Click here to switch to the map view.

The map label for this gene is lysR [H]

Identifier: 73542275

GI number: 73542275

Start: 2840992

End: 2842008

Strand: Direct

Name: lysR [H]

Synonym: Reut_A2590

Alternate gene names: 73542275

Gene position: 2840992-2842008 (Clockwise)

Preceding gene: 73542271

Following gene: 73542276

Centisome position: 74.63

GC content: 67.35

Gene sequence:

>1017_bases
ATGTCTTTAGGCTATGGGCTGCACTTTCCCAGCGTCCCGACCATGCGTTTGCGCCAGATCGAAGTGTTTCGCGCCATCAT
GCTGACCGGCACCGTCAGCGAGGCGGCGCGCCTGCTGCACGTCTCGCAGCCGGTGGTCACGCGCGTGCTGCAGCATGCCG
AAGCCTCGCTCGGCTTCCGGCTGTTCGAGCGCGTGCGCGGCCGCTTGCAGGCCACGCCGGAAGCCAACGCACTGTATGGC
GATGTCGAAAGGCTATATGGCGAGATCGACCGCGTGCGGCGAGTCTCGGAAAGCCTGCGCCACAAGGGCGCCGGGCGCCT
GCGGGTCGCTGCCACGCCGAGCCTCGCGGAGCCGCTGCTGGTGCCTGCGGTGCGCGGCTTTTGCGCGCGCTATCCCGACA
CACAGGTGCAGGTGCTGACCCACCATACCGACGAGATCGTCGATGCGCTGCTCGCGAACCAGATCGATCTCGGCTTCGCC
TTTTCGCCGCCGCGGCACGAAGCGATCACATGCGAACCGGTGGCCGCAGGCCACATGCTGCTGGCGGTACCGCGACAGCA
GCCGCTGCCCGCAGGCGGACGCCGCCATGTGGTGCCGATGCACAAACTGATGGAGCGGCCTTTCATCGGCTACGACGACA
ATAGCTCGCTGGGCCTGCTGGTGCGCCAGACCCTGGCCCGGCATGCGCTGGAACCACATTCGACGCTCGAAGTGCAGACG
TATTCGCTCGCGTTGTCGCTGGTGGAAGCCGGACTGGGCATGGCTTTGCTTGACCAGTTCACGGCATTGAGTGCCAGCAC
GGCGCGCGTGTCGCTGCACGCCGTGCAGCCTGCCCTGCCGTTCGAGATCCAGCTGCTGCGCGCGAGCCACCGCGCCGCGT
CGAGTCTCGTCGACGACATGCGCGACGAGTTTGCGCAGGCCGCCGCGGCACTGGCCGCGACCTTGCCGGACCGGCTCGAA
GCGCCCGTTGCCAGCTTTGACGCCACCGCCACTACTGCCACCAGAGGACGGGATTGA

Upstream 100 bases:

>100_bases
ATCACTACCCGCATTGCCATCCTTGTCGCTTGCTGTTCATTCAATGGCGTCAGCGTAGTCGAGTGCACGCGGCTTGCCCA
ATGCCAATACGTGCCAGAAT

Downstream 100 bases:

>100_bases
TTGACAGCCTCGCGCGGCCTGCACCATCATCAAGGCGCCCGAACGGTGCCCTCAACCAGCCATGTTCGTACTGACCCTGC
TCCTCCTGATCCTGATCAGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSLGYGLHFPSVPTMRLRQIEVFRAIMLTGTVSEAARLLHVSQPVVTRVLQHAEASLGFRLFERVRGRLQATPEANALYG
DVERLYGEIDRVRRVSESLRHKGAGRLRVAATPSLAEPLLVPAVRGFCARYPDTQVQVLTHHTDEIVDALLANQIDLGFA
FSPPRHEAITCEPVAAGHMLLAVPRQQPLPAGGRRHVVPMHKLMERPFIGYDDNSSLGLLVRQTLARHALEPHSTLEVQT
YSLALSLVEAGLGMALLDQFTALSASTARVSLHAVQPALPFEIQLLRASHRAASSLVDDMRDEFAQAAAALAATLPDRLE
APVASFDATATTATRGRD

Sequences:

>Translated_338_residues
MSLGYGLHFPSVPTMRLRQIEVFRAIMLTGTVSEAARLLHVSQPVVTRVLQHAEASLGFRLFERVRGRLQATPEANALYG
DVERLYGEIDRVRRVSESLRHKGAGRLRVAATPSLAEPLLVPAVRGFCARYPDTQVQVLTHHTDEIVDALLANQIDLGFA
FSPPRHEAITCEPVAAGHMLLAVPRQQPLPAGGRRHVVPMHKLMERPFIGYDDNSSLGLLVRQTLARHALEPHSTLEVQT
YSLALSLVEAGLGMALLDQFTALSASTARVSLHAVQPALPFEIQLLRASHRAASSLVDDMRDEFAQAAAALAATLPDRLE
APVASFDATATTATRGRD
>Mature_337_residues
SLGYGLHFPSVPTMRLRQIEVFRAIMLTGTVSEAARLLHVSQPVVTRVLQHAEASLGFRLFERVRGRLQATPEANALYGD
VERLYGEIDRVRRVSESLRHKGAGRLRVAATPSLAEPLLVPAVRGFCARYPDTQVQVLTHHTDEIVDALLANQIDLGFAF
SPPRHEAITCEPVAAGHMLLAVPRQQPLPAGGRRHVVPMHKLMERPFIGYDDNSSLGLLVRQTLARHALEPHSTLEVQTY
SLALSLVEAGLGMALLDQFTALSASTARVSLHAVQPALPFEIQLLRASHRAASSLVDDMRDEFAQAAAALAATLPDRLEA
PVASFDATATTATRGRD

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=326, Percent_Identity=29.7546012269939, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI145693105, Length=241, Percent_Identity=26.5560165975104, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI157672245, Length=237, Percent_Identity=26.5822784810127, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788481, Length=262, Percent_Identity=24.8091603053435, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787879, Length=277, Percent_Identity=25.9927797833935, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788748, Length=291, Percent_Identity=22.3367697594502, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788296, Length=249, Percent_Identity=25.3012048192771, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787806, Length=243, Percent_Identity=23.4567901234568, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36839; Mature: 36708

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLGYGLHFPSVPTMRLRQIEVFRAIMLTGTVSEAARLLHVSQPVVTRVLQHAEASLGFR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LFERVRGRLQATPEANALYGDVERLYGEIDRVRRVSESLRHKGAGRLRVAATPSLAEPLL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
VPAVRGFCARYPDTQVQVLTHHTDEIVDALLANQIDLGFAFSPPRHEAITCEPVAAGHML
HHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCEE
LAVPRQQPLPAGGRRHVVPMHKLMERPFIGYDDNSSLGLLVRQTLARHALEPHSTLEVQT
EEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEHHH
YSLALSLVEAGLGMALLDQFTALSASTARVSLHAVQPALPFEIQLLRASHRAASSLVDDM
HHHHHHHHHHCCCHHHHHHHHHHCCCHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
RDEFAQAAAALAATLPDRLEAPVASFDATATTATRGRD
HHHHHHHHHHHHHHCHHHHHCCHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SLGYGLHFPSVPTMRLRQIEVFRAIMLTGTVSEAARLLHVSQPVVTRVLQHAEASLGFR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LFERVRGRLQATPEANALYGDVERLYGEIDRVRRVSESLRHKGAGRLRVAATPSLAEPLL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
VPAVRGFCARYPDTQVQVLTHHTDEIVDALLANQIDLGFAFSPPRHEAITCEPVAAGHML
HHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCEE
LAVPRQQPLPAGGRRHVVPMHKLMERPFIGYDDNSSLGLLVRQTLARHALEPHSTLEVQT
EEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEHHH
YSLALSLVEAGLGMALLDQFTALSASTARVSLHAVQPALPFEIQLLRASHRAASSLVDDM
HHHHHHHHHHCCCHHHHHHHHHHCCCHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
RDEFAQAAAALAATLPDRLEAPVASFDATATTATRGRD
HHHHHHHHHHHHHHCHHHHHCCHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]