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The map label for this gene is divL [H]

Identifier: 75674244

GI number: 75674244

Start: 50291

End: 52807

Strand: Direct

Name: divL [H]

Synonym: Nwi_0045

Alternate gene names: 75674244

Gene position: 50291-52807 (Clockwise)

Preceding gene: 75674243

Following gene: 75674245

Centisome position: 1.48

GC content: 66.98

Gene sequence:

>2517_bases
ATGTCAGGCGTAATCGGGGTGATGCGTCGGACCTTGCTGTCATGCACCTCGCTGGTGCCGGGCGGCATCGCGGGCGCCGG
CGCGGTCAGCCTCATCGACACCTCACCTGCCTGGGCCGCAGAACCGGCGCTGAACGAGCGGCTGATCCAGGCCTTCATGA
ATCTCAGCCGACAGGATCTGACGGCGCTGGCGATGGCGCTTGGCGTGCTGAGCTTCTCGGTGGTCGCCGCTATCCTGCTG
ATGCGCACGCGCATCCGCGCCGCCGCAAATGAGCAGCGTTTGCGCAGCGAGCTCCGCGAACTTCAATCGGAGGCCGACCG
TTTTCGCGCGCTGCTGTTCGTGGAACCGCAGATTCTGATTTCGTGGGGCGCGGGCGAGGAACGGCCCCAGATCAGCGGCG
ATATCGCGCTGCTGTTGCCGCAGGATGCAAAACAGCCCTTGCGGATTCTGGCGTTCGGAACCTGGCTGCCGCCCGAGCCG
GCGTTGCAGATGGATCACGCGGTCGATGCGCTGCGCAGCGCCGGAGAAGGTTTCCTGCTCAATCTGGTCACCTCGGCCGG
CCGCACCGTGGAAGCGATGGGCCGCGCCATCGGCGGCCAGGCCATCGTGCGCATCCGTGATCTCGGCGGCCTGCGGCGCG
ACCTCGCCGAGATGACGCTGCGGCACGACAGTCTGCTGGCGGAGACGGAAATGCTGCGGGCCTTCGCGACCGCGGCGCCC
TGGCCGCTCTGGGCGAGAGGCAAGGACGGCAAGCTTTCCTTCGCCAACCAGGCCTATGCGCGCGCTACCGAGGCCGCCGA
CTCGGCCGACGCCATCCAGCGCAACCTCGAACTGCTCGACAGCGAGGACCGGACCGCGATGTCGCGGGCGCTGAACGACC
ATGCCACCTTTGCCGCGCGATTGCCGATCATCATCGGCGGCGAGCGGCGCATGTACGACGTTCACGCACTCCGGACCGGC
GGCGGAAGCGCCGGCATCGCGCTCGACGCCAGCGAGGCGACGGCGCTGAGCGGGGCGCTGGCGCGGATGGCGGACGCGCA
TCGCCGGACCCTCGACCAACTGTCATCCGGCGTCGCCGTGTTCGACGGCCAGCGGCGGCTCGCTTTCTACAACGACTCCT
ACCGCCGGCTGTGGGACCTCGACCGGCCCTTCCTCGACGGACATCCCGACGATTCCAGCGTGCTCGATCGCCTGCGCGCG
GGGCGCAAGTTGCCGGAGCAGCCCGACTTCCGCGCCTGGAAAGCCCGCCTGCACGAAGCCTATCGCGCCAACGAGGCCGT
CAAGGACGTATGGTATCTGCCGGACGGACGCGCGCTCAGCATCGTCACCACGCCGAATCCGGAAGGCGGCGTCACCTATC
TGTTCGACGATGTCACCGAAAGCCTGGATCTGGCCCGCCGATATGACCGGCTTATCAACGTGCAGCGCGAGACCCTCGAC
AGCCTGACCGAAGCGGTCGCGGTGTTCGGCAGCAACGGCCGCGCGCAGCTTTTCAATCCGGCCTTCGCGCGGATGTGGAA
GCTTTCGCCCGAGGCGCTGGCGCAGCAGCCGCATATCGATACGGTCGAGGCGTGGTGCAAGCCGCTGTTCGACGACGACG
ACGCCTGGCGGACGATCCACAAGGCCGTCACCGGCATCGACAATCGCACCGCGGTGCCGCTCAAGCTCGAGCGCAAGGAC
GGCAGCATCCTGGACTGCATGACCATGCCGCTGCCCGACGGCGCCACCATGCTGACCTTCCACGACATCACCGATAGCGA
GAACGTGGAGCGCGCGCTGCGCGAACGCAACGATGCGCTCGAGGCCGCCGACCAGATGAAGGTCGATTTCGTCCACCACG
TCTCATACGAACTGCGCTCGCCCCTGACGACCATCATCGGCTTCGCGCACCTCATGAACGATCCCGGCACCGGACCGCTC
ACCGAGAAGCAGGCCGAATATGTCAACTACATCACCTCGTCGACCGACGCGCTGCTGGCGCTGACCAACAACATCCTCGA
CCTCGCCACCATCGATGCGGGCGCCATGACGCTCGAACTCGGGCCGGTCGACGTCCGCAAGACCATCGCGGCGGCGGCGG
AAGGCATTCAGGACCGGCTGACCCGCGACCGCATCGTGCTGAATGTCGACGTCGATCCGGACATCGGCGACTTCATCGGC
GACGAGCGCCGCATCATTCAGGTCCTCTATAATCTACTTGCCAACGCCGCGGGCTTCTCGCCACCGGACGCCGTGATCAC
GGTCAGCGCCCGGCGCACCGAACACAGCGTGAGGTTCGCCGTGATGGACGAAGGCCCCGGCATTCCGCCGGACGTCAGGG
ACAAGGCGTTCGACTGGTTCGAAAGTTACGCGAACGGATCGCGGCATCGCGGCGCGGGCCTTGGCCTCTCGCTGGTGCGC
TCCTTCGTTGAACTCCACGGCGGACGCGTGCATTTCGATCCCGCCATCAAGAGCGGGACCAGGGTCGTTTGCGACTTTCC
GCTCGACCGGGGCGCCCACCGGAACGCCGCCGAATGA

Upstream 100 bases:

>100_bases
GGACTCTAGCCCCTCGAATCCGCTTAAGCATAATGGTGGTCGATTCGTGAACGGCGAACGGGTTGCCGATCGAATATCAT
CGCGCGGTTTTGGGGCAAAG

Downstream 100 bases:

>100_bases
GCGAGCCGTCGAGATTCGCGACCGCGCTCGTCAACGAGACCGCGACCGCGCATCTGATGGCCGACCTCGCACTGCTGATC
GGTCCCGGCGACGTCATCAC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 838; Mature: 837

Protein sequence:

>838_residues
MSGVIGVMRRTLLSCTSLVPGGIAGAGAVSLIDTSPAWAAEPALNERLIQAFMNLSRQDLTALAMALGVLSFSVVAAILL
MRTRIRAAANEQRLRSELRELQSEADRFRALLFVEPQILISWGAGEERPQISGDIALLLPQDAKQPLRILAFGTWLPPEP
ALQMDHAVDALRSAGEGFLLNLVTSAGRTVEAMGRAIGGQAIVRIRDLGGLRRDLAEMTLRHDSLLAETEMLRAFATAAP
WPLWARGKDGKLSFANQAYARATEAADSADAIQRNLELLDSEDRTAMSRALNDHATFAARLPIIIGGERRMYDVHALRTG
GGSAGIALDASEATALSGALARMADAHRRTLDQLSSGVAVFDGQRRLAFYNDSYRRLWDLDRPFLDGHPDDSSVLDRLRA
GRKLPEQPDFRAWKARLHEAYRANEAVKDVWYLPDGRALSIVTTPNPEGGVTYLFDDVTESLDLARRYDRLINVQRETLD
SLTEAVAVFGSNGRAQLFNPAFARMWKLSPEALAQQPHIDTVEAWCKPLFDDDDAWRTIHKAVTGIDNRTAVPLKLERKD
GSILDCMTMPLPDGATMLTFHDITDSENVERALRERNDALEAADQMKVDFVHHVSYELRSPLTTIIGFAHLMNDPGTGPL
TEKQAEYVNYITSSTDALLALTNNILDLATIDAGAMTLELGPVDVRKTIAAAAEGIQDRLTRDRIVLNVDVDPDIGDFIG
DERRIIQVLYNLLANAAGFSPPDAVITVSARRTEHSVRFAVMDEGPGIPPDVRDKAFDWFESYANGSRHRGAGLGLSLVR
SFVELHGGRVHFDPAIKSGTRVVCDFPLDRGAHRNAAE

Sequences:

>Translated_838_residues
MSGVIGVMRRTLLSCTSLVPGGIAGAGAVSLIDTSPAWAAEPALNERLIQAFMNLSRQDLTALAMALGVLSFSVVAAILL
MRTRIRAAANEQRLRSELRELQSEADRFRALLFVEPQILISWGAGEERPQISGDIALLLPQDAKQPLRILAFGTWLPPEP
ALQMDHAVDALRSAGEGFLLNLVTSAGRTVEAMGRAIGGQAIVRIRDLGGLRRDLAEMTLRHDSLLAETEMLRAFATAAP
WPLWARGKDGKLSFANQAYARATEAADSADAIQRNLELLDSEDRTAMSRALNDHATFAARLPIIIGGERRMYDVHALRTG
GGSAGIALDASEATALSGALARMADAHRRTLDQLSSGVAVFDGQRRLAFYNDSYRRLWDLDRPFLDGHPDDSSVLDRLRA
GRKLPEQPDFRAWKARLHEAYRANEAVKDVWYLPDGRALSIVTTPNPEGGVTYLFDDVTESLDLARRYDRLINVQRETLD
SLTEAVAVFGSNGRAQLFNPAFARMWKLSPEALAQQPHIDTVEAWCKPLFDDDDAWRTIHKAVTGIDNRTAVPLKLERKD
GSILDCMTMPLPDGATMLTFHDITDSENVERALRERNDALEAADQMKVDFVHHVSYELRSPLTTIIGFAHLMNDPGTGPL
TEKQAEYVNYITSSTDALLALTNNILDLATIDAGAMTLELGPVDVRKTIAAAAEGIQDRLTRDRIVLNVDVDPDIGDFIG
DERRIIQVLYNLLANAAGFSPPDAVITVSARRTEHSVRFAVMDEGPGIPPDVRDKAFDWFESYANGSRHRGAGLGLSLVR
SFVELHGGRVHFDPAIKSGTRVVCDFPLDRGAHRNAAE
>Mature_837_residues
SGVIGVMRRTLLSCTSLVPGGIAGAGAVSLIDTSPAWAAEPALNERLIQAFMNLSRQDLTALAMALGVLSFSVVAAILLM
RTRIRAAANEQRLRSELRELQSEADRFRALLFVEPQILISWGAGEERPQISGDIALLLPQDAKQPLRILAFGTWLPPEPA
LQMDHAVDALRSAGEGFLLNLVTSAGRTVEAMGRAIGGQAIVRIRDLGGLRRDLAEMTLRHDSLLAETEMLRAFATAAPW
PLWARGKDGKLSFANQAYARATEAADSADAIQRNLELLDSEDRTAMSRALNDHATFAARLPIIIGGERRMYDVHALRTGG
GSAGIALDASEATALSGALARMADAHRRTLDQLSSGVAVFDGQRRLAFYNDSYRRLWDLDRPFLDGHPDDSSVLDRLRAG
RKLPEQPDFRAWKARLHEAYRANEAVKDVWYLPDGRALSIVTTPNPEGGVTYLFDDVTESLDLARRYDRLINVQRETLDS
LTEAVAVFGSNGRAQLFNPAFARMWKLSPEALAQQPHIDTVEAWCKPLFDDDDAWRTIHKAVTGIDNRTAVPLKLERKDG
SILDCMTMPLPDGATMLTFHDITDSENVERALRERNDALEAADQMKVDFVHHVSYELRSPLTTIIGFAHLMNDPGTGPLT
EKQAEYVNYITSSTDALLALTNNILDLATIDAGAMTLELGPVDVRKTIAAAAEGIQDRLTRDRIVLNVDVDPDIGDFIGD
ERRIIQVLYNLLANAAGFSPPDAVITVSARRTEHSVRFAVMDEGPGIPPDVRDKAFDWFESYANGSRHRGAGLGLSLVRS
FVELHGGRVHFDPAIKSGTRVVCDFPLDRGAHRNAAE

Specific function: Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=29.2887029288703, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1789149, Length=242, Percent_Identity=30.9917355371901, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1786600, Length=278, Percent_Identity=27.3381294964029, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI145693157, Length=259, Percent_Identity=26.6409266409266, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788713, Length=300, Percent_Identity=26.6666666666667, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790861, Length=256, Percent_Identity=27.734375, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI48994928, Length=230, Percent_Identity=31.304347826087, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=30.1724137931034, Blast_Score=87, Evalue=6e-18,
Organism=Escherichia coli, GI1786912, Length=252, Percent_Identity=26.5873015873016, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1790300, Length=353, Percent_Identity=24.3626062322946, Blast_Score=77, Evalue=6e-15,
Organism=Escherichia coli, GI1790436, Length=228, Percent_Identity=28.9473684210526, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=27.0742358078603, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=26.2222222222222, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 91906; Mature: 91775

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGVIGVMRRTLLSCTSLVPGGIAGAGAVSLIDTSPAWAAEPALNERLIQAFMNLSRQDL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHH
TALAMALGVLSFSVVAAILLMRTRIRAAANEQRLRSELRELQSEADRFRALLFVEPQILI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEE
SWGAGEERPQISGDIALLLPQDAKQPLRILAFGTWLPPEPALQMDHAVDALRSAGEGFLL
EECCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEE
NLVTSAGRTVEAMGRAIGGQAIVRIRDLGGLRRDLAEMTLRHDSLLAETEMLRAFATAAP
HHHHHCCCHHHHHHHHCCCHHEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WPLWARGKDGKLSFANQAYARATEAADSADAIQRNLELLDSEDRTAMSRALNDHATFAAR
CCCEECCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEE
LPIIIGGERRMYDVHALRTGGGSAGIALDASEATALSGALARMADAHRRTLDQLSSGVAV
CCEEECCCCEEEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
FDGQRRLAFYNDSYRRLWDLDRPFLDGHPDDSSVLDRLRAGRKLPEQPDFRAWKARLHEA
ECCCCEEEEECCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
YRANEAVKDVWYLPDGRALSIVTTPNPEGGVTYLFDDVTESLDLARRYDRLINVQRETLD
HHHHHHHHHHEECCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
SLTEAVAVFGSNGRAQLFNPAFARMWKLSPEALAQQPHIDTVEAWCKPLFDDDDAWRTIH
HHHHHHHHHCCCCCCEECCHHHHHHHCCCHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHH
KAVTGIDNRTAVPLKLERKDGSILDCMTMPLPDGATMLTFHDITDSENVERALRERNDAL
HHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
EAADQMKVDFVHHVSYELRSPLTTIIGFAHLMNDPGTGPLTEKQAEYVNYITSSTDALLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHH
LTNNILDLATIDAGAMTLELGPVDVRKTIAAAAEGIQDRLTRDRIVLNVDVDPDIGDFIG
HHHCCHHEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHCC
DERRIIQVLYNLLANAAGFSPPDAVITVSARRTEHSVRFAVMDEGPGIPPDVRDKAFDWF
CHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHH
ESYANGSRHRGAGLGLSLVRSFVELHGGRVHFDPAIKSGTRVVCDFPLDRGAHRNAAE
HHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SGVIGVMRRTLLSCTSLVPGGIAGAGAVSLIDTSPAWAAEPALNERLIQAFMNLSRQDL
CCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHH
TALAMALGVLSFSVVAAILLMRTRIRAAANEQRLRSELRELQSEADRFRALLFVEPQILI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEE
SWGAGEERPQISGDIALLLPQDAKQPLRILAFGTWLPPEPALQMDHAVDALRSAGEGFLL
EECCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEE
NLVTSAGRTVEAMGRAIGGQAIVRIRDLGGLRRDLAEMTLRHDSLLAETEMLRAFATAAP
HHHHHCCCHHHHHHHHCCCHHEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WPLWARGKDGKLSFANQAYARATEAADSADAIQRNLELLDSEDRTAMSRALNDHATFAAR
CCCEECCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEE
LPIIIGGERRMYDVHALRTGGGSAGIALDASEATALSGALARMADAHRRTLDQLSSGVAV
CCEEECCCCEEEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
FDGQRRLAFYNDSYRRLWDLDRPFLDGHPDDSSVLDRLRAGRKLPEQPDFRAWKARLHEA
ECCCCEEEEECCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
YRANEAVKDVWYLPDGRALSIVTTPNPEGGVTYLFDDVTESLDLARRYDRLINVQRETLD
HHHHHHHHHHEECCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
SLTEAVAVFGSNGRAQLFNPAFARMWKLSPEALAQQPHIDTVEAWCKPLFDDDDAWRTIH
HHHHHHHHHCCCCCCEECCHHHHHHHCCCHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHH
KAVTGIDNRTAVPLKLERKDGSILDCMTMPLPDGATMLTFHDITDSENVERALRERNDAL
HHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
EAADQMKVDFVHHVSYELRSPLTTIIGFAHLMNDPGTGPLTEKQAEYVNYITSSTDALLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHH
LTNNILDLATIDAGAMTLELGPVDVRKTIAAAAEGIQDRLTRDRIVLNVDVDPDIGDFIG
HHHCCHHEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHCC
DERRIIQVLYNLLANAAGFSPPDAVITVSARRTEHSVRFAVMDEGPGIPPDVRDKAFDWF
CHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHH
ESYANGSRHRGAGLGLSLVRSFVELHGGRVHFDPAIKSGTRVVCDFPLDRGAHRNAAE
HHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10557274; 11259647 [H]