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The map label for this gene is hsaA [H]

Identifier: 73541232

GI number: 73541232

Start: 1661387

End: 1662628

Strand: Direct

Name: hsaA [H]

Synonym: Reut_A1542

Alternate gene names: 73541232

Gene position: 1661387-1662628 (Clockwise)

Preceding gene: 73541231

Following gene: 73541233

Centisome position: 43.65

GC content: 65.38

Gene sequence:

>1242_bases
ATGCAAACATCAACGCCAGCCACAAGACAAAATCACAAGGAGACCGCGGTGCATCACGACAACAATCCCAAGGAACTGGC
GGCACGCCTGATCGCGCGCGCCGAGCAGATGATTCCCGTGCTGGCGCAGCGCGCCGCGCAGGCAGAAGCCGAGGGACGCA
TTCCCGAGGAGACCGTGGCCGACATGCAGGCCGCGGGCTTCTTCAAGGTACTGCAGCCGCGCCGCTACGGCGGCTATGAG
CTGGACCCGCAAACCTTCTTTCGCGTCCAGATGGCGCTGGCCAAAGGTTGCATGTCGACGGCCTGGGTCTACGGCGTGGT
GGGCGTGCACAACTGGCAACTGGCGCTGTTCGACGAGCGCGCCCAGCAAGAGGTGTGGGGCAACAATGCTTCGACGCTGA
TCGCCTCGACCTACATGCCGGTCGGCAAGGTGACGCCGGTGGAAGGCGGCTTCCGCTTTTCAGGGCACTGGAAGTTCTCC
AGCGGCAGCGAGCTGTGCGAGTGGATCTTCCTGGGCGGGCTCGTGCCGCCGTCCGAGCCGGGCGGTGCTTATGACTACCG
CACCTTCCTGCTGCCGCGCTCCGACTACAAGATCGTGCGCAACTGGGATGTGCTGGGCCTGCGTGCCACCGGCAGCCATG
ACATCGTCGTCGATGATGTATTCGTGCCCGAGTACCGCACCCACCGTGCCGTCGATGGCGCCATGGGCACCAGCCCGGGC
CTGGCGCAGAACAACGTGCCGCTGTACCGGCTGCCGTTCGCGCAGATCTTCGTGCGCGCGGTCTGCACCGCCTGCATCGG
CGCGCTCGAAGGCACGCTGGACGATTTCGTCGCCTATGCCGATGGCCGCGTGAGCAGCAACGGCGGCAGCAAGACCGCAG
AGGATGGTGGCGCCCAACTTGCATGCGCTAACGCCGCGATTGCCATTGACGAGATGCGCACCATTCTCGAACGCAACTTC
GACGAACTGCTTGCGCTCGCCCGCGAGGGCGGCCAGATGCCGACGCCGCGCCGGCTGCATTTCCGCTACCAGTCGTCGCA
GGTGGCCGAGCGCTGCGCGCAGCTTGCCAACAGCCTGCTGCGCTATGCGGGCGGCAATGGTATCTACCGCAGCAACCCGA
TGGTGCGCCGCTTCATGGACCTGCACGCGGCACGCGCCCACTACGCCAACAACCTGGACCGCTTCGGCCAGAACCTCGGC
GGCGTGATGATGGGCCGTGCCAACACCGATTTCTTCATCTGA

Upstream 100 bases:

>100_bases
GCGGGAGAGGGGCCGGGGTGAGATGCCAGCGCATCCATGAAATGCCTGGCGTAATCGCGCGTGGGCTAGTCCCATCAGAC
GATGGCACCCGAACCCGCGG

Downstream 100 bases:

>100_bases
GCCGCGCTTCGCTCAAGGGAACCGATCATGAGCCAGAGCACAGCGCGCAAGCAGCCGGCGGAATTCGATGTGGTGGTGGT
GGGCTCCGGCGCGGGCGGCA

Product: hypothetical protein

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MQTSTPATRQNHKETAVHHDNNPKELAARLIARAEQMIPVLAQRAAQAEAEGRIPEETVADMQAAGFFKVLQPRRYGGYE
LDPQTFFRVQMALAKGCMSTAWVYGVVGVHNWQLALFDERAQQEVWGNNASTLIASTYMPVGKVTPVEGGFRFSGHWKFS
SGSELCEWIFLGGLVPPSEPGGAYDYRTFLLPRSDYKIVRNWDVLGLRATGSHDIVVDDVFVPEYRTHRAVDGAMGTSPG
LAQNNVPLYRLPFAQIFVRAVCTACIGALEGTLDDFVAYADGRVSSNGGSKTAEDGGAQLACANAAIAIDEMRTILERNF
DELLALAREGGQMPTPRRLHFRYQSSQVAERCAQLANSLLRYAGGNGIYRSNPMVRRFMDLHAARAHYANNLDRFGQNLG
GVMMGRANTDFFI

Sequences:

>Translated_413_residues
MQTSTPATRQNHKETAVHHDNNPKELAARLIARAEQMIPVLAQRAAQAEAEGRIPEETVADMQAAGFFKVLQPRRYGGYE
LDPQTFFRVQMALAKGCMSTAWVYGVVGVHNWQLALFDERAQQEVWGNNASTLIASTYMPVGKVTPVEGGFRFSGHWKFS
SGSELCEWIFLGGLVPPSEPGGAYDYRTFLLPRSDYKIVRNWDVLGLRATGSHDIVVDDVFVPEYRTHRAVDGAMGTSPG
LAQNNVPLYRLPFAQIFVRAVCTACIGALEGTLDDFVAYADGRVSSNGGSKTAEDGGAQLACANAAIAIDEMRTILERNF
DELLALAREGGQMPTPRRLHFRYQSSQVAERCAQLANSLLRYAGGNGIYRSNPMVRRFMDLHAARAHYANNLDRFGQNLG
GVMMGRANTDFFI
>Mature_413_residues
MQTSTPATRQNHKETAVHHDNNPKELAARLIARAEQMIPVLAQRAAQAEAEGRIPEETVADMQAAGFFKVLQPRRYGGYE
LDPQTFFRVQMALAKGCMSTAWVYGVVGVHNWQLALFDERAQQEVWGNNASTLIASTYMPVGKVTPVEGGFRFSGHWKFS
SGSELCEWIFLGGLVPPSEPGGAYDYRTFLLPRSDYKIVRNWDVLGLRATGSHDIVVDDVFVPEYRTHRAVDGAMGTSPG
LAQNNVPLYRLPFAQIFVRAVCTACIGALEGTLDDFVAYADGRVSSNGGSKTAEDGGAQLACANAAIAIDEMRTILERNF
DELLALAREGGQMPTPRRLHFRYQSSQVAERCAQLANSLLRYAGGNGIYRSNPMVRRFMDLHAARAHYANNLDRFGQNLG
GVMMGRANTDFFI

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 45549; Mature: 45549

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTSTPATRQNHKETAVHHDNNPKELAARLIARAEQMIPVLAQRAAQAEAEGRIPEETVA
CCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
DMQAAGFFKVLQPRRYGGYELDPQTFFRVQMALAKGCMSTAWVYGVVGVHNWQLALFDER
HHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEEHHH
AQQEVWGNNASTLIASTYMPVGKVTPVEGGFRFSGHWKFSSGSELCEWIFLGGLVPPSEP
HHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCC
GGAYDYRTFLLPRSDYKIVRNWDVLGLRATGSHDIVVDDVFVPEYRTHRAVDGAMGTSPG
CCCCCEEEEEECCCCCEEEECCEEEEEEECCCCCEEEECEECCCHHHHHHHCCCCCCCCC
LAQNNVPLYRLPFAQIFVRAVCTACIGALEGTLDDFVAYADGRVSSNGGSKTAEDGGAQL
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEE
ACANAAIAIDEMRTILERNFDELLALAREGGQMPTPRRLHFRYQSSQVAERCAQLANSLL
EECCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHH
RYAGGNGIYRSNPMVRRFMDLHAARAHYANNLDRFGQNLGGVMMGRANTDFFI
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
>Mature Secondary Structure
MQTSTPATRQNHKETAVHHDNNPKELAARLIARAEQMIPVLAQRAAQAEAEGRIPEETVA
CCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
DMQAAGFFKVLQPRRYGGYELDPQTFFRVQMALAKGCMSTAWVYGVVGVHNWQLALFDER
HHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEEHHH
AQQEVWGNNASTLIASTYMPVGKVTPVEGGFRFSGHWKFSSGSELCEWIFLGGLVPPSEP
HHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCC
GGAYDYRTFLLPRSDYKIVRNWDVLGLRATGSHDIVVDDVFVPEYRTHRAVDGAMGTSPG
CCCCCEEEEEECCCCCEEEECCEEEEEEECCCCCEEEECEECCCHHHHHHHCCCCCCCCC
LAQNNVPLYRLPFAQIFVRAVCTACIGALEGTLDDFVAYADGRVSSNGGSKTAEDGGAQL
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEE
ACANAAIAIDEMRTILERNFDELLALAREGGQMPTPRRLHFRYQSSQVAERCAQLANSLL
EECCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHH
RYAGGNGIYRSNPMVRRFMDLHAARAHYANNLDRFGQNLGGVMMGRANTDFFI
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA