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The map label for this gene is cobC [H]

Identifier: 73540368

GI number: 73540368

Start: 710273

End: 711295

Strand: Reverse

Name: cobC [H]

Synonym: Reut_A0662

Alternate gene names: 73540368

Gene position: 711295-710273 (Counterclockwise)

Preceding gene: 73540369

Following gene: 73540367

Centisome position: 18.69

GC content: 69.89

Gene sequence:

>1023_bases
ATGAAATTCGCGCTGGCCCCCATTCGCCACGGCGGCGACCTGCAGGCCGCCGTACGCCGCTATGGCCAGCCTGTTGGTGA
ATGGCTGGACCTGTCTACCGGCATCAATCCGACGGGCTACCCCGTGCCGCCGATTCCGGCCGAGGCCTGGCAGCGCCTGC
CGGAGGACAACGACGGCCTGGCGGAAATTGCCTCCCAAGCGTTCGGTGCGCCTCAAGCCCTGCCTGTCGCGGGCTCGCAG
GCCGCGATCCGCACGCTGCCGCAACTCCTCGCGCGCGGACGCGTCGGCGTGGCCGCGCTCGGCTACAGCGAGTACGCGCC
AGCGTTCGCCGCCGCCGGCCATGACGTTGTGCTGCTCGGCGAATCGGACTTCGCCCAGCCATCGCTGGCAGACGGCCTCG
ACCACCTCGTCGTGGTCAATCCGAATAACCCGTCAGGCCGTTTGCTTGCGCCGCAAACGTTACTGGCCTGGCATGCGACG
CTGGCCGCGCGTGGCGGCACGCTGCTTGTCGATGAGGCCTTTATCGACTGCACGCCGCAGCATTCGGTCGCGGCGCACAG
CGGCGCCCCGGGGCTCGTGGTACTGCGCTCGCTCGGCAAGTTCTACGGGCTCGCCGGCGTACGCTGTGGCTTCGTGCTTG
GGGAAGCTGCGTTGCTCGAAGCGTTGCGCGAACGGCTGGGCCACTGGACCGTATCGGGCCCGGCGCGCGTGATCGCTCGC
GCGGCGCTGGCCGACCATGGCTGGCAGGCTGCCAACCGAGATCGTCTGGCCGCGTGGGCCGAACGACTGCGCGCGCTGCT
GGCAAGCCACGGCCTTGCACCGGTGATGCAACCCCTGTTCTGCTGGGTGCCGCTTCAACACGCCGCGAATCTGCACGACG
CGCTGGCCCGCCATGGCGTCTGGACGCGCCGCTTCGATGCCGCTGGCGACTGCGCGCCGGGCCTTCGGCTCGGACTGCCA
CCCGATTCGCCGCACGCATGGCAACAACTGGAAACCGCGCTGTCCGCCGTCACGCGCGCCTGA

Upstream 100 bases:

>100_bases
TGGCCTGCCTGCAACTGGTGCAGCGCACGCTGTGGCTCTGGCTAGCAATAGCCATTGCCAGCGCCGCGGCGCTGCACTGG
CTCCCTGCCCTGTTGAGCCT

Downstream 100 bases:

>100_bases
ACGCACTCTGACCCGCATGCTCCTCGTCCGCCAGATCGCTGCAGCTGTGCTGCTTGTCGCCACCACTCAGGCCATGGCCA
CTGTTTCGGCTGTCGATGAC

Product: putative threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKFALAPIRHGGDLQAAVRRYGQPVGEWLDLSTGINPTGYPVPPIPAEAWQRLPEDNDGLAEIASQAFGAPQALPVAGSQ
AAIRTLPQLLARGRVGVAALGYSEYAPAFAAAGHDVVLLGESDFAQPSLADGLDHLVVVNPNNPSGRLLAPQTLLAWHAT
LAARGGTLLVDEAFIDCTPQHSVAAHSGAPGLVVLRSLGKFYGLAGVRCGFVLGEAALLEALRERLGHWTVSGPARVIAR
AALADHGWQAANRDRLAAWAERLRALLASHGLAPVMQPLFCWVPLQHAANLHDALARHGVWTRRFDAAGDCAPGLRLGLP
PDSPHAWQQLETALSAVTRA

Sequences:

>Translated_340_residues
MKFALAPIRHGGDLQAAVRRYGQPVGEWLDLSTGINPTGYPVPPIPAEAWQRLPEDNDGLAEIASQAFGAPQALPVAGSQ
AAIRTLPQLLARGRVGVAALGYSEYAPAFAAAGHDVVLLGESDFAQPSLADGLDHLVVVNPNNPSGRLLAPQTLLAWHAT
LAARGGTLLVDEAFIDCTPQHSVAAHSGAPGLVVLRSLGKFYGLAGVRCGFVLGEAALLEALRERLGHWTVSGPARVIAR
AALADHGWQAANRDRLAAWAERLRALLASHGLAPVMQPLFCWVPLQHAANLHDALARHGVWTRRFDAAGDCAPGLRLGLP
PDSPHAWQQLETALSAVTRA
>Mature_340_residues
MKFALAPIRHGGDLQAAVRRYGQPVGEWLDLSTGINPTGYPVPPIPAEAWQRLPEDNDGLAEIASQAFGAPQALPVAGSQ
AAIRTLPQLLARGRVGVAALGYSEYAPAFAAAGHDVVLLGESDFAQPSLADGLDHLVVVNPNNPSGRLLAPQTLLAWHAT
LAARGGTLLVDEAFIDCTPQHSVAAHSGAPGLVVLRSLGKFYGLAGVRCGFVLGEAALLEALRERLGHWTVSGPARVIAR
AALADHGWQAANRDRLAAWAERLRALLASHGLAPVMQPLFCWVPLQHAANLHDALARHGVWTRRFDAAGDCAPGLRLGLP
PDSPHAWQQLETALSAVTRA

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=155, Percent_Identity=35.4838709677419, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 35874; Mature: 35874

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFALAPIRHGGDLQAAVRRYGQPVGEWLDLSTGINPTGYPVPPIPAEAWQRLPEDNDGL
CCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCH
AEIASQAFGAPQALPVAGSQAAIRTLPQLLARGRVGVAALGYSEYAPAFAAAGHDVVLLG
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHCCHHHHCCCCEEEEC
ESDFAQPSLADGLDHLVVVNPNNPSGRLLAPQTLLAWHATLAARGGTLLVDEAFIDCTPQ
CCCCCCCCHHCCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHCCCEEEEECHHHCCCCC
HSVAAHSGAPGLVVLRSLGKFYGLAGVRCGFVLGEAALLEALRERLGHWTVSGPARVIAR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AALADHGWQAANRDRLAAWAERLRALLASHGLAPVMQPLFCWVPLQHAANLHDALARHGV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WTRRFDAAGDCAPGLRLGLPPDSPHAWQQLETALSAVTRA
CCEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFALAPIRHGGDLQAAVRRYGQPVGEWLDLSTGINPTGYPVPPIPAEAWQRLPEDNDGL
CCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCH
AEIASQAFGAPQALPVAGSQAAIRTLPQLLARGRVGVAALGYSEYAPAFAAAGHDVVLLG
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHCCHHHHCCCCEEEEC
ESDFAQPSLADGLDHLVVVNPNNPSGRLLAPQTLLAWHATLAARGGTLLVDEAFIDCTPQ
CCCCCCCCHHCCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHCCCEEEEECHHHCCCCC
HSVAAHSGAPGLVVLRSLGKFYGLAGVRCGFVLGEAALLEALRERLGHWTVSGPARVIAR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AALADHGWQAANRDRLAAWAERLRALLASHGLAPVMQPLFCWVPLQHAANLHDALARHGV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WTRRFDAAGDCAPGLRLGLPPDSPHAWQQLETALSAVTRA
CCEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]