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The map label for this gene is alkK [H]

Identifier: 73541092

GI number: 73541092

Start: 1511136

End: 1512761

Strand: Direct

Name: alkK [H]

Synonym: Reut_A1398

Alternate gene names: 73541092

Gene position: 1511136-1512761 (Clockwise)

Preceding gene: 73541091

Following gene: 73541093

Centisome position: 39.7

GC content: 61.99

Gene sequence:

>1626_bases
ATGGCATTGATGGGTCAAATGATGAGCGCGCCGCTGCTCATTTCCTCCATCATCCGGCACGCTGCCCGCTATTACGGCAG
CACCGAAATCGTCTCGCGACGTACCGAAGGCGACCTTCACCGCTATACCTATCGCGATTGCGAGCTGCGTGCCCGCAAGA
TGGCCCAGGCATTAGCTGCGCTTGGCGTGCAGCAGGGCGATCGTGTTGGTACCTTGGCCTGGAATGGTTACCGGCACCTC
GAAATCTACTATGGCGTGTCGGGCATGGGCGCCGTCTGCCATACGATCAACCCGCGCCTGTTCCCCGAGCAAATTGCCTA
TATCGTCAATCACGCCGACGATGGTTATGTGTTCTTCGACCTGACTTTCCTGCCGCTTGTGGAAGGCGTGGCGCCGCATT
GCCCGAATGTGAAGGGCTGGGTGCTGATGAGCGACCGTGCCCATATGCCGGCGGAGTCCAAGGGGAAGCTGCTGTGCTAT
GAAGAATTGATCGACGCGCAGGACGGCAACTATGATTGGCCGGACCTCGACGAAAACCAGGCGTCGAGCCTGTGCTACAC
CTCCGGTACGACCGGCAATCCGAAGGGCGCGCTGTATTCGCACCGCTCGACGGTGCTGCATTCCTACGCGTCCGCGCTGC
CCGATGCACTGGGCTGCTCGGCGCGCGACGTGATCCTGCCGGTGGTCCCGATGTTCCATGTCAACGCCTGGGGCCTGCCA
TATTCGGTGCCGCTCGTCGGTGCGAAGCTCGTGTTGCCTGGCCCCAAGCTGGACGGGGCTTCCGTGTATGAGTTGTTCGA
GCAAGAAAAGGTGACCTTCTCCGCCGGCGTGCCGACGGTATGGCTGGGCCTGCTGCAGCATGTGCAGGCCAACAACCTGA
AGTTCTCCACCTTCCGCCGCACCGTGATCGGCGGGTCGGCGGTGCCACCGGCAATGATCCGCGCGCTGCGGGCGCTGGAT
GTCGAAGTCATCCACGGCTGGGGAATGACCGAGATGTCACCACTGGGCACCACCTGCAAGCTGTTGGCCAAGCACGAGGA
GTTGTCCGAGGAGGCGTCCCAGAAGGTCCTTGAGAAGCAGGGCCGCGTGCTGTTCGGGGTGGATATGAAGATTGTCGATG
GCGACGGCAAGGAGTTGCCCTGGGACGGCAAGGCCTTCGGCGACCTGCTGGTGCGCGGTCCCTGGATCATCGAGCGCTAC
TTCCGCAATGACACCAATCCGCTCGTCGACGGCTGGTTTCCGACCGGCGACGTGGCCACCATCGATCCCGACGGCTACAT
GCAGATCACCGACCGCAGCAAGGACGTGATCAAGTCCGGCGGCGAATGGATCTCGTCGATCGATATCGAGAACGTGGCCG
CGGCCCACCCGGCCGTGCATATGGCCGCCTGCATTTCCGTGCATCACCCGAAGTGGGACGAGCGCCCGCTGCTGGTCGTG
GTGAAGAAGCCGAGCGCCGAAGTCACCAGGGAAGAGTTGCTGAAATTCTTTGAGGGCAAGGTCGCCAAATGGTGGATTCC
TGACGACGTGGCCTTCGTCAGCGAAATCCCGCTGACCGCTACCGGCAAGATGCAGAAGCTCAAGCTGCGCGACCAGTTCA
AGGACTACCGCCTGCCGACAGCCTGA

Upstream 100 bases:

>100_bases
AATCCCGTTGACGTTGTTTGAGTGCGTGGGAACAATCGCCAAAAAATAGAACGGTTGTTCGTTTTCAGACGATAAATACT
AAAATTCAGGAGACTGTTTC

Downstream 100 bases:

>100_bases
GGCGGAACGGGCATTCGCCACGCCGTGCCTGCTTGCGGCACGGTGTTGGCGAGGCAGCCGGGCGAGCAACAACAGGGTCC
GCCCGGCGAGCCGCAATCGA

Product: long-chain-fatty-acid--CoA ligase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MALMGQMMSAPLLISSIIRHAARYYGSTEIVSRRTEGDLHRYTYRDCELRARKMAQALAALGVQQGDRVGTLAWNGYRHL
EIYYGVSGMGAVCHTINPRLFPEQIAYIVNHADDGYVFFDLTFLPLVEGVAPHCPNVKGWVLMSDRAHMPAESKGKLLCY
EELIDAQDGNYDWPDLDENQASSLCYTSGTTGNPKGALYSHRSTVLHSYASALPDALGCSARDVILPVVPMFHVNAWGLP
YSVPLVGAKLVLPGPKLDGASVYELFEQEKVTFSAGVPTVWLGLLQHVQANNLKFSTFRRTVIGGSAVPPAMIRALRALD
VEVIHGWGMTEMSPLGTTCKLLAKHEELSEEASQKVLEKQGRVLFGVDMKIVDGDGKELPWDGKAFGDLLVRGPWIIERY
FRNDTNPLVDGWFPTGDVATIDPDGYMQITDRSKDVIKSGGEWISSIDIENVAAAHPAVHMAACISVHHPKWDERPLLVV
VKKPSAEVTREELLKFFEGKVAKWWIPDDVAFVSEIPLTATGKMQKLKLRDQFKDYRLPTA

Sequences:

>Translated_541_residues
MALMGQMMSAPLLISSIIRHAARYYGSTEIVSRRTEGDLHRYTYRDCELRARKMAQALAALGVQQGDRVGTLAWNGYRHL
EIYYGVSGMGAVCHTINPRLFPEQIAYIVNHADDGYVFFDLTFLPLVEGVAPHCPNVKGWVLMSDRAHMPAESKGKLLCY
EELIDAQDGNYDWPDLDENQASSLCYTSGTTGNPKGALYSHRSTVLHSYASALPDALGCSARDVILPVVPMFHVNAWGLP
YSVPLVGAKLVLPGPKLDGASVYELFEQEKVTFSAGVPTVWLGLLQHVQANNLKFSTFRRTVIGGSAVPPAMIRALRALD
VEVIHGWGMTEMSPLGTTCKLLAKHEELSEEASQKVLEKQGRVLFGVDMKIVDGDGKELPWDGKAFGDLLVRGPWIIERY
FRNDTNPLVDGWFPTGDVATIDPDGYMQITDRSKDVIKSGGEWISSIDIENVAAAHPAVHMAACISVHHPKWDERPLLVV
VKKPSAEVTREELLKFFEGKVAKWWIPDDVAFVSEIPLTATGKMQKLKLRDQFKDYRLPTA
>Mature_540_residues
ALMGQMMSAPLLISSIIRHAARYYGSTEIVSRRTEGDLHRYTYRDCELRARKMAQALAALGVQQGDRVGTLAWNGYRHLE
IYYGVSGMGAVCHTINPRLFPEQIAYIVNHADDGYVFFDLTFLPLVEGVAPHCPNVKGWVLMSDRAHMPAESKGKLLCYE
ELIDAQDGNYDWPDLDENQASSLCYTSGTTGNPKGALYSHRSTVLHSYASALPDALGCSARDVILPVVPMFHVNAWGLPY
SVPLVGAKLVLPGPKLDGASVYELFEQEKVTFSAGVPTVWLGLLQHVQANNLKFSTFRRTVIGGSAVPPAMIRALRALDV
EVIHGWGMTEMSPLGTTCKLLAKHEELSEEASQKVLEKQGRVLFGVDMKIVDGDGKELPWDGKAFGDLLVRGPWIIERYF
RNDTNPLVDGWFPTGDVATIDPDGYMQITDRSKDVIKSGGEWISSIDIENVAAAHPAVHMAACISVHHPKWDERPLLVVV
KKPSAEVTREELLKFFEGKVAKWWIPDDVAFVSEIPLTATGKMQKLKLRDQFKDYRLPTA

Specific function: Unknown

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=527, Percent_Identity=27.134724857685, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI187761345, Length=542, Percent_Identity=26.3837638376384, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI187761343, Length=542, Percent_Identity=26.3837638376384, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI38505220, Length=508, Percent_Identity=24.6062992125984, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI157311624, Length=511, Percent_Identity=24.4618395303327, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI157311622, Length=511, Percent_Identity=24.4618395303327, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI42544132, Length=512, Percent_Identity=24.0234375, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI122937307, Length=518, Percent_Identity=25.6756756756757, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI58082049, Length=513, Percent_Identity=24.1715399610136, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI28416953, Length=566, Percent_Identity=24.3816254416961, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI145693145, Length=504, Percent_Identity=26.3888888888889, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1788107, Length=523, Percent_Identity=25.4302103250478, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI221142682, Length=518, Percent_Identity=22.7799227799228, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1786810, Length=358, Percent_Identity=28.2122905027933, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1789201, Length=363, Percent_Identity=25.068870523416, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788595, Length=301, Percent_Identity=26.2458471760797, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786529, Length=540, Percent_Identity=23.3333333333333, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994694, Length=573, Percent_Identity=24.956369982548, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71994703, Length=573, Percent_Identity=24.956369982548, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71994690, Length=573, Percent_Identity=24.956369982548, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17560308, Length=538, Percent_Identity=27.1375464684015, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17558820, Length=519, Percent_Identity=26.0115606936416, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17531443, Length=494, Percent_Identity=24.4939271255061, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=372, Percent_Identity=29.3010752688172, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17538037, Length=556, Percent_Identity=23.2014388489209, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17557194, Length=523, Percent_Identity=24.6653919694073, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17559526, Length=531, Percent_Identity=24.2937853107345, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71985884, Length=360, Percent_Identity=26.3888888888889, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71996755, Length=507, Percent_Identity=22.879684418146, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17560140, Length=493, Percent_Identity=21.2981744421907, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319699, Length=396, Percent_Identity=27.5252525252525, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320852, Length=326, Percent_Identity=27.3006134969325, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24581924, Length=560, Percent_Identity=26.9642857142857, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI21355181, Length=494, Percent_Identity=24.4939271255061, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18859661, Length=399, Percent_Identity=27.8195488721804, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24648260, Length=500, Percent_Identity=24.6, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19922652, Length=500, Percent_Identity=22.4, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21356947, Length=502, Percent_Identity=23.7051792828685, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24648253, Length=533, Percent_Identity=21.0131332082552, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24653035, Length=506, Percent_Identity=20.1581027667984, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356441, Length=465, Percent_Identity=21.7204301075269, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24667955, Length=410, Percent_Identity=22.6829268292683, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI20130357, Length=366, Percent_Identity=22.6775956284153, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI62472339, Length=410, Percent_Identity=22.6829268292683, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24667959, Length=410, Percent_Identity=22.6829268292683, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24648257, Length=507, Percent_Identity=20.3155818540434, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161076582, Length=509, Percent_Identity=20.0392927308448, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 59981; Mature: 59849

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALMGQMMSAPLLISSIIRHAARYYGSTEIVSRRTEGDLHRYTYRDCELRARKMAQALAA
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHH
LGVQQGDRVGTLAWNGYRHLEIYYGVSGMGAVCHTINPRLFPEQIAYIVNHADDGYVFFD
HCCCCCCCEEEEEECCEEEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCEEEEE
LTFLPLVEGVAPHCPNVKGWVLMSDRAHMPAESKGKLLCYEELIDAQDGNYDWPDLDENQ
EHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCCCCCCC
ASSLCYTSGTTGNPKGALYSHRSTVLHSYASALPDALGCSARDVILPVVPMFHVNAWGLP
CCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCHHHCCCCCCHHHCCCHHHEEECCCCC
YSVPLVGAKLVLPGPKLDGASVYELFEQEKVTFSAGVPTVWLGLLQHVQANNLKFSTFRR
EECCCCCEEEEECCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHCCCEEHHHHHH
TVIGGSAVPPAMIRALRALDVEVIHGWGMTEMSPLGTTCKLLAKHEELSEEASQKVLEKQ
HHCCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GRVLFGVDMKIVDGDGKELPWDGKAFGDLLVRGPWIIERYFRNDTNPLVDGWFPTGDVAT
CCEEEEEEEEEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEE
IDPDGYMQITDRSKDVIKSGGEWISSIDIENVAAAHPAVHMAACISVHHPKWDERPLLVV
ECCCCCEEECCCCHHHHHCCCHHHHHCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEE
VKKPSAEVTREELLKFFEGKVAKWWIPDDVAFVSEIPLTATGKMQKLKLRDQFKDYRLPT
EECCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
A
C
>Mature Secondary Structure 
ALMGQMMSAPLLISSIIRHAARYYGSTEIVSRRTEGDLHRYTYRDCELRARKMAQALAA
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHH
LGVQQGDRVGTLAWNGYRHLEIYYGVSGMGAVCHTINPRLFPEQIAYIVNHADDGYVFFD
HCCCCCCCEEEEEECCEEEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCEEEEE
LTFLPLVEGVAPHCPNVKGWVLMSDRAHMPAESKGKLLCYEELIDAQDGNYDWPDLDENQ
EHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCCCCCCC
ASSLCYTSGTTGNPKGALYSHRSTVLHSYASALPDALGCSARDVILPVVPMFHVNAWGLP
CCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCHHHCCCCCCHHHCCCHHHEEECCCCC
YSVPLVGAKLVLPGPKLDGASVYELFEQEKVTFSAGVPTVWLGLLQHVQANNLKFSTFRR
EECCCCCEEEEECCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHCCCEEHHHHHH
TVIGGSAVPPAMIRALRALDVEVIHGWGMTEMSPLGTTCKLLAKHEELSEEASQKVLEKQ
HHCCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GRVLFGVDMKIVDGDGKELPWDGKAFGDLLVRGPWIIERYFRNDTNPLVDGWFPTGDVAT
CCEEEEEEEEEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEE
IDPDGYMQITDRSKDVIKSGGEWISSIDIENVAAAHPAVHMAACISVHHPKWDERPLLVV
ECCCCCEEECCCCHHHHHCCCHHHHHCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEE
VKKPSAEVTREELLKFFEGKVAKWWIPDDVAFVSEIPLTATGKMQKLKLRDQFKDYRLPT
EECCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]