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The map label for this gene is gltC [H]

Identifier: 73540987

GI number: 73540987

Start: 1381203

End: 1382165

Strand: Direct

Name: gltC [H]

Synonym: Reut_A1293

Alternate gene names: 73540987

Gene position: 1381203-1382165 (Clockwise)

Preceding gene: 73540984

Following gene: 73540988

Centisome position: 36.29

GC content: 65.11

Gene sequence:

>963_bases
ATGCACTCAAGGCTACAATGCCGACCGTTCCCAACGGCCGTTCCGACAACGTTCATGCATGCCCGGATCCTGCGCTATCT
GGATGAGGTGGTACGCCGCGGCTCCATCCGCAAGGCCGCCGAGTCTCTGCATGTGGCGCCCACGGCGATCAACCGGCAGA
TCCTCGATCTGGAAGCCGAGCTTGGTGCGCCGGTCTTCGACCGCATCAACAAACGTCTGCGCCTGACACCGCTTGGTGAG
ATGGTGCTCGCGCACGTCCGGCAGACACTGCGTGAGCATGAGGCGCTGCGTGAGCGGATCGAAGAGTTCAAAGGTGCCCG
GAGGGGCGAGGTGACGGTAGCGGTGACGGCCGGGCTGGCCGGATCGTTGATGCCGTCGCTGACCCACGAATTTCACCAGC
GGTATCCGGGCATTGTTGTGCGGGTGGTCGACCTGCCGATTGCCGATATCGTCCTGGCTGTCGAGCAGGGCGACGCTGAC
CTCGGCCTCGGCTATGACCTGCCTGCCGCGCCGGCGCTGCGGATCCTGGGGACGAGCGACTGGCAGATCGGTGCTGTGGT
ACCTCCCGGTCATGAGTTGGCGGCACAACCGTCGGTCTTGCTAAGTGAATGCGTCGGCTATCCGCTCGTGCTGCCGGCGC
CATCGCTATCCATCCGCGCGATTCTCGACGATGCCTTTGCGCGTCATGCAATTGACGTGACGCCTGCTGCCGAGTCGACC
TCGATGGCGCTGATCCAGCGCCTGGTCATGCTGGGTAGCGGCATTGCGCTGCTCAATCCACTCGACATCATGGATGAGCG
CGAGCGCGGTGCTCTCGTCCTGGTGCCGCTGCGCGACCGCTACCTGCGGCGCCAGACGCTGGCGCTCGTCGCACGCGCGC
AGACCGTGCTGAGTCCGGCGGCCGAGTTGATGGCGGCAGATATCGGCGAGCGGTTGGCCGCGCTGTTCGCGCAAGGGCAT
TGA

Upstream 100 bases:

>100_bases
AGAGTCCGCTGCTCTACCAACTGAGCTAACGCCCCAACGAAGAAAAAGATTTTAGCAAGGTATCTAGTAAGACGCAATAG
GGAAGTGGAAATTTCTTTTG

Downstream 100 bases:

>100_bases
TCGCGTAGGTGTCCACTTTTTGTGGACATCGTTGGCGAAATTCTGCGCTTTCGGATTGACGGCGCGAGTCATAGACTCGC
CCCATGCCAATCCGCCGAGA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MHSRLQCRPFPTAVPTTFMHARILRYLDEVVRRGSIRKAAESLHVAPTAINRQILDLEAELGAPVFDRINKRLRLTPLGE
MVLAHVRQTLREHEALRERIEEFKGARRGEVTVAVTAGLAGSLMPSLTHEFHQRYPGIVVRVVDLPIADIVLAVEQGDAD
LGLGYDLPAAPALRILGTSDWQIGAVVPPGHELAAQPSVLLSECVGYPLVLPAPSLSIRAILDDAFARHAIDVTPAAEST
SMALIQRLVMLGSGIALLNPLDIMDERERGALVLVPLRDRYLRRQTLALVARAQTVLSPAAELMAADIGERLAALFAQGH

Sequences:

>Translated_320_residues
MHSRLQCRPFPTAVPTTFMHARILRYLDEVVRRGSIRKAAESLHVAPTAINRQILDLEAELGAPVFDRINKRLRLTPLGE
MVLAHVRQTLREHEALRERIEEFKGARRGEVTVAVTAGLAGSLMPSLTHEFHQRYPGIVVRVVDLPIADIVLAVEQGDAD
LGLGYDLPAAPALRILGTSDWQIGAVVPPGHELAAQPSVLLSECVGYPLVLPAPSLSIRAILDDAFARHAIDVTPAAEST
SMALIQRLVMLGSGIALLNPLDIMDERERGALVLVPLRDRYLRRQTLALVARAQTVLSPAAELMAADIGERLAALFAQGH
>Mature_320_residues
MHSRLQCRPFPTAVPTTFMHARILRYLDEVVRRGSIRKAAESLHVAPTAINRQILDLEAELGAPVFDRINKRLRLTPLGE
MVLAHVRQTLREHEALRERIEEFKGARRGEVTVAVTAGLAGSLMPSLTHEFHQRYPGIVVRVVDLPIADIVLAVEQGDAD
LGLGYDLPAAPALRILGTSDWQIGAVVPPGHELAAQPSVLLSECVGYPLVLPAPSLSIRAILDDAFARHAIDVTPAAEST
SMALIQRLVMLGSGIALLNPLDIMDERERGALVLVPLRDRYLRRQTLALVARAQTVLSPAAELMAADIGERLAALFAQGH

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787530, Length=243, Percent_Identity=28.8065843621399, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1787601, Length=230, Percent_Identity=26.9565217391304, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI157672245, Length=231, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789204, Length=254, Percent_Identity=25.9842519685039, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788296, Length=245, Percent_Identity=26.530612244898, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI145693105, Length=273, Percent_Identity=24.5421245421245, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1790399, Length=300, Percent_Identity=23.6666666666667, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788887, Length=301, Percent_Identity=25.2491694352159, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI87082132, Length=308, Percent_Identity=25.3246753246753, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788297, Length=245, Percent_Identity=25.7142857142857, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790262, Length=261, Percent_Identity=27.5862068965517, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788748, Length=301, Percent_Identity=25.2491694352159, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1789506, Length=254, Percent_Identity=20.8661417322835, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789173, Length=281, Percent_Identity=27.4021352313167, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1790208, Length=161, Percent_Identity=29.8136645962733, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787949, Length=175, Percent_Identity=25.1428571428571, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34870; Mature: 34870

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSRLQCRPFPTAVPTTFMHARILRYLDEVVRRGSIRKAAESLHVAPTAINRQILDLEAE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHCHHHEEHHHH
LGAPVFDRINKRLRLTPLGEMVLAHVRQTLREHEALRERIEEFKGARRGEVTVAVTAGLA
HCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCH
GSLMPSLTHEFHQRYPGIVVRVVDLPIADIVLAVEQGDADLGLGYDLPAAPALRILGTSD
HHHHHHHHHHHHHHCCCEEEEEECCCHHHHEEEEECCCCCCCCCCCCCCCCCEEEECCCC
WQIGAVVPPGHELAAQPSVLLSECVGYPLVLPAPSLSIRAILDDAFARHAIDVTPAAEST
CEEEEECCCCHHHHCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCEECCCCCCHH
SMALIQRLVMLGSGIALLNPLDIMDERERGALVLVPLRDRYLRRQTLALVARAQTVLSPA
HHHHHHHHHHHCCCHHHCCCHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHH
AELMAADIGERLAALFAQGH
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHSRLQCRPFPTAVPTTFMHARILRYLDEVVRRGSIRKAAESLHVAPTAINRQILDLEAE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHCHHHEEHHHH
LGAPVFDRINKRLRLTPLGEMVLAHVRQTLREHEALRERIEEFKGARRGEVTVAVTAGLA
HCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCH
GSLMPSLTHEFHQRYPGIVVRVVDLPIADIVLAVEQGDADLGLGYDLPAAPALRILGTSD
HHHHHHHHHHHHHHCCCEEEEEECCCHHHHEEEEECCCCCCCCCCCCCCCCCEEEECCCC
WQIGAVVPPGHELAAQPSVLLSECVGYPLVLPAPSLSIRAILDDAFARHAIDVTPAAEST
CEEEEECCCCHHHHCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCEECCCCCCHH
SMALIQRLVMLGSGIALLNPLDIMDERERGALVLVPLRDRYLRRQTLALVARAQTVLSPA
HHHHHHHHHHHCCCHHHCCCHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHH
AELMAADIGERLAALFAQGH
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]