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The map label for this gene is hisG [H]

Identifier: 73542796

GI number: 73542796

Start: 3419658

End: 3420332

Strand: Reverse

Name: hisG [H]

Synonym: Reut_A3112

Alternate gene names: 73542796

Gene position: 3420332-3419658 (Counterclockwise)

Preceding gene: 73542797

Following gene: 73542795

Centisome position: 89.85

GC content: 65.48

Gene sequence:

>675_bases
ATGAGCCCCGCATTCAACGCTTCGCCCAACCAGCTCACGCTGGCGCTTTCCAAGGGCCGCATCTTCAAGGAAACGCTGCC
GCTGCTCGAAGCCGCCGGCATCCGTGTCATGGAAGATCCGGAGACGTCGCGCAAGCTGATCCTGCCGACGTCCGATCCGG
CTGTGCGCGTGATCATCGTGCGCGCATCGGACGTGCCGACCTACGTGCAATACGGCGCGGCCGATTTCGGCGTGGCCGGC
AAGGACGTGCTGATGGAGCACGGCATGACCGGGTTGTACGCGCCGATCGACCTGAACATTGCACGCTGCCGCATGTCGGT
AGCGGTGCCGGCCGGGTTTGACTATGCCAACGCCGTGCGCCAGGGCGCGCGCCTGTCGGTGGCGACCAAGTATGTGCAGA
CCGCGCGCGAGCACTTCGCCAAGAAGGGCGTGCACGTCGACCTGATCAAGCTGTACGGCTCGATGGAGCTGGGCCCGCTG
GTGGGCCTGTCGGATGCCATCGTCGACCTGGTCAGCACGGGCGGCACGCTGCGCGCGAACAACCTGGTGGAAGTCGAAGA
GATCGTGCAGATTTCGTCGCGGCTGGTGGTGAACCAGGCTGCGCTGAAGCTCAAGCGCGAACGGCTGACGCCGATTCTCG
ACGCGTTCGAGAAGGCATCGGCGGCGCTGGCCTGA

Upstream 100 bases:

>100_bases
TGATCGATCGCATCTACCATCTGGACCGCGGTTACGACCGCATGGAAGACAAGTTGTCGGCAGTCGGCGCCAAGATCCGC
CGCATCGCCTGAGGAACCCG

Downstream 100 bases:

>100_bases
GGCCTGCGTCCCAGATAGGAATGGAGTCATGAACGCAACCGAAATGGAAAACGTGTCGATCCGCCGGCTCGATTCAAGCG
ATCCGCGCTTCGCGCAAGCG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSPAFNASPNQLTLALSKGRIFKETLPLLEAAGIRVMEDPETSRKLILPTSDPAVRVIIVRASDVPTYVQYGAADFGVAG
KDVLMEHGMTGLYAPIDLNIARCRMSVAVPAGFDYANAVRQGARLSVATKYVQTAREHFAKKGVHVDLIKLYGSMELGPL
VGLSDAIVDLVSTGGTLRANNLVEVEEIVQISSRLVVNQAALKLKRERLTPILDAFEKASAALA

Sequences:

>Translated_224_residues
MSPAFNASPNQLTLALSKGRIFKETLPLLEAAGIRVMEDPETSRKLILPTSDPAVRVIIVRASDVPTYVQYGAADFGVAG
KDVLMEHGMTGLYAPIDLNIARCRMSVAVPAGFDYANAVRQGARLSVATKYVQTAREHFAKKGVHVDLIKLYGSMELGPL
VGLSDAIVDLVSTGGTLRANNLVEVEEIVQISSRLVVNQAALKLKRERLTPILDAFEKASAALA
>Mature_223_residues
SPAFNASPNQLTLALSKGRIFKETLPLLEAAGIRVMEDPETSRKLILPTSDPAVRVIIVRASDVPTYVQYGAADFGVAGK
DVLMEHGMTGLYAPIDLNIARCRMSVAVPAGFDYANAVRQGARLSVATKYVQTAREHFAKKGVHVDLIKLYGSMELGPLV
GLSDAIVDLVSTGGTLRANNLVEVEEIVQISSRLVVNQAALKLKRERLTPILDAFEKASAALA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=209, Percent_Identity=30.622009569378, Blast_Score=89, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=198, Percent_Identity=30.8080808080808, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 24058; Mature: 23927

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPAFNASPNQLTLALSKGRIFKETLPLLEAAGIRVMEDPETSRKLILPTSDPAVRVIIV
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCEEEEEE
RASDVPTYVQYGAADFGVAGKDVLMEHGMTGLYAPIDLNIARCRMSVAVPAGFDYANAVR
ECCCCCHHHHCCCCCCCCCCHHHHHHCCCCCEECCCCCCHHHEEEEEECCCCCCHHHHHH
QGARLSVATKYVQTAREHFAKKGVHVDLIKLYGSMELGPLVGLSDAIVDLVSTGGTLRAN
CCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHCCCEEECC
NLVEVEEIVQISSRLVVNQAALKLKRERLTPILDAFEKASAALA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPAFNASPNQLTLALSKGRIFKETLPLLEAAGIRVMEDPETSRKLILPTSDPAVRVIIV
CCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCEEEEEE
RASDVPTYVQYGAADFGVAGKDVLMEHGMTGLYAPIDLNIARCRMSVAVPAGFDYANAVR
ECCCCCHHHHCCCCCCCCCCHHHHHHCCCCCEECCCCCCHHHEEEEEECCCCCCHHHHHH
QGARLSVATKYVQTAREHFAKKGVHVDLIKLYGSMELGPLVGLSDAIVDLVSTGGTLRAN
CCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHCCCEEECC
NLVEVEEIVQISSRLVVNQAALKLKRERLTPILDAFEKASAALA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA