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The map label for this gene is devR [H]

Identifier: 73542427

GI number: 73542427

Start: 3009749

End: 3010408

Strand: Direct

Name: devR [H]

Synonym: Reut_A2742

Alternate gene names: 73542427

Gene position: 3009749-3010408 (Clockwise)

Preceding gene: 73542420

Following gene: 73542429

Centisome position: 79.07

GC content: 63.79

Gene sequence:

>660_bases
ATGTCGAACGCTGCACCGACGTTGTTGGTGGTCGATGATCATCCTATGGCCTTGTCCGGCACTACCGCATTCCTGACGGA
GGTGATGCCTGATGTTGCAGTCCACGCCGCTGGCAGCGCCAGGGAGGCATTGACGAGCCTTCAGCAGGGCCTGCGTCCTG
ATATTGTCCTGCTCGATATCTGGCTGAACGATGGCACGGGTTTCGATGCCATGCAGACGTTCAAGACCGTGATTCCGGGC
GCCCGCTTCATTTTCATGTCAGCTGAGGCCACGCCTGAAATCGTCGGGCGCGCCCGCGCGCTGTCGGCCTGCGGCTTCGT
AGGAAAGCACCTCGATGCTCACGCCTTTACCTCGGCTGTACGGAAGGTATTGGCCGGCGACACGTCGTTTCCGACCGATG
AGGCTCTCAGCGGCCGCGCCCAGTCGTTCGGACCGGCCCACGGGATCCCCGTCACGCCGGCCGAGCTTGGCCTGACGCCG
CGCCAGGGCTCTGTACTCGCGCTCGTACTCGAAGGCCTGCCCAACAAGGTGATCGCGCGCCGGCTAGGCCTGACCGAGAA
CACGGTAAAGGAGCACGTTTCCGCCATCCTGCAGCGGCTCGGCGTGCGTACGCGCATGCAGGTCATGTCCCGCATGGAGC
GCTTCCGCCTGCGCCAGTAA

Upstream 100 bases:

>100_bases
CGCTTCCCACGCTCTGATAGAGTGGATCCTACGTCCACGCGCCAATTTTGTGCATGCTGGTGACAACAAGGACGAAACGG
GAAATTAGACGGGAATTAGC

Downstream 100 bases:

>100_bases
GTCGGAACGCCGGTGGGACACACGCCGTCAGGCGGGGCGCAGCCAGCGACGCAGCAGCATGCGCAGTGAAGCCGGATCGA
CGGGCTTCGGCAGCACAAAA

Product: LuxR response regulator receiver

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MSNAAPTLLVVDDHPMALSGTTAFLTEVMPDVAVHAAGSAREALTSLQQGLRPDIVLLDIWLNDGTGFDAMQTFKTVIPG
ARFIFMSAEATPEIVGRARALSACGFVGKHLDAHAFTSAVRKVLAGDTSFPTDEALSGRAQSFGPAHGIPVTPAELGLTP
RQGSVLALVLEGLPNKVIARRLGLTENTVKEHVSAILQRLGVRTRMQVMSRMERFRLRQ

Sequences:

>Translated_219_residues
MSNAAPTLLVVDDHPMALSGTTAFLTEVMPDVAVHAAGSAREALTSLQQGLRPDIVLLDIWLNDGTGFDAMQTFKTVIPG
ARFIFMSAEATPEIVGRARALSACGFVGKHLDAHAFTSAVRKVLAGDTSFPTDEALSGRAQSFGPAHGIPVTPAELGLTP
RQGSVLALVLEGLPNKVIARRLGLTENTVKEHVSAILQRLGVRTRMQVMSRMERFRLRQ
>Mature_218_residues
SNAAPTLLVVDDHPMALSGTTAFLTEVMPDVAVHAAGSAREALTSLQQGLRPDIVLLDIWLNDGTGFDAMQTFKTVIPGA
RFIFMSAEATPEIVGRARALSACGFVGKHLDAHAFTSAVRKVLAGDTSFPTDEALSGRAQSFGPAHGIPVTPAELGLTPR
QGSVLALVLEGLPNKVIARRLGLTENTVKEHVSAILQRLGVRTRMQVMSRMERFRLRQ

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. When phosphorylated binds the promoter of at least its own and Acr (hspX) gene in response to hypoxia. Activates its own transcription under hy

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786747, Length=212, Percent_Identity=26.8867924528302, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787473, Length=194, Percent_Identity=32.4742268041237, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788521, Length=208, Percent_Identity=28.3653846153846, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790102, Length=210, Percent_Identity=29.0476190476191, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23451; Mature: 23320

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAAPTLLVVDDHPMALSGTTAFLTEVMPDVAVHAAGSAREALTSLQQGLRPDIVLLDI
CCCCCCEEEEECCCCCEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEE
WLNDGTGFDAMQTFKTVIPGARFIFMSAEATPEIVGRARALSACGFVGKHLDAHAFTSAV
EECCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKVLAGDTSFPTDEALSGRAQSFGPAHGIPVTPAELGLTPRQGSVLALVLEGLPNKVIAR
HHHHHCCCCCCCHHHHCCCHHCCCCCCCCCCCHHHHCCCCCCCCEEEHHHHCCCHHHHHH
RLGLTENTVKEHVSAILQRLGVRTRMQVMSRMERFRLRQ
HHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNAAPTLLVVDDHPMALSGTTAFLTEVMPDVAVHAAGSAREALTSLQQGLRPDIVLLDI
CCCCCEEEEECCCCCEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEE
WLNDGTGFDAMQTFKTVIPGARFIFMSAEATPEIVGRARALSACGFVGKHLDAHAFTSAV
EECCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKVLAGDTSFPTDEALSGRAQSFGPAHGIPVTPAELGLTPRQGSVLALVLEGLPNKVIAR
HHHHHCCCCCCCHHHHCCCHHCCCCCCCCCCCHHHHCCCCCCCCEEEHHHHCCCHHHHHH
RLGLTENTVKEHVSAILQRLGVRTRMQVMSRMERFRLRQ
HHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]