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The map label for this gene is mhpC [H]

Identifier: 73541204

GI number: 73541204

Start: 1634074

End: 1634955

Strand: Direct

Name: mhpC [H]

Synonym: Reut_A1513

Alternate gene names: 73541204

Gene position: 1634074-1634955 (Clockwise)

Preceding gene: 73541192

Following gene: 73541205

Centisome position: 42.93

GC content: 67.01

Gene sequence:

>882_bases
ATGTCCGCTACGTCACAGCCGGCCACGCCAGCCGCCACGCCTTCGTCGCTGCACCCATCGCTGCCGATGGGACGCTTCAT
CACCACGGCCGCGGGCCTGCGGCTGCACTGCCTGGATACGGGCAGTGGCGAGCCCGTGGTATTCATCCATGGCAGCGGCC
CGGGCGCGAGCGGCCACAGCAACTTCCGCCACAACGTGCCGTCGTTTGGCGCGGCGGGTTTCCGCACCGTGGTGGTGGAC
CTGCCGGGCTACGGGCTGTCGTCCAAGCCGGATGACGTCGAATACACGCTGGACTTCTTCGTCGCCGCACTGCGCGAACA
ACTGCTGGCGCTGGAACTGCCGCGCTGCGTGCTGGTCGGCAATTCGCTCGGCGGCGCGATTGCGCTGCAGTACGCGCTCG
ATTATCCGGAGCATGTCAGCCGGCTCGTGATGATGGCGCCGGGCGGTGTCGAAGAGCGCGAGACCTATTTCCAGATGGCC
GGCATCCAGCGCATGGTGTCGCTGTTCACCGGCGGGCACATGAACCCGGACACCATGCGGCAACTGCTGCAGCTGCTGGT
CCACGACGCCAGCCTTGTGACCGACGCGCTGGTCGACGAACGCATGGCCGTGTGCCGCGAACAGCCGCGCGAGGTCTTGT
CGACCATGCGTGTGCCGAACCTGACCGAGCGGCTTGGCGAGATCCAGTGCCCGGTGCTGGGCTTCTGGGGCACCGAAGAC
CAGTTCAATCCCGCGGGCGGCGCCATGAAGTTCCTCGCCGGCTGCGCCGATGCGCGCTTCGTGATGATCAACCGCTGCGG
CCATTGGGTAATGGTCGAGCACGCGGACTACTTCAACCGCGAGTGCCTCGGCTTCCTGGCCGATACGGCAACGGCCCGCT
GA

Upstream 100 bases:

>100_bases
ATCGTAGGAGAAGCGGCCATGCCGATCGTAGTCCGAATGAACGATGCCCGGCGCGCGCCCGCCCAGCACTATCGTCGCCA
CTACAACGGGAGACGCCATC

Downstream 100 bases:

>100_bases
ACCGCTCAGGAGAACCATGATGGTTGACAACGCCACCAGGAAAGCCACGCTGCAGCAATACGTGGAACGTTTCAACGCCG
CAGACGCGCAAGGCGTTGCC

Product: Alpha/beta hydrolase fold

Products: NA

Alternate protein names: 2-hydroxy-6-ketonona-2,4-diene-1,9-dioic acid 5,6-hydrolase; 2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioic acid 5,6-hydrolase; 2-hydroxy-6-oxonona-2,4-diene-1,9-dioic acid 5,6-hydrolase [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MSATSQPATPAATPSSLHPSLPMGRFITTAAGLRLHCLDTGSGEPVVFIHGSGPGASGHSNFRHNVPSFGAAGFRTVVVD
LPGYGLSSKPDDVEYTLDFFVAALREQLLALELPRCVLVGNSLGGAIALQYALDYPEHVSRLVMMAPGGVEERETYFQMA
GIQRMVSLFTGGHMNPDTMRQLLQLLVHDASLVTDALVDERMAVCREQPREVLSTMRVPNLTERLGEIQCPVLGFWGTED
QFNPAGGAMKFLAGCADARFVMINRCGHWVMVEHADYFNRECLGFLADTATAR

Sequences:

>Translated_293_residues
MSATSQPATPAATPSSLHPSLPMGRFITTAAGLRLHCLDTGSGEPVVFIHGSGPGASGHSNFRHNVPSFGAAGFRTVVVD
LPGYGLSSKPDDVEYTLDFFVAALREQLLALELPRCVLVGNSLGGAIALQYALDYPEHVSRLVMMAPGGVEERETYFQMA
GIQRMVSLFTGGHMNPDTMRQLLQLLVHDASLVTDALVDERMAVCREQPREVLSTMRVPNLTERLGEIQCPVLGFWGTED
QFNPAGGAMKFLAGCADARFVMINRCGHWVMVEHADYFNRECLGFLADTATAR
>Mature_292_residues
SATSQPATPAATPSSLHPSLPMGRFITTAAGLRLHCLDTGSGEPVVFIHGSGPGASGHSNFRHNVPSFGAAGFRTVVVDL
PGYGLSSKPDDVEYTLDFFVAALREQLLALELPRCVLVGNSLGGAIALQYALDYPEHVSRLVMMAPGGVEERETYFQMAG
IQRMVSLFTGGHMNPDTMRQLLQLLVHDASLVTDALVDERMAVCREQPREVLSTMRVPNLTERLGEIQCPVLGFWGTEDQ
FNPAGGAMKFLAGCADARFVMINRCGHWVMVEHADYFNRECLGFLADTATAR

Specific function: Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6- oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mhpC alpha/beta hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI27597073, Length=132, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI218777840, Length=310, Percent_Identity=25.1612903225806, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI13376164, Length=310, Percent_Identity=25.1612903225806, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI189027141, Length=250, Percent_Identity=25.2, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87081721, Length=292, Percent_Identity=32.8767123287671, Blast_Score=154, Evalue=8e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.7.1.-

Molecular weight: Translated: 31757; Mature: 31626

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATSQPATPAATPSSLHPSLPMGRFITTAAGLRLHCLDTGSGEPVVFIHGSGPGASGHS
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCC
NFRHNVPSFGAAGFRTVVVDLPGYGLSSKPDDVEYTLDFFVAALREQLLALELPRCVLVG
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
NSLGGAIALQYALDYPEHVSRLVMMAPGGVEERETYFQMAGIQRMVSLFTGGHMNPDTMR
CCCCCCEEEEEHHCCHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QLLQLLVHDASLVTDALVDERMAVCREQPREVLSTMRVPNLTERLGEIQCPVLGFWGTED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCCC
QFNPAGGAMKFLAGCADARFVMINRCGHWVMVEHADYFNRECLGFLADTATAR
CCCCCCHHHHHHHHCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SATSQPATPAATPSSLHPSLPMGRFITTAAGLRLHCLDTGSGEPVVFIHGSGPGASGHS
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCC
NFRHNVPSFGAAGFRTVVVDLPGYGLSSKPDDVEYTLDFFVAALREQLLALELPRCVLVG
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
NSLGGAIALQYALDYPEHVSRLVMMAPGGVEERETYFQMAGIQRMVSLFTGGHMNPDTMR
CCCCCCEEEEEHHCCHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QLLQLLVHDASLVTDALVDERMAVCREQPREVLSTMRVPNLTERLGEIQCPVLGFWGTED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCCC
QFNPAGGAMKFLAGCADARFVMINRCGHWVMVEHADYFNRECLGFLADTATAR
CCCCCCHHHHHHHHCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA