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The map label for this gene is strD [H]

Identifier: 73540199

GI number: 73540199

Start: 536220

End: 536957

Strand: Reverse

Name: strD [H]

Synonym: Reut_A0493

Alternate gene names: 73540199

Gene position: 536957-536220 (Counterclockwise)

Preceding gene: 73540200

Following gene: 73540198

Centisome position: 14.11

GC content: 69.65

Gene sequence:

>738_bases
TTGAAAGCCATGATCTTTGCCGCGGGCCGCGGCGACCGCATGCGCCCGCTGACCGACACCTGCCCCAAGCCGCTGCTGCC
GGTCGGCGGCAAGCCGTTGATCGTCTGGAAGATCGAGGCGCTGGTGCGCGCGGGCCTGCGCGACATCGTCATCAACCATG
CGTGGCTCGGCGAGCAGATCGAGGCGGCGCTGGGCGATGGCAGCCGCTATGGCGCGCGCATCGCGTACTCTGCCGAAGGC
AGCGCGCTCGAGACCGCCGGCGGCATTGCGAAGGCCTTGCCGCTGCTGTCGCACGCGCCGGAACGCGGCGAGATCTTCCT
TGCGGTTTCCGGCGATATCTTCTGCGAGTACGACTTCCGCACGCTGTTGCCGCGTGCGCGCCAGATGGCCGGCTTGCCGT
CCCCGCGCATGCATCTGGTGATGGTGCCGAACCCGCCGTTCCACCCGGCAGGCGACTTCGCGCTGCGAGCCGACGGCCTG
CTTGCACTGGACACTGCGCCGGACGCCGAGCGCCTGACCTTCGGCAACATCGGCCTCTATGACACGCGCCTGTTCACCGA
CATCGCCCCTGGCACCAGGGTCGCGATGACCCCGAGCTACCGCGCAGCCATCGCGGCAGGCACAGCCAGCGGCGAGCGCT
TCGACGGCCTGTGGGAAAACGTCGGCACGCCTGCCCAGCTTGCCGCACTGAACGACGCTGTCGCCTCGCGCGGTACCGCG
ATCGCAGGCGGCGCCTGA

Upstream 100 bases:

>100_bases
TCGCCGGCCTGGTGGCGATCGTGATCGCCGCGCGCACGCGCAGCATCGGCTGGACCATCATTGGCGGCATGGCTACCCTG
CTCGCCATGGAGACCCTGAT

Downstream 100 bases:

>100_bases
GCCGCTTGCCAGCGCCGCCGGGCCCTGCGCGCCGGCGGCGTTAGAATCTGATGCATTCCCCCTACACAGTTGGCGATCCT
ATGTCCGCACCCGATTCAGC

Product: nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MKAMIFAAGRGDRMRPLTDTCPKPLLPVGGKPLIVWKIEALVRAGLRDIVINHAWLGEQIEAALGDGSRYGARIAYSAEG
SALETAGGIAKALPLLSHAPERGEIFLAVSGDIFCEYDFRTLLPRARQMAGLPSPRMHLVMVPNPPFHPAGDFALRADGL
LALDTAPDAERLTFGNIGLYDTRLFTDIAPGTRVAMTPSYRAAIAAGTASGERFDGLWENVGTPAQLAALNDAVASRGTA
IAGGA

Sequences:

>Translated_245_residues
MKAMIFAAGRGDRMRPLTDTCPKPLLPVGGKPLIVWKIEALVRAGLRDIVINHAWLGEQIEAALGDGSRYGARIAYSAEG
SALETAGGIAKALPLLSHAPERGEIFLAVSGDIFCEYDFRTLLPRARQMAGLPSPRMHLVMVPNPPFHPAGDFALRADGL
LALDTAPDAERLTFGNIGLYDTRLFTDIAPGTRVAMTPSYRAAIAAGTASGERFDGLWENVGTPAQLAALNDAVASRGTA
IAGGA
>Mature_245_residues
MKAMIFAAGRGDRMRPLTDTCPKPLLPVGGKPLIVWKIEALVRAGLRDIVINHAWLGEQIEAALGDGSRYGARIAYSAEG
SALETAGGIAKALPLLSHAPERGEIFLAVSGDIFCEYDFRTLLPRARQMAGLPSPRMHLVMVPNPPFHPAGDFALRADGL
LALDTAPDAERLTFGNIGLYDTRLFTDIAPGTRVAMTPSYRAAIAAGTASGERFDGLWENVGTPAQLAALNDAVASRGTA
IAGGA

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=129, Percent_Identity=34.1085271317829, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI11761619, Length=129, Percent_Identity=34.1085271317829, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=125, Percent_Identity=34.4, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=123, Percent_Identity=38.2113821138211, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355443, Length=123, Percent_Identity=34.1463414634146, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24644084, Length=123, Percent_Identity=34.1463414634146, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 25846; Mature: 25846

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMIFAAGRGDRMRPLTDTCPKPLLPVGGKPLIVWKIEALVRAGLRDIVINHAWLGEQI
CCEEEEECCCCCCCCCCHHCCCCCCCCCCCCEEEEEEHHHHHHCCHHHHHHHHHHCCHHH
EAALGDGSRYGARIAYSAEGSALETAGGIAKALPLLSHAPERGEIFLAVSGDIFCEYDFR
HHHHCCCCCCCEEEEEECCCCCHHHHCHHHHHHHHHHCCCCCCCEEEEECCCEEEEECHH
TLLPRARQMAGLPSPRMHLVMVPNPPFHPAGDFALRADGLLALDTAPDAERLTFGNIGLY
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCCCEEECCCCCC
DTRLFTDIAPGTRVAMTPSYRAAIAAGTASGERFDGLWENVGTPAQLAALNDAVASRGTA
HHHHHHCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCE
IAGGA
ECCCC
>Mature Secondary Structure
MKAMIFAAGRGDRMRPLTDTCPKPLLPVGGKPLIVWKIEALVRAGLRDIVINHAWLGEQI
CCEEEEECCCCCCCCCCHHCCCCCCCCCCCCEEEEEEHHHHHHCCHHHHHHHHHHCCHHH
EAALGDGSRYGARIAYSAEGSALETAGGIAKALPLLSHAPERGEIFLAVSGDIFCEYDFR
HHHHCCCCCCCEEEEEECCCCCHHHHCHHHHHHHHHHCCCCCCCEEEEECCCEEEEECHH
TLLPRARQMAGLPSPRMHLVMVPNPPFHPAGDFALRADGLLALDTAPDAERLTFGNIGLY
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCCCEEECCCCCC
DTRLFTDIAPGTRVAMTPSYRAAIAAGTASGERFDGLWENVGTPAQLAALNDAVASRGTA
HHHHHHCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCE
IAGGA
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]