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The map label for this gene is czcS [H]

Identifier: 73541503

GI number: 73541503

Start: 1983862

End: 1985265

Strand: Reverse

Name: czcS [H]

Synonym: Reut_A1814

Alternate gene names: 73541503

Gene position: 1985265-1983862 (Counterclockwise)

Preceding gene: 73541504

Following gene: 73541496

Centisome position: 52.15

GC content: 62.75

Gene sequence:

>1404_bases
GTGACACAGGCACGCTCACTGACCACGCGTCTCGCGCTGTCATTTGCGCTGATCGCAGGCTGTGCCTTTGCCGGCGTCGG
CATGTACCTGTACCAGGCGCTCGCCACGCAGATTATCGAACGCGATGACGCGGAGCTGCTGCGCAAGGCGACTCGCGCGC
GTGCCGAACTGGCCGAACGCGACGGCAGCGCGGCGGAGCCATTGCGCGAACTGGGCAAGGTGGTATCCGGCAATGACGAA
TACGGCCTGCGGGTGCGATCGCCTGACGGGACCGTGCTTTTGGCGGCTGGCGCCGATGCGGGAACCATTCCCGAGGTGGC
TAGCCTTGCAGCGGGCGTGCCGATTGACGGCAATGCGATTCAGTCATGGAGCACAAGCCATGGCTACCCGGTGCGCGGTG
TACTCATGCTGGCTCCGGCCGGGGCAGGATCTGGGCAGCCGCAGGTGGTGCTTTATCAGGTTGCCGCCTCGCGCCTGGCG
CTGCTGCGCACCTATCGATGGAAAGTCATGATCGCAGCATGCCTCGGCGCGCTGGGTGCCGGCTTGCTTGGCTATGCCGC
ACTACATGCCGGTATGGCCCCACTCAGGCGGATCGCAGCCGGGACGAAGACGGTCACTTTCTCAAGCGGTGCCTTGCCTG
TCGATCCGTCGGAGCTTCCAGCCGAGCTGAACGAGCTGGCGCAGGCGCTCCAGCACATGATCGAACGGCTACGTGAACGG
TACGAGCGGCTGTCACAGTTCTCTGCCGATCTTGCACACGACTTTCGAACGCCGATTGGCAACCTGCTCGGGCAAACACA
GGTGGCGCTCGCGAGCGACCGCTCTGCAGACGAATACCAGGCGTTGCTGGCGTCGAACATCGAGGAGTATGAGCGTCTGG
CCCGCATGATCGAAAACATGCTGTTCCTGGCGCGAGCGGACAACGCACGGGTAGCTCTCAACTATGCTGACCTGGACCTG
GCCGTGGAACTGGACCGGCAGGCCGACTACTTTGAGTTGCTCGCGGATTCGAGGCAGATAACCATATCCGTCGACGCACG
CGGGATGGTCTTTGCTGATGCTTTCCTGCTGCGTCGAGCCATTGGCAACCTGATCTCGAATGCAGTGCGTTATTCCCCGC
CAGGGGCACAGATCGGATTGTCGGCTCGCCAGCTTGAGGGCGAGGCCAGAATCGAAGTCAGCAATCCGGGGCCGGGGATT
GCGGCCGAGCATCTGCCTAAGCTGTTCGACCGCTTTTTCCGCGGCGATCCGGCGCGCGCCAATTCGCTTGAGTCTTCAGG
CATCGGACTGGCCATCGTGAAGACCATCATGGAACTTCACCATGGCTCCGTGCAGGCCGAATCGACGCCGGGCGAAATGA
CCATCTTCCGACTGGTCTTTCCTGAACGCCCGGCATCTCCCTGA

Upstream 100 bases:

>100_bases
TGGCCATCCGCCGCCTGCGCGCAAAGATGGACGACCACTTCGCGCCCAAGCTGATCCACAGCGTACGCGGCATCGGCTAC
GTCCTCGAAATTCGGCCATC

Downstream 100 bases:

>100_bases
GCTGCTTTTTTTTAGCCTTCCGACGATTGGTGCGCGCCATCCAGGTAAGGATCGCGCGCATTGTTGTTGGCGCCATCGGT
GAAAGGATCGCGTTGACGGT

Product: heavy metal sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MTQARSLTTRLALSFALIAGCAFAGVGMYLYQALATQIIERDDAELLRKATRARAELAERDGSAAEPLRELGKVVSGNDE
YGLRVRSPDGTVLLAAGADAGTIPEVASLAAGVPIDGNAIQSWSTSHGYPVRGVLMLAPAGAGSGQPQVVLYQVAASRLA
LLRTYRWKVMIAACLGALGAGLLGYAALHAGMAPLRRIAAGTKTVTFSSGALPVDPSELPAELNELAQALQHMIERLRER
YERLSQFSADLAHDFRTPIGNLLGQTQVALASDRSADEYQALLASNIEEYERLARMIENMLFLARADNARVALNYADLDL
AVELDRQADYFELLADSRQITISVDARGMVFADAFLLRRAIGNLISNAVRYSPPGAQIGLSARQLEGEARIEVSNPGPGI
AAEHLPKLFDRFFRGDPARANSLESSGIGLAIVKTIMELHHGSVQAESTPGEMTIFRLVFPERPASP

Sequences:

>Translated_467_residues
MTQARSLTTRLALSFALIAGCAFAGVGMYLYQALATQIIERDDAELLRKATRARAELAERDGSAAEPLRELGKVVSGNDE
YGLRVRSPDGTVLLAAGADAGTIPEVASLAAGVPIDGNAIQSWSTSHGYPVRGVLMLAPAGAGSGQPQVVLYQVAASRLA
LLRTYRWKVMIAACLGALGAGLLGYAALHAGMAPLRRIAAGTKTVTFSSGALPVDPSELPAELNELAQALQHMIERLRER
YERLSQFSADLAHDFRTPIGNLLGQTQVALASDRSADEYQALLASNIEEYERLARMIENMLFLARADNARVALNYADLDL
AVELDRQADYFELLADSRQITISVDARGMVFADAFLLRRAIGNLISNAVRYSPPGAQIGLSARQLEGEARIEVSNPGPGI
AAEHLPKLFDRFFRGDPARANSLESSGIGLAIVKTIMELHHGSVQAESTPGEMTIFRLVFPERPASP
>Mature_466_residues
TQARSLTTRLALSFALIAGCAFAGVGMYLYQALATQIIERDDAELLRKATRARAELAERDGSAAEPLRELGKVVSGNDEY
GLRVRSPDGTVLLAAGADAGTIPEVASLAAGVPIDGNAIQSWSTSHGYPVRGVLMLAPAGAGSGQPQVVLYQVAASRLAL
LRTYRWKVMIAACLGALGAGLLGYAALHAGMAPLRRIAAGTKTVTFSSGALPVDPSELPAELNELAQALQHMIERLRERY
ERLSQFSADLAHDFRTPIGNLLGQTQVALASDRSADEYQALLASNIEEYERLARMIENMLFLARADNARVALNYADLDLA
VELDRQADYFELLADSRQITISVDARGMVFADAFLLRRAIGNLISNAVRYSPPGAQIGLSARQLEGEARIEVSNPGPGIA
AEHLPKLFDRFFRGDPARANSLESSGIGLAIVKTIMELHHGSVQAESTPGEMTIFRLVFPERPASP

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=467, Percent_Identity=33.8329764453961, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1788279, Length=465, Percent_Identity=32.258064516129, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=31.9634703196347, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788393, Length=261, Percent_Identity=28.3524904214559, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=29.5652173913043, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1789403, Length=465, Percent_Identity=25.5913978494624, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790861, Length=271, Percent_Identity=30.6273062730627, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=31.1965811965812, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=234, Percent_Identity=29.9145299145299, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=29.4372294372294, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=27.4261603375527, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=247, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789808, Length=226, Percent_Identity=26.1061946902655, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=22.8215767634855, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=225, Percent_Identity=24, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI48994928, Length=242, Percent_Identity=24.3801652892562, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=245, Percent_Identity=24.0816326530612, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=23.6607142857143, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50078; Mature: 49947

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQARSLTTRLALSFALIAGCAFAGVGMYLYQALATQIIERDDAELLRKATRARAELAER
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
DGSAAEPLRELGKVVSGNDEYGLRVRSPDGTVLLAAGADAGTIPEVASLAAGVPIDGNAI
CCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCC
QSWSTSHGYPVRGVLMLAPAGAGSGQPQVVLYQVAASRLALLRTYRWKVMIAACLGALGA
CCCCCCCCCCCEEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLLGYAALHAGMAPLRRIAAGTKTVTFSSGALPVDPSELPAELNELAQALQHMIERLRER
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YERLSQFSADLAHDFRTPIGNLLGQTQVALASDRSADEYQALLASNIEEYERLARMIENM
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHH
LFLARADNARVALNYADLDLAVELDRQADYFELLADSRQITISVDARGMVFADAFLLRRA
HHHEECCCCEEEEEEECEEEEEEECCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHH
IGNLISNAVRYSPPGAQIGLSARQLEGEARIEVSNPGPGIAAEHLPKLFDRFFRGDPARA
HHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC
NSLESSGIGLAIVKTIMELHHGSVQAESTPGEMTIFRLVFPERPASP
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
TQARSLTTRLALSFALIAGCAFAGVGMYLYQALATQIIERDDAELLRKATRARAELAER
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
DGSAAEPLRELGKVVSGNDEYGLRVRSPDGTVLLAAGADAGTIPEVASLAAGVPIDGNAI
CCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCC
QSWSTSHGYPVRGVLMLAPAGAGSGQPQVVLYQVAASRLALLRTYRWKVMIAACLGALGA
CCCCCCCCCCCEEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLLGYAALHAGMAPLRRIAAGTKTVTFSSGALPVDPSELPAELNELAQALQHMIERLRER
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YERLSQFSADLAHDFRTPIGNLLGQTQVALASDRSADEYQALLASNIEEYERLARMIENM
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHH
LFLARADNARVALNYADLDLAVELDRQADYFELLADSRQITISVDARGMVFADAFLLRRA
HHHEECCCCEEEEEEECEEEEEEECCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHH
IGNLISNAVRYSPPGAQIGLSARQLEGEARIEVSNPGPGIAAEHLPKLFDRFFRGDPARA
HHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC
NSLESSGIGLAIVKTIMELHHGSVQAESTPGEMTIFRLVFPERPASP
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]