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The map label for this gene is czcR [H]

Identifier: 73541504

GI number: 73541504

Start: 1985262

End: 1985936

Strand: Reverse

Name: czcR [H]

Synonym: Reut_A1815

Alternate gene names: 73541504

Gene position: 1985936-1985262 (Counterclockwise)

Preceding gene: 73541508

Following gene: 73541503

Centisome position: 52.17

GC content: 63.56

Gene sequence:

>675_bases
ATGAAGATTCTTGTTGTGGAAGACGAGCCCAAGACGGGCGAATACCTGCGCAAAGGCCTGACCGAGTCATCCTTTGTGGT
CGATGTCGCGGTGACGGGCGGAGATGGCCTGCACCAGGCCACGGAACACGAATACGACCTGATCATCCTGGATGTCATGC
TGCCGGGCATGAGCGGGTGGGACGTGCTCAGGCAGCTGCGCGAGCGCAAGGACACGCCGGTCCTGTTCCTGACGGCCAGG
GACGAAGTGGAAGACCGTGTCCGCGGCCTGGAGCTCGGCGGCGACGACTATCTTGCCAAACCGTTTGCCTTTGTCGAACT
GCTCGCGCGGGTACGCACGCTGCTGCGGCGCGGACCGGTACGCGAGGCCGACCGTATCGAAATCGGCGACCTGGAGATCG
ACGTGATCCGCCATCGCGTCACCCGGGCTGGCCAGCGCATCGACCTGACTCCGCGCGAATTCGCCCTGCTGCATTTCCTG
GCCAGGCGGCATGGGGAGGTGCTCAGCCGCACGCACATTGCCTCCCAGGTGTGGGACATGAACTTCGACAGCGATACCAA
TGTGGTGGACGTGGCCATCCGCCGCCTGCGCGCAAAGATGGACGACCACTTCGCGCCCAAGCTGATCCACAGCGTACGCG
GCATCGGCTACGTCCTCGAAATTCGGCCATCGTGA

Upstream 100 bases:

>100_bases
TTACAGTCTTGTCATCCTGAGCGGCAAGCAGCGCCGCTATCATCGGATTGCAGAAAGCAGGCATGCGCGGTAAGCGCACG
GGGCCTGGAACGGAAAGACC

Downstream 100 bases:

>100_bases
CACAGGCACGCTCACTGACCACGCGTCTCGCGCTGTCATTTGCGCTGATCGCAGGCTGTGCCTTTGCCGGCGTCGGCATG
TACCTGTACCAGGCGCTCGC

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKILVVEDEPKTGEYLRKGLTESSFVVDVAVTGGDGLHQATEHEYDLIILDVMLPGMSGWDVLRQLRERKDTPVLFLTAR
DEVEDRVRGLELGGDDYLAKPFAFVELLARVRTLLRRGPVREADRIEIGDLEIDVIRHRVTRAGQRIDLTPREFALLHFL
ARRHGEVLSRTHIASQVWDMNFDSDTNVVDVAIRRLRAKMDDHFAPKLIHSVRGIGYVLEIRPS

Sequences:

>Translated_224_residues
MKILVVEDEPKTGEYLRKGLTESSFVVDVAVTGGDGLHQATEHEYDLIILDVMLPGMSGWDVLRQLRERKDTPVLFLTAR
DEVEDRVRGLELGGDDYLAKPFAFVELLARVRTLLRRGPVREADRIEIGDLEIDVIRHRVTRAGQRIDLTPREFALLHFL
ARRHGEVLSRTHIASQVWDMNFDSDTNVVDVAIRRLRAKMDDHFAPKLIHSVRGIGYVLEIRPS
>Mature_224_residues
MKILVVEDEPKTGEYLRKGLTESSFVVDVAVTGGDGLHQATEHEYDLIILDVMLPGMSGWDVLRQLRERKDTPVLFLTAR
DEVEDRVRGLELGGDDYLAKPFAFVELLARVRTLLRRGPVREADRIEIGDLEIDVIRHRVTRAGQRIDLTPREFALLHFL
ARRHGEVLSRTHIASQVWDMNFDSDTNVVDVAIRRLRAKMDDHFAPKLIHSVRGIGYVLEIRPS

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=61.4349775784753, Blast_Score=278, Evalue=2e-76,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=55.2995391705069, Blast_Score=241, Evalue=3e-65,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=40.9090909090909, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=39.5555555555556, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=37.8378378378378, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=35.9090909090909, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=39.4736842105263, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=34.8017621145374, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=35.6164383561644, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=30.9417040358744, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.0044052863436, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=34.5132743362832, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=34.6320346320346, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788713, Length=105, Percent_Identity=34.2857142857143, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI48994928, Length=115, Percent_Identity=34.7826086956522, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25585; Mature: 25585

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVVEDEPKTGEYLRKGLTESSFVVDVAVTGGDGLHQATEHEYDLIILDVMLPGMSGW
CEEEEEECCCCHHHHHHHCCCCCCEEEEEEEECCCCCHHCCCCCCCEEEEEECCCCCCHH
DVLRQLRERKDTPVLFLTARDEVEDRVRGLELGGDDYLAKPFAFVELLARVRTLLRRGPV
HHHHHHHHCCCCCEEEEEECHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
READRIEIGDLEIDVIRHRVTRAGQRIDLTPREFALLHFLARRHGEVLSRTHIASQVWDM
CCCCCEEECCCHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NFDSDTNVVDVAIRRLRAKMDDHFAPKLIHSVRGIGYVLEIRPS
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure
MKILVVEDEPKTGEYLRKGLTESSFVVDVAVTGGDGLHQATEHEYDLIILDVMLPGMSGW
CEEEEEECCCCHHHHHHHCCCCCCEEEEEEEECCCCCHHCCCCCCCEEEEEECCCCCCHH
DVLRQLRERKDTPVLFLTARDEVEDRVRGLELGGDDYLAKPFAFVELLARVRTLLRRGPV
HHHHHHHHCCCCCEEEEEECHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
READRIEIGDLEIDVIRHRVTRAGQRIDLTPREFALLHFLARRHGEVLSRTHIASQVWDM
CCCCCEEECCCHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NFDSDTNVVDVAIRRLRAKMDDHFAPKLIHSVRGIGYVLEIRPS
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]