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The map label for this gene is penA [H]

Identifier: 73542669

GI number: 73542669

Start: 3275752

End: 3277554

Strand: Reverse

Name: penA [H]

Synonym: Reut_A2985

Alternate gene names: 73542669

Gene position: 3277554-3275752 (Counterclockwise)

Preceding gene: 73542670

Following gene: 73542668

Centisome position: 86.1

GC content: 67.0

Gene sequence:

>1803_bases
ATGACCATGGCACGCAGCGGCAACGCCTCGCGCAATCGCCCGAACAACTCGCGTCCGCGCACCGGGCAGTTTTCGGCCAG
CCCCGTGCTGGGCCTGCGCCTGCCAATGTGGCGCTCCAAGTTTGTCGTGTTCCTGATGTTCGCGGCATTCGTGGCGCTGG
CCGTGCGCGCGCTGTGGATCCAGGGGCCCGGTAACCAGTTCTATGAGGCAGAAGGCAAGAAGCGCTTCCAGCGCACGCTC
GAGCTGCCGGCCACGCGCGGCAAGATCCTGGACCGCAACGGCCTGGTGCTGGCCACCAGCCTGCCGGTCAAGGCGATCTG
GGCCGTGCCCGAGGATGTGCCGAACCAGGTCGAGGCCGCGAAGATCCGCCAGCTCGCGAAGCTGCTCGACATGTCCGAGA
AGGACCTGAGCCGCAAGCTGTCCGAGGACAAGAGCTTTGTCTACCTGAAGCGCCAGGTCCAGCCCGACGCGGCCGAGAAG
ATTGCCGCGCTGAAGATCGAAGGCATCCACCAGACCCGCGAATACAAGCGCTTCTACCCGGAAGGGGAGGCGATGGCGCA
CATCGTCGGGTTCACCAATGTGGAAGACCGCGGCCAGGAAGGCGTGGAGCTGGCACGCGAGGCCGGCCTGGCCGGGCGGC
CCGGCGCGCGCCAGGTGATCAAGGATCGCCTCGGCCGTGTGGTCGAGGACGTCGGCATCCTCAAGACCCCGCGCGACGGC
GAGGACATGCAGCTGTCGATCGACGCCAAGATCCAGTACCTCGCCTACAACGAGCTGAAGGCCGTGGTCGAGCGCAACAA
GGCCAAGGCGGCCAGCGCGGTGGTGCTCGACGCCCAGACCGGCGAAGTGCTGGCGCTGGCCAACTGGCCGACCTACAACC
CGAACGACCGCACCCGGCTGTCGGGCGAACAGCTGCGCAACCGCGTGCTGACCGACACCTTCGAGCCCGGCTCGATGATG
AAGCCGATCACGATCGGCCTCGCGCTGCAGCTCAAGCGCGTGACCCCGTCCACGGTCGTCGTCACCACCGGCAAGTACAA
CTTCGAAGGCGCCACCATCACCGATACCCACAACTACGGCGCGCTGACCGTGGGCGGCGTGATCCAGAAGTCGAGCAATA
TCGGCACGACCAAGATCGCGATGATGATGAAGCCGCAGGAAATGTGGGACATGTTCACCAGCGTCGGCCTGGGCCAGGCG
CCGAAGATCGGCTTCCCGGGCGCCGTGGCGGGCCGCGTGCGTCCGTTCAAGAGCTGGCGTCCGATCGAACAGGCCACCAT
GTCGTACGGCTACGGCCTGTCGGTGTCGCTGTTCCAGATGGCGCACGCCTACACGGTCTTCGCGCATGACGGCGAGATCA
TCCCCGTATCGATGTTCCGCACCAATGGCCCCGTGACCGGCGAACGCATCCTGTCGCCTCAGGTCGCGCGCGACGTGCGC
GCCATGCTTGAAACCGTGACGGCGCCCGGCGGCACCGCGCCCGAGGCGCAGGTGATGGGCTACCGCGTCGGCGGCAAGAC
CGGTACCGCATACAAGCACGAAGGCCGCGGCTACAACCGCAGCAAGTACCGCGCATCGTTCATCGGCCTGGCGCCGATGT
CGAACCCGCGCGTGATCGTCGCCGTCAGCGTGGACGAGCCGACCGCCGGCAGCCACTACGGTGGCGCGGTGGCCGGCCCG
GTCTTCGCCGCGATCACCGGCGGCACGCTGCGTGCGCTGAATGTCCAGCCCGATTCGCCGATCCGCCAACTGGTGGTCAG
CGACAAGGTGCAGGAAAGCGAACCGTGGAGCTCGACGCAATGA

Upstream 100 bases:

>100_bases
TCATGGCAGGCAGGACCCAGTACCTGTCGGGCATCGTGCTGCCGCCGGCGGCACCGGCGCCCGCGGCAGCCGCATCCGCC
CCTGCCGGGGAGGAACGTCC

Downstream 100 bases:

>100_bases
CGGCCAAGCCGCTGCTCCCGCTCGAAGTCACCGCACAGGCCAGCGACGCGCTGGCCTGGCTGCGTACCAAGGTGCCGGCC
AGTGCCCGGCTGACCGGCGA

Product: peptidoglycan synthetase FtsI

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 600; Mature: 599

Protein sequence:

>600_residues
MTMARSGNASRNRPNNSRPRTGQFSASPVLGLRLPMWRSKFVVFLMFAAFVALAVRALWIQGPGNQFYEAEGKKRFQRTL
ELPATRGKILDRNGLVLATSLPVKAIWAVPEDVPNQVEAAKIRQLAKLLDMSEKDLSRKLSEDKSFVYLKRQVQPDAAEK
IAALKIEGIHQTREYKRFYPEGEAMAHIVGFTNVEDRGQEGVELAREAGLAGRPGARQVIKDRLGRVVEDVGILKTPRDG
EDMQLSIDAKIQYLAYNELKAVVERNKAKAASAVVLDAQTGEVLALANWPTYNPNDRTRLSGEQLRNRVLTDTFEPGSMM
KPITIGLALQLKRVTPSTVVVTTGKYNFEGATITDTHNYGALTVGGVIQKSSNIGTTKIAMMMKPQEMWDMFTSVGLGQA
PKIGFPGAVAGRVRPFKSWRPIEQATMSYGYGLSVSLFQMAHAYTVFAHDGEIIPVSMFRTNGPVTGERILSPQVARDVR
AMLETVTAPGGTAPEAQVMGYRVGGKTGTAYKHEGRGYNRSKYRASFIGLAPMSNPRVIVAVSVDEPTAGSHYGGAVAGP
VFAAITGGTLRALNVQPDSPIRQLVVSDKVQESEPWSSTQ

Sequences:

>Translated_600_residues
MTMARSGNASRNRPNNSRPRTGQFSASPVLGLRLPMWRSKFVVFLMFAAFVALAVRALWIQGPGNQFYEAEGKKRFQRTL
ELPATRGKILDRNGLVLATSLPVKAIWAVPEDVPNQVEAAKIRQLAKLLDMSEKDLSRKLSEDKSFVYLKRQVQPDAAEK
IAALKIEGIHQTREYKRFYPEGEAMAHIVGFTNVEDRGQEGVELAREAGLAGRPGARQVIKDRLGRVVEDVGILKTPRDG
EDMQLSIDAKIQYLAYNELKAVVERNKAKAASAVVLDAQTGEVLALANWPTYNPNDRTRLSGEQLRNRVLTDTFEPGSMM
KPITIGLALQLKRVTPSTVVVTTGKYNFEGATITDTHNYGALTVGGVIQKSSNIGTTKIAMMMKPQEMWDMFTSVGLGQA
PKIGFPGAVAGRVRPFKSWRPIEQATMSYGYGLSVSLFQMAHAYTVFAHDGEIIPVSMFRTNGPVTGERILSPQVARDVR
AMLETVTAPGGTAPEAQVMGYRVGGKTGTAYKHEGRGYNRSKYRASFIGLAPMSNPRVIVAVSVDEPTAGSHYGGAVAGP
VFAAITGGTLRALNVQPDSPIRQLVVSDKVQESEPWSSTQ
>Mature_599_residues
TMARSGNASRNRPNNSRPRTGQFSASPVLGLRLPMWRSKFVVFLMFAAFVALAVRALWIQGPGNQFYEAEGKKRFQRTLE
LPATRGKILDRNGLVLATSLPVKAIWAVPEDVPNQVEAAKIRQLAKLLDMSEKDLSRKLSEDKSFVYLKRQVQPDAAEKI
AALKIEGIHQTREYKRFYPEGEAMAHIVGFTNVEDRGQEGVELAREAGLAGRPGARQVIKDRLGRVVEDVGILKTPRDGE
DMQLSIDAKIQYLAYNELKAVVERNKAKAASAVVLDAQTGEVLALANWPTYNPNDRTRLSGEQLRNRVLTDTFEPGSMMK
PITIGLALQLKRVTPSTVVVTTGKYNFEGATITDTHNYGALTVGGVIQKSSNIGTTKIAMMMKPQEMWDMFTSVGLGQAP
KIGFPGAVAGRVRPFKSWRPIEQATMSYGYGLSVSLFQMAHAYTVFAHDGEIIPVSMFRTNGPVTGERILSPQVARDVRA
MLETVTAPGGTAPEAQVMGYRVGGKTGTAYKHEGRGYNRSKYRASFIGLAPMSNPRVIVAVSVDEPTAGSHYGGAVAGPV
FAAITGGTLRALNVQPDSPIRQLVVSDKVQESEPWSSTQ

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=548, Percent_Identity=41.4233576642336, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1786854, Length=566, Percent_Identity=23.4982332155477, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 65553; Mature: 65422

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMARSGNASRNRPNNSRPRTGQFSASPVLGLRLPMWRSKFVVFLMFAAFVALAVRALWI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHEEE
QGPGNQFYEAEGKKRFQRTLELPATRGKILDRNGLVLATSLPVKAIWAVPEDVPNQVEAA
ECCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCEEEEECCCEEEEEECCCCCCCHHHHH
KIRQLAKLLDMSEKDLSRKLSEDKSFVYLKRQVQPDAAEKIAALKIEGIHQTREYKRFYP
HHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHEEEEEECCHHHHHHHHHHCC
EGEAMAHIVGFTNVEDRGQEGVELAREAGLAGRPGARQVIKDRLGRVVEDVGILKTPRDG
CCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
EDMQLSIDAKIQYLAYNELKAVVERNKAKAASAVVLDAQTGEVLALANWPTYNPNDRTRL
CCEEEEEECEEEEEEHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEECCCCCCCCCCCCC
SGEQLRNRVLTDTFEPGSMMKPITIGLALQLKRVTPSTVVVTTGKYNFEGATITDTHNYG
CHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEECCCEECCCCEEECCCCCC
ALTVGGVIQKSSNIGTTKIAMMMKPQEMWDMFTSVGLGQAPKIGFPGAVAGRVRPFKSWR
CEEECCEEECCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
PIEQATMSYGYGLSVSLFQMAHAYTVFAHDGEIIPVSMFRTNGPVTGERILSPQVARDVR
CHHHHHHHCCCCCCHHHHHHHHEEEEEECCCCEEEEEEEECCCCCCHHHHCCHHHHHHHH
AMLETVTAPGGTAPEAQVMGYRVGGKTGTAYKHEGRGYNRSKYRASFIGLAPMSNPRVIV
HHHHHHCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCHHEEEEEEECCCCCCCEEE
AVSVDEPTAGSHYGGAVAGPVFAAITGGTLRALNVQPDSPIRQLVVSDKVQESEPWSSTQ
EEECCCCCCCCCCCCCHHHHHHHEECCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TMARSGNASRNRPNNSRPRTGQFSASPVLGLRLPMWRSKFVVFLMFAAFVALAVRALWI
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHEEE
QGPGNQFYEAEGKKRFQRTLELPATRGKILDRNGLVLATSLPVKAIWAVPEDVPNQVEAA
ECCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCEEEEECCCEEEEEECCCCCCCHHHHH
KIRQLAKLLDMSEKDLSRKLSEDKSFVYLKRQVQPDAAEKIAALKIEGIHQTREYKRFYP
HHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHEEEEEECCHHHHHHHHHHCC
EGEAMAHIVGFTNVEDRGQEGVELAREAGLAGRPGARQVIKDRLGRVVEDVGILKTPRDG
CCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
EDMQLSIDAKIQYLAYNELKAVVERNKAKAASAVVLDAQTGEVLALANWPTYNPNDRTRL
CCEEEEEECEEEEEEHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEECCCCCCCCCCCCC
SGEQLRNRVLTDTFEPGSMMKPITIGLALQLKRVTPSTVVVTTGKYNFEGATITDTHNYG
CHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEECCCEECCCCEEECCCCCC
ALTVGGVIQKSSNIGTTKIAMMMKPQEMWDMFTSVGLGQAPKIGFPGAVAGRVRPFKSWR
CEEECCEEECCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
PIEQATMSYGYGLSVSLFQMAHAYTVFAHDGEIIPVSMFRTNGPVTGERILSPQVARDVR
CHHHHHHHCCCCCCHHHHHHHHEEEEEECCCCEEEEEEEECCCCCCHHHHCCHHHHHHHH
AMLETVTAPGGTAPEAQVMGYRVGGKTGTAYKHEGRGYNRSKYRASFIGLAPMSNPRVIV
HHHHHHCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCHHEEEEEEECCCCCCCEEE
AVSVDEPTAGSHYGGAVAGPVFAAITGGTLRALNVQPDSPIRQLVVSDKVQESEPWSSTQ
EEECCCCCCCCCCCCCHHHHHHHEECCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]