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The map label for this gene is hmuV [H]

Identifier: 73542927

GI number: 73542927

Start: 3557547

End: 3558236

Strand: Reverse

Name: hmuV [H]

Synonym: Reut_A3243

Alternate gene names: 73542927

Gene position: 3558236-3557547 (Counterclockwise)

Preceding gene: 73542928

Following gene: 73542923

Centisome position: 93.48

GC content: 67.1

Gene sequence:

>690_bases
ATGCTTTCTACACGCGGAATGACTTGCCATCGCGGCACGCGCCGGGTACTCGACGGCATTGATCTCGATCTTCATGCTGG
CGAAGTGCTCGGCGTACTGGGCGCCAACGGCGCCGGCAAGACCACGCTGCTCGCGGTGCTCGCCGGCGAGCTCGAGGCCA
GCGGCGGCGCCGTCACGCTTGATACGCGCCCGCTGCGCGAGTGGAAACCCGCTGCGCTTTCACGCCGCCGAGCGGTGCTG
CCGCAGTCGGCATCGCTCGGCTTCGACCTGTCCGTGCGCGAAGTGATCGCGATGGGCGCCTATCCGTTTCCCGAGCTGAG
TCCCGATGACGAGGCGGCGCTGATGGCGCGCGCGCTGGTACAGGTGCCTGCCGCGCGTTCGCCGGGCCAGTATCGGATGC
TGTTTCTCGATGAACCGATTTCCAGCCTGGACCCGCGCCACCAGCTCTTGTTGCTGCACGCTGTCCGGGCCTTGAGCCGC
GAAGAGGATTTGGCGGTGTTCGTCGTGCTCCACGACGTCAACCTGGCCGCGCGGTGGTGCGATCGCCTGCTGCTGCTGTC
GAACGGGCGCACGATTGCCCACGGCACGCCGGTCGATGTGCTGACGCCGCAGAACATGGAACGCGTGTACACGCTGCCCG
CGCGTGTGACAGTGGACGACGTGCCGTCGGTGACGTTCTGCCTGCCTTGA

Upstream 100 bases:

>100_bases
CGTGTTGTCGTGATTCCCGCGGAACTGCCGATCGGCATCGTCACGAGCCTCGTCGGCGGGCCGTTCCTCCTGTGGATGCT
GGCACGCAGAGGGAATTGAG

Downstream 100 bases:

>100_bases
GCGCGCCGCCTAGCGCGGCACCTTGAACGCCTTGCGCGCGCGCAGTGCTTCGGTCCGGGTCCAGCAGCCGTCCTGGTGGT
CGTTGACGAGGCCCATCGCC

Product: ABC transporter related

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MLSTRGMTCHRGTRRVLDGIDLDLHAGEVLGVLGANGAGKTTLLAVLAGELEASGGAVTLDTRPLREWKPAALSRRRAVL
PQSASLGFDLSVREVIAMGAYPFPELSPDDEAALMARALVQVPAARSPGQYRMLFLDEPISSLDPRHQLLLLHAVRALSR
EEDLAVFVVLHDVNLAARWCDRLLLLSNGRTIAHGTPVDVLTPQNMERVYTLPARVTVDDVPSVTFCLP

Sequences:

>Translated_229_residues
MLSTRGMTCHRGTRRVLDGIDLDLHAGEVLGVLGANGAGKTTLLAVLAGELEASGGAVTLDTRPLREWKPAALSRRRAVL
PQSASLGFDLSVREVIAMGAYPFPELSPDDEAALMARALVQVPAARSPGQYRMLFLDEPISSLDPRHQLLLLHAVRALSR
EEDLAVFVVLHDVNLAARWCDRLLLLSNGRTIAHGTPVDVLTPQNMERVYTLPARVTVDDVPSVTFCLP
>Mature_229_residues
MLSTRGMTCHRGTRRVLDGIDLDLHAGEVLGVLGANGAGKTTLLAVLAGELEASGGAVTLDTRPLREWKPAALSRRRAVL
PQSASLGFDLSVREVIAMGAYPFPELSPDDEAALMARALVQVPAARSPGQYRMLFLDEPISSLDPRHQLLLLHAVRALSR
EEDLAVFVVLHDVNLAARWCDRLLLLSNGRTIAHGTPVDVLTPQNMERVYTLPARVTVDDVPSVTFCLP

Specific function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system [H]

COG id: COG4559

COG function: function code P; ABC-type hemin transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1786345, Length=225, Percent_Identity=37.3333333333333, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790739, Length=252, Percent_Identity=31.7460317460317, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786803, Length=248, Percent_Identity=29.4354838709677, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI87082268, Length=232, Percent_Identity=28.0172413793103, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI48994943, Length=224, Percent_Identity=29.0178571428571, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788002, Length=218, Percent_Identity=31.651376146789, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1787370, Length=226, Percent_Identity=29.2035398230088, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786398, Length=230, Percent_Identity=26.9565217391304, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI48994997, Length=227, Percent_Identity=27.7533039647577, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787029, Length=229, Percent_Identity=26.6375545851528, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1786703, Length=200, Percent_Identity=31.5, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1786253, Length=205, Percent_Identity=28.780487804878, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081709, Length=223, Percent_Identity=25.5605381165919, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787500, Length=214, Percent_Identity=25.7009345794392, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1788506, Length=227, Percent_Identity=28.6343612334802, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787712, Length=211, Percent_Identity=26.5402843601896, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788761, Length=203, Percent_Identity=28.0788177339901, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787164, Length=219, Percent_Identity=29.6803652968037, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87081791, Length=223, Percent_Identity=26.457399103139, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789991, Length=225, Percent_Identity=25.3333333333333, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789586, Length=224, Percent_Identity=22.7678571428571, Blast_Score=62, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24582014, Length=208, Percent_Identity=28.3653846153846, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24582012, Length=208, Percent_Identity=28.3653846153846, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR015863
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 24800; Mature: 24800

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSTRGMTCHRGTRRVLDGIDLDLHAGEVLGVLGANGAGKTTLLAVLAGELEASGGAVTL
CCCCCCCCHHCCHHHHHCCCCCEEECCCEEEEECCCCCCHHHEEEHHHHHHCCCCCEEEE
DTRPLREWKPAALSRRRAVLPQSASLGFDLSVREVIAMGAYPFPELSPDDEAALMARALV
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
QVPAARSPGQYRMLFLDEPISSLDPRHQLLLLHAVRALSREEDLAVFVVLHDVNLAARWC
HCCCCCCCCCEEEEEEECCHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHH
DRLLLLSNGRTIAHGTPVDVLTPQNMERVYTLPARVTVDDVPSVTFCLP
HHEEEEECCCEEECCCCCEEECCCCCCEEEECCCEEEECCCCCEEEECC
>Mature Secondary Structure
MLSTRGMTCHRGTRRVLDGIDLDLHAGEVLGVLGANGAGKTTLLAVLAGELEASGGAVTL
CCCCCCCCHHCCHHHHHCCCCCEEECCCEEEEECCCCCCHHHEEEHHHHHHCCCCCEEEE
DTRPLREWKPAALSRRRAVLPQSASLGFDLSVREVIAMGAYPFPELSPDDEAALMARALV
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
QVPAARSPGQYRMLFLDEPISSLDPRHQLLLLHAVRALSREEDLAVFVVLHDVNLAARWC
HCCCCCCCCCEEEEEEECCHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHH
DRLLLLSNGRTIAHGTPVDVLTPQNMERVYTLPARVTVDDVPSVTFCLP
HHEEEEECCCEEECCCCCEEECCCCCCEEEECCCEEEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA