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The map label for this gene is ribB [H]

Identifier: 73541226

GI number: 73541226

Start: 1655011

End: 1656108

Strand: Reverse

Name: ribB [H]

Synonym: Reut_A1536

Alternate gene names: 73541226

Gene position: 1656108-1655011 (Counterclockwise)

Preceding gene: 73541227

Following gene: 73541221

Centisome position: 43.51

GC content: 71.95

Gene sequence:

>1098_bases
ATGAACGCCGCCATGCTCCCGCCGATGCTGGACGTGCTCGCGGCGCTGGCTGCGGGACAGCGTGTGGTGGTGCTCGAAGA
CGAGACCGACGAAGCCCTTGGCTGCGTGCTGGTCGCCGCCGAGCGCGCCACCGAGGGCGACGTCAACTTCATGGCCGCCG
AGGCCCGCGGACTGGTCTGCATGGCGATCACCGAGGCGCGCCGCCAGCGGCTGCAGTTGCCGCCCATGGCCGCCAACCAT
CGCCAGCGCGAGCGCTACACGGTGTCGATCGAAGCCGCCAGCGGCGTCAGCACCGGCATTTCCGCCGCGGACCGCGCGCT
GACGCTGCGCGTGGCCGCGGCACGGCTCGCACAACCGGCGGATCTGGTCCAGCCTGGCCACATCTTTCCTGTGGTGGCGC
AGCCTGATGGCGTTCTGCGCCGCGCGGGCTTTGCCGAAGCGTGCTCCGACCTGCCGTCGCTGGCCGGATGCGTCGCGTCG
GGCGCTTATGCGATGCTGCTCGACGATGCCGGCGACCTGCTGCGCGGCCCCGCCCTGCTCGCGTTCGCGCAGCGCCACGG
CCTGCCCGCGGTATCGATCAGCGGGCTGATCCACCACCGGCTGCTGACCGAAGGCGCGCTGCGCCGCACGCGCACCTCCG
AACTGAACACGCCTTATGGCCGCTTTGCCGTGCATGCCTACCATGACGTGCCGGTCGATGCGCTGCACCTGGCGCTGGTG
CTGGGGCAACCCGACCCGGCCAAGGCCGTGCTGACGCGCGTGCAAACGGTGGAGATGCAGCGCGACGTGCTCGGCTTCGG
CACGCCGGCGCTGCCGGCCTGGAACCTGGAGCGATCGCTCGCGCGCATCGGTGCCGAAGGCTGCGGCGTGCTGGTGCTGC
TCGATGAACGCGAATCGCCGCAGCAGCGGCTGGAGCGGCTCGCCGCGCCGGCCGCCGCTACGCCCGCCCCGGCGTTTGCG
CAGCGCGCACTGGGCGTAGGGGCGCAGATCCTGCGCGACGTGGGCGCGCGCAAGCTACGCCTGCTAAGCCATCCGGTGCC
TTACCGCACGGTCGCCGGCTTCGAGCTGGAAGTCACGGAGTTCGTGCCGCCCGCCTGA

Upstream 100 bases:

>100_bases
TGAGCATGCAGGGCGTGCTCGATGCCGCGAGCCATGCGCTCGATGCCGCCGCTGCGTCATTGCGCCAGGCTTTCGCCGCC
AGCGGCACGCAGGAGGCAGC

Downstream 100 bases:

>100_bases
ACAAGGCGGGCAACGATACCGATGGGGGCTACGCGCGGCCGAAGCAGTCTGTAAAGCTGCGCGTGAAGCGTTCCACGTCG
GCGTCCGGCAGGTGGTTGAT

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase II

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MNAAMLPPMLDVLAALAAGQRVVVLEDETDEALGCVLVAAERATEGDVNFMAAEARGLVCMAITEARRQRLQLPPMAANH
RQRERYTVSIEAASGVSTGISAADRALTLRVAAARLAQPADLVQPGHIFPVVAQPDGVLRRAGFAEACSDLPSLAGCVAS
GAYAMLLDDAGDLLRGPALLAFAQRHGLPAVSISGLIHHRLLTEGALRRTRTSELNTPYGRFAVHAYHDVPVDALHLALV
LGQPDPAKAVLTRVQTVEMQRDVLGFGTPALPAWNLERSLARIGAEGCGVLVLLDERESPQQRLERLAAPAAATPAPAFA
QRALGVGAQILRDVGARKLRLLSHPVPYRTVAGFELEVTEFVPPA

Sequences:

>Translated_365_residues
MNAAMLPPMLDVLAALAAGQRVVVLEDETDEALGCVLVAAERATEGDVNFMAAEARGLVCMAITEARRQRLQLPPMAANH
RQRERYTVSIEAASGVSTGISAADRALTLRVAAARLAQPADLVQPGHIFPVVAQPDGVLRRAGFAEACSDLPSLAGCVAS
GAYAMLLDDAGDLLRGPALLAFAQRHGLPAVSISGLIHHRLLTEGALRRTRTSELNTPYGRFAVHAYHDVPVDALHLALV
LGQPDPAKAVLTRVQTVEMQRDVLGFGTPALPAWNLERSLARIGAEGCGVLVLLDERESPQQRLERLAAPAAATPAPAFA
QRALGVGAQILRDVGARKLRLLSHPVPYRTVAGFELEVTEFVPPA
>Mature_365_residues
MNAAMLPPMLDVLAALAAGQRVVVLEDETDEALGCVLVAAERATEGDVNFMAAEARGLVCMAITEARRQRLQLPPMAANH
RQRERYTVSIEAASGVSTGISAADRALTLRVAAARLAQPADLVQPGHIFPVVAQPDGVLRRAGFAEACSDLPSLAGCVAS
GAYAMLLDDAGDLLRGPALLAFAQRHGLPAVSISGLIHHRLLTEGALRRTRTSELNTPYGRFAVHAYHDVPVDALHLALV
LGQPDPAKAVLTRVQTVEMQRDVLGFGTPALPAWNLERSLARIGAEGCGVLVLLDERESPQQRLERLAAPAAATPAPAFA
QRALGVGAQILRDVGARKLRLLSHPVPYRTVAGFELEVTEFVPPA

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=192, Percent_Identity=43.2291666666667, Blast_Score=146, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320695, Length=205, Percent_Identity=31.219512195122, Blast_Score=106, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 38704; Mature: 38704

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAAMLPPMLDVLAALAAGQRVVVLEDETDEALGCVLVAAERATEGDVNFMAAEARGLVC
CCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHEEEEEEECCCCCCCCEEEEECCCCEEE
MAITEARRQRLQLPPMAANHRQRERYTVSIEAASGVSTGISAADRALTLRVAAARLAQPA
EEEHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCH
DLVQPGHIFPVVAQPDGVLRRAGFAEACSDLPSLAGCVASGAYAMLLDDAGDLLRGPALL
HHCCCCCEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCHHHH
AFAQRHGLPAVSISGLIHHRLLTEGALRRTRTSELNTPYGRFAVHAYHDVPVDALHLALV
HHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHEEHE
LGQPDPAKAVLTRVQTVEMQRDVLGFGTPALPAWNLERSLARIGAEGCGVLVLLDERESP
ECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCH
QQRLERLAAPAAATPAPAFAQRALGVGAQILRDVGARKLRLLSHPVPYRTVAGFELEVTE
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEECC
FVPPA
CCCCC
>Mature Secondary Structure
MNAAMLPPMLDVLAALAAGQRVVVLEDETDEALGCVLVAAERATEGDVNFMAAEARGLVC
CCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHEEEEEEECCCCCCCCEEEEECCCCEEE
MAITEARRQRLQLPPMAANHRQRERYTVSIEAASGVSTGISAADRALTLRVAAARLAQPA
EEEHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCH
DLVQPGHIFPVVAQPDGVLRRAGFAEACSDLPSLAGCVASGAYAMLLDDAGDLLRGPALL
HHCCCCCEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCHHHH
AFAQRHGLPAVSISGLIHHRLLTEGALRRTRTSELNTPYGRFAVHAYHDVPVDALHLALV
HHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHEEHE
LGQPDPAKAVLTRVQTVEMQRDVLGFGTPALPAWNLERSLARIGAEGCGVLVLLDERESP
ECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCH
QQRLERLAAPAAATPAPAFAQRALGVGAQILRDVGARKLRLLSHPVPYRTVAGFELEVTE
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEECC
FVPPA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1339274 [H]