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The map label for this gene is hmp [H]

Identifier: 73541236

GI number: 73541236

Start: 1665807

End: 1666871

Strand: Direct

Name: hmp [H]

Synonym: Reut_A1546

Alternate gene names: 73541236

Gene position: 1665807-1666871 (Clockwise)

Preceding gene: 73541235

Following gene: 73541237

Centisome position: 43.76

GC content: 69.39

Gene sequence:

>1065_bases
ATGGTGCAAGCGCAATTTCACCGGCTGCAGATCGCCGAAGTCGTGGCGGAGACGGACCAGGCGCATTCGCTGGTCTTCGC
GCTGCCTGAGAGCCTGCGCGACACCTTTGCCTACCGGCCGGGCCAGTTCCTGACGCTGCGCGTGCCGGTAGACGGCGTGC
CGCAGCAGCGCTGTTATTCGCTGTCGAGCGCGCCCGACGTCGACAGCGCGCTGCGCGTGACGATCAAGCGCGTGCAGGGC
GGGCGGGTTTCCAACTGGGTCTGCGACCACCTCGGTGCCGGCGATACGGTAGAAGTCATGCCGCCCGCCGGGGTGTTCAC
GCCACCCACGCTGCACGGCGACTTCCTGCTGCTGGCCGGCGGCAGCGGCATCACGCCGGTGCTGTCGATCGCCAAGGCGG
CGCTGCGCCATGGGCGCGGCACGGTGACCCTGGTCTATGCCAATCGCGACGAGCAATCGGTAATCTTCCGCGAAGCGCTG
GGCGAACTGGCGCGGCGTCATCCTGGCCGGCTGCGCGTGATCCACTGGCTCGACAGCGTGCAGGGTCCGCCCAGCCAGCG
CCAGGTCGAAGAGCTGGTGCGGCCGTGGAGCCTGGCCGAGTGCTTTATCTGCGGGCCCGGCCCGTTCATGGACAGCGCGC
AGGCGGCACTGCAGGAACTGGGCGTGCCGCGCGGCAAGCTGCACGTGGAACGCTTCGTGTCGCTGCCGGACCGCACGTCG
GCACCTGTGCAAGCAGTGATGCCAGCGGCATCCACCGTAGTCACGCCAGTCCCGGTGGCGACCATGCACGGCGCCGCGCT
GACCGTGCAGCTCGATGGGGAAACCCACCAGGTCAGCGTCGCGCCCGATGAAACCGTGCTCGACGCCATGCAGCGCGCCG
GCGTGGCGGCCCCCAATTCCTGCCGTGCCGGCTTGTGCGGCGCGTGCATGTGCCAGGTGACGCAGGGCGACGTCACGCTC
GGCGAAAACCATGTGCTCGACCAGGCCGACCTGGAGTCGGGCTGGACCCTGGCTTGCCAGGCCCGCCCCGCGAGCGGCGA
CATCCACCTCAAGTTCCCGGATTGA

Upstream 100 bases:

>100_bases
TACTGTTCCTGGCCTCCGATGAATCGCGTTTCATCAATGGCGCCGAGCTGCGCATCGACAACGCGCAGTCCATCATGGGC
GTCGCCTGACGCAAACGACT

Downstream 100 bases:

>100_bases
CATGACCACATCTGACACCATCGACGCTATTGCGGCATCGGCCGGGACCGGCATGGCAGCGCGCGACGACATCCCGGCGA
CTATTCCGGAACTGGTGCGG

Product: ferredoxin:oxidoreductase FAD/NAD(P)-binding:oxidoreductase FAD-binding region

Products: NA

Alternate protein names: Rieske-type oxygenase; RO [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MVQAQFHRLQIAEVVAETDQAHSLVFALPESLRDTFAYRPGQFLTLRVPVDGVPQQRCYSLSSAPDVDSALRVTIKRVQG
GRVSNWVCDHLGAGDTVEVMPPAGVFTPPTLHGDFLLLAGGSGITPVLSIAKAALRHGRGTVTLVYANRDEQSVIFREAL
GELARRHPGRLRVIHWLDSVQGPPSQRQVEELVRPWSLAECFICGPGPFMDSAQAALQELGVPRGKLHVERFVSLPDRTS
APVQAVMPAASTVVTPVPVATMHGAALTVQLDGETHQVSVAPDETVLDAMQRAGVAAPNSCRAGLCGACMCQVTQGDVTL
GENHVLDQADLESGWTLACQARPASGDIHLKFPD

Sequences:

>Translated_354_residues
MVQAQFHRLQIAEVVAETDQAHSLVFALPESLRDTFAYRPGQFLTLRVPVDGVPQQRCYSLSSAPDVDSALRVTIKRVQG
GRVSNWVCDHLGAGDTVEVMPPAGVFTPPTLHGDFLLLAGGSGITPVLSIAKAALRHGRGTVTLVYANRDEQSVIFREAL
GELARRHPGRLRVIHWLDSVQGPPSQRQVEELVRPWSLAECFICGPGPFMDSAQAALQELGVPRGKLHVERFVSLPDRTS
APVQAVMPAASTVVTPVPVATMHGAALTVQLDGETHQVSVAPDETVLDAMQRAGVAAPNSCRAGLCGACMCQVTQGDVTL
GENHVLDQADLESGWTLACQARPASGDIHLKFPD
>Mature_354_residues
MVQAQFHRLQIAEVVAETDQAHSLVFALPESLRDTFAYRPGQFLTLRVPVDGVPQQRCYSLSSAPDVDSALRVTIKRVQG
GRVSNWVCDHLGAGDTVEVMPPAGVFTPPTLHGDFLLLAGGSGITPVLSIAKAALRHGRGTVTLVYANRDEQSVIFREAL
GELARRHPGRLRVIHWLDSVQGPPSQRQVEELVRPWSLAECFICGPGPFMDSAQAALQELGVPRGKLHVERFVSLPDRTS
APVQAVMPAASTVVTPVPVATMHGAALTVQLDGETHQVSVAPDETVLDAMQRAGVAAPNSCRAGLCGACMCQVTQGDVTL
GENHVLDQADLESGWTLACQARPASGDIHLKFPD

Specific function: Catalyzes the opening of ring B of 1,4-androstadiene- 3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta- cleavage [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI49574502, Length=255, Percent_Identity=27.4509803921569, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787658, Length=363, Percent_Identity=34.7107438016529, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1787098, Length=348, Percent_Identity=27.8735632183908, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788903, Length=216, Percent_Identity=30.0925925925926, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788104, Length=348, Percent_Identity=22.7011494252874, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323510, Length=192, Percent_Identity=30.2083333333333, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322146, Length=235, Percent_Identity=23.4042553191489, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24655635, Length=211, Percent_Identity=27.9620853080569, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 37902; Mature: 37902

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQAQFHRLQIAEVVAETDQAHSLVFALPESLRDTFAYRPGQFLTLRVPVDGVPQQRCYS
CCCCHHHHHHHHHHHHHCCHHHHEEECCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHC
LSSAPDVDSALRVTIKRVQGGRVSNWVCDHLGAGDTVEVMPPAGVFTPPTLHGDFLLLAG
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEC
GSGITPVLSIAKAALRHGRGTVTLVYANRDEQSVIFREALGELARRHPGRLRVIHWLDSV
CCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHC
QGPPSQRQVEELVRPWSLAECFICGPGPFMDSAQAALQELGVPRGKLHVERFVSLPDRTS
CCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
APVQAVMPAASTVVTPVPVATMHGAALTVQLDGETHQVSVAPDETVLDAMQRAGVAAPNS
CCHHHHHCCHHHEECCCCCEEECCEEEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCCC
CRAGLCGACMCQVTQGDVTLGENHVLDQADLESGWTLACQARPASGDIHLKFPD
CCCCCCCHHEEEEECCCEEECCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCC
>Mature Secondary Structure
MVQAQFHRLQIAEVVAETDQAHSLVFALPESLRDTFAYRPGQFLTLRVPVDGVPQQRCYS
CCCCHHHHHHHHHHHHHCCHHHHEEECCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHC
LSSAPDVDSALRVTIKRVQGGRVSNWVCDHLGAGDTVEVMPPAGVFTPPTLHGDFLLLAG
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEC
GSGITPVLSIAKAALRHGRGTVTLVYANRDEQSVIFREALGELARRHPGRLRVIHWLDSV
CCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHC
QGPPSQRQVEELVRPWSLAECFICGPGPFMDSAQAALQELGVPRGKLHVERFVSLPDRTS
CCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
APVQAVMPAASTVVTPVPVATMHGAALTVQLDGETHQVSVAPDETVLDAMQRAGVAAPNS
CCHHHHHCCHHHEECCCCCEEECCEEEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCCC
CRAGLCGACMCQVTQGDVTLGENHVLDQADLESGWTLACQARPASGDIHLKFPD
CCCCCCCHHEEEEECCCEEECCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD [C]

Metal ions: Iron-Sulfur [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]