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The map label for this gene is clpP [H]

Identifier: 73541074

GI number: 73541074

Start: 1487724

End: 1488374

Strand: Direct

Name: clpP [H]

Synonym: Reut_A1380

Alternate gene names: 73541074

Gene position: 1487724-1488374 (Clockwise)

Preceding gene: 73541073

Following gene: 73541075

Centisome position: 39.08

GC content: 63.13

Gene sequence:

>651_bases
ATGACCCGCAATGATTTGCTTGACCGTCTCGCCACCACGCAGGCTTCGGCGCTGGAAACCCAGGGTCTGGGGCTGGTGCC
GATGGTCGTCGAGCAGTCCGGCCGGGGCGAGCGTGCCTACGACATCTATTCGCGCCTGCTGAAGGAGCGTGTGGTGTTCC
TGGTTGGCGAGGTCAATGACCAGACCGCCAACCTGGTGGTGGCGCAATTGCTGTTCCTGGAAAGCGAGAACCCGGACAAG
GATATTTCGCTGTACATCAACTCGCCGGGCGGTTCGGTCTCGGCAGGCCTGGCGATCTACGACACGATGCAGTTCGTCAA
GCCCGATGTGCAGACGCTGTGCATGGGCATGGCAGCAAGCATGGGCGCGTTCCTGCTCGCGGCCGGTGCCAAGGGCAAGC
GCTCGGCGCTGCCTAACTCGCGCATCATGATCCACCAGCCGCTTGGCGGCGCGCGTGGCCAGGCTTCCGATATCGAGATC
CAGGCCCGGGAGATCCTGTACCTGCGCGAGCGCCTGAACAGCATCCTGTCCGAAGTGACCGGCCAACCGGTCGAGAAGAT
TGCGCGCGATACCGATCGCGACAACTTCATGAGCGGCGACCAGGCAGTGGACTACGGCCTGATCGACAAGGTTATTGCCC
GCCGCAGCTGA

Upstream 100 bases:

>100_bases
GCAAGCCTGAGGTCCGGCATGATCCGCAGTCCCCGCGCCGTAGTGCGGGGGCGTGAAGCCCGGCGTTCCTTGCCATCCAA
CGATACCCTGGAGAACTTGC

Downstream 100 bases:

>100_bases
TGCTGCGGGCCGCTGCGGCAAGGTTGTGCGCGGCGGCACGTCGGCTGGCCAAACGGCACAGGCTACACCCGAACGAGGCC
TTGTGCCTCGTTTTTTGCAT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTRNDLLDRLATTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVVFLVGEVNDQTANLVVAQLLFLESENPDK
DISLYINSPGGSVSAGLAIYDTMQFVKPDVQTLCMGMAASMGAFLLAAGAKGKRSALPNSRIMIHQPLGGARGQASDIEI
QAREILYLRERLNSILSEVTGQPVEKIARDTDRDNFMSGDQAVDYGLIDKVIARRS

Sequences:

>Translated_216_residues
MTRNDLLDRLATTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVVFLVGEVNDQTANLVVAQLLFLESENPDK
DISLYINSPGGSVSAGLAIYDTMQFVKPDVQTLCMGMAASMGAFLLAAGAKGKRSALPNSRIMIHQPLGGARGQASDIEI
QAREILYLRERLNSILSEVTGQPVEKIARDTDRDNFMSGDQAVDYGLIDKVIARRS
>Mature_215_residues
TRNDLLDRLATTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVVFLVGEVNDQTANLVVAQLLFLESENPDKD
ISLYINSPGGSVSAGLAIYDTMQFVKPDVQTLCMGMAASMGAFLLAAGAKGKRSALPNSRIMIHQPLGGARGQASDIEIQ
AREILYLRERLNSILSEVTGQPVEKIARDTDRDNFMSGDQAVDYGLIDKVIARRS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=198, Percent_Identity=57.5757575757576, Blast_Score=239, Evalue=9e-64,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=67.0103092783505, Blast_Score=294, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=55.3763440860215, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=57.8947368421053, Blast_Score=235, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23534; Mature: 23403

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRNDLLDRLATTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVVFLVGEVND
CCHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCHHHHHHHHHHHHHHEEEEECCCC
QTANLVVAQLLFLESENPDKDISLYINSPGGSVSAGLAIYDTMQFVKPDVQTLCMGMAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
MGAFLLAAGAKGKRSALPNSRIMIHQPLGGARGQASDIEIQAREILYLRERLNSILSEVT
HHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GQPVEKIARDTDRDNFMSGDQAVDYGLIDKVIARRS
CCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRNDLLDRLATTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVVFLVGEVND
CHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCHHHHHHHHHHHHHHEEEEECCCC
QTANLVVAQLLFLESENPDKDISLYINSPGGSVSAGLAIYDTMQFVKPDVQTLCMGMAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
MGAFLLAAGAKGKRSALPNSRIMIHQPLGGARGQASDIEIQAREILYLRERLNSILSEVT
HHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GQPVEKIARDTDRDNFMSGDQAVDYGLIDKVIARRS
CCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]