Click here to switch to the map view.

The map label for this gene is guaA [H]

Identifier: 73541543

GI number: 73541543

Start: 2030371

End: 2031990

Strand: Reverse

Name: guaA [H]

Synonym: Reut_A1854

Alternate gene names: 73541543

Gene position: 2031990-2030371 (Counterclockwise)

Preceding gene: 73541544

Following gene: 73541542

Centisome position: 53.38

GC content: 64.2

Gene sequence:

>1620_bases
ATGCACGACAAAATCCTTATTCTTGATTTCGGTTCGCAGGTCACGCAGCTGATCGCCCGCCGCGTTCGCGAGGCGCACGT
CTACTGCGAGATCCACCCGAATGATGTGAGCGACGAATTCGTCCGCGAATACGCGCCCAAGGGCATCATTCTGTCGGGCA
GCCACGCGAGCACGTACGAAGACCATCAGCTGCGCGCACCGCAGGCCGTGTGGGATCTGGGCGTGCCCGTGCTGGGCATC
TGCTACGGCATGCAGACCATGGCCGTGCAGCTTGGCGGCAAGGTCGAATGGAGCGACCACCGCGAGTTCGGCTACGCCGA
GGTGCGCGCCCATGGCCACACCCCGCTGCTCAAGGACATCGAGGATTTCTCCACGGCCGAAGGCCACGGCATGCTCAAGG
TCTGGATGAGCCACGGCGACAAGGTCGCCGCGCTGCCGCCGGGCTTCAAGCTGATGGCATCCACGCCGAGCTGCCCGATC
GCCGGCATGGCCGACGAGGCGCGTGGCTACTACGCCGTCCAGTTCCACCCGGAAGTCACGCACACTTCGAAGGGCCGCGA
GATGATCGAGCGCTTCGTGCTGGGCATCTGCCGCGCCAAGGCAGACTGGGTGATGAAGGACCACATCGAGGAAGCCGTCG
CGCTGATCCGCAAGCAGGTCGGTGACGAGGAAGTGATCCTCGGCCTGTCCGGTGGCGTGGATTCCTCGGTGGCCGCCGCG
CTGATCCACCGCGCGATCGGCGACCAACTCACCTGTGTGTTCGTCGACCACGGCCTGCTGCGCCTGGACGAAGGCAAGAT
GGTGATGGACATGTTCGCCGGCCGCCTGCATGCGAAGGTCGTCCACATCGACGCATCGGAACAGTTCCTCGGCCACCTGG
CCGGCGTGACCGACCCCGAGCAGAAGCGCAAGATCATCGGCCGCGAATTCGTTGAAGTCTTCCAGGCAGAAGCCAAGAAG
CTCAGCAACGCCAAGTGGCTGGCGCAAGGGACGATCTATCCGGATGTGGTCGAGTCGGGCGGTACCAAGACCAAGAAGGC
AACCACGATCAAGAGCCACCACAACGTTGGTGGCCTACCCGAGACGCTGGGCCTGAAGCTGCTGGAGCCGCTGCGCGACC
TGTTCAAGGACGAAGTCCGCCAACTGGGTGTGGCGCTCGGCCTGCCGCCCGAAATGGTGTACCGCCATCCGTTCCCGGGC
CCGGGCCTCGGCGTGCGTATCCTCGGCGAAGTCAAGCGCGACTACGCCGATCTGCTGCGCCGTGCCGATGCGATTTTCAT
CGAGGAACTGCGCAAGACCATCGCGACCGAGCAGGACGCAGCCGCCGGCCTGTGCGAGCCGCAGCAGGTGGGCAAGAGCT
GGTATGACCTGACCAGCCAGGCGTTCGCCGTATTCCTGCCGGTGAAGTCGGTCGGTGTGATGGGCGATGGCCGGACCTAT
GACTACGTCGTCGCGCTGCGTGCGGTGCAGACTACCGACTTCATGACGGCGCACTGGGCGCATCTGCCGTATTCGTTGCT
CGGTCGATGCTCGAACCGCATCATCAATGAAGTCCGGGGTCTGAACCGGGTCGTTTATGACGTGTCGGGGAAGCCGCCTG
CGACGATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
GACAGCCGGCGCGAGCCGGTCATCACGCCGCCGCCCGGCTACGGCCCCGGCACGGAAGTGACAACCGAACCCCAGCCGGA
AGATACGCCACACGTCCATC

Downstream 100 bases:

>100_bases
GTTGACGTCGTCTGAAGTCAATTGCTGACTATCGGCAATGCCAAGAAACCCGCGAAAAATCGCGGGTTTCGTCTTTCTGG
CTATCGACCTTCATGGTTGT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREYAPKGIILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTPLLKDIEDFSTAEGHGMLKVWMSHGDKVAALPPGFKLMASTPSCPI
AGMADEARGYYAVQFHPEVTHTSKGREMIERFVLGICRAKADWVMKDHIEEAVALIRKQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHIDASEQFLGHLAGVTDPEQKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRQLGVALGLPPEMVYRHPFPG
PGLGVRILGEVKRDYADLLRRADAIFIEELRKTIATEQDAAAGLCEPQQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVVALRAVQTTDFMTAHWAHLPYSLLGRCSNRIINEVRGLNRVVYDVSGKPPATIEWE

Sequences:

>Translated_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREYAPKGIILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTPLLKDIEDFSTAEGHGMLKVWMSHGDKVAALPPGFKLMASTPSCPI
AGMADEARGYYAVQFHPEVTHTSKGREMIERFVLGICRAKADWVMKDHIEEAVALIRKQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHIDASEQFLGHLAGVTDPEQKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRQLGVALGLPPEMVYRHPFPG
PGLGVRILGEVKRDYADLLRRADAIFIEELRKTIATEQDAAAGLCEPQQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVVALRAVQTTDFMTAHWAHLPYSLLGRCSNRIINEVRGLNRVVYDVSGKPPATIEWE
>Mature_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREYAPKGIILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTPLLKDIEDFSTAEGHGMLKVWMSHGDKVAALPPGFKLMASTPSCPI
AGMADEARGYYAVQFHPEVTHTSKGREMIERFVLGICRAKADWVMKDHIEEAVALIRKQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHIDASEQFLGHLAGVTDPEQKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRQLGVALGLPPEMVYRHPFPG
PGLGVRILGEVKRDYADLLRRADAIFIEELRKTIATEQDAAAGLCEPQQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVVALRAVQTTDFMTAHWAHLPYSLLGRCSNRIINEVRGLNRVVYDVSGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=563, Percent_Identity=33.7477797513321, Blast_Score=269, Evalue=5e-72,
Organism=Escherichia coli, GI1788854, Length=536, Percent_Identity=63.6194029850746, Blast_Score=695, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=580, Percent_Identity=34.8275862068965, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71992710, Length=580, Percent_Identity=34.8275862068965, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI133901714, Length=580, Percent_Identity=34.8275862068965, Blast_Score=280, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6323873, Length=548, Percent_Identity=47.992700729927, Blast_Score=503, Evalue=1e-143,
Organism=Drosophila melanogaster, GI281365319, Length=560, Percent_Identity=35.1785714285714, Blast_Score=288, Evalue=5e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 59611; Mature: 59611

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREYAPKGIILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCCEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTPLLKDI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEECCCCCHHHHH
EDFSTAEGHGMLKVWMSHGDKVAALPPGFKLMASTPSCPIAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCC
HTSKGREMIERFVLGICRAKADWVMKDHIEEAVALIRKQVGDEEVILGLSGGVDSSVAAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHIDASEQFLGHLAGVTDPE
HHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCHH
QKRKIIGREFVEVFQAEAKKLSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCCEEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRQLGVALGLPPEMVYRHPFPGPGLGVRILGEVKRDYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRKTIATEQDAAAGLCEPQQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHCCCCHHHCCCCCHHHHCHHHHHHHHHHEEEEEEHHHHCCCCCCCCE
DYVVALRAVQTTDFMTAHWAHLPYSLLGRCSNRIINEVRGLNRVVYDVSGKPPATIEWE
EHEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEECC
>Mature Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREYAPKGIILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCCEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTPLLKDI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEECCCCCHHHHH
EDFSTAEGHGMLKVWMSHGDKVAALPPGFKLMASTPSCPIAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCC
HTSKGREMIERFVLGICRAKADWVMKDHIEEAVALIRKQVGDEEVILGLSGGVDSSVAAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHIDASEQFLGHLAGVTDPE
HHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCHH
QKRKIIGREFVEVFQAEAKKLSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCCEEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRQLGVALGLPPEMVYRHPFPGPGLGVRILGEVKRDYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRKTIATEQDAAAGLCEPQQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHCCCCHHHCCCCCHHHHCHHHHHHHHHHEEEEEEHHHHCCCCCCCCE
DYVVALRAVQTTDFMTAHWAHLPYSLLGRCSNRIINEVRGLNRVVYDVSGKPPATIEWE
EHEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA