases:

>100_bases
ATCACGGGAGCGTTTCCGCTCTGACGGAATCAATGCGGACTCCAGCATTTTGATTTGACGTGTTTCTTCACGCGAACCGG
ATTCCACTTCGCTAGATAAC

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MLVIGLTGSIGMGKSTTARLFSEAGVPVYDADATVHAIYEGEAAFLVEAAFPGTTVNGKVDREKLSAKVVHDAAAMKRLE
QIVHPLLYDYRQAFLQQAERSGAAVAVIDVPLLFETGGERSVDAVVVVTTTPEIQRERILARGNMTSEKLKAIQARQLPD
AEKRKRADFVVDTSHGVDAVRTQIREILAAAAKMPRRRS

Sequences:

>Translated_199_residues
MLVIGLTGSIGMGKSTTARLFSEAGVPVYDADATVHAIYEGEAAFLVEAAFPGTTVNGKVDREKLSAKVVHDAAAMKRLE
QIVHPLLYDYRQAFLQQAERSGAAVAVIDVPLLFETGGERSVDAVVVVTTTPEIQRERILARGNMTSEKLKAIQARQLPD
AEKRKRADFVVDTSHGVDAVRTQIREILAAAAKMPRRRS
>Mature_199_residues
MLVIGLTGSIGMGKSTTARLFSEAGVPVYDADATVHAIYEGEAAFLVEAAFPGTTVNGKVDREKLSAKVVHDAAAMKRLE
QIVHPLLYDYRQAFLQQAERSGAAVAVIDVPLLFETGGERSVDAVVVVTTTPEIQRERILARGNMTSEKLKAIQARQLPD
AEKRKRADFVVDTSHGVDAVRTQIREILAAAAKMPRRRS

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=192, Percent_Identity=27.6041666666667, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI191252795, Length=192, Percent_Identity=27.6041666666667, Blast_Score=68, Evalue=4e-12,
Organism=Escherichia coli, GI1786292, Length=186, Percent_Identity=30.1075268817204, Blast_Score=70, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17554944, Length=211, Percent_Identity=27.9620853080569, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320402, Length=200, Percent_Identity=29, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644728, Length=189, Percent_Identity=30.6878306878307, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_NITWN (Q3SWG9)

Other databases:

- EMBL:   CP000115
- RefSeq:   YP_316724.1
- ProteinModelPortal:   Q3SWG9
- SMR:   Q3SWG9
- STRING:   Q3SWG9
- GeneID:   3674304
- GenomeReviews:   CP000115_GR
- KEGG:   nwi:Nwi_0104
- NMPDR:   fig|323098.3.peg.493
- eggNOG:   COG0237
- HOGENOM:   HBG650290
- OMA:   LSAKVVH
- ProtClustDB:   PRK00081
- BioCyc:   NWIN323098:NWI_0104-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 21613; Mature: 21613

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS51219 DPCK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVIGLTGSIGMGKSTTARLFSEAGVPVYDADATVHAIYEGEAAFLVEAAFPGTTVNGKV
CEEEEECCCCCCCCHHHHHHHHHCCCEEEECCCEEEEEEECCEEEEEEECCCCCCCCCCC
DREKLSAKVVHDAAAMKRLEQIVHPLLYDYRQAFLQQAERSGAAVAVIDVPLLFETGGER
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCC
SVDAVVVVTTTPEIQRERILARGNMTSEKLKAIQARQLPDAEKRKRADFVVDTSHGVDAV
CCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHCCCEEEECCCCHHHH
RTQIREILAAAAKMPRRRS
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLVIGLTGSIGMGKSTTARLFSEAGVPVYDADATVHAIYEGEAAFLVEAAFPGTTVNGKV
CEEEEECCCCCCCCHHHHHHHHHCCCEEEECCCEEEEEEECCEEEEEEECCCCCCCCCCC
DREKLSAKVVHDAAAMKRLEQIVHPLLYDYRQAFLQQAERSGAAVAVIDVPLLFETGGER
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCC
SVDAVVVVTTTPEIQRERILARGNMTSEKLKAIQARQLPDAEKRKRADFVVDTSHGVDAV
CCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHCCCEEEECCCCHHHH
RTQIREILAAAAKMPRRRS
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA