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The map label for this gene is hemC [H]

Identifier: 73540406

GI number: 73540406

Start: 759141

End: 760145

Strand: Direct

Name: hemC [H]

Synonym: Reut_A0700

Alternate gene names: 73540406

Gene position: 759141-760145 (Clockwise)

Preceding gene: 73540404

Following gene: 73540407

Centisome position: 19.94

GC content: 66.27

Gene sequence:

>1005_bases
ATGCATGCATCCGCCTTCCCGACTTCTTCTACCGCCGTGTCCAGCAGCCTTCCGCACAAGCTTGTCATCGCCTCCCGCGA
GAGCCGTCTGGCCATGTGGCAGGCTGAATATGTGCGTGCTGCGCTGCAACAATACTATCCCGCGTGCGATGTGTCCATTC
TGGGCATGACCACGCGCGGAGACCAGATTCTAGACCGGACTTTGTCGAAAGTCGGCGGAAAGGGTTTGTTTGTCAAAGAG
CTGGAATTCGCGATGGCCGAAGGCCGGGCCGATCTCGCGGTGCATTCGCTGAAGGATGTACCGATGGAGTTGCCCGACGG
CTTCGCGCTGACCGCGGTGATGGAGCGCGAGGATCCGCGCGATGCGCTGGTTTCATCGACGTTTGCATCGCTCGAAGAGA
TGCCGGCCGGGACCGTGGTCGGCACCTCGAGCCTGCGTCGCGAGGCCGCGCTGCGCGCGCGTTATCCGCATCTGGTCATC
AAGCCACTGCGCGGCAATCTAGATACCCGCCTGGGCAAGCTCGATCGCGGCGAATACGGCGCGATCATCCTGGCCGCGGC
CGGTCTGAAGCGGCTGGGCCTTGGCGATCGCATCCGCGCACTGATCGCGCCGGAGGCTTCGCTGCCTGCAGCGGGACAGG
GCGCGCTTGGTATCGAAATCCTGTCGACGCGTCCCGATGTCGCCGCGTGGCTATCTCCACTGAACCACCAGCCGACCGCG
CTCGCGGTCACGGCAGAACGGGCGGTGTCGCGCATGCTTGGCGGCTCGTGCCAGGTGCCGCTGGCCGCGCATGCGCGCTG
GGTTGGCGACCAATTGCGGCTCGATGCCTTCGTGGCCATGCCCGATGGCTCGCGGCAGACGCGTGCATCGGCCGCCGGTC
TGGTGGTCGATGCTGCGGCGGCTGAGGCACTTGGCGCGTCGGCCGCGCGGGATCTGCTCTCGCAGGGCGCCGCCGAGATT
CTCGCCGCGCTGGCCGACACACCGGCTCCCCAAGATCCAGCCTGA

Upstream 100 bases:

>100_bases
CGGCCGGGGCGCGCAGCATGCTGCGTCATGCAATCTCCTCTTGCTTTACTTCTGTCCGATGGTGCGGAGCGGCGATTGGG
TCGCGTGCTAACATTGACGA

Downstream 100 bases:

>100_bases
GGCCGGCCCATGCCCCGCCCGACTGTCGTTGTCACACGACCCGCCGGGCAGTCCCGGCAACTGACAGAAGCGCTCCAGGC
CGCAGGGCTCGATGTCCTCG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MHASAFPTSSTAVSSSLPHKLVIASRESRLAMWQAEYVRAALQQYYPACDVSILGMTTRGDQILDRTLSKVGGKGLFVKE
LEFAMAEGRADLAVHSLKDVPMELPDGFALTAVMEREDPRDALVSSTFASLEEMPAGTVVGTSSLRREAALRARYPHLVI
KPLRGNLDTRLGKLDRGEYGAIILAAAGLKRLGLGDRIRALIAPEASLPAAGQGALGIEILSTRPDVAAWLSPLNHQPTA
LAVTAERAVSRMLGGSCQVPLAAHARWVGDQLRLDAFVAMPDGSRQTRASAAGLVVDAAAAEALGASAARDLLSQGAAEI
LAALADTPAPQDPA

Sequences:

>Translated_334_residues
MHASAFPTSSTAVSSSLPHKLVIASRESRLAMWQAEYVRAALQQYYPACDVSILGMTTRGDQILDRTLSKVGGKGLFVKE
LEFAMAEGRADLAVHSLKDVPMELPDGFALTAVMEREDPRDALVSSTFASLEEMPAGTVVGTSSLRREAALRARYPHLVI
KPLRGNLDTRLGKLDRGEYGAIILAAAGLKRLGLGDRIRALIAPEASLPAAGQGALGIEILSTRPDVAAWLSPLNHQPTA
LAVTAERAVSRMLGGSCQVPLAAHARWVGDQLRLDAFVAMPDGSRQTRASAAGLVVDAAAAEALGASAARDLLSQGAAEI
LAALADTPAPQDPA
>Mature_334_residues
MHASAFPTSSTAVSSSLPHKLVIASRESRLAMWQAEYVRAALQQYYPACDVSILGMTTRGDQILDRTLSKVGGKGLFVKE
LEFAMAEGRADLAVHSLKDVPMELPDGFALTAVMEREDPRDALVSSTFASLEEMPAGTVVGTSSLRREAALRARYPHLVI
KPLRGNLDTRLGKLDRGEYGAIILAAAGLKRLGLGDRIRALIAPEASLPAAGQGALGIEILSTRPDVAAWLSPLNHQPTA
LAVTAERAVSRMLGGSCQVPLAAHARWVGDQLRLDAFVAMPDGSRQTRASAAGLVVDAAAAEALGASAARDLLSQGAAEI
LAALADTPAPQDPA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=329, Percent_Identity=41.3373860182371, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI66933009, Length=329, Percent_Identity=41.3373860182371, Blast_Score=226, Evalue=2e-59,
Organism=Escherichia coli, GI48994974, Length=314, Percent_Identity=54.4585987261147, Blast_Score=318, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6319996, Length=319, Percent_Identity=37.3040752351097, Blast_Score=200, Evalue=3e-52,
Organism=Drosophila melanogaster, GI20130425, Length=259, Percent_Identity=44.7876447876448, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35071; Mature: 35071

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHASAFPTSSTAVSSSLPHKLVIASRESRLAMWQAEYVRAALQQYYPACDVSILGMTTRG
CCCCCCCCCCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
DQILDRTLSKVGGKGLFVKELEFAMAEGRADLAVHSLKDVPMELPDGFALTAVMEREDPR
HHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCHH
DALVSSTFASLEEMPAGTVVGTSSLRREAALRARYPHLVIKPLRGNLDTRLGKLDRGEYG
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCCCCC
AIILAAAGLKRLGLGDRIRALIAPEASLPAAGQGALGIEILSTRPDVAAWLSPLNHQPTA
EEEEEECCHHHCCCCHHHHHEECCCCCCCCCCCCCEEEEEECCCCHHHHHHCCCCCCCCE
LAVTAERAVSRMLGGSCQVPLAAHARWVGDQLRLDAFVAMPDGSRQTRASAAGLVVDAAA
EEEEHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHCCCEEEHHH
AEALGASAARDLLSQGAAEILAALADTPAPQDPA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MHASAFPTSSTAVSSSLPHKLVIASRESRLAMWQAEYVRAALQQYYPACDVSILGMTTRG
CCCCCCCCCCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
DQILDRTLSKVGGKGLFVKELEFAMAEGRADLAVHSLKDVPMELPDGFALTAVMEREDPR
HHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCHH
DALVSSTFASLEEMPAGTVVGTSSLRREAALRARYPHLVIKPLRGNLDTRLGKLDRGEYG
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCCCCC
AIILAAAGLKRLGLGDRIRALIAPEASLPAAGQGALGIEILSTRPDVAAWLSPLNHQPTA
EEEEEECCHHHCCCCHHHHHEECCCCCCCCCCCCCEEEEEECCCCHHHHHHCCCCCCCCE
LAVTAERAVSRMLGGSCQVPLAAHARWVGDQLRLDAFVAMPDGSRQTRASAAGLVVDAAA
EEEEHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHCCCEEEHHH
AEALGASAARDLLSQGAAEILAALADTPAPQDPA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]