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The map label for this gene is pacS [H]

Identifier: 73541731

GI number: 73541731

Start: 2240359

End: 2242908

Strand: Reverse

Name: pacS [H]

Synonym: Reut_A2043

Alternate gene names: 73541731

Gene position: 2242908-2240359 (Counterclockwise)

Preceding gene: 73541732

Following gene: 73541730

Centisome position: 58.92

GC content: 67.02

Gene sequence:

>2550_bases
ATGTCCGCCCCACACGCCAACCTCCTTGCGGACCCTCCGTCGTCCGCCCTCCAGAACGCTTCCGTCAAGCGCACGGCGCC
GGCCGCACGGTCGGCGTGTTTCCATTGTGGGCAGCCAGTGCCCGCGGGCCAGGCGTTGGCCGAGGAGATGGCCGGCCAGC
GGCGCGTATTTTGCTGTGGCGGATGCCAGACCCTGGCACGCACGCTTCACTCCGCCGGCTTTGCCCATCTCTATGGGGAC
GAGGCACGCTTTGCCCGTCCCATCGATGACTCCGCCAGGCGGGAATCCGAACCGGTCTGGGCGGCCTACGATACGCCTGA
ACTTCGCAGCCAGTTCGTGCGCCCGCTTGAAGGCGGCCGCGCCGAGATCACGCTGGCGCCCGAAAGCATCCGTTGCGCGG
CCTGCGCCTGGCTGATCGAGCAGCATCTGGGGCGCTTGCCTGGCGTGGAATCCACGATCGCAAACGTGGCGACGCGCCGC
GTCGTTGTGCGATGGCGCGATGCGGAGCAGACGGTTTCCGGCCTGCTGGCCGCATTGGCCGAGATCGGCTACGTAGCATG
GCCGTTCGAGGTCTCCCGCAGCGACGAGGCTGACCGTCGTGCGCGTCGCAGCCTGCTGATGCGTATGGCCGTAGCCATGC
TCGGCATGATGCAGGTGATGATGTACGCGTGGCCGATCTACACGCACGAGGCCACGATTGACCCCGGCATGCTGCAATTG
ATGCGCTGGGCCAGCCTGGCCCTGACGTTGCCGGTCGTCTTCTATTCGGCATCGCCGATCTTCTCGGGTGCCCGGCGCAG
CCTGCGCCAGCGGCATCTAGGCATGGATGTGCCGGTCGCTATCGGCGTTGCCGCCGGGTTTGTGGCCAGCACCGTGGCGA
CAGTGCGCGGTGTTGGCGAGGTGTATTTCGATTCTGTGACGATGTTCGTCGCCTTCCTGCTGGCCGCGCGCTATCTGGAG
TTGCGTGTACGGCAAGCCTCGCGCAGCGGCGCCGAAATGCTGGCGCGCCAGTTGCCGGCGACATGCGAGCGGCTTGGTGC
GGAAGGCGCGGCGCCGGAGCGGGTACCGGTCGCGCGCCTTCAGCACGGAGATCGCATCCGGGTCAGGGCGGGGGAAATCA
TTCCCGCCGACGGCACGATCGTATCGGGCGCGAGTGAACTTGACGAATCCATGCTGACCGGTGAAAGCCGGCCCGTGCAT
CGCACCGTGGGCGACATGGCGCTGGCGGGGTGCTACAACACCGCCAGCCCCCTGGAAATCGCGGTGGATCACGTTGGCGC
TGGCACGCGGCTGGCCGAGATCGTGGCCGTGCTTGATCGCGCGCTGGCGGAGAAGCCGCGCCTTGCGGCATTGGCTGACC
GTGTCGCTGGCTGGTTCGTGGCCACGTTGCTCGTGCTGGCTGCGTTGACCGGCGTGGTATGGGCGCTCTGGATTGACCCT
TCAAGGGCCCTGCTGGTCACCGTCGCGGTGCTGGTCGTCAGCTGCCCGTGCGCGCTTTCCCTTGCCACGCCGGCTGCGCT
GGCTGCAGCGGGTGCCGCGCTGTCGCGACGCGGCCTGTTGCTCACGCGGTCACATGCGCTGGAGACGCTGGCAGGCGTGA
CGGATGTCGTGCTGGACAAGACTGGCACCTTGACCGAAGGATGCTTTGCGCTGACGGGGCAACAGACGCTCGGGCCCAAG
CCTGCGGCCCAATGCCTGGCGCTGGCGGCTGCCATGGAGGCGGGCAGTGAACATCCGATAGGGCGGGCGCTGGTTAGCGC
CGCTGGCAGCGCTGGTGTCGATATCGGCGGCGCGTCCATGGCCACCGTACGCAATGTGCCGGGGCAGGGGGTCGAGGCTC
AAATGCAGGGCAAGCGCTTTCGACTCGGGCGCACCGCCTTTGTGGCCGGAATCCGCAATGTAAACGGTGAGGAGCAGATC
AAAGAAGCAGACACCGTTTCGGTTCCAGGGTCGACGCAGGTATGGCTCGGCGATGAAGCGGGCATGCTGGCTGTCTTCGC
ATTGTCCGACAAGGCGCGCGAATCGACGCCGCAACTGCTGGAGGCACTGAGCCGACATGGGGCGCGTTGCCACCTGGTCA
GCGGCGACAGCGCCGAGACCGTGCAATGGTGGGCGTCGCGCTTCGGTATGGATCACGCCATCGGCGCCGTATCACCGGAA
GGCAAGCGCGACTATGTCGCGAAGCTTCAGCGCAAGGGCGCCGTTGTGCTGGCGGTCGGCGATGGCATCAACGACGCGCC
AGTACTTGCGCAGGCGCAGGTGTCTATCGCCATCGGTAGCGGCGCTCCGCTTGCACAGGCAGGTGCCGATGCAGTCCTGA
CCCACGGCAACGTCGCCGACATCGCGCACGCGCTTGCGCTGGCGCGTCAGACCCGCCGCGTGGTGCGGCAAAACCTTGGC
TGGGCCTTCTTCTACAACGTGGTTGCCATTCCGCTGGCAGCCACGGGCGTTGTCACGGCGTGGATGGCAGGGATCGGCAT
GTCGGTGTCGTCGCTGCTGGTGGTGGCCAATGCCTGGCGCCTTTTGCGCGCGGGCAGAAACGGAGTCTAG

Upstream 100 bases:

>100_bases
GTTGCGGCCGGATTAGCGAAGGCAGCCGGCCATTATTGACCTATATCAAGGCCGATTTGGAGATCGGCATATACCCTCCA
ACGGGTAAAAAAAGATCTCC

Downstream 100 bases:

>100_bases
GAGTCTGGGAATGGAAACGCTGTACCTGTTGGTCCCAATGAGCCTGGTCCTTGTCGTGGTCATCGCCGGTGCCTTGTGGT
GGGCGCTGCACGCCGGGCAG

Product: ATPase, E1-E2 type:copper-translocating P-type ATPase:heavy metal translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 849; Mature: 848

Protein sequence:

>849_residues
MSAPHANLLADPPSSALQNASVKRTAPAARSACFHCGQPVPAGQALAEEMAGQRRVFCCGGCQTLARTLHSAGFAHLYGD
EARFARPIDDSARRESEPVWAAYDTPELRSQFVRPLEGGRAEITLAPESIRCAACAWLIEQHLGRLPGVESTIANVATRR
VVVRWRDAEQTVSGLLAALAEIGYVAWPFEVSRSDEADRRARRSLLMRMAVAMLGMMQVMMYAWPIYTHEATIDPGMLQL
MRWASLALTLPVVFYSASPIFSGARRSLRQRHLGMDVPVAIGVAAGFVASTVATVRGVGEVYFDSVTMFVAFLLAARYLE
LRVRQASRSGAEMLARQLPATCERLGAEGAAPERVPVARLQHGDRIRVRAGEIIPADGTIVSGASELDESMLTGESRPVH
RTVGDMALAGCYNTASPLEIAVDHVGAGTRLAEIVAVLDRALAEKPRLAALADRVAGWFVATLLVLAALTGVVWALWIDP
SRALLVTVAVLVVSCPCALSLATPAALAAAGAALSRRGLLLTRSHALETLAGVTDVVLDKTGTLTEGCFALTGQQTLGPK
PAAQCLALAAAMEAGSEHPIGRALVSAAGSAGVDIGGASMATVRNVPGQGVEAQMQGKRFRLGRTAFVAGIRNVNGEEQI
KEADTVSVPGSTQVWLGDEAGMLAVFALSDKARESTPQLLEALSRHGARCHLVSGDSAETVQWWASRFGMDHAIGAVSPE
GKRDYVAKLQRKGAVVLAVGDGINDAPVLAQAQVSIAIGSGAPLAQAGADAVLTHGNVADIAHALALARQTRRVVRQNLG
WAFFYNVVAIPLAATGVVTAWMAGIGMSVSSLLVVANAWRLLRAGRNGV

Sequences:

>Translated_849_residues
MSAPHANLLADPPSSALQNASVKRTAPAARSACFHCGQPVPAGQALAEEMAGQRRVFCCGGCQTLARTLHSAGFAHLYGD
EARFARPIDDSARRESEPVWAAYDTPELRSQFVRPLEGGRAEITLAPESIRCAACAWLIEQHLGRLPGVESTIANVATRR
VVVRWRDAEQTVSGLLAALAEIGYVAWPFEVSRSDEADRRARRSLLMRMAVAMLGMMQVMMYAWPIYTHEATIDPGMLQL
MRWASLALTLPVVFYSASPIFSGARRSLRQRHLGMDVPVAIGVAAGFVASTVATVRGVGEVYFDSVTMFVAFLLAARYLE
LRVRQASRSGAEMLARQLPATCERLGAEGAAPERVPVARLQHGDRIRVRAGEIIPADGTIVSGASELDESMLTGESRPVH
RTVGDMALAGCYNTASPLEIAVDHVGAGTRLAEIVAVLDRALAEKPRLAALADRVAGWFVATLLVLAALTGVVWALWIDP
SRALLVTVAVLVVSCPCALSLATPAALAAAGAALSRRGLLLTRSHALETLAGVTDVVLDKTGTLTEGCFALTGQQTLGPK
PAAQCLALAAAMEAGSEHPIGRALVSAAGSAGVDIGGASMATVRNVPGQGVEAQMQGKRFRLGRTAFVAGIRNVNGEEQI
KEADTVSVPGSTQVWLGDEAGMLAVFALSDKARESTPQLLEALSRHGARCHLVSGDSAETVQWWASRFGMDHAIGAVSPE
GKRDYVAKLQRKGAVVLAVGDGINDAPVLAQAQVSIAIGSGAPLAQAGADAVLTHGNVADIAHALALARQTRRVVRQNLG
WAFFYNVVAIPLAATGVVTAWMAGIGMSVSSLLVVANAWRLLRAGRNGV
>Mature_848_residues
SAPHANLLADPPSSALQNASVKRTAPAARSACFHCGQPVPAGQALAEEMAGQRRVFCCGGCQTLARTLHSAGFAHLYGDE
ARFARPIDDSARRESEPVWAAYDTPELRSQFVRPLEGGRAEITLAPESIRCAACAWLIEQHLGRLPGVESTIANVATRRV
VVRWRDAEQTVSGLLAALAEIGYVAWPFEVSRSDEADRRARRSLLMRMAVAMLGMMQVMMYAWPIYTHEATIDPGMLQLM
RWASLALTLPVVFYSASPIFSGARRSLRQRHLGMDVPVAIGVAAGFVASTVATVRGVGEVYFDSVTMFVAFLLAARYLEL
RVRQASRSGAEMLARQLPATCERLGAEGAAPERVPVARLQHGDRIRVRAGEIIPADGTIVSGASELDESMLTGESRPVHR
TVGDMALAGCYNTASPLEIAVDHVGAGTRLAEIVAVLDRALAEKPRLAALADRVAGWFVATLLVLAALTGVVWALWIDPS
RALLVTVAVLVVSCPCALSLATPAALAAAGAALSRRGLLLTRSHALETLAGVTDVVLDKTGTLTEGCFALTGQQTLGPKP
AAQCLALAAAMEAGSEHPIGRALVSAAGSAGVDIGGASMATVRNVPGQGVEAQMQGKRFRLGRTAFVAGIRNVNGEEQIK
EADTVSVPGSTQVWLGDEAGMLAVFALSDKARESTPQLLEALSRHGARCHLVSGDSAETVQWWASRFGMDHAIGAVSPEG
KRDYVAKLQRKGAVVLAVGDGINDAPVLAQAQVSIAIGSGAPLAQAGADAVLTHGNVADIAHALALARQTRRVVRQNLGW
AFFYNVVAIPLAATGVVTAWMAGIGMSVSSLLVVANAWRLLRAGRNGV

Specific function: May play a role in the osmotic adaptation [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=786, Percent_Identity=27.6081424936387, Blast_Score=263, Evalue=8e-70,
Organism=Homo sapiens, GI115529486, Length=850, Percent_Identity=26, Blast_Score=250, Evalue=5e-66,
Organism=Homo sapiens, GI55743073, Length=504, Percent_Identity=28.3730158730159, Blast_Score=190, Evalue=6e-48,
Organism=Escherichia coli, GI1786691, Length=741, Percent_Identity=31.7139001349528, Blast_Score=278, Evalue=7e-76,
Organism=Escherichia coli, GI1789879, Length=733, Percent_Identity=29.4679399727149, Blast_Score=212, Evalue=6e-56,
Organism=Escherichia coli, GI1786914, Length=466, Percent_Identity=28.9699570815451, Blast_Score=122, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17556548, Length=771, Percent_Identity=25.4215304798962, Blast_Score=216, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6320475, Length=764, Percent_Identity=26.5706806282723, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6319772, Length=701, Percent_Identity=27.3894436519258, Blast_Score=241, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6321430, Length=242, Percent_Identity=24.3801652892562, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221329854, Length=865, Percent_Identity=24.1618497109827, Blast_Score=178, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 89467; Mature: 89336

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPHANLLADPPSSALQNASVKRTAPAARSACFHCGQPVPAGQALAEEMAGQRRVFCCG
CCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEC
GCQTLARTLHSAGFAHLYGDEARFARPIDDSARRESEPVWAAYDTPELRSQFVRPLEGGR
CHHHHHHHHHHCCCCEEECCCHHHCCCCCHHHHHCCCCEEEECCCHHHHHHHHHHCCCCC
AEITLAPESIRCAACAWLIEQHLGRLPGVESTIANVATRRVVVRWRDAEQTVSGLLAALA
EEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHH
EIGYVAWPFEVSRSDEADRRARRSLLMRMAVAMLGMMQVMMYAWPIYTHEATIDPGMLQL
HCCCEECCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHH
MRWASLALTLPVVFYSASPIFSGARRSLRQRHLGMDVPVAIGVAAGFVASTVATVRGVGE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VYFDSVTMFVAFLLAARYLELRVRQASRSGAEMLARQLPATCERLGAEGAAPERVPVARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHH
QHGDRIRVRAGEIIPADGTIVSGASELDESMLTGESRPVHRTVGDMALAGCYNTASPLEI
CCCCEEEEEECCEECCCCCEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHH
AVDHVGAGTRLAEIVAVLDRALAEKPRLAALADRVAGWFVATLLVLAALTGVVWALWIDP
HHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
SRALLVTVAVLVVSCPCALSLATPAALAAAGAALSRRGLLLTRSHALETLAGVTDVVLDK
CHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHCC
TGTLTEGCFALTGQQTLGPKPAAQCLALAAAMEAGSEHPIGRALVSAAGSAGVDIGGASM
CCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCH
ATVRNVPGQGVEAQMQGKRFRLGRTAFVAGIRNVNGEEQIKEADTVSVPGSTQVWLGDEA
HHHHCCCCCCCCHHHCCCHHCCCHHHHHHHHHCCCCHHHHHCCCCEECCCCCEEEECCCC
GMLAVFALSDKARESTPQLLEALSRHGARCHLVSGDSAETVQWWASRFGMDHAIGAVSPE
CEEEEEEECCHHHCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCHHHCCCCCCC
GKRDYVAKLQRKGAVVLAVGDGINDAPVLAQAQVSIAIGSGAPLAQAGADAVLTHGNVAD
CCHHHHHHHHHCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCHHHCCCCCEEECCCHHH
IAHALALARQTRRVVRQNLGWAFFYNVVAIPLAATGVVTAWMAGIGMSVSSLLVVANAWR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
LLRAGRNGV
HHHCCCCCC
>Mature Secondary Structure 
SAPHANLLADPPSSALQNASVKRTAPAARSACFHCGQPVPAGQALAEEMAGQRRVFCCG
CCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEC
GCQTLARTLHSAGFAHLYGDEARFARPIDDSARRESEPVWAAYDTPELRSQFVRPLEGGR
CHHHHHHHHHHCCCCEEECCCHHHCCCCCHHHHHCCCCEEEECCCHHHHHHHHHHCCCCC
AEITLAPESIRCAACAWLIEQHLGRLPGVESTIANVATRRVVVRWRDAEQTVSGLLAALA
EEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHH
EIGYVAWPFEVSRSDEADRRARRSLLMRMAVAMLGMMQVMMYAWPIYTHEATIDPGMLQL
HCCCEECCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHH
MRWASLALTLPVVFYSASPIFSGARRSLRQRHLGMDVPVAIGVAAGFVASTVATVRGVGE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VYFDSVTMFVAFLLAARYLELRVRQASRSGAEMLARQLPATCERLGAEGAAPERVPVARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHH
QHGDRIRVRAGEIIPADGTIVSGASELDESMLTGESRPVHRTVGDMALAGCYNTASPLEI
CCCCEEEEEECCEECCCCCEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHH
AVDHVGAGTRLAEIVAVLDRALAEKPRLAALADRVAGWFVATLLVLAALTGVVWALWIDP
HHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
SRALLVTVAVLVVSCPCALSLATPAALAAAGAALSRRGLLLTRSHALETLAGVTDVVLDK
CHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHCC
TGTLTEGCFALTGQQTLGPKPAAQCLALAAAMEAGSEHPIGRALVSAAGSAGVDIGGASM
CCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCH
ATVRNVPGQGVEAQMQGKRFRLGRTAFVAGIRNVNGEEQIKEADTVSVPGSTQVWLGDEA
HHHHCCCCCCCCHHHCCCHHCCCHHHHHHHHHCCCCHHHHHCCCCEECCCCCEEEECCCC
GMLAVFALSDKARESTPQLLEALSRHGARCHLVSGDSAETVQWWASRFGMDHAIGAVSPE
CEEEEEEECCHHHCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCHHHCCCCCCC
GKRDYVAKLQRKGAVVLAVGDGINDAPVLAQAQVSIAIGSGAPLAQAGADAVLTHGNVAD
CCHHHHHHHHHCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCHHHCCCCCEEECCCHHH
IAHALALARQTRRVVRQNLGWAFFYNVVAIPLAATGVVTAWMAGIGMSVSSLLVVANAWR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
LLRAGRNGV
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]