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The map label for this gene is pepP [H]

Identifier: 73540198

GI number: 73540198

Start: 534745

End: 536169

Strand: Reverse

Name: pepP [H]

Synonym: Reut_A0492

Alternate gene names: 73540198

Gene position: 536169-534745 (Counterclockwise)

Preceding gene: 73540199

Following gene: 73540197

Centisome position: 14.09

GC content: 67.86

Gene sequence:

>1425_bases
ATGCATTCCCCCTACACAGTTGGCGATCCTATGTCCGCACCCGATTCAGCCCTCTTGTCCGCCTGCCGCGATCGCCGCGC
GCGCGTGTTGCAGCACCTGCGCGCTAGCGGCGGTGGCGTGGCCATCCTGCCCACGGCGCCGGAAGCCATGCGCAACCGCG
ACAGCGACTATCCGTACCGGCACGACAGCTATTTCTATTACCTGACCGGCTTCACCGAGCCCGAGTCCGTGCTGGTGCTG
GTGGCCGGCCAGGGTGCCGAACCCGACCGCAGCATCCTTTTCTGCCGCCCCAAGCATGAGGAACGCGAGATCTGGGACGG
CTTCCGCTACGGCCCGGAAGGCGCACGCGCGACCTTCGGCTTCGATGAAGCGCATTCGGTCGAGGAAATCGATGAGATCC
TGCCTGGCCTGCTCGCCAATCGCGCGCAGCTCGCGTATCCGCTCGCTGCCTCGACGCGCACCGACATGCAGGTGCGCCGC
TGGCTCGACGCGGTGCGCATGCAGGGCCGCGCGGGTGTTGCAGCGCCCTCGGTTGCAACCGACATCCGCACGCTGCTCGA
CGAAATGCGGCTGATCAAGGATACCGGCGAACTGGCCACCATGCGCCGCGCCGGCGAAATCTCGGCAGGCGCCCACGTGC
GCGCCATGCAGGCCTCGCGTCACGGCCTGCGGGAATACCACCTCGAAGCCGAGCTGCTGTACGAATTCCGCCGCCACGGC
GCGCAGAGCGTGGCCTACAACTCGATCGTCGCGGCGGGTCCCAATGCCTGCGTGCTGCACTACCGCGCGGGCCCCGCCGA
ACTGCGCGACGGCGACCTGTGCCTGATCGATGCCGGCTGCGAATTCGATGGCTACGCGTCCGATATCACGCGCACGTTCC
CCGTATCGGGCCGCTTTTCGCCGGCCCAGCGCGAACTTTATGACCTGGTGCTGGCCGCACAGGACGCCGCCATTGCCGAG
ACGCGCGTCGGCGTGCCGTACAACGTGCCGCACGATGCCGCGGTGCGCGTGCTCGCGCAGGGCATGCTCGACACCGGCCT
GCTCGATCGCAACAAGGAAGGCACGCTCGACGACGTGCTGGCCAGCGGCAGCTATCGCCGCTTCTACATGCACCGCACCG
GCCACTGGCTCGGCATGGACGTGCATGACGTAGGCGAATACCGCACGGCCACGCCCGCGGCAGACGGCGAACGCCCGTGG
CGGCCGCTGGAGGCGGGCATGGTGGTGACGGTCGAACCCGGCATCTACGTGCGCCCTGCCGAGGACGTGCCCGAGCGCTA
CTGGCATATCGGCATCCGCATCGAGGACGATGCCGTGGTCACGAACGGCGACTGCGAGATCATCACGCGCGGCGTGCCGG
TCAAGGCCGACGAGATCGAAGCGCTGATGCGAGACCGCAACACCCTGAACGGAGGCAAGGCATGA

Upstream 100 bases:

>100_bases
TGAACGACGCTGTCGCCTCGCGCGGTACCGCGATCGCAGGCGGCGCCTGAGCCGCTTGCCAGCGCCGCCGGGCCCTGCGC
GCCGGCGGCGTTAGAATCTG

Downstream 100 bases:

>100_bases
TCGGATGGCTGCGCCGACTGTTCCCCGGCAATACCGGAACACCGCATAACCCGCCTGTAAAGCGCCACGTCGATCCGAGC
GAACCGTTCGTGATCAACCT

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MHSPYTVGDPMSAPDSALLSACRDRRARVLQHLRASGGGVAILPTAPEAMRNRDSDYPYRHDSYFYYLTGFTEPESVLVL
VAGQGAEPDRSILFCRPKHEEREIWDGFRYGPEGARATFGFDEAHSVEEIDEILPGLLANRAQLAYPLAASTRTDMQVRR
WLDAVRMQGRAGVAAPSVATDIRTLLDEMRLIKDTGELATMRRAGEISAGAHVRAMQASRHGLREYHLEAELLYEFRRHG
AQSVAYNSIVAAGPNACVLHYRAGPAELRDGDLCLIDAGCEFDGYASDITRTFPVSGRFSPAQRELYDLVLAAQDAAIAE
TRVGVPYNVPHDAAVRVLAQGMLDTGLLDRNKEGTLDDVLASGSYRRFYMHRTGHWLGMDVHDVGEYRTATPAADGERPW
RPLEAGMVVTVEPGIYVRPAEDVPERYWHIGIRIEDDAVVTNGDCEIITRGVPVKADEIEALMRDRNTLNGGKA

Sequences:

>Translated_474_residues
MHSPYTVGDPMSAPDSALLSACRDRRARVLQHLRASGGGVAILPTAPEAMRNRDSDYPYRHDSYFYYLTGFTEPESVLVL
VAGQGAEPDRSILFCRPKHEEREIWDGFRYGPEGARATFGFDEAHSVEEIDEILPGLLANRAQLAYPLAASTRTDMQVRR
WLDAVRMQGRAGVAAPSVATDIRTLLDEMRLIKDTGELATMRRAGEISAGAHVRAMQASRHGLREYHLEAELLYEFRRHG
AQSVAYNSIVAAGPNACVLHYRAGPAELRDGDLCLIDAGCEFDGYASDITRTFPVSGRFSPAQRELYDLVLAAQDAAIAE
TRVGVPYNVPHDAAVRVLAQGMLDTGLLDRNKEGTLDDVLASGSYRRFYMHRTGHWLGMDVHDVGEYRTATPAADGERPW
RPLEAGMVVTVEPGIYVRPAEDVPERYWHIGIRIEDDAVVTNGDCEIITRGVPVKADEIEALMRDRNTLNGGKA
>Mature_474_residues
MHSPYTVGDPMSAPDSALLSACRDRRARVLQHLRASGGGVAILPTAPEAMRNRDSDYPYRHDSYFYYLTGFTEPESVLVL
VAGQGAEPDRSILFCRPKHEEREIWDGFRYGPEGARATFGFDEAHSVEEIDEILPGLLANRAQLAYPLAASTRTDMQVRR
WLDAVRMQGRAGVAAPSVATDIRTLLDEMRLIKDTGELATMRRAGEISAGAHVRAMQASRHGLREYHLEAELLYEFRRHG
AQSVAYNSIVAAGPNACVLHYRAGPAELRDGDLCLIDAGCEFDGYASDITRTFPVSGRFSPAQRELYDLVLAAQDAAIAE
TRVGVPYNVPHDAAVRVLAQGMLDTGLLDRNKEGTLDDVLASGSYRRFYMHRTGHWLGMDVHDVGEYRTATPAADGERPW
RPLEAGMVVTVEPGIYVRPAEDVPERYWHIGIRIEDDAVVTNGDCEIITRGVPVKADEIEALMRDRNTLNGGKA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=447, Percent_Identity=31.9910514541387, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI149589008, Length=474, Percent_Identity=30.168776371308, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI260593665, Length=303, Percent_Identity=35.6435643564356, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI260593663, Length=481, Percent_Identity=27.4428274428274, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI1789275, Length=439, Percent_Identity=44.4191343963554, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1790282, Length=298, Percent_Identity=31.8791946308725, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788728, Length=269, Percent_Identity=31.5985130111524, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17508215, Length=473, Percent_Identity=29.5983086680761, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71989583, Length=286, Percent_Identity=30.4195804195804, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320922, Length=418, Percent_Identity=29.6650717703349, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6321118, Length=438, Percent_Identity=32.4200913242009, Blast_Score=192, Evalue=9e-50,
Organism=Drosophila melanogaster, GI19920384, Length=507, Percent_Identity=33.5305719921105, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI21357079, Length=502, Percent_Identity=31.6733067729084, Blast_Score=195, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 52381; Mature: 52381

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSPYTVGDPMSAPDSALLSACRDRRARVLQHLRASGGGVAILPTAPEAMRNRDSDYPYR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCCCCCCCC
HDSYFYYLTGFTEPESVLVLVAGQGAEPDRSILFCRPKHEEREIWDGFRYGPEGARATFG
CCCEEEEEECCCCCCEEEEEEECCCCCCCCCEEEECCCCCHHHHHCCCCCCCCCCEEECC
FDEAHSVEEIDEILPGLLANRAQLAYPLAASTRTDMQVRRWLDAVRMQGRAGVAAPSVAT
CCCCCCHHHHHHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
DIRTLLDEMRLIKDTGELATMRRAGEISAGAHVRAMQASRHGLREYHLEAELLYEFRRHG
HHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AQSVAYNSIVAAGPNACVLHYRAGPAELRDGDLCLIDAGCEFDGYASDITRTFPVSGRFS
CHHHHHCCEEECCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHCCEECCCCCCCC
PAQRELYDLVLAAQDAAIAETRVGVPYNVPHDAAVRVLAQGMLDTGLLDRNKEGTLDDVL
HHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
ASGSYRRFYMHRTGHWLGMDVHDVGEYRTATPAADGERPWRPLEAGMVVTVEPGIYVRPA
CCCCCEEEEEEECCCEECCCHHHCCCCCCCCCCCCCCCCCCHHHCCEEEEECCCEEEECC
EDVPERYWHIGIRIEDDAVVTNGDCEIITRGVPVKADEIEALMRDRNTLNGGKA
HHHCCCCEEEEEEEECCEEEECCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MHSPYTVGDPMSAPDSALLSACRDRRARVLQHLRASGGGVAILPTAPEAMRNRDSDYPYR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCCCCCCCC
HDSYFYYLTGFTEPESVLVLVAGQGAEPDRSILFCRPKHEEREIWDGFRYGPEGARATFG
CCCEEEEEECCCCCCEEEEEEECCCCCCCCCEEEECCCCCHHHHHCCCCCCCCCCEEECC
FDEAHSVEEIDEILPGLLANRAQLAYPLAASTRTDMQVRRWLDAVRMQGRAGVAAPSVAT
CCCCCCHHHHHHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
DIRTLLDEMRLIKDTGELATMRRAGEISAGAHVRAMQASRHGLREYHLEAELLYEFRRHG
HHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AQSVAYNSIVAAGPNACVLHYRAGPAELRDGDLCLIDAGCEFDGYASDITRTFPVSGRFS
CHHHHHCCEEECCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHCCEECCCCCCCC
PAQRELYDLVLAAQDAAIAETRVGVPYNVPHDAAVRVLAQGMLDTGLLDRNKEGTLDDVL
HHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
ASGSYRRFYMHRTGHWLGMDVHDVGEYRTATPAADGERPWRPLEAGMVVTVEPGIYVRPA
CCCCCEEEEEEECCCEECCCHHHCCCCCCCCCCCCCCCCCCHHHCCEEEEECCCEEEECC
EDVPERYWHIGIRIEDDAVVTNGDCEIITRGVPVKADEIEALMRDRNTLNGGKA
HHHCCCCEEEEEEEECCEEEECCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]