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The map label for this gene is ybiC [H]

Identifier: 73541189

GI number: 73541189

Start: 1618477

End: 1619571

Strand: Direct

Name: ybiC [H]

Synonym: Reut_A1498

Alternate gene names: 73541189

Gene position: 1618477-1619571 (Clockwise)

Preceding gene: 73541187

Following gene: 73541190

Centisome position: 42.52

GC content: 67.95

Gene sequence:

>1095_bases
ATGAGTGATCACCGAATTCCGACCGCCGGACTGCATCAGTGGGTGGTCGACCTCTGGCTGGCCGCCGGGTCCGATGAACG
CGAAGCTGCGCTGACCGCTGATCACCTGGTCGGCGCCAACCTGTCAGGCCACGATTCGCACGGTGTGGGGATGATCCCCA
AGTACGTGATGTCGTGGCAGGCCGACCAGCTGCAGCTGAACCAGCAGGTCAGCGTGGTGCACGAGTCGGGCGGCATCCTG
AGCCTCGACGGCAACCGCGGCATGGGCCAGGCCGTGACCGAACAGGCCATGCGGCTGGGCATCGAACGGGCGCAGGATCA
TGGCGTATGCGTGCTGGGGCTGCGCCGTTCGCACCATCTGGGCCGCGTGGGACACTGGGCGGAGCAGGCCACTGCGGCCG
GCATGATCTCGATCCACTTCGTGAACGTGCTGTCCAAGCCGATCGTCGCGCCGCATGGCGGCTACGATCCGCGCTTCGGC
ACCAATCCGTTCACGATCGGCGTGCCGGTGCCCGGCCAGCCGCCGCTGGTGCTGGACTTTGCCACCAGCGCCATTGCGCT
GGGCAAGGTGCGCGTGGCCAACAACAAGGGCGTGCCTGTGCCGCCGGGCTGCCTGATGGACGCGAACGGCTATCCCACCG
CCGATCCCGGCGTCATGTTCCCGCCCCCGGGCACGCCGCAAGGCGCGCTGCGCACGTTCGGCGAGCACAAGGGCTATGTG
CTCGCCGTGATGTGCGAACTGCTGGGCGCGGCCGTGACTGGCGGCCACACGATCCGGCCGGAAACGCTCACGCATGAGCA
CGCGGTCTGGAACAACATGCTGGCGATCATTTTCGATCCGGCGCGGCTTGGCAGCAGCACCACGTTCGGCCATGAAGTGG
AAGCGTTCGTCGAGTGGATGAAGGCATCGCGGCTGCAGCCAGGCAACGACGCCATCCGGCTGCCTGGCGACCCCGAGCGC
GCATGGCGCCAGGCCCGTGCCGAATTCATCCCCGTGGACAGCGGCACGCTTTCCCAGCTCGACGATGCCGCCGCGCGCGT
GTTGCAGGCACGCGGCAAGTCGCCCGGTCCACTTTCCGCGCTCGCGGCCGAATGA

Upstream 100 bases:

>100_bases
CGGCGCACCCGAATATTCGCGCGAACAGGAGACACAGGATGCATTTTTCACATCTCGGGATGCGGCCGGTACTGGCCGCG
CCTTGTCACGCGGAGCCAGC

Downstream 100 bases:

>100_bases
ACAGGAATCCCGACGATGACCACTCCCTCCGTTATCCCGCATCTGCCCCAGATCCATCCGCTGCCCAACCGGTTTCGCGC
CGACATCCTGGCGCGCAAGC

Product: hypothetical protein

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSDHRIPTAGLHQWVVDLWLAAGSDEREAALTADHLVGANLSGHDSHGVGMIPKYVMSWQADQLQLNQQVSVVHESGGIL
SLDGNRGMGQAVTEQAMRLGIERAQDHGVCVLGLRRSHHLGRVGHWAEQATAAGMISIHFVNVLSKPIVAPHGGYDPRFG
TNPFTIGVPVPGQPPLVLDFATSAIALGKVRVANNKGVPVPPGCLMDANGYPTADPGVMFPPPGTPQGALRTFGEHKGYV
LAVMCELLGAAVTGGHTIRPETLTHEHAVWNNMLAIIFDPARLGSSTTFGHEVEAFVEWMKASRLQPGNDAIRLPGDPER
AWRQARAEFIPVDSGTLSQLDDAAARVLQARGKSPGPLSALAAE

Sequences:

>Translated_364_residues
MSDHRIPTAGLHQWVVDLWLAAGSDEREAALTADHLVGANLSGHDSHGVGMIPKYVMSWQADQLQLNQQVSVVHESGGIL
SLDGNRGMGQAVTEQAMRLGIERAQDHGVCVLGLRRSHHLGRVGHWAEQATAAGMISIHFVNVLSKPIVAPHGGYDPRFG
TNPFTIGVPVPGQPPLVLDFATSAIALGKVRVANNKGVPVPPGCLMDANGYPTADPGVMFPPPGTPQGALRTFGEHKGYV
LAVMCELLGAAVTGGHTIRPETLTHEHAVWNNMLAIIFDPARLGSSTTFGHEVEAFVEWMKASRLQPGNDAIRLPGDPER
AWRQARAEFIPVDSGTLSQLDDAAARVLQARGKSPGPLSALAAE
>Mature_363_residues
SDHRIPTAGLHQWVVDLWLAAGSDEREAALTADHLVGANLSGHDSHGVGMIPKYVMSWQADQLQLNQQVSVVHESGGILS
LDGNRGMGQAVTEQAMRLGIERAQDHGVCVLGLRRSHHLGRVGHWAEQATAAGMISIHFVNVLSKPIVAPHGGYDPRFGT
NPFTIGVPVPGQPPLVLDFATSAIALGKVRVANNKGVPVPPGCLMDANGYPTADPGVMFPPPGTPQGALRTFGEHKGYVL
AVMCELLGAAVTGGHTIRPETLTHEHAVWNNMLAIIFDPARLGSSTTFGHEVEAFVEWMKASRLQPGNDAIRLPGDPERA
WRQARAEFIPVDSGTLSQLDDAAARVLQARGKSPGPLSALAAE

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=350, Percent_Identity=50.2857142857143, Blast_Score=335, Evalue=2e-93,
Organism=Escherichia coli, GI1786727, Length=336, Percent_Identity=29.4642857142857, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790000, Length=297, Percent_Identity=24.2424242424242, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17507179, Length=323, Percent_Identity=28.4829721362229, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17536633, Length=343, Percent_Identity=27.1137026239067, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI45553211, Length=320, Percent_Identity=25.9375, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24667912, Length=320, Percent_Identity=25.9375, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24667908, Length=320, Percent_Identity=25.9375, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24667904, Length=320, Percent_Identity=25.9375, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24658010, Length=310, Percent_Identity=24.1935483870968, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24648360, Length=344, Percent_Identity=24.4186046511628, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 38705; Mature: 38574

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDHRIPTAGLHQWVVDLWLAAGSDEREAALTADHLVGANLSGHDSHGVGMIPKYVMSWQ
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCC
ADQLQLNQQVSVVHESGGILSLDGNRGMGQAVTEQAMRLGIERAQDHGVCVLGLRRSHHL
HHHHHHCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
GRVGHWAEQATAAGMISIHFVNVLSKPIVAPHGGYDPRFGTNPFTIGVPVPGQPPLVLDF
CHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEE
ATSAIALGKVRVANNKGVPVPPGCLMDANGYPTADPGVMFPPPGTPQGALRTFGEHKGYV
CCCCEEECEEEEECCCCCCCCCCCEECCCCCCCCCCCEECCCCCCCHHHHHHHHCCCCHH
LAVMCELLGAAVTGGHTIRPETLTHEHAVWNNMLAIIFDPARLGSSTTFGHEVEAFVEWM
HHHHHHHHHHHHCCCCEECCCCCCHHHHHHHCEEEEEECHHHCCCCCCCCHHHHHHHHHH
KASRLQPGNDAIRLPGDPERAWRQARAEFIPVDSGTLSQLDDAAARVLQARGKSPGPLSA
HHHCCCCCCCEEECCCCHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHH
LAAE
HCCC
>Mature Secondary Structure 
SDHRIPTAGLHQWVVDLWLAAGSDEREAALTADHLVGANLSGHDSHGVGMIPKYVMSWQ
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCC
ADQLQLNQQVSVVHESGGILSLDGNRGMGQAVTEQAMRLGIERAQDHGVCVLGLRRSHHL
HHHHHHCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
GRVGHWAEQATAAGMISIHFVNVLSKPIVAPHGGYDPRFGTNPFTIGVPVPGQPPLVLDF
CHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEE
ATSAIALGKVRVANNKGVPVPPGCLMDANGYPTADPGVMFPPPGTPQGALRTFGEHKGYV
CCCCEEECEEEEECCCCCCCCCCCEECCCCCCCCCCCEECCCCCCCHHHHHHHHCCCCHH
LAVMCELLGAAVTGGHTIRPETLTHEHAVWNNMLAIIFDPARLGSSTTFGHEVEAFVEWM
HHHHHHHHHHHHCCCCEECCCCCCHHHHHHHCEEEEEECHHHCCCCCCCCHHHHHHHHHH
KASRLQPGNDAIRLPGDPERAWRQARAEFIPVDSGTLSQLDDAAARVLQARGKSPGPLSA
HHHCCCCCCCEEECCCCHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHH
LAAE
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]