Click here to switch to the map view.

The map label for this gene is dctA [H]

Identifier: 73541410

GI number: 73541410

Start: 1859151

End: 1860425

Strand: Reverse

Name: dctA [H]

Synonym: Reut_A1721

Alternate gene names: 73541410

Gene position: 1860425-1859151 (Counterclockwise)

Preceding gene: 73541411

Following gene: 73541409

Centisome position: 48.87

GC content: 65.41

Gene sequence:

>1275_bases
ATGAACACGACCAAGCTATATGCCTTTGCCCTCAACCCGTGGGTCGTGATCGGGAGCCTGACGCTGGGCGGCGCCATGGG
CCTCCTGTGGCCCGCGATGGCGCAGGCGCTCGGCGTGGTAGGTGATCTGTACGTCGATCTGCTCAAAATGACCACGCTGC
CCTTCATGGTGTCGGCGGTGATCTTCAGCCTGCAGCGCCTGTTTCGCGACGGCGGCGCCTCGCGCCTGCTGATCCGGGTG
GTGACGGTGTTCGTCGGCGCCTCGGTGCTGGTGGCGCTGGTGGCCGCGGTGGTGCTGATGCTGCTGAGCCCGGGCACCAA
CCTGTCCGCCGCCACCATGCAGACGTTTGGCGCCATGGTCGGCCATGACAGCAATTCCAGCGATACCGTCATGAACCTGT
ACGGTGCCGACATTCCGGAGAAGTCGCTGCGGTTTTCCGATGTGCTGACCAGCCTGATTCCGACCAATATCTTTGCCGCG
CTGGCCAACGGCGACGCGCTCAAGGCGCTCGTGTTCGCGCTGCTGTTCGGGCTGGCGGTGGGACGCGTGCCGGAACGCAT
CTCGATTGGCCTGAGCCTGTCGCTGGAGACGATCTATCACGCCTGCCAGAAGCTGATGCACTGGCTCAGCTACCCGCTGC
CGGTGATCCTGTTCTGCATGAGCGCGGCCCAGCTCGGCAAGTCTGGCTTCGAGCCGCTGCAGGCCATGCTGCAGTTCGTC
ATTGCCTTCTTCGTGGCGTCGGTGCTGCTGCTGGCGCTGGCGGTGGCCATCATCTGGAAGCGTTCCAGCCAGAGCCTGAG
TGACACCCTTAACGCACTGCGCGCGCCGTTCGCCCTGGCCTTGGCCACGCGCAACAGCGCTGCGTGTATGCCCAGCATGA
TCGAAAGCCTGGTCGACAGGTTGGGCTTTGCGCGCGCGCGCGTGGAGCTGCTGGTGCCGCTGGCGGTGTCGCTGCTGCGG
GTGGGGCCGATGGTGTACTACGTGTGCGCCACGCTGTTCATCGCACAGCTCTACGGGCGTGCGCTCGGCCCGGTCGAGAT
CGCCACGGTGGTGATGGCCTCGGTGCTGGCGGGCTTTGCCTCGGCTGGCATGACCGGCCTGGTCACGGTGTCACTGGTCG
GCATGACCTGCGCCTACCTCGGCCTGCCGTTCGAGGCGGCCTTCATTCTGTTCCTGGCGGTCGATCCCGTCTGCGACATG
CTGCGCACGCTGATCCTGGTGATCGGTAATGCGGCCGCGGTCTCGGTGATCTGCCCGCGTCCTCTCAAGATCTGA

Upstream 100 bases:

>100_bases
TGGCCTTTGTCAACCAGTTCCTGGCGGAGCGGCCCAAGCACCTCGAAGTGGCTGATGTGCTCGAAGCCGCCGCGCAATAA
ACACCAGGAGAGAAACCAAG

Downstream 100 bases:

>100_bases
CTCTGACAGCACGAGGCGCGTCATGGCGATGATTGGCATTCTGGGCGGCATGGGGCCGCTGGCGACGGTGGACTTCATGG
ACCGCGTGGTTCGGCTGACC

Product: Sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNTTKLYAFALNPWVVIGSLTLGGAMGLLWPAMAQALGVVGDLYVDLLKMTTLPFMVSAVIFSLQRLFRDGGASRLLIRV
VTVFVGASVLVALVAAVVLMLLSPGTNLSAATMQTFGAMVGHDSNSSDTVMNLYGADIPEKSLRFSDVLTSLIPTNIFAA
LANGDALKALVFALLFGLAVGRVPERISIGLSLSLETIYHACQKLMHWLSYPLPVILFCMSAAQLGKSGFEPLQAMLQFV
IAFFVASVLLLALAVAIIWKRSSQSLSDTLNALRAPFALALATRNSAACMPSMIESLVDRLGFARARVELLVPLAVSLLR
VGPMVYYVCATLFIAQLYGRALGPVEIATVVMASVLAGFASAGMTGLVTVSLVGMTCAYLGLPFEAAFILFLAVDPVCDM
LRTLILVIGNAAAVSVICPRPLKI

Sequences:

>Translated_424_residues
MNTTKLYAFALNPWVVIGSLTLGGAMGLLWPAMAQALGVVGDLYVDLLKMTTLPFMVSAVIFSLQRLFRDGGASRLLIRV
VTVFVGASVLVALVAAVVLMLLSPGTNLSAATMQTFGAMVGHDSNSSDTVMNLYGADIPEKSLRFSDVLTSLIPTNIFAA
LANGDALKALVFALLFGLAVGRVPERISIGLSLSLETIYHACQKLMHWLSYPLPVILFCMSAAQLGKSGFEPLQAMLQFV
IAFFVASVLLLALAVAIIWKRSSQSLSDTLNALRAPFALALATRNSAACMPSMIESLVDRLGFARARVELLVPLAVSLLR
VGPMVYYVCATLFIAQLYGRALGPVEIATVVMASVLAGFASAGMTGLVTVSLVGMTCAYLGLPFEAAFILFLAVDPVCDM
LRTLILVIGNAAAVSVICPRPLKI
>Mature_424_residues
MNTTKLYAFALNPWVVIGSLTLGGAMGLLWPAMAQALGVVGDLYVDLLKMTTLPFMVSAVIFSLQRLFRDGGASRLLIRV
VTVFVGASVLVALVAAVVLMLLSPGTNLSAATMQTFGAMVGHDSNSSDTVMNLYGADIPEKSLRFSDVLTSLIPTNIFAA
LANGDALKALVFALLFGLAVGRVPERISIGLSLSLETIYHACQKLMHWLSYPLPVILFCMSAAQLGKSGFEPLQAMLQFV
IAFFVASVLLLALAVAIIWKRSSQSLSDTLNALRAPFALALATRNSAACMPSMIESLVDRLGFARARVELLVPLAVSLLR
VGPMVYYVCATLFIAQLYGRALGPVEIATVVMASVLAGFASAGMTGLVTVSLVGMTCAYLGLPFEAAFILFLAVDPVCDM
LRTLILVIGNAAAVSVICPRPLKI

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1790514, Length=392, Percent_Identity=27.0408163265306, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789947, Length=414, Percent_Identity=22.9468599033816, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71996953, Length=420, Percent_Identity=25.2380952380952, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17537407, Length=427, Percent_Identity=26.2295081967213, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71983106, Length=413, Percent_Identity=24.6973365617433, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983099, Length=413, Percent_Identity=24.6973365617433, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44917; Mature: 44917

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCC
>Mature Secondary Structure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CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA