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The map label for this gene is lpd [H]

Identifier: 73541000

GI number: 73541000

Start: 1400326

End: 1402107

Strand: Direct

Name: lpd [H]

Synonym: Reut_A1306

Alternate gene names: 73541000

Gene position: 1400326-1402107 (Clockwise)

Preceding gene: 73540999

Following gene: 73541004

Centisome position: 36.79

GC content: 65.21

Gene sequence:

>1782_bases
ATGAGTGTGATCGAAGTCAAGGTGCCGGATATCGGCGATTTCGACGCGGTGGAACTGATCGAGGTCCTGATCAAGCCGGG
CGATACGGTCGAGCAGGAACAGTCGCTGATCGTGCTGGAATCGGACAAGGCCAGCATGGAAGTGCCGTCGCCGGTGGCCG
GCAAGGTGGTCGACGTGCGCGTGAACGTCGGTGACAAGGTCGGGCAGGGCACGGTGATCTGCACGGTGGAAGCGGAAGCC
GCTGCGGCTGCGCCCGCACCGGCGCCGGCTCCTGCACCCGCCGCGGCACCGGCTCCGGCGGCCGCGCCTGCTCCTGCTCC
GGCAGCAGCGAGCCATGCTGGTGGCGCTGATATCCAGTGCGAGATGCTCGTACTGGGCGCCGGCCCCGGTGGCTACTCGG
CTGCCTTCCGTGCGGCTGACCTCGGCATGAACACTGTGCTGGTCGAACGCTACGCTACGCTCGGTGGCGTCTGCCTGAAC
GTCGGATGCATCCCGTCGAAGGCACTGCTGCACAACGCTGCGGTTATCGACGAAGCCAAGGCACTCGCTGCCCACGGCAT
CCTGTTCGGCGAAGCCAAGATCGATCTGGACGGCCTGCGCCACTACAAGAACCAGGTGGTCGGCAAGCTGACCGGCGGCC
TGGCCGGCATGGCCAAGGCGCGCAAGGTGCAGGTCGTGCGCGGCATCGGCACTTTCCTCGATCCGCATCACCTTGAAGTG
GATGCGACCGAAGGCGAGGGCAAGCAGACCACGGGCAAGAAGACGGTGATCCGCTTCGAGAAGGCCATCATCGCCGCTGG
CAGCCAGGCGGTGAAGCTGCCGTTCATCCCTGAAGATCCGCGCATCGTCGATTCGACCGGCGCGCTGGAACTGCCGGAGG
TGCCGAACAAGATGCTGGTCGTCGGTGGCGGCATCATTGGCCTGGAAATGGCGACGGTGTACAGCACGCTGGGCGCGGAC
ATCGACGTCGTCGAAATGCTGCCGGGCCTGATGAGCGGCGCCGACCGTGATCTCGTCAAGGTCTGGGAGAAGAAGAACAA
GGACCGTTTCGGCAAGGTAATGCTGAACACGAAGACCGTCGCGGTGGAAGCCAAGCCGGACGGCATCTACGTGAAGTTCG
AAGGTGAGCAGGCACCGGCCGAGCCGCAGCGCTACGACCTGGTGCTGGTGTCGGTCGGCCGCTCGCCCAACGGCAAGCGC
ATCGGTGCGGAAAAGGCCGGCGTGGCCGTGACTGACCGTGGTTTCATCAACGTCGATTCGCAAATGCGCACGAACGTGCC
GAATATCTTCGCGATCGGTGACGTGGTGGGCCAACCGATGCTGGCGCACAAGGCGGTGCACGAGGCCCACGTGGCCGCGG
AAGCCGCCCATGGCGAGAAGGCTTACTTCGACGCCAAGCAGATCCCGTCGGTGGCCTTCACCGATCCAGAAGTGGCCTGG
GCTGGTCTGACCGAGGACCAGTGCAAGGAGCAGGGCATCAAGTACAGCAAGGGCGTGTTCCCGTGGGCTGCCTCGGGCCG
TGCGATTGCCAACGGCCGTGACGAAGGCTTCACCAAGCTGATCTTCGACGAGGAAACCCACCGCATCATCGGCGGCGGCA
TCGTCGGCACGCATGCCGGCGACCTGATCAGCGAAGTGTGCCTGGCCATCGAGATGGGCGCGGATGCCGTGGATATCGGC
AAGACCATCCACCCGCACCCGACGCTGGGCGAGTCGATCGGCATGGCGGCCGAAATCTACGAGGGCACCTGCACCGACGT
GCCGCCCCCGCGCAAGCGCTGA

Upstream 100 bases:

>100_bases
ACCGTAAGGCTGCACGAAGCCGGCGCCGCCGGCGCAGCGGCAACCAACAACGACGGCGCGCCCTGAAGCCACGCAGGCCG
GCGCGCATTGAGGAGCAAAT

Downstream 100 bases:

>100_bases
TCGCAGCAAGGCACCAGAAACGAAACCCGCCCACGTGGCGGGTTTCGTTTTCGCAAATTGCGCAATTAACCGACAGGAAT
TTGAACCCTCCGACGACGCC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MSVIEVKVPDIGDFDAVELIEVLIKPGDTVEQEQSLIVLESDKASMEVPSPVAGKVVDVRVNVGDKVGQGTVICTVEAEA
AAAAPAPAPAPAPAAAPAPAAAPAPAPAAASHAGGADIQCEMLVLGAGPGGYSAAFRAADLGMNTVLVERYATLGGVCLN
VGCIPSKALLHNAAVIDEAKALAAHGILFGEAKIDLDGLRHYKNQVVGKLTGGLAGMAKARKVQVVRGIGTFLDPHHLEV
DATEGEGKQTTGKKTVIRFEKAIIAAGSQAVKLPFIPEDPRIVDSTGALELPEVPNKMLVVGGGIIGLEMATVYSTLGAD
IDVVEMLPGLMSGADRDLVKVWEKKNKDRFGKVMLNTKTVAVEAKPDGIYVKFEGEQAPAEPQRYDLVLVSVGRSPNGKR
IGAEKAGVAVTDRGFINVDSQMRTNVPNIFAIGDVVGQPMLAHKAVHEAHVAAEAAHGEKAYFDAKQIPSVAFTDPEVAW
AGLTEDQCKEQGIKYSKGVFPWAASGRAIANGRDEGFTKLIFDEETHRIIGGGIVGTHAGDLISEVCLAIEMGADAVDIG
KTIHPHPTLGESIGMAAEIYEGTCTDVPPPRKR

Sequences:

>Translated_593_residues
MSVIEVKVPDIGDFDAVELIEVLIKPGDTVEQEQSLIVLESDKASMEVPSPVAGKVVDVRVNVGDKVGQGTVICTVEAEA
AAAAPAPAPAPAPAAAPAPAAAPAPAPAAASHAGGADIQCEMLVLGAGPGGYSAAFRAADLGMNTVLVERYATLGGVCLN
VGCIPSKALLHNAAVIDEAKALAAHGILFGEAKIDLDGLRHYKNQVVGKLTGGLAGMAKARKVQVVRGIGTFLDPHHLEV
DATEGEGKQTTGKKTVIRFEKAIIAAGSQAVKLPFIPEDPRIVDSTGALELPEVPNKMLVVGGGIIGLEMATVYSTLGAD
IDVVEMLPGLMSGADRDLVKVWEKKNKDRFGKVMLNTKTVAVEAKPDGIYVKFEGEQAPAEPQRYDLVLVSVGRSPNGKR
IGAEKAGVAVTDRGFINVDSQMRTNVPNIFAIGDVVGQPMLAHKAVHEAHVAAEAAHGEKAYFDAKQIPSVAFTDPEVAW
AGLTEDQCKEQGIKYSKGVFPWAASGRAIANGRDEGFTKLIFDEETHRIIGGGIVGTHAGDLISEVCLAIEMGADAVDIG
KTIHPHPTLGESIGMAAEIYEGTCTDVPPPRKR
>Mature_592_residues
SVIEVKVPDIGDFDAVELIEVLIKPGDTVEQEQSLIVLESDKASMEVPSPVAGKVVDVRVNVGDKVGQGTVICTVEAEAA
AAAPAPAPAPAPAAAPAPAAAPAPAPAAASHAGGADIQCEMLVLGAGPGGYSAAFRAADLGMNTVLVERYATLGGVCLNV
GCIPSKALLHNAAVIDEAKALAAHGILFGEAKIDLDGLRHYKNQVVGKLTGGLAGMAKARKVQVVRGIGTFLDPHHLEVD
ATEGEGKQTTGKKTVIRFEKAIIAAGSQAVKLPFIPEDPRIVDSTGALELPEVPNKMLVVGGGIIGLEMATVYSTLGADI
DVVEMLPGLMSGADRDLVKVWEKKNKDRFGKVMLNTKTVAVEAKPDGIYVKFEGEQAPAEPQRYDLVLVSVGRSPNGKRI
GAEKAGVAVTDRGFINVDSQMRTNVPNIFAIGDVVGQPMLAHKAVHEAHVAAEAAHGEKAYFDAKQIPSVAFTDPEVAWA
GLTEDQCKEQGIKYSKGVFPWAASGRAIANGRDEGFTKLIFDEETHRIIGGGIVGTHAGDLISEVCLAIEMGADAVDIGK
TIHPHPTLGESIGMAAEIYEGTCTDVPPPRKR

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransfer

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=41.991341991342, Blast_Score=329, Evalue=4e-90,
Organism=Homo sapiens, GI50301238, Length=478, Percent_Identity=26.7782426778243, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI33519430, Length=434, Percent_Identity=26.9585253456221, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI33519428, Length=434, Percent_Identity=26.9585253456221, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI33519426, Length=434, Percent_Identity=26.9585253456221, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI148277071, Length=456, Percent_Identity=26.7543859649123, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI148277065, Length=456, Percent_Identity=26.7543859649123, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI291045266, Length=441, Percent_Identity=26.7573696145125, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI22035672, Length=444, Percent_Identity=27.2522522522523, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI291045268, Length=450, Percent_Identity=25.1111111111111, Blast_Score=108, Evalue=2e-23,
Organism=Escherichia coli, GI1786307, Length=478, Percent_Identity=64.6443514644351, Blast_Score=621, Evalue=1e-179,
Organism=Escherichia coli, GI87082354, Length=468, Percent_Identity=27.991452991453, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI87081717, Length=462, Percent_Identity=27.7056277056277, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1789915, Length=449, Percent_Identity=28.9532293986637, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1786305, Length=73, Percent_Identity=60.2739726027397, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32565766, Length=457, Percent_Identity=41.3566739606127, Blast_Score=330, Evalue=9e-91,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=28.6012526096033, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=446, Percent_Identity=24.4394618834081, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71983419, Length=448, Percent_Identity=24.3303571428571, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71982272, Length=451, Percent_Identity=26.3858093126386, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17559934, Length=241, Percent_Identity=26.9709543568465, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=460, Percent_Identity=40.4347826086956, Blast_Score=307, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6325240, Length=476, Percent_Identity=27.5210084033613, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6325166, Length=472, Percent_Identity=27.1186440677966, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21358499, Length=486, Percent_Identity=40.1234567901235, Blast_Score=340, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24640551, Length=525, Percent_Identity=28.1904761904762, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24640553, Length=493, Percent_Identity=28.1947261663286, Blast_Score=122, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24640549, Length=476, Percent_Identity=28.5714285714286, Blast_Score=121, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17737741, Length=480, Percent_Identity=26.4583333333333, Blast_Score=110, Evalue=4e-24,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 61816; Mature: 61685

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIEVKVPDIGDFDAVELIEVLIKPGDTVEQEQSLIVLESDKASMEVPSPVAGKVVDVR
CCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEE
VNVGDKVGQGTVICTVEAEAAAAAPAPAPAPAPAAAPAPAAAPAPAPAAASHAGGADIQC
EECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
EMLVLGAGPGGYSAAFRAADLGMNTVLVERYATLGGVCLNVGCIPSKALLHNAAVIDEAK
EEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHH
ALAAHGILFGEAKIDLDGLRHYKNQVVGKLTGGLAGMAKARKVQVVRGIGTFLDPHHLEV
HHHHCCEEEECEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHEEHHHHHHHHCCCCEEEE
DATEGEGKQTTGKKTVIRFEKAIIAAGSQAVKLPFIPEDPRIVDSTGALELPEVPNKMLV
ECCCCCCCCCCCCHHHEEEHHHHHHCCCCEEEECCCCCCCCEECCCCCEECCCCCCCEEE
VGGGIIGLEMATVYSTLGADIDVVEMLPGLMSGADRDLVKVWEKKNKDRFGKVMLNTKTV
EECCEEEHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEEEE
AVEAKPDGIYVKFEGEQAPAEPQRYDLVLVSVGRSPNGKRIGAEKAGVAVTDRGFINVDS
EEEECCCEEEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCEEEECH
QMRTNVPNIFAIGDVVGQPMLAHKAVHEAHVAAEAAHGEKAYFDAKQIPSVAFTDPEVAW
HHHCCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHCCCCHHEECHHHCCCEEECCCCCEE
AGLTEDQCKEQGIKYSKGVFPWAASGRAIANGRDEGFTKLIFDEETHRIIGGGIVGTHAG
ECCCHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCCCCEEEECCEECCCHH
DLISEVCLAIEMGADAVDIGKTIHPHPTLGESIGMAAEIYEGTCTDVPPPRKR
HHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SVIEVKVPDIGDFDAVELIEVLIKPGDTVEQEQSLIVLESDKASMEVPSPVAGKVVDVR
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEE
VNVGDKVGQGTVICTVEAEAAAAAPAPAPAPAPAAAPAPAAAPAPAPAAASHAGGADIQC
EECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
EMLVLGAGPGGYSAAFRAADLGMNTVLVERYATLGGVCLNVGCIPSKALLHNAAVIDEAK
EEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHH
ALAAHGILFGEAKIDLDGLRHYKNQVVGKLTGGLAGMAKARKVQVVRGIGTFLDPHHLEV
HHHHCCEEEECEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHEEHHHHHHHHCCCCEEEE
DATEGEGKQTTGKKTVIRFEKAIIAAGSQAVKLPFIPEDPRIVDSTGALELPEVPNKMLV
ECCCCCCCCCCCCHHHEEEHHHHHHCCCCEEEECCCCCCCCEECCCCCEECCCCCCCEEE
VGGGIIGLEMATVYSTLGADIDVVEMLPGLMSGADRDLVKVWEKKNKDRFGKVMLNTKTV
EECCEEEHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEEEE
AVEAKPDGIYVKFEGEQAPAEPQRYDLVLVSVGRSPNGKRIGAEKAGVAVTDRGFINVDS
EEEECCCEEEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCEEEECH
QMRTNVPNIFAIGDVVGQPMLAHKAVHEAHVAAEAAHGEKAYFDAKQIPSVAFTDPEVAW
HHHCCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHCCCCHHEECHHHCCCEEECCCCCEE
AGLTEDQCKEQGIKYSKGVFPWAASGRAIANGRDEGFTKLIFDEETHRIIGGGIVGTHAG
ECCCHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCCCCEEEECCEECCCHH
DLISEVCLAIEMGADAVDIGKTIHPHPTLGESIGMAAEIYEGTCTDVPPPRKR
HHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]