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The map label for this gene is ubiE [H]

Identifier: 75674240

GI number: 75674240

Start: 45682

End: 46479

Strand: Direct

Name: ubiE [H]

Synonym: Nwi_0041

Alternate gene names: 75674240

Gene position: 45682-46479 (Clockwise)

Preceding gene: 75674238

Following gene: 75674241

Centisome position: 1.34

GC content: 64.16

Gene sequence:

>798_bases
ATGGCAGGCTATGGTCCGGTTATGGAGAAGACGGGCATGGATCGCGAGGACCAGACGACGCATTTCGGCTTCAGGGACGT
CCCCCTGGGGGACAAGCAGACGCTGGTGAACGACGTCTTTCACAGCGTCGCGCGGCGTTACGACCTGATGAACGATCTGA
TGTCCGGCGGGCTGCACCGCGTCTGGAAGGACGCGATGATCACGACGCTGAATCCGCCGCGCAACGATGCGCCGTTTTCG
CTGCTCGACGTCGCCGGCGGCACCGGAGACATCGCCTTCCGCGCGGCGAAAGCCGCGGGGTCCGGATTTCAGGCCACCGT
GTGCGACATCAATCCGGACATGCTCGCGGTCGGCCGCGAGCGTGCGACCAAGCAGCATCGCGATCATCAGGTGTCGTTCG
TCGAAGGCAACGCCGAGACCCTGGCGTTCGCGGATCGCGGTTTCGACGCCTACACCATCGCCTTCGGCATCCGCAACGTG
CCGCGCATCGACGCGGCGCTGCGCGAGGCGTTTCGGGTGCTGAGACCGGGCGGCCGGTTTCTCTGCCTTGAATTCTCGAC
GGTCGATGTGCCCGGACTCGACAAGATCTACGACCTGTTTTCCTTCAAGATGATACCGCCGCTCGGCCGCGCCGTCACAG
GCGACGCCGACTCCTATCGGTATCTAGTCGAATCAATCCGCAAGTTTCCCAAGCCGAACGCCTTCGCCGAGATGATCCGT
GACGCCGGCTTCGCCCGCGTGTCCTGGCAGGCGCTTTCCGGCGGCATCGTCGCGTTGCATTCGGGCTGGCGTTTGTGA

Upstream 100 bases:

>100_bases
TTGTCCGGCGTTTCAGGCCGAAGTCTCACCTTCTTCGCTGAACACAAGCCAATTATAGAATGGATCGGCCGGCTCGACCT
CGCTTGTAGCGCAGCGCAGC

Downstream 100 bases:

>100_bases
TCTCCGCACTGGGCCATGTCGCGCGGCTGGCGCGCGCCGCGTTCGTGTTCGCGCGCGAGGGCGTGTTCGGCGTGGTCGAT
CCATCGCTGGTGCCGGCTCC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MAGYGPVMEKTGMDREDQTTHFGFRDVPLGDKQTLVNDVFHSVARRYDLMNDLMSGGLHRVWKDAMITTLNPPRNDAPFS
LLDVAGGTGDIAFRAAKAAGSGFQATVCDINPDMLAVGRERATKQHRDHQVSFVEGNAETLAFADRGFDAYTIAFGIRNV
PRIDAALREAFRVLRPGGRFLCLEFSTVDVPGLDKIYDLFSFKMIPPLGRAVTGDADSYRYLVESIRKFPKPNAFAEMIR
DAGFARVSWQALSGGIVALHSGWRL

Sequences:

>Translated_265_residues
MAGYGPVMEKTGMDREDQTTHFGFRDVPLGDKQTLVNDVFHSVARRYDLMNDLMSGGLHRVWKDAMITTLNPPRNDAPFS
LLDVAGGTGDIAFRAAKAAGSGFQATVCDINPDMLAVGRERATKQHRDHQVSFVEGNAETLAFADRGFDAYTIAFGIRNV
PRIDAALREAFRVLRPGGRFLCLEFSTVDVPGLDKIYDLFSFKMIPPLGRAVTGDADSYRYLVESIRKFPKPNAFAEMIR
DAGFARVSWQALSGGIVALHSGWRL
>Mature_264_residues
AGYGPVMEKTGMDREDQTTHFGFRDVPLGDKQTLVNDVFHSVARRYDLMNDLMSGGLHRVWKDAMITTLNPPRNDAPFSL
LDVAGGTGDIAFRAAKAAGSGFQATVCDINPDMLAVGRERATKQHRDHQVSFVEGNAETLAFADRGFDAYTIAFGIRNVP
RIDAALREAFRVLRPGGRFLCLEFSTVDVPGLDKIYDLFSFKMIPPLGRAVTGDADSYRYLVESIRKFPKPNAFAEMIRD
AGFARVSWQALSGGIVALHSGWRL

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=279, Percent_Identity=48.3870967741936, Blast_Score=259, Evalue=2e-69,
Organism=Escherichia coli, GI48994983, Length=253, Percent_Identity=45.8498023715415, Blast_Score=229, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17557039, Length=250, Percent_Identity=47.6, Blast_Score=225, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6323526, Length=262, Percent_Identity=45.8015267175573, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24641702, Length=263, Percent_Identity=47.148288973384, Blast_Score=244, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 29266; Mature: 29134

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGYGPVMEKTGMDREDQTTHFGFRDVPLGDKQTLVNDVFHSVARRYDLMNDLMSGGLHR
CCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
VWKDAMITTLNPPRNDAPFSLLDVAGGTGDIAFRAAKAAGSGFQATVCDINPDMLAVGRE
HHHHHHEEECCCCCCCCCEEEEEECCCCCHHHEEEHHHCCCCCEEEEECCCCCHHHHHHH
RATKQHRDHQVSFVEGNAETLAFADRGFDAYTIAFGIRNVPRIDAALREAFRVLRPGGRF
HHHHHHCCCEEEEEECCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCE
LCLEFSTVDVPGLDKIYDLFSFKMIPPLGRAVTGDADSYRYLVESIRKFPKPNAFAEMIR
EEEEECCCCCCCHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHCCCCHHHHHHHH
DAGFARVSWQALSGGIVALHSGWRL
HCCCCEEEHHHHCCCEEEECCCCCC
>Mature Secondary Structure 
AGYGPVMEKTGMDREDQTTHFGFRDVPLGDKQTLVNDVFHSVARRYDLMNDLMSGGLHR
CCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
VWKDAMITTLNPPRNDAPFSLLDVAGGTGDIAFRAAKAAGSGFQATVCDINPDMLAVGRE
HHHHHHEEECCCCCCCCCEEEEEECCCCCHHHEEEHHHCCCCCEEEEECCCCCHHHHHHH
RATKQHRDHQVSFVEGNAETLAFADRGFDAYTIAFGIRNVPRIDAALREAFRVLRPGGRF
HHHHHHCCCEEEEEECCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCE
LCLEFSTVDVPGLDKIYDLFSFKMIPPLGRAVTGDADSYRYLVESIRKFPKPNAFAEMIR
EEEEECCCCCCCHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHCCCCHHHHHHHH
DAGFARVSWQALSGGIVALHSGWRL
HCCCCEEEHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA