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The map label for this gene is ctaD [H]

Identifier: 73540021

GI number: 73540021

Start: 345920

End: 347524

Strand: Direct

Name: ctaD [H]

Synonym: Reut_A0315

Alternate gene names: 73540021

Gene position: 345920-347524 (Clockwise)

Preceding gene: 73540020

Following gene: 73540022

Centisome position: 9.09

GC content: 62.62

Gene sequence:

>1605_bases
ATGAGTACTGCTACCCCCGACGCAATCGGCCATCCGCACGATCACGCGCACGACCACGCGCATGATCACCCGCATGGCTG
GCGCCGCTGGTTGTTCGCCACCAACCACAAGGACATCGGCACGCTGTACCTGCTGTTCGCGTTCATCATGCTGTTGTCGG
GCGGCTTGCTGGCACTGCTGATCCGCCTGGAGCTGTTCGAGCCGGGCCTGCAGTTCTTCCGCCCCGAGCTGTTCAACCAG
TTCACAACCATGCATGGCCTGATCATGGTGTTCGGTGCGATCATGCCGGCCTTCGTGGGTTTCGCGAACTGGATGATCCC
GCTGCAGATCGGCGCGTCCGACATGGCGTTCGCGCGCATGAACAACTTCAGCTTCTGGCTGATGCCGCCGGCCGCGCTGC
TGCTAGCCGGTTCGTTCTTCGCACCGGGCGGCGCCACCGCCGCCGGCTGGACGCTGTACGCGCCGCTGTCGGTGCAAATG
GGTCCGGGCATGGACATGGCCATCTTCGCCATGCACATCATGGGCGCGTCGTCGATCATGGGCTCGATCAACATCATCGT
GACCATCCTCAACATGCGCGCCCCGGGCATGACGCTGATGAAGATGCCGATGTTCTGCTGGACGTGGCTGATCACCGCCT
ACCTGCTGATCGCCGTGATGCCCGTGCTGGCCGGCGCCATCACCATGGTGCTGACTGATCGCCACTTCGGCACGAGCTTC
TTCTCGGCTGCCGGCGGCGGTGACCCGGTGATGTACCAGCACATCTTCTGGTTCTTCGGCCACCCCGAGGTGTACATCAT
GATCCTGCCGGCTTTCGGGATCATCTCGCAGGTCGTGCCGGCGTTTGCCCGCAAGCGCCTGTTCGGCTACAGCTCGATGG
TGTACGCGACTGCTTCGATCGCCATCCTGTCGTTCATCGTATGGGCGCACCACATGTTCACGACGGGCATGCCGGTGACG
GGCCAGCTGTTCTTCATGTACGCGACCATGCTGATCGCGGTGCCGACGGCCGTGAAGATCTTCAACTGGATCGCGACGAT
GTGGCGCGGCTCGATGACTTTCGAGACCCCGATGCTGTTCTCGATCGGCTTCATCTTCGTGTTCACCATCGGCGGCTTCA
CCGGCCTGATGCCGGCCGTGGCGCCGATCGACATCCAGCTGCAGGACACCTACTTCATCGTGGCGCACTTCCACTATGTG
CTGGTGGCCGGCTCGCTGTTCGCGCTGTTTGCGGGCTTCTACTACTGGGGTCCGAAGTGGAGCGGTTTCATGTACAACGA
AACCCGCGGCCAGATCCATTTCTGGGGCTCGATCATCTTCTTCAACGTTACCTTCTTCCCGATGCACTTCCTGGGTCTGG
CCGGCATGCCGCGTCGCTACGCCGACTACCCGACCCAGTTCGCGGACTTCAACGCGATCGCGTCGATCGGGGCACTGGGC
TTCGGCCTGATGCAGGTGTACTTCTTCTTCTTCGTGGTGCTGCCGTCCTACCGTGGCGGCGAGAAGGCCGCGGACAAGCC
CTGGGAAGGTGCCGAGGGCCTGGAGTGGACCGTGCCGTCGCCGGCGCCGTTCCACACCTTTGAAGTGCCGCCGCAAGTTC
GCTAA

Upstream 100 bases:

>100_bases
AGCCCGCCAAAGACCAGGGCAGCAAGCAGGCCAGCATCGCGGGCGACCGCACCGCAGGCTGACCGGCTGAAGACAGGACA
GGATTAGAGGAGCATTTGCG

Downstream 100 bases:

>100_bases
GCACTAGTCGCAACAAGGCTTCGGGAGACGCAACGCCGTCTCCCGGGCCGGCAGGTAACACAAGATGCAGGCTCCACAAA
AAAACCCATCGCAAACTGAC

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MSTATPDAIGHPHDHAHDHAHDHPHGWRRWLFATNHKDIGTLYLLFAFIMLLSGGLLALLIRLELFEPGLQFFRPELFNQ
FTTMHGLIMVFGAIMPAFVGFANWMIPLQIGASDMAFARMNNFSFWLMPPAALLLAGSFFAPGGATAAGWTLYAPLSVQM
GPGMDMAIFAMHIMGASSIMGSINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSF
FSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIISQVVPAFARKRLFGYSSMVYATASIAILSFIVWAHHMFTTGMPVT
GQLFFMYATMLIAVPTAVKIFNWIATMWRGSMTFETPMLFSIGFIFVFTIGGFTGLMPAVAPIDIQLQDTYFIVAHFHYV
LVAGSLFALFAGFYYWGPKWSGFMYNETRGQIHFWGSIIFFNVTFFPMHFLGLAGMPRRYADYPTQFADFNAIASIGALG
FGLMQVYFFFFVVLPSYRGGEKAADKPWEGAEGLEWTVPSPAPFHTFEVPPQVR

Sequences:

>Translated_534_residues
MSTATPDAIGHPHDHAHDHAHDHPHGWRRWLFATNHKDIGTLYLLFAFIMLLSGGLLALLIRLELFEPGLQFFRPELFNQ
FTTMHGLIMVFGAIMPAFVGFANWMIPLQIGASDMAFARMNNFSFWLMPPAALLLAGSFFAPGGATAAGWTLYAPLSVQM
GPGMDMAIFAMHIMGASSIMGSINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSF
FSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIISQVVPAFARKRLFGYSSMVYATASIAILSFIVWAHHMFTTGMPVT
GQLFFMYATMLIAVPTAVKIFNWIATMWRGSMTFETPMLFSIGFIFVFTIGGFTGLMPAVAPIDIQLQDTYFIVAHFHYV
LVAGSLFALFAGFYYWGPKWSGFMYNETRGQIHFWGSIIFFNVTFFPMHFLGLAGMPRRYADYPTQFADFNAIASIGALG
FGLMQVYFFFFVVLPSYRGGEKAADKPWEGAEGLEWTVPSPAPFHTFEVPPQVR
>Mature_533_residues
STATPDAIGHPHDHAHDHAHDHPHGWRRWLFATNHKDIGTLYLLFAFIMLLSGGLLALLIRLELFEPGLQFFRPELFNQF
TTMHGLIMVFGAIMPAFVGFANWMIPLQIGASDMAFARMNNFSFWLMPPAALLLAGSFFAPGGATAAGWTLYAPLSVQMG
PGMDMAIFAMHIMGASSIMGSINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSFF
SAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIISQVVPAFARKRLFGYSSMVYATASIAILSFIVWAHHMFTTGMPVTG
QLFFMYATMLIAVPTAVKIFNWIATMWRGSMTFETPMLFSIGFIFVFTIGGFTGLMPAVAPIDIQLQDTYFIVAHFHYVL
VAGSLFALFAGFYYWGPKWSGFMYNETRGQIHFWGSIIFFNVTFFPMHFLGLAGMPRRYADYPTQFADFNAIASIGALGF
GLMQVYFFFFVVLPSYRGGEKAADKPWEGAEGLEWTVPSPAPFHTFEVPPQVR

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=512, Percent_Identity=49.8046875, Blast_Score=462, Evalue=1e-130,
Organism=Escherichia coli, GI1786634, Length=517, Percent_Identity=42.3597678916828, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6226519, Length=530, Percent_Identity=46.6037735849057, Blast_Score=477, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6226524, Length=323, Percent_Identity=50.1547987616099, Blast_Score=325, Evalue=8e-90,
Organism=Saccharomyces cerevisiae, GI6226523, Length=247, Percent_Identity=46.5587044534413, Blast_Score=216, Evalue=6e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 59635; Mature: 59504

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.9 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTATPDAIGHPHDHAHDHAHDHPHGWRRWLFATNHKDIGTLYLLFAFIMLLSGGLLALL
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHCCHHHHH
IRLELFEPGLQFFRPELFNQFTTMHGLIMVFGAIMPAFVGFANWMIPLQIGASDMAFARM
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHH
NNFSFWLMPPAALLLAGSFFAPGGATAAGWTLYAPLSVQMGPGMDMAIFAMHIMGASSIM
CCCEEEECCHHHHHHHCCCCCCCCCCCCCEEEEECEEEECCCCCCHHHHHHHHHHHHHHH
GSINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSF
HHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
FSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIISQVVPAFARKRLFGYSSMVYATASI
HHCCCCCCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AILSFIVWAHHMFTTGMPVTGQLFFMYATMLIAVPTAVKIFNWIATMWRGSMTFETPMLF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
SIGFIFVFTIGGFTGLMPAVAPIDIQLQDTYFIVAHFHYVLVAGSLFALFAGFYYWGPKW
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
SGFMYNETRGQIHFWGSIIFFNVTFFPMHFLGLAGMPRRYADYPTQFADFNAIASIGALG
CCEEEECCCCCEEEEEEEEEEHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHH
FGLMQVYFFFFVVLPSYRGGEKAADKPWEGAEGLEWTVPSPAPFHTFEVPPQVR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEECCCCCCC
>Mature Secondary Structure 
STATPDAIGHPHDHAHDHAHDHPHGWRRWLFATNHKDIGTLYLLFAFIMLLSGGLLALL
CCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHCCHHHHH
IRLELFEPGLQFFRPELFNQFTTMHGLIMVFGAIMPAFVGFANWMIPLQIGASDMAFARM
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHH
NNFSFWLMPPAALLLAGSFFAPGGATAAGWTLYAPLSVQMGPGMDMAIFAMHIMGASSIM
CCCEEEECCHHHHHHHCCCCCCCCCCCCCEEEEECEEEECCCCCCHHHHHHHHHHHHHHH
GSINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSF
HHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
FSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIISQVVPAFARKRLFGYSSMVYATASI
HHCCCCCCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AILSFIVWAHHMFTTGMPVTGQLFFMYATMLIAVPTAVKIFNWIATMWRGSMTFETPMLF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
SIGFIFVFTIGGFTGLMPAVAPIDIQLQDTYFIVAHFHYVLVAGSLFALFAGFYYWGPKW
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
SGFMYNETRGQIHFWGSIIFFNVTFFPMHFLGLAGMPRRYADYPTQFADFNAIASIGALG
CCEEEECCCCCEEEEEEEEEEHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHH
FGLMQVYFFFFVVLPSYRGGEKAADKPWEGAEGLEWTVPSPAPFHTFEVPPQVR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]