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The map label for this gene is phbA [H]

Identifier: 73541042

GI number: 73541042

Start: 1449321

End: 1450502

Strand: Direct

Name: phbA [H]

Synonym: Reut_A1348

Alternate gene names: 73541042

Gene position: 1449321-1450502 (Clockwise)

Preceding gene: 73541041

Following gene: 73541043

Centisome position: 38.07

GC content: 66.16

Gene sequence:

>1182_bases
ATGACCGATATCGTCATCGTTTCCGCCGCCCGTACCGCCGTTGGCAAGTTTGGCGGTTCGCTCGCGAAGATTCCCGCCCC
GGAACTGGGCGCGATCGCCATCAAGGCTGCCCTGGAACGTGCAGGCGTGAAGCCGGAACAGGTCAGCGAAGTGATCATGG
GCCAGGTGCTCACGGCCGGTTCGGGCCAGAACCCGGCGCGCCAGGCATCCATCAAGGCGGGCCTGCCCTCGTCGGTGCCG
GCCATGACCATCAACAAGGTGTGCGGCTCGGGCCTGAAGGCCGTGATGCTGGCCGCCAACGCTATCCTCGCCGGTGAAGC
CGAGATCGTCGTGGCCGGCGGCCAGGAGAACATGAGCGCAGCACCGCACGTGCTGCCGGGCTCGCGCGATGGCTTCCGCA
TGGGCGACGCCAAGCTGGTCGACACGATGATCGTCGACGGCCTGTGGGACGTGTACAACCAGTACCACATGGGCATTACG
GCGGAGAACGTCGCCAAGGAATACGGCATTACCCGCGAAGCGCAGGACGAGTTCGCCGTGGCCTCGCAAAACAAGGCCGA
GGCTGCGCAGAAGGCCGGCAAGTTCGATGATGAAATCGTCCCGGTGATGATTCCGCAGCGCAAAGGCGACCCGGTGGCAT
TCAAGACGGACGAGTTCGTCCGCCAGGGCGCCACGCTGGACAACATGTCAGGCCTGAAGCCCGCCTTTGACAAGGCCGGC
ACGGTGACCGCCGCCAATGCCTCGGGCATCAACGACGGCGCTGCCGCCGTGGTGGTGATGTCGGCCGCCAAGGCCAAGGA
ACTGGGCCTGACCCCGCTGGCCACGATCAAGGCCTACGCCAATGCCGGCGTGGACCCGAAGGTCATGGGCATGGGCCCGG
TGCCGGCATCCAAGCGCTGCCTGTCGCGTGCAGGTTGGGGCGTGGGCGACCTGGACCTGATGGAAATCAACGAGGCCTTC
GCCGCGCAGGCGCTGGCCGTGCACCAGCAGATGGGCTGGGACACCTCCAAGGTCAACGTGAACGGCGGCGCCATTGCCAT
CGGTCACCCGATCGGTGCGTCGGGCTGCCGTATCCTGGTGACGCTGCTGCATGAGATGAAGCGCCGCGATGCGAAGAAGG
GGCTCGCCTCGCTGTGCATCGGCGGCGGCATGGGTGTGGCGCTGGCGGTCGAGCGCAATTAA

Upstream 100 bases:

>100_bases
CGGGCCGTTACGTCAAGGCCAAGGCATGACTCTTGCGAGCGGTCCCGCTATTCCGGGACCTGCCCGCTGACCCCTAAGCT
ATTCATTGAGAGGACTCCAA

Downstream 100 bases:

>100_bases
AGGGATATGCCTGTCCGCGCGACCGTTCGCGTGGCCGGGCGAAGATAACGAAGAGCCAATCAAGGAGCAGACATGACTCA
GCGCATTGCATATGTGACCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDIVIVSAARTAVGKFGGSLAKIPAPELGAIAIKAALERAGVKPEQVSEVIMGQVLTAGSGQNPARQASIKAGLPSSVP
AMTINKVCGSGLKAVMLAANAILAGEAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGIT
AENVAKEYGITREAQDEFAVASQNKAEAAQKAGKFDDEIVPVMIPQRKGDPVAFKTDEFVRQGATLDNMSGLKPAFDKAG
TVTAANASGINDGAAAVVVMSAAKAKELGLTPLATIKAYANAGVDPKVMGMGPVPASKRCLSRAGWGVGDLDLMEINEAF
AAQALAVHQQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMKRRDAKKGLASLCIGGGMGVALAVERN

Sequences:

>Translated_393_residues
MTDIVIVSAARTAVGKFGGSLAKIPAPELGAIAIKAALERAGVKPEQVSEVIMGQVLTAGSGQNPARQASIKAGLPSSVP
AMTINKVCGSGLKAVMLAANAILAGEAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGIT
AENVAKEYGITREAQDEFAVASQNKAEAAQKAGKFDDEIVPVMIPQRKGDPVAFKTDEFVRQGATLDNMSGLKPAFDKAG
TVTAANASGINDGAAAVVVMSAAKAKELGLTPLATIKAYANAGVDPKVMGMGPVPASKRCLSRAGWGVGDLDLMEINEAF
AAQALAVHQQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMKRRDAKKGLASLCIGGGMGVALAVERN
>Mature_392_residues
TDIVIVSAARTAVGKFGGSLAKIPAPELGAIAIKAALERAGVKPEQVSEVIMGQVLTAGSGQNPARQASIKAGLPSSVPA
MTINKVCGSGLKAVMLAANAILAGEAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITA
ENVAKEYGITREAQDEFAVASQNKAEAAQKAGKFDDEIVPVMIPQRKGDPVAFKTDEFVRQGATLDNMSGLKPAFDKAGT
VTAANASGINDGAAAVVVMSAAKAKELGLTPLATIKAYANAGVDPKVMGMGPVPASKRCLSRAGWGVGDLDLMEINEAFA
AQALAVHQQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMKRRDAKKGLASLCIGGGMGVALAVERN

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=57.2890025575448, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=46.0559796437659, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=44.8717948717949, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=41.5189873417722, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=31.1320754716981, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=31.6326530612245, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=60.8142493638677, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=60.8142493638677, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=44.3069306930693, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=40.8521303258145, Blast_Score=264, Evalue=6e-72,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=34.9633251833741, Blast_Score=212, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=45.8974358974359, Blast_Score=334, Evalue=5e-92,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=43.6692506459948, Blast_Score=311, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=42.4242424242424, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17535917, Length=397, Percent_Identity=33.7531486146096, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=33.1775700934579, Blast_Score=193, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=43.5768261964735, Blast_Score=302, Evalue=7e-83,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=38.5964912280702, Blast_Score=230, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=57.3979591836735, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=46.3104325699746, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=46.6666666666667, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.0588235294118, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24585051, Length=427, Percent_Identity=23.4192037470726, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40395; Mature: 40264

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIVIVSAARTAVGKFGGSLAKIPAPELGAIAIKAALERAGVKPEQVSEVIMGQVLTAG
CCCEEEEEHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQASIKAGLPSSVPAMTINKVCGSGLKAVMLAANAILAGEAEIVVAGGQENMSA
CCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHEECCCEEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITAENVAKEYGITREAQDEFAV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHH
ASQNKAEAAQKAGKFDDEIVPVMIPQRKGDPVAFKTDEFVRQGATLDNMSGLKPAFDKAG
HCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCEEECHHHHHCCCCCCCCCCCCHHHHCCC
TVTAANASGINDGAAAVVVMSAAKAKELGLTPLATIKAYANAGVDPKVMGMGPVPASKRC
CEEECCCCCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHH
LSRAGWGVGDLDLMEINEAFAAQALAVHQQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMKRRDAKKGLASLCIGGGMGVALAVERN
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure 
TDIVIVSAARTAVGKFGGSLAKIPAPELGAIAIKAALERAGVKPEQVSEVIMGQVLTAG
CCEEEEEHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQASIKAGLPSSVPAMTINKVCGSGLKAVMLAANAILAGEAEIVVAGGQENMSA
CCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHEECCCEEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITAENVAKEYGITREAQDEFAV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHH
ASQNKAEAAQKAGKFDDEIVPVMIPQRKGDPVAFKTDEFVRQGATLDNMSGLKPAFDKAG
HCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCEEECHHHHHCCCCCCCCCCCCHHHHCCC
TVTAANASGINDGAAAVVVMSAAKAKELGLTPLATIKAYANAGVDPKVMGMGPVPASKRC
CEEECCCCCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHH
LSRAGWGVGDLDLMEINEAFAAQALAVHQQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMKRRDAKKGLASLCIGGGMGVALAVERN
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]