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The map label for this gene is pqqL [C]

Identifier: 73540041

GI number: 73540041

Start: 364718

End: 366238

Strand: Direct

Name: pqqL [C]

Synonym: Reut_A0335

Alternate gene names: 73540041

Gene position: 364718-366238 (Clockwise)

Preceding gene: 73540039

Following gene: 73540042

Centisome position: 9.58

GC content: 64.3

Gene sequence:

>1521_bases
ATGAACCATCGCACTGTCGTGACCGGAACGGGCGGTACCCGCCCTAAACCCATTCCCGCCCCTGCCGAATGCCGGGCGCG
CCTGGAACGCCTGGCACGGCGGGCGCTGCCGGTCCTGCTGCTGGCGGCGCTGCCCTGGACTGCCGGCGCGCAAACGCCGC
GCACTGTCGCTTCCCCCATGCCATCCGGGCAGACTGCTCCGGTAGACGCCACGGCACAGGGCACCACCGAGTACAAGCTG
TCCAATGGACTACGCCTGATCGTCAAGGAAGACCACCGAGCGCCCACGGTGGCGCACCAGATCTGGTACCGCGTCGGCGG
TATCGACGAAGTCAGTGGCACCACGGGCGTCGCCCATATGCTCGAACACATGATGTTCAAGGGCACGCCCAAGGTCGGCG
TGGGCGAATTCTCCAAGCAGGTCGCCGCGCTGGGCGGCCGCGAAAACGCCATGACTAACCGCGACTTCACGCTGTATTAC
CAGCAGATCGGCAAGCAATACCTGCCGAAGATGATGGAGCTCGAAGCCGACCGTATGGCCAACCTGATCTTCAACAAGGG
CGAGTTCGACCGCGAGATGAAGGTGGTGATGGAAGAGCGGCGCCTGCGCACCGATGACTCTGCGCGTGGCACGGTCTACG
AGCAGTTGCTGGCCAACGTCTATGTCGCTGCACCTTACCGGCATCCGGTAATCGGGTGGATGGACGACCTCGTCAACATG
CGCCTGGAAGACGTCCAGTCCTGGTACCGGAGCTGGTACGTCCCGAACAACGCCACGGTAATCGTGACCGGCGACGTCAA
TCCGGCCGAGGTCCGCGCTTTGGCCGAGCGCTACTACGGCAAGCTCAAGCCGCGCCCGCTGCCGCTGCGCAAGGAGCAGA
TCGACCCGCCGCAACTGGGCATCAAGCGCGTCTGGGTCAAGGCGCCAGCCGAGAACCCGTACATGGTGATGGCCTACAAG
GTGCCGCGCCTGCGCGACGTGGAGAAGGATGTCGATCCCTATGCGCTCGAAGTCCTGGCCGCGGTGCTCAACGGTTACGA
CAACGCGCGCCTGACGCGTGAACTGGTGCGCGAACAGCGCCTGGCCGACGACGTCAATGTCGGCTACGACAGCATCAACC
GCGGCAATTCGCTGTTTGTGCTCGATGGCACGCCGGCCGACGGCCATACCACCGAGCAGATCGAGGCCGCGCTGCGCGAG
GAAATCCAGCGCATTGCCAGGAACGGTGTTTCGCCGGAAGAGCTCAAGCGCGTCAAGGCGCAGGTCGTGGCCAGCCAGAT
CTACAAGCGCGATTCCGTGTTCGGCCAAGGCATGGAGATCGGCGTGGCAGAGATCTCCGATATCTCGTGGCGCAAGATCG
ACCGCATCCTCGACAAGATCAAGGAAGTCACGCCGGCGCAGGTCCAGGCTGTGGCCGCGAAGTACTTCACCGACGACAAC
CTGACCGTGGCCACGCTGTTGCCGCAGCCGATCGATCCCAACAAGCCCAAGGCCAAGGCCCCCGAAGGCCTGCGCCACTG
A

Upstream 100 bases:

>100_bases
CCTGTCGTTGTGGTGCGTAGCCGCTATTGCGTATAGTTCGTAACACAGCGGATTCATGGGCACATGAATCGATCGGCAAA
ATTCTAACAGACGGGGTTGC

Downstream 100 bases:

>100_bases
GGAGCCACGCATGTCCCTGTCCGACATTACGATTCCTTCACCGCGCGCGCTGCGCCGGCTGGCGGGCGCGGCCCTGGGAG
CGCTGGCGCTGCTGGCCACG

Product: peptidase M16, C-terminal:peptidase M16, N-terminal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MNHRTVVTGTGGTRPKPIPAPAECRARLERLARRALPVLLLAALPWTAGAQTPRTVASPMPSGQTAPVDATAQGTTEYKL
SNGLRLIVKEDHRAPTVAHQIWYRVGGIDEVSGTTGVAHMLEHMMFKGTPKVGVGEFSKQVAALGGRENAMTNRDFTLYY
QQIGKQYLPKMMELEADRMANLIFNKGEFDREMKVVMEERRLRTDDSARGTVYEQLLANVYVAAPYRHPVIGWMDDLVNM
RLEDVQSWYRSWYVPNNATVIVTGDVNPAEVRALAERYYGKLKPRPLPLRKEQIDPPQLGIKRVWVKAPAENPYMVMAYK
VPRLRDVEKDVDPYALEVLAAVLNGYDNARLTRELVREQRLADDVNVGYDSINRGNSLFVLDGTPADGHTTEQIEAALRE
EIQRIARNGVSPEELKRVKAQVVASQIYKRDSVFGQGMEIGVAEISDISWRKIDRILDKIKEVTPAQVQAVAAKYFTDDN
LTVATLLPQPIDPNKPKAKAPEGLRH

Sequences:

>Translated_506_residues
MNHRTVVTGTGGTRPKPIPAPAECRARLERLARRALPVLLLAALPWTAGAQTPRTVASPMPSGQTAPVDATAQGTTEYKL
SNGLRLIVKEDHRAPTVAHQIWYRVGGIDEVSGTTGVAHMLEHMMFKGTPKVGVGEFSKQVAALGGRENAMTNRDFTLYY
QQIGKQYLPKMMELEADRMANLIFNKGEFDREMKVVMEERRLRTDDSARGTVYEQLLANVYVAAPYRHPVIGWMDDLVNM
RLEDVQSWYRSWYVPNNATVIVTGDVNPAEVRALAERYYGKLKPRPLPLRKEQIDPPQLGIKRVWVKAPAENPYMVMAYK
VPRLRDVEKDVDPYALEVLAAVLNGYDNARLTRELVREQRLADDVNVGYDSINRGNSLFVLDGTPADGHTTEQIEAALRE
EIQRIARNGVSPEELKRVKAQVVASQIYKRDSVFGQGMEIGVAEISDISWRKIDRILDKIKEVTPAQVQAVAAKYFTDDN
LTVATLLPQPIDPNKPKAKAPEGLRH
>Mature_506_residues
MNHRTVVTGTGGTRPKPIPAPAECRARLERLARRALPVLLLAALPWTAGAQTPRTVASPMPSGQTAPVDATAQGTTEYKL
SNGLRLIVKEDHRAPTVAHQIWYRVGGIDEVSGTTGVAHMLEHMMFKGTPKVGVGEFSKQVAALGGRENAMTNRDFTLYY
QQIGKQYLPKMMELEADRMANLIFNKGEFDREMKVVMEERRLRTDDSARGTVYEQLLANVYVAAPYRHPVIGWMDDLVNM
RLEDVQSWYRSWYVPNNATVIVTGDVNPAEVRALAERYYGKLKPRPLPLRKEQIDPPQLGIKRVWVKAPAENPYMVMAYK
VPRLRDVEKDVDPYALEVLAAVLNGYDNARLTRELVREQRLADDVNVGYDSINRGNSLFVLDGTPADGHTTEQIEAALRE
EIQRIARNGVSPEELKRVKAQVVASQIYKRDSVFGQGMEIGVAEISDISWRKIDRILDKIKEVTPAQVQAVAAKYFTDDN
LTVATLLPQPIDPNKPKAKAPEGLRH

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI46593007, Length=203, Percent_Identity=27.0935960591133, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI94538354, Length=201, Percent_Identity=26.865671641791, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1787770, Length=215, Percent_Identity=33.953488372093, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17553678, Length=436, Percent_Identity=22.7064220183486, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71999683, Length=204, Percent_Identity=25.9803921568627, Blast_Score=83, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323192, Length=218, Percent_Identity=23.394495412844, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323421, Length=329, Percent_Identity=21.580547112462, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21357875, Length=210, Percent_Identity=29.5238095238095, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24646943, Length=210, Percent_Identity=29.5238095238095, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 56669; Mature: 56669

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHRTVVTGTGGTRPKPIPAPAECRARLERLARRALPVLLLAALPWTAGAQTPRTVASPM
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCC
PSGQTAPVDATAQGTTEYKLSNGLRLIVKEDHRAPTVAHQIWYRVGGIDEVSGTTGVAHM
CCCCCCCCCCCCCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
LEHMMFKGTPKVGVGEFSKQVAALGGRENAMTNRDFTLYYQQIGKQYLPKMMELEADRMA
HHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NLIFNKGEFDREMKVVMEERRLRTDDSARGTVYEQLLANVYVAAPYRHPVIGWMDDLVNM
HHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEECCCCCCHHHHHHHHHHH
RLEDVQSWYRSWYVPNNATVIVTGDVNPAEVRALAERYYGKLKPRPLPLRKEQIDPPQLG
HHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHC
IKRVWVKAPAENPYMVMAYKVPRLRDVEKDVDPYALEVLAAVLNGYDNARLTRELVREQR
CEEEEEECCCCCCEEEEEEECCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LADDVNVGYDSINRGNSLFVLDGTPADGHTTEQIEAALREEIQRIARNGVSPEELKRVKA
HHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QVVASQIYKRDSVFGQGMEIGVAEISDISWRKIDRILDKIKEVTPAQVQAVAAKYFTDDN
HHHHHHHHHHHHHCCCCCEECHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
LTVATLLPQPIDPNKPKAKAPEGLRH
CEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNHRTVVTGTGGTRPKPIPAPAECRARLERLARRALPVLLLAALPWTAGAQTPRTVASPM
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCC
PSGQTAPVDATAQGTTEYKLSNGLRLIVKEDHRAPTVAHQIWYRVGGIDEVSGTTGVAHM
CCCCCCCCCCCCCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
LEHMMFKGTPKVGVGEFSKQVAALGGRENAMTNRDFTLYYQQIGKQYLPKMMELEADRMA
HHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NLIFNKGEFDREMKVVMEERRLRTDDSARGTVYEQLLANVYVAAPYRHPVIGWMDDLVNM
HHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEECCCCCCHHHHHHHHHHH
RLEDVQSWYRSWYVPNNATVIVTGDVNPAEVRALAERYYGKLKPRPLPLRKEQIDPPQLG
HHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHC
IKRVWVKAPAENPYMVMAYKVPRLRDVEKDVDPYALEVLAAVLNGYDNARLTRELVREQR
CEEEEEECCCCCCEEEEEEECCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LADDVNVGYDSINRGNSLFVLDGTPADGHTTEQIEAALREEIQRIARNGVSPEELKRVKA
HHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QVVASQIYKRDSVFGQGMEIGVAEISDISWRKIDRILDKIKEVTPAQVQAVAAKYFTDDN
HHHHHHHHHHHHHCCCCCEECHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
LTVATLLPQPIDPNKPKAKAPEGLRH
CEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]