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The map label for this gene is murC [H]

Identifier: 73542662

GI number: 73542662

Start: 3266286

End: 3267713

Strand: Reverse

Name: murC [H]

Synonym: Reut_A2978

Alternate gene names: 73542662

Gene position: 3267713-3266286 (Counterclockwise)

Preceding gene: 73542663

Following gene: 73542661

Centisome position: 85.84

GC content: 66.6

Gene sequence:

>1428_bases
ATGAAGCATATCGTCAAAAACATCCACTTCGTAGGCATCGGCGGCGCCGGCATGAGCGGCATCGCGGAGGTCCTGCTGAA
CCTGGGCTACAAGGTCTCGGGTTCCGATGTGGGCAGCAACGCCGCCACGCGGCGCCTGGCTTCGCTCGGTGCCACGGTCA
TGCACGGGCATGACGCGGCGAACATCGCCGGTGCGAACGCCGTGGTGGTTTCCACGGCCGTGAGCGGGGACAACCCCGAA
GTGCTGGCCGCCCGCAGCAAGCGTATCCCGGTGGTGCCGCGCGCGGTGATGCTGGCCGAGTTGATGCGCCTGAAGCAGGG
CGTCGCCATTGCCGGCACGCACGGCAAGACCACGACCACGAGCCTGGTGGCGTCGGTGCTGGCCGAGGGCGGGCTCGACC
CGACCTTCGTGATCGGCGGCCGCCTGAATTCCGCGGGTGCTAATGCGCGCCTGGGCACGGGCGATTTCATCGTGGCCGAA
GCCGATGAATCCGATGCCTCGTTCCTGAACCTGTTCCCGGTCATCGAAGTCATCACGAACATCGATGCCGACCACATGGA
CACCTACGGGCACGACTTCGCTCGGCTCAAGCAGGCGTTCATCGAATTCACGCAGCGCCTGCCGTTCTACGGCATCGCCG
TGCTGTGCGTGGACGATCCGAACGTGCGCGAGATTCTGCCATTCGTGTCCAAGCCTGTCGTGCGCTATGGCTTTGCCGAG
GATGCACAGATCCGCGCTGTCAATGCGCGCGCAGTCGATGGCCAGATGCATTTCACCGTGCTGCGCCACCTCAACGGCCA
TGCCGAACCGCCACTCGACGTGGTGCTGAACCTGCCCGGCCTGCACAACGTGCAGAACGCGCTGGCCGCGATCGCGATTG
CGACGGAACTGGAAGTCCCGGACGCCGCGATCGTCAAGGCGCTGCGCGAGTTCCACGGCGTAGGACGCCGCTTCCAGCGC
TACGGCGAAGTGGCCACGGCGGATGGCACCGGCACGTTCACGCTGGTCGACGACTACGGGCACCACCCGGTGGAAATGGC
CGCTACGCTCTCCGCCGCGCGCGGCGCGTTCCCGGGCCGCCGCCTGGTGCTGGCGTTCCAGCCGCACCGTTTCACGCGCA
CGCGCGATTGCTTCGAGGATTTCGTCAAGGTGCTCGGCACCGTTGATGCGTTGTTGCTGGCCGAGGTCTATGCCGCCGGC
GAAGCGCCGATCGTCGCGGCCGATGGCCGCGCGCTGACCCGTGCGCTGCGCGTGGCGGCCAAGGTAGAACCTGTTTTCGT
GGAGCAGATGGAAGAGATGCCGCAGGCCATCATGAATGCCGCCAGGCCTGGCGACGTGGTCGTAACGATGGGAGCCGGCT
CGATCGGCGCGGTACCGGGACAGGTGGTCTCGCACCAGCAGCCGCTGCAGGCGGGAGGTGCGGCATGA

Upstream 100 bases:

>100_bases
GCCTGGCGCGCGGACTGGCCAAGCCTGAGGCAACCCGGCGCGTCGCCGAGGTATGCAGCCAGATGGCCAGGGACTGAAGC
CCAATACATGTAGTGACTCA

Downstream 100 bases:

>100_bases
GCTTCGTCGCCAATCCCAAGATCGACCCGAAATCGCTGGGCAAGGTCGGCGTGCTGTATGGCGGCCGCTCGGCCGAGCGC
GAGATTTCGCTGATGTCCGG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYKVSGSDVGSNAATRRLASLGATVMHGHDAANIAGANAVVVSTAVSGDNPE
VLAARSKRIPVVPRAVMLAELMRLKQGVAIAGTHGKTTTTSLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAE
ADESDASFLNLFPVIEVITNIDADHMDTYGHDFARLKQAFIEFTQRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
DAQIRAVNARAVDGQMHFTVLRHLNGHAEPPLDVVLNLPGLHNVQNALAAIAIATELEVPDAAIVKALREFHGVGRRFQR
YGEVATADGTGTFTLVDDYGHHPVEMAATLSAARGAFPGRRLVLAFQPHRFTRTRDCFEDFVKVLGTVDALLLAEVYAAG
EAPIVAADGRALTRALRVAAKVEPVFVEQMEEMPQAIMNAARPGDVVVTMGAGSIGAVPGQVVSHQQPLQAGGAA

Sequences:

>Translated_475_residues
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYKVSGSDVGSNAATRRLASLGATVMHGHDAANIAGANAVVVSTAVSGDNPE
VLAARSKRIPVVPRAVMLAELMRLKQGVAIAGTHGKTTTTSLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAE
ADESDASFLNLFPVIEVITNIDADHMDTYGHDFARLKQAFIEFTQRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
DAQIRAVNARAVDGQMHFTVLRHLNGHAEPPLDVVLNLPGLHNVQNALAAIAIATELEVPDAAIVKALREFHGVGRRFQR
YGEVATADGTGTFTLVDDYGHHPVEMAATLSAARGAFPGRRLVLAFQPHRFTRTRDCFEDFVKVLGTVDALLLAEVYAAG
EAPIVAADGRALTRALRVAAKVEPVFVEQMEEMPQAIMNAARPGDVVVTMGAGSIGAVPGQVVSHQQPLQAGGAA
>Mature_475_residues
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYKVSGSDVGSNAATRRLASLGATVMHGHDAANIAGANAVVVSTAVSGDNPE
VLAARSKRIPVVPRAVMLAELMRLKQGVAIAGTHGKTTTTSLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAE
ADESDASFLNLFPVIEVITNIDADHMDTYGHDFARLKQAFIEFTQRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
DAQIRAVNARAVDGQMHFTVLRHLNGHAEPPLDVVLNLPGLHNVQNALAAIAIATELEVPDAAIVKALREFHGVGRRFQR
YGEVATADGTGTFTLVDDYGHHPVEMAATLSAARGAFPGRRLVLAFQPHRFTRTRDCFEDFVKVLGTVDALLLAEVYAAG
EAPIVAADGRALTRALRVAAKVEPVFVEQMEEMPQAIMNAARPGDVVVTMGAGSIGAVPGQVVSHQQPLQAGGAA

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=457, Percent_Identity=54.0481400437637, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1790680, Length=467, Percent_Identity=29.1220556745182, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 50030; Mature: 50030

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYKVSGSDVGSNAATRRLASLGATVMHGHDAA
CCCHHCCEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCHHEECCCCC
NIAGANAVVVSTAVSGDNPEVLAARSKRIPVVPRAVMLAELMRLKQGVAIAGTHGKTTTT
CCCCCCEEEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAEADESDASFLNLFPVIEVITN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHC
IDADHMDTYGHDFARLKQAFIEFTQRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
CCCHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHCCHHHCCCCC
DAQIRAVNARAVDGQMHFTVLRHLNGHAEPPLDVVLNLPGLHNVQNALAAIAIATELEVP
CCEEEEEECEEECCHHHHHHHHHHCCCCCCCHHEEEECCCCHHHHHHHHHHHHHHCCCCC
DAAIVKALREFHGVGRRFQRYGEVATADGTGTFTLVDDYGHHPVEMAATLSAARGAFPGR
CHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCC
RLVLAFQPHRFTRTRDCFEDFVKVLGTVDALLLAEVYAAGEAPIVAADGRALTRALRVAA
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHH
KVEPVFVEQMEEMPQAIMNAARPGDVVVTMGAGSIGAVPGQVVSHQQPLQAGGAA
HCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYKVSGSDVGSNAATRRLASLGATVMHGHDAA
CCCHHCCEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCHHEECCCCC
NIAGANAVVVSTAVSGDNPEVLAARSKRIPVVPRAVMLAELMRLKQGVAIAGTHGKTTTT
CCCCCCEEEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAEADESDASFLNLFPVIEVITN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHC
IDADHMDTYGHDFARLKQAFIEFTQRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
CCCHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHCCHHHCCCCC
DAQIRAVNARAVDGQMHFTVLRHLNGHAEPPLDVVLNLPGLHNVQNALAAIAIATELEVP
CCEEEEEECEEECCHHHHHHHHHHCCCCCCCHHEEEECCCCHHHHHHHHHHHHHHCCCCC
DAAIVKALREFHGVGRRFQRYGEVATADGTGTFTLVDDYGHHPVEMAATLSAARGAFPGR
CHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCC
RLVLAFQPHRFTRTRDCFEDFVKVLGTVDALLLAEVYAAGEAPIVAADGRALTRALRVAA
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHH
KVEPVFVEQMEEMPQAIMNAARPGDVVVTMGAGSIGAVPGQVVSHQQPLQAGGAA
HCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA