Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 73542487

GI number: 73542487

Start: 3071129

End: 3071965

Strand: Direct

Name: proC [H]

Synonym: Reut_A2802

Alternate gene names: 73542487

Gene position: 3071129-3071965 (Clockwise)

Preceding gene: 73542486

Following gene: 73542492

Centisome position: 80.68

GC content: 67.74

Gene sequence:

>837_bases
ATGCTCGACACCCTGACCTTCGGCTTCCTTGGCGGCGGCAATATGGCCACCGCGCTGATCAGCGGCCTGATCGCCCGCGG
CGTGCCCGCCGGTTCGATCCGCGTGGTCGATCCGTTCCCCGATGCGCAGCAGCGCCTGGTGCGCGACCTGCGCGTGCATG
TCGCCGGCGCACCCGACGCGGCGTTCGGTGGGTCCGACGTCCTGGTGCTGGCCGTCAAGCCACAGCAGTTCCGTGAAGCC
GCCGCCAGCTTGCTGCCGCACCTGCCTGCGACTGGCGCCGGCAACCTGATCATCAGCGTCGCCGCCGGGATTCGCCTGCA
GGACATGGAGCGCTGGCTGGGCGGCCGCACGCGTCTGGTGCGCGCCATGCCGAATACGCCCGCACTGTCGGGCATGGGTA
TGACGGGCTTGGCCGCGCCCGCCGGACTATCGCAACACGATCGCGCGATTGCCTCCGCCGTGGCGGAAGCCGTGGGCAAG
AGCGCATGGGTCGATGGCGATGAGCAGATCGACGCGGTTACGGCCATTTCGGGCAGCGGTCCGGCTTATGTGTTCTATTT
CATCGAAGCGATGGAACGTGCGGCGACGGAACTCGGCCTGACCACGCAGCAGGGTCGCGAGCTTGCGGTGCAGACTTTCC
TCGGGGCAGCCACGCTGGCCGGGCAATCGACGGAACCGGTCGCTACGTTGCGCGAGCGGGTGACATCCAAGGGTGGCACG
ACGTATGCGGCGCTCACTGCCATGGAAAGCGCTGGAATCGGCGATGCTTTCGTGCGCGCCATGCAGGCTGCAGCGGCGCG
TGGGAAGGAGATGGGGGAAGAGTTCGGGAAGGATTGA

Upstream 100 bases:

>100_bases
AGAAGGCGCCACCATCGTGCGCATCGGCACGGCCATTTTCGGCGCACGCGCTTGAGCGCCACGACAGCATTTCCCTACAC
CATTCCAGCCAGAGACTGAC

Downstream 100 bases:

>100_bases
GCGGGCGTTTAATCTGACAGGGCGCTCGCCATACAGCAGACCGGCTCCCCCCTCCCTTGTGAAGGGGAGAGGGGAGAAAA
CCTAGCGGATCGCGTAGGCC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MLDTLTFGFLGGGNMATALISGLIARGVPAGSIRVVDPFPDAQQRLVRDLRVHVAGAPDAAFGGSDVLVLAVKPQQFREA
AASLLPHLPATGAGNLIISVAAGIRLQDMERWLGGRTRLVRAMPNTPALSGMGMTGLAAPAGLSQHDRAIASAVAEAVGK
SAWVDGDEQIDAVTAISGSGPAYVFYFIEAMERAATELGLTTQQGRELAVQTFLGAATLAGQSTEPVATLRERVTSKGGT
TYAALTAMESAGIGDAFVRAMQAAAARGKEMGEEFGKD

Sequences:

>Translated_278_residues
MLDTLTFGFLGGGNMATALISGLIARGVPAGSIRVVDPFPDAQQRLVRDLRVHVAGAPDAAFGGSDVLVLAVKPQQFREA
AASLLPHLPATGAGNLIISVAAGIRLQDMERWLGGRTRLVRAMPNTPALSGMGMTGLAAPAGLSQHDRAIASAVAEAVGK
SAWVDGDEQIDAVTAISGSGPAYVFYFIEAMERAATELGLTTQQGRELAVQTFLGAATLAGQSTEPVATLRERVTSKGGT
TYAALTAMESAGIGDAFVRAMQAAAARGKEMGEEFGKD
>Mature_278_residues
MLDTLTFGFLGGGNMATALISGLIARGVPAGSIRVVDPFPDAQQRLVRDLRVHVAGAPDAAFGGSDVLVLAVKPQQFREA
AASLLPHLPATGAGNLIISVAAGIRLQDMERWLGGRTRLVRAMPNTPALSGMGMTGLAAPAGLSQHDRAIASAVAEAVGK
SAWVDGDEQIDAVTAISGSGPAYVFYFIEAMERAATELGLTTQQGRELAVQTFLGAATLAGQSTEPVATLRERVTSKGGT
TYAALTAMESAGIGDAFVRAMQAAAARGKEMGEEFGKD

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=278, Percent_Identity=32.0143884892086, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI24797097, Length=278, Percent_Identity=32.0143884892086, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI21361454, Length=278, Percent_Identity=30.5755395683453, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI198041662, Length=269, Percent_Identity=29.7397769516729, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1786585, Length=268, Percent_Identity=33.955223880597, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17569021, Length=272, Percent_Identity=30.8823529411765, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17540664, Length=292, Percent_Identity=29.7945205479452, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320861, Length=294, Percent_Identity=27.891156462585, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=33.4545454545455, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=35.5805243445693, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=36.094674556213, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28609; Mature: 28609

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDTLTFGFLGGGNMATALISGLIARGVPAGSIRVVDPFPDAQQRLVRDLRVHVAGAPDA
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCC
AFGGSDVLVLAVKPQQFREAAASLLPHLPATGAGNLIISVAAGIRLQDMERWLGGRTRLV
CCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHCCHHEEE
RAMPNTPALSGMGMTGLAAPAGLSQHDRAIASAVAEAVGKSAWVDGDEQIDAVTAISGSG
EECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEECCCC
PAYVFYFIEAMERAATELGLTTQQGRELAVQTFLGAATLAGQSTEPVATLRERVTSKGGT
CEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
TYAALTAMESAGIGDAFVRAMQAAAARGKEMGEEFGKD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDTLTFGFLGGGNMATALISGLIARGVPAGSIRVVDPFPDAQQRLVRDLRVHVAGAPDA
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCC
AFGGSDVLVLAVKPQQFREAAASLLPHLPATGAGNLIISVAAGIRLQDMERWLGGRTRLV
CCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHCCHHEEE
RAMPNTPALSGMGMTGLAAPAGLSQHDRAIASAVAEAVGKSAWVDGDEQIDAVTAISGSG
EECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEECCCC
PAYVFYFIEAMERAATELGLTTQQGRELAVQTFLGAATLAGQSTEPVATLRERVTSKGGT
CEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
TYAALTAMESAGIGDAFVRAMQAAAARGKEMGEEFGKD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]