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The map label for this gene is lpxD [H]

Identifier: 73541560

GI number: 73541560

Start: 2046573

End: 2047661

Strand: Reverse

Name: lpxD [H]

Synonym: Reut_A1871

Alternate gene names: 73541560

Gene position: 2047661-2046573 (Counterclockwise)

Preceding gene: 73541561

Following gene: 73541559

Centisome position: 53.79

GC content: 65.66

Gene sequence:

>1089_bases
ATGCAGACACCCACACTGGGGCAGCTCGCCACCGAAAACGGCGCGCAGGTTGTGGGTGATCCCGACCTCGCGATCATCGG
CCTGGCTCCGCTGGATCAGGCCGGTTCCGGCGAACTCTCGTTCCTCTCCAATCCGCTGTACCTTGCCCAGGCGTTGTCGT
CCGCGGCTGGCGCGGTGATCGTGTCCGCGGCGGACCTGGAGCGCATCCGCGCCGAAGGGCAGGCCGACGGGCGCAACTGG
CTTGTGGCGCGCAATCCGTATGTGTGCTTCGCGCGGATTGCGCAGCGCTTCGACAAGGCCAACCAGGACGCGCGTACGGG
TATCGATCCGCGCGCCAGCGTTGCTGCGGATGTCACGGTTCCCGCTTCGTGCTTTATCGGCCCGAACGTGGTGATCGAGT
CCGGTGCGCGTATCGGCGAGCGCGTGCGCATCGTCGCGAACAGCTTCGTCGGCGCGCATGCCGAGATCGGCGACGACTCG
CTGCTGTACGCCAATGTGTCGGTCTACCACCATTGTGTGGTCGGCGCGCGCGCGATCCTGCACAGCGGGGTCGTGATCGG
TGCGGACGGGTTCGGCTTTGCGCCCGACATCGGTCCCACCGGCGTTGAATACGTGAAGATTCCGCAGACCGGCCGCGCCG
TGCTCGGCAACGATGTCGAAGTGGGCGCCAATACCGCCATCGACCGTGGCGCGATGGCCGACACCGTGATCGAAGACGGC
TGCAAGATCGACAACCAGGTCCAGATCGCGCACAACGTGCGCGTCGGCGCGCATACTGTGATTGCCGGCTGCGCCGCAGT
CTCGGGCAGTACGCATATCGGCCGGTTCTGCGTGATCGGCGGTGCCGCGAATTTCTCGGGGCACCTGAAGATTGCCGACC
GCACCACGGTGTCCGGCGGGACTTCGATCACCAAATCCATTACAAAGCCCGGTGGCCACTTCACCAGCGTGTTTCCGTTC
CTGCCACACGGCGAATGGGAGCGCAATGCCGCGATCGTGCGTGGCCTGACCAAGCTGCGTGAACGCGTCATGCAACTGGA
GCGCCGCCTGCGCGGCCAGTCCGCCGGGACCCAAACCTCACAAGACTAA

Upstream 100 bases:

>100_bases
TACGTGAACCCGCGCATCGACATCACGGACGATGTGATGAAGGCGCTGAACGCTGGCGGCAAGTAAGCCGCTGGCCGTTC
TTTTTTCAGGAAGTACCGCC

Downstream 100 bases:

>100_bases
GAGAAACATCATGACCGCCGCCGAGATCGACATCCGCCAGATTCTGAAACTGCTGCCGCATCGCTATCCGATGCTGCTGG
TGGACCGTGTGCTCGAATTC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MQTPTLGQLATENGAQVVGDPDLAIIGLAPLDQAGSGELSFLSNPLYLAQALSSAAGAVIVSAADLERIRAEGQADGRNW
LVARNPYVCFARIAQRFDKANQDARTGIDPRASVAADVTVPASCFIGPNVVIESGARIGERVRIVANSFVGAHAEIGDDS
LLYANVSVYHHCVVGARAILHSGVVIGADGFGFAPDIGPTGVEYVKIPQTGRAVLGNDVEVGANTAIDRGAMADTVIEDG
CKIDNQVQIAHNVRVGAHTVIAGCAAVSGSTHIGRFCVIGGAANFSGHLKIADRTTVSGGTSITKSITKPGGHFTSVFPF
LPHGEWERNAAIVRGLTKLRERVMQLERRLRGQSAGTQTSQD

Sequences:

>Translated_362_residues
MQTPTLGQLATENGAQVVGDPDLAIIGLAPLDQAGSGELSFLSNPLYLAQALSSAAGAVIVSAADLERIRAEGQADGRNW
LVARNPYVCFARIAQRFDKANQDARTGIDPRASVAADVTVPASCFIGPNVVIESGARIGERVRIVANSFVGAHAEIGDDS
LLYANVSVYHHCVVGARAILHSGVVIGADGFGFAPDIGPTGVEYVKIPQTGRAVLGNDVEVGANTAIDRGAMADTVIEDG
CKIDNQVQIAHNVRVGAHTVIAGCAAVSGSTHIGRFCVIGGAANFSGHLKIADRTTVSGGTSITKSITKPGGHFTSVFPF
LPHGEWERNAAIVRGLTKLRERVMQLERRLRGQSAGTQTSQD
>Mature_362_residues
MQTPTLGQLATENGAQVVGDPDLAIIGLAPLDQAGSGELSFLSNPLYLAQALSSAAGAVIVSAADLERIRAEGQADGRNW
LVARNPYVCFARIAQRFDKANQDARTGIDPRASVAADVTVPASCFIGPNVVIESGARIGERVRIVANSFVGAHAEIGDDS
LLYANVSVYHHCVVGARAILHSGVVIGADGFGFAPDIGPTGVEYVKIPQTGRAVLGNDVEVGANTAIDRGAMADTVIEDG
CKIDNQVQIAHNVRVGAHTVIAGCAAVSGSTHIGRFCVIGGAANFSGHLKIADRTTVSGGTSITKSITKPGGHFTSVFPF
LPHGEWERNAAIVRGLTKLRERVMQLERRLRGQSAGTQTSQD

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=353, Percent_Identity=40.7932011331445, Blast_Score=265, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 37737; Mature: 37737

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPTLGQLATENGAQVVGDPDLAIIGLAPLDQAGSGELSFLSNPLYLAQALSSAAGAVI
CCCCCCCHHHCCCCCEEECCCCEEEEEECCCCCCCCCCCCHHCCHHHHHHHHHHCCCEEE
VSAADLERIRAEGQADGRNWLVARNPYVCFARIAQRFDKANQDARTGIDPRASVAADVTV
EEHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEC
PASCFIGPNVVIESGARIGERVRIVANSFVGAHAEIGDDSLLYANVSVYHHCVVGARAIL
CCCEECCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHH
HSGVVIGADGFGFAPDIGPTGVEYVKIPQTGRAVLGNDVEVGANTAIDRGAMADTVIEDG
HCCEEEECCCCCCCCCCCCCCCEEEEECCCCCEECCCCEEECCCCCCCCCCHHHHHHHCC
CKIDNQVQIAHNVRVGAHTVIAGCAAVSGSTHIGRFCVIGGAANFSGHLKIADRTTVSGG
CCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEECCEEECCC
TSITKSITKPGGHFTSVFPFLPHGEWERNAAIVRGLTKLRERVMQLERRLRGQSAGTQTS
CHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
QD
CC
>Mature Secondary Structure
MQTPTLGQLATENGAQVVGDPDLAIIGLAPLDQAGSGELSFLSNPLYLAQALSSAAGAVI
CCCCCCCHHHCCCCCEEECCCCEEEEEECCCCCCCCCCCCHHCCHHHHHHHHHHCCCEEE
VSAADLERIRAEGQADGRNWLVARNPYVCFARIAQRFDKANQDARTGIDPRASVAADVTV
EEHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEC
PASCFIGPNVVIESGARIGERVRIVANSFVGAHAEIGDDSLLYANVSVYHHCVVGARAIL
CCCEECCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHH
HSGVVIGADGFGFAPDIGPTGVEYVKIPQTGRAVLGNDVEVGANTAIDRGAMADTVIEDG
HCCEEEECCCCCCCCCCCCCCCEEEEECCCCCEECCCCEEECCCCCCCCCCHHHHHHHCC
CKIDNQVQIAHNVRVGAHTVIAGCAAVSGSTHIGRFCVIGGAANFSGHLKIADRTTVSGG
CCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEECCEEECCC
TSITKSITKPGGHFTSVFPFLPHGEWERNAAIVRGLTKLRERVMQLERRLRGQSAGTQTS
CHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
QD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA