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The map label for this gene is mutL [H]

Identifier: 73542454

GI number: 73542454

Start: 3036977

End: 3038935

Strand: Direct

Name: mutL [H]

Synonym: Reut_A2769

Alternate gene names: 73542454

Gene position: 3036977-3038935 (Clockwise)

Preceding gene: 73542452

Following gene: 73542455

Centisome position: 79.78

GC content: 67.13

Gene sequence:

>1959_bases
ATGCCAGCCTCCGCCTCCCGCACCGCGCAGCCGCCACGGCCGATCCGTCCCCTGCCCGACCAGCTCATCAGCCAGATTGC
CGCCGGCGAAGTCGTGGAACGGCCGGCATCCGTGGTCAAGGAACTGCTCGAAAATGCACTCGACGCAGGGACAAGCCAGC
TCGGCATCCGGCTCGAAGAAGGCGGCGTGAGGCGCATCGTCATCACGGACAACGGCTGCGGCATTCCGCCCGCCGAACTG
CCCGTCGCGCTGATGCGCCATGCCACCAGCAAGATCGCTTCGCTCGACGAACTCGAGGCCGTACTGACCCTCGGTTTCCG
CGGCGAGGCCCTTGCATCGATTGCGTCCGTCTCGCAACTCTCGCTGACCAGCCGTACCGCCAGCGACGCGCACGCCACGC
AGGTCAGTGCCGATACCGGCGCAATGCAGCCGGCTTCGGGCGGCGTCGGCACCACCGTCGATGTCCAGCATCTCTACTTC
AACACGCCAGCGCGCCGAAAGTTCCTCAAATCGGAACAAACAGAGCTAGGTCACTGCCTGGAAATGGTCCGCCGCGTGGC
ACTGGCCCGCCCAGACGTGGCCATTTCGGTCCATCACAACGGCAAGCCGCTGGAACACTGGAACGCCGGTGACGTGGCCA
CGCGCACCGCACAGGTCCTCGGCAGCGATTTCGCCCGTGCACGGCTGCCGCTCGACGAGGAAGCCGGCGACCTGCATCTG
TATGGCTTTGCAGGGTTGCCCACGGCCTCGCGCGGCCGCCCGGACCAGCAGTATTTCTTCGTGAACGGCCGCTTTGTGCG
CGACAAGCTGCTTAATCATGCCGTGCGCAGCGCCTACCAGGACGTACTGCATGGCGACCGCTTCCCGTCCTACGTGCTGT
GCCTGGACCTGCCGCCGGAAATGGTGGACGTGAACGTCCATCCGTCCAAGATCGAGGTGCGCTTCCGCGAATCGCGCTCC
GTGCATCAGTTCGTCTATCACGCCGTGCAGCGCTGTCTCGCGCGCCAGGCTGGTGAGAACGGCGACAGCCTGCACACCGG
GACCGACGTCGAAGACGTGCCGGCAGCAGGCGGCGCGGGCGAACTGCGCGAGCCCCGCGCGCCATACGGTGGCACGGCGA
GCAGCGGCAGCCAGTGGATCAACTATTCGGCGGCGCGCCAGACCGAACTCGGCATTGCGCAGCCACGCCAGGCTTATCTG
GGCATGGTGCGCGAAGCCACCATGCCGCGGCCTTACGTGCCATCGTCCCAGCCGCCCGCGTGGCTCGCCGATGCGCAAGC
CGCGCGCGCCGATGAACCGCCGAGCCTGCTCGATGGTGTGGCCCCGGCCCGCATGGCGCTGCCGATTGCGGAAGACGCTA
CGGAAGGCGCTGAGGACCACCCGCTCGGCTACGCGATTGCCCAGCTCCACGGCATCTACGTGCTCGCGCAGAACGCGCGG
GGCCTTGTGCTCGTCGACATGCACGCGGCGCACGAGCGCATCCTGTACGAGCAGATCAAGGACGCGCTTGATGCACGCGA
TCTCGCCGTGCAGCCGCTGCTGCTGCCCGTGACGCTACCGGCAAACCCCGTGGAAATCGGCACTGCCGAAGAACATCGCG
AAACGCTCGAACTGCTCGGCTTCGACATCGCTCCCGTATCGCCCACCACGCTCGCGGTGCGTGCCGTGCCGGCGCTGCTG
CAGCAGGCCGACGCAGAAGCGCTGGCCCGAGACGTGCTGCGCGACCTGCACTCCTATGGCGGATCCCGAGTGCTGGCCGA
GCGCCGCAACGAACTGCTGGCCACGCTGGCCTGCCACAGCGCTGTGCGCGCCAACCGCAAGCTCACGCTGGAAGAGATGA
ACGCGCTGCTGCGCCAGATGGAACAGACCGAACGCGCCGACCAGTGCAATCACGGCCGCCCGACGTGGGTTCAGCTGAGC
GTGTCTGAGCTCGATCGTCTTTTCCTGCGCGGCCAGTAA

Upstream 100 bases:

>100_bases
CACCAAGCGCGACATCATACAAGACCCGCCCGACGCATCGGTCACCTGGCGGGGCTTGCGCGGCCATCTCGCGTGTGGCG
CGCCACGTATAATCGCCCGC

Downstream 100 bases:

>100_bases
CACCGCGTTTTTCACCGCGTTCGCGCACTACGCCTTGCAGAAGTCCTGATGTCCGCCCTGCCTTCGTCCGAACACCCGCC
CGTCGTCTGCCTGCTGGGCC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MPASASRTAQPPRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGTSQLGIRLEEGGVRRIVITDNGCGIPPAEL
PVALMRHATSKIASLDELEAVLTLGFRGEALASIASVSQLSLTSRTASDAHATQVSADTGAMQPASGGVGTTVDVQHLYF
NTPARRKFLKSEQTELGHCLEMVRRVALARPDVAISVHHNGKPLEHWNAGDVATRTAQVLGSDFARARLPLDEEAGDLHL
YGFAGLPTASRGRPDQQYFFVNGRFVRDKLLNHAVRSAYQDVLHGDRFPSYVLCLDLPPEMVDVNVHPSKIEVRFRESRS
VHQFVYHAVQRCLARQAGENGDSLHTGTDVEDVPAAGGAGELREPRAPYGGTASSGSQWINYSAARQTELGIAQPRQAYL
GMVREATMPRPYVPSSQPPAWLADAQAARADEPPSLLDGVAPARMALPIAEDATEGAEDHPLGYAIAQLHGIYVLAQNAR
GLVLVDMHAAHERILYEQIKDALDARDLAVQPLLLPVTLPANPVEIGTAEEHRETLELLGFDIAPVSPTTLAVRAVPALL
QQADAEALARDVLRDLHSYGGSRVLAERRNELLATLACHSAVRANRKLTLEEMNALLRQMEQTERADQCNHGRPTWVQLS
VSELDRLFLRGQ

Sequences:

>Translated_652_residues
MPASASRTAQPPRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGTSQLGIRLEEGGVRRIVITDNGCGIPPAEL
PVALMRHATSKIASLDELEAVLTLGFRGEALASIASVSQLSLTSRTASDAHATQVSADTGAMQPASGGVGTTVDVQHLYF
NTPARRKFLKSEQTELGHCLEMVRRVALARPDVAISVHHNGKPLEHWNAGDVATRTAQVLGSDFARARLPLDEEAGDLHL
YGFAGLPTASRGRPDQQYFFVNGRFVRDKLLNHAVRSAYQDVLHGDRFPSYVLCLDLPPEMVDVNVHPSKIEVRFRESRS
VHQFVYHAVQRCLARQAGENGDSLHTGTDVEDVPAAGGAGELREPRAPYGGTASSGSQWINYSAARQTELGIAQPRQAYL
GMVREATMPRPYVPSSQPPAWLADAQAARADEPPSLLDGVAPARMALPIAEDATEGAEDHPLGYAIAQLHGIYVLAQNAR
GLVLVDMHAAHERILYEQIKDALDARDLAVQPLLLPVTLPANPVEIGTAEEHRETLELLGFDIAPVSPTTLAVRAVPALL
QQADAEALARDVLRDLHSYGGSRVLAERRNELLATLACHSAVRANRKLTLEEMNALLRQMEQTERADQCNHGRPTWVQLS
VSELDRLFLRGQ
>Mature_651_residues
PASASRTAQPPRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGTSQLGIRLEEGGVRRIVITDNGCGIPPAELP
VALMRHATSKIASLDELEAVLTLGFRGEALASIASVSQLSLTSRTASDAHATQVSADTGAMQPASGGVGTTVDVQHLYFN
TPARRKFLKSEQTELGHCLEMVRRVALARPDVAISVHHNGKPLEHWNAGDVATRTAQVLGSDFARARLPLDEEAGDLHLY
GFAGLPTASRGRPDQQYFFVNGRFVRDKLLNHAVRSAYQDVLHGDRFPSYVLCLDLPPEMVDVNVHPSKIEVRFRESRSV
HQFVYHAVQRCLARQAGENGDSLHTGTDVEDVPAAGGAGELREPRAPYGGTASSGSQWINYSAARQTELGIAQPRQAYLG
MVREATMPRPYVPSSQPPAWLADAQAARADEPPSLLDGVAPARMALPIAEDATEGAEDHPLGYAIAQLHGIYVLAQNARG
LVLVDMHAAHERILYEQIKDALDARDLAVQPLLLPVTLPANPVEIGTAEEHRETLELLGFDIAPVSPTTLAVRAVPALLQ
QADAEALARDVLRDLHSYGGSRVLAERRNELLATLACHSAVRANRKLTLEEMNALLRQMEQTERADQCNHGRPTWVQLSV
SELDRLFLRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=358, Percent_Identity=32.122905027933, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI4505911, Length=327, Percent_Identity=31.1926605504587, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI189458898, Length=327, Percent_Identity=31.1926605504587, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI189458896, Length=379, Percent_Identity=29.023746701847, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI4505913, Length=352, Percent_Identity=28.6931818181818, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI310128478, Length=352, Percent_Identity=28.6931818181818, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI263191589, Length=265, Percent_Identity=28.3018867924528, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=27.4576271186441, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI91992162, Length=267, Percent_Identity=25.8426966292135, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI91992160, Length=267, Percent_Identity=25.8426966292135, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790612, Length=570, Percent_Identity=39.2982456140351, Blast_Score=342, Evalue=6e-95,
Organism=Caenorhabditis elegans, GI71991825, Length=328, Percent_Identity=32.9268292682927, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=26.7441860465116, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323819, Length=314, Percent_Identity=35.6687898089172, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=342, Percent_Identity=27.7777777777778, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323063, Length=146, Percent_Identity=29.4520547945205, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136968, Length=338, Percent_Identity=31.6568047337278, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI17136970, Length=356, Percent_Identity=26.4044943820225, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 70697; Mature: 70566

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASASRTAQPPRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGTSQLGIRLEE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEC
GGVRRIVITDNGCGIPPAELPVALMRHATSKIASLDELEAVLTLGFRGEALASIASVSQL
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SLTSRTASDAHATQVSADTGAMQPASGGVGTTVDVQHLYFNTPARRKFLKSEQTELGHCL
HHHHCCCCCHHHHEECCCCCCCCCCCCCCCCEEEEEHEEECCHHHHHHHHHHHHHHHHHH
EMVRRVALARPDVAISVHHNGKPLEHWNAGDVATRTAQVLGSDFARARLPLDEEAGDLHL
HHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
YGFAGLPTASRGRPDQQYFFVNGRFVRDKLLNHAVRSAYQDVLHGDRFPSYVLCLDLPPE
EEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCC
MVDVNVHPSKIEVRFRESRSVHQFVYHAVQRCLARQAGENGDSLHTGTDVEDVPAAGGAG
CEEECCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCC
ELREPRAPYGGTASSGSQWINYSAARQTELGIAQPRQAYLGMVREATMPRPYVPSSQPPA
CCCCCCCCCCCCCCCCCCCEECHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
WLADAQAARADEPPSLLDGVAPARMALPIAEDATEGAEDHPLGYAIAQLHGIYVLAQNAR
HHHCCHHHCCCCCHHHHHCCCCHHHCCCCHHCCCCCCCCCCHHHHHHHHCEEEEEEECCC
GLVLVDMHAAHERILYEQIKDALDARDLAVQPLLLPVTLPANPVEIGTAEEHRETLELLG
CEEEEECHHHHHHHHHHHHHHHHCHHHHEECCEEEEEECCCCCCCCCCHHHHHHHHHHHC
FDIAPVSPTTLAVRAVPALLQQADAEALARDVLRDLHSYGGSRVLAERRNELLATLACHS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AVRANRKLTLEEMNALLRQMEQTERADQCNHGRPTWVQLSVSELDRLFLRGQ
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
PASASRTAQPPRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGTSQLGIRLEE
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEC
GGVRRIVITDNGCGIPPAELPVALMRHATSKIASLDELEAVLTLGFRGEALASIASVSQL
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SLTSRTASDAHATQVSADTGAMQPASGGVGTTVDVQHLYFNTPARRKFLKSEQTELGHCL
HHHHCCCCCHHHHEECCCCCCCCCCCCCCCCEEEEEHEEECCHHHHHHHHHHHHHHHHHH
EMVRRVALARPDVAISVHHNGKPLEHWNAGDVATRTAQVLGSDFARARLPLDEEAGDLHL
HHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
YGFAGLPTASRGRPDQQYFFVNGRFVRDKLLNHAVRSAYQDVLHGDRFPSYVLCLDLPPE
EEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCC
MVDVNVHPSKIEVRFRESRSVHQFVYHAVQRCLARQAGENGDSLHTGTDVEDVPAAGGAG
CEEECCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCC
ELREPRAPYGGTASSGSQWINYSAARQTELGIAQPRQAYLGMVREATMPRPYVPSSQPPA
CCCCCCCCCCCCCCCCCCCEECHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
WLADAQAARADEPPSLLDGVAPARMALPIAEDATEGAEDHPLGYAIAQLHGIYVLAQNAR
HHHCCHHHCCCCCHHHHHCCCCHHHCCCCHHCCCCCCCCCCHHHHHHHHCEEEEEEECCC
GLVLVDMHAAHERILYEQIKDALDARDLAVQPLLLPVTLPANPVEIGTAEEHRETLELLG
CEEEEECHHHHHHHHHHHHHHHHCHHHHEECCEEEEEECCCCCCCCCCHHHHHHHHHHHC
FDIAPVSPTTLAVRAVPALLQQADAEALARDVLRDLHSYGGSRVLAERRNELLATLACHS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AVRANRKLTLEEMNALLRQMEQTERADQCNHGRPTWVQLSVSELDRLFLRGQ
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]