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The map label for this gene is uppS [H]

Identifier: 73541566

GI number: 73541566

Start: 2054259

End: 2055044

Strand: Reverse

Name: uppS [H]

Synonym: Reut_A1877

Alternate gene names: 73541566

Gene position: 2055044-2054259 (Counterclockwise)

Preceding gene: 73541567

Following gene: 73541565

Centisome position: 53.99

GC content: 66.16

Gene sequence:

>786_bases
GTGTCGTCTGCCATCATGCAGCACATCAGTTCTACGCTCGCCGTCCCCGACAGTACCTATGTGCCCCGCCACGTTGCCAT
CATCATGGATGGCAACGGCCGCTGGGCGACGCAGCGCCATCTGCCACGCGTGGCCGGTCACAGCCGCGGGCTGGATGCCG
TTCGGGCGGTGGTCGAGGCCAGCGCCGCGCGCGGCGTGCAGTTCCTGACGCTGTTCGCGTTCAGCTCCGAGAACTGGCGT
CGTCCTGCCGACGAGGTATCGTTCCTGATGCGCCTGTTCATGACTGCCTTGCGCCGCGAGGTGGTCAAGATGCATGCGAA
CAGCATCCGCTTGCGCGTGGTGGGAGATCTGGGCCGGTTCAGTCCCCGCATCCAGCAGCTGATCAAGGATGCCGAGGCGC
GCACCGCCGGCAACACCGGCATGACGGTGACCATTGCCGCCAACTACGGCGGCCGATGGGACCTGCTGCAGGCCATGCGC
AAGATGCTGGCCCGCTCGCCGATGCTCGATCCCGAATCGATCGACGAATCGGTGCTGGCGCCGCACCTGGCGATGTCCTA
CGCACCGGAGCCGGACCTGTTCATCCGCACCGGCGGCGAACAGCGCATCAGCAATTTCCTGTTGTGGCAGCTCGCCTATT
CCGAGCTGTACTTCACCGATGTCTTCTGGCCGGACTTCGACGCGGCCGAACTGGACAAGGCCTTTGCCTCGTACCGCCAG
CGCGAACGCCGCTTTGGCCGCACCAGCGCGCAGCTGGTGGCGCCGGGGCTGTCCGGCACTGCCTGA

Upstream 100 bases:

>100_bases
CGACAAGTATGTGGCGGAAATCGACAAGATGGTCGCCGAGAAAGAGAAGGAGATCATGACGGTCTGACGGTTTCCCGGCG
CTCTGCCGCCGGGACCTTCA

Downstream 100 bases:

>100_bases
GCGGCAGGTCATTCAACTTTCCACGGGACTAGCAGCGCATGCTTCTCACCCGCGTCATCACCGCCCTGTGCCTGTTGCTG
CTGATCCTGCCGATCCTGTT

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSSAIMQHISSTLAVPDSTYVPRHVAIIMDGNGRWATQRHLPRVAGHSRGLDAVRAVVEASAARGVQFLTLFAFSSENWR
RPADEVSFLMRLFMTALRREVVKMHANSIRLRVVGDLGRFSPRIQQLIKDAEARTAGNTGMTVTIAANYGGRWDLLQAMR
KMLARSPMLDPESIDESVLAPHLAMSYAPEPDLFIRTGGEQRISNFLLWQLAYSELYFTDVFWPDFDAAELDKAFASYRQ
RERRFGRTSAQLVAPGLSGTA

Sequences:

>Translated_261_residues
MSSAIMQHISSTLAVPDSTYVPRHVAIIMDGNGRWATQRHLPRVAGHSRGLDAVRAVVEASAARGVQFLTLFAFSSENWR
RPADEVSFLMRLFMTALRREVVKMHANSIRLRVVGDLGRFSPRIQQLIKDAEARTAGNTGMTVTIAANYGGRWDLLQAMR
KMLARSPMLDPESIDESVLAPHLAMSYAPEPDLFIRTGGEQRISNFLLWQLAYSELYFTDVFWPDFDAAELDKAFASYRQ
RERRFGRTSAQLVAPGLSGTA
>Mature_260_residues
SSAIMQHISSTLAVPDSTYVPRHVAIIMDGNGRWATQRHLPRVAGHSRGLDAVRAVVEASAARGVQFLTLFAFSSENWRR
PADEVSFLMRLFMTALRREVVKMHANSIRLRVVGDLGRFSPRIQQLIKDAEARTAGNTGMTVTIAANYGGRWDLLQAMRK
MLARSPMLDPESIDESVLAPHLAMSYAPEPDLFIRTGGEQRISNFLLWQLAYSELYFTDVFWPDFDAAELDKAFASYRQR
ERRFGRTSAQLVAPGLSGTA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=34.375, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=34.375, Blast_Score=139, Evalue=2e-33,
Organism=Escherichia coli, GI1786371, Length=240, Percent_Identity=53.75, Blast_Score=266, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=34.8017621145374, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6319474, Length=214, Percent_Identity=33.6448598130841, Blast_Score=118, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=213, Percent_Identity=32.3943661971831, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=36.3636363636364, Blast_Score=141, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29219; Mature: 29088

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAIMQHISSTLAVPDSTYVPRHVAIIMDGNGRWATQRHLPRVAGHSRGLDAVRAVVEA
CCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHCHHHHCCCCCHHHHHHHHHH
SAARGVQFLTLFAFSSENWRRPADEVSFLMRLFMTALRREVVKMHANSIRLRVVGDLGRF
HHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHC
SPRIQQLIKDAEARTAGNTGMTVTIAANYGGRWDLLQAMRKMLARSPMLDPESIDESVLA
CHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCHHHHH
PHLAMSYAPEPDLFIRTGGEQRISNFLLWQLAYSELYFTDVFWPDFDAAELDKAFASYRQ
HHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
RERRFGRTSAQLVAPGLSGTA
HHHHHCCCHHHHCCCCCCCCC
>Mature Secondary Structure 
SSAIMQHISSTLAVPDSTYVPRHVAIIMDGNGRWATQRHLPRVAGHSRGLDAVRAVVEA
CHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHCHHHHCCCCCHHHHHHHHHH
SAARGVQFLTLFAFSSENWRRPADEVSFLMRLFMTALRREVVKMHANSIRLRVVGDLGRF
HHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHC
SPRIQQLIKDAEARTAGNTGMTVTIAANYGGRWDLLQAMRKMLARSPMLDPESIDESVLA
CHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCHHHHH
PHLAMSYAPEPDLFIRTGGEQRISNFLLWQLAYSELYFTDVFWPDFDAAELDKAFASYRQ
HHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
RERRFGRTSAQLVAPGLSGTA
HHHHHCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]