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The map label for this gene is ctaC [H]

Identifier: 73540020

GI number: 73540020

Start: 344616

End: 345881

Strand: Direct

Name: ctaC [H]

Synonym: Reut_A0314

Alternate gene names: 73540020

Gene position: 344616-345881 (Clockwise)

Preceding gene: 73540019

Following gene: 73540021

Centisome position: 9.05

GC content: 62.56

Gene sequence:

>1266_bases
ATGAAAATGTGGAAGAAGGCATCCGCAGTTTGTCTGGCGAGCGCATCCCTGCTTGCCAGCCAGGCGGCCCTGGCGGTCAG
TGACATGCCCGGCGGTCCCGCCGTGCGTCAGCTGAACCTGACCGAGCCGGTCACGAAGATCGCCGAACAGATTCACTGGC
TGAACTGGATGATGTTGATCATCTGCACGGTGATCTTCGTTGCCGTGTTCGGCGTGATGTTCTATTCCGTGTTCACGCAC
CGCAAGGCCAAGGGTGCGAAGCCTGCTTCCTTCCACGAAAGCATCACGGTCGAAGTGGTCTGGACCATCGTCCCGTTCCT
GATCGTGATCGCCATGGCCCTGCCCGCCACCAAGACCGTGGTGGCCATGAAGGACACCACCAACTCCGACGTCACCATCA
AGGCCACTGGCTACCAGTGGAAGTGGGGCTACGACTACCTGAAGGGCGAGGGCGAAGGCATCTCCTTCGTTTCCACGCTG
ACCACGCCGCGCGAACAGATCAACAACGAAGCGCCGAAGTCGAACACCTACCTGATGGAAGTCGACAACGAGCTCGTGGT
ACCGGTCAACAAGAAGGTGCGCATCGTCACGACCGCCAATGACGTGATCCACGCGTGGATGATTCCGGCATTCGGCGTCA
AGCAGGATGCGATCCCCGGCTTCGTGCGCGACACGTGGTTCAAGGCCGAGAAAATCGGCGTGTACCGCGGCCAGTGCGCC
GAGCTTTGCGGCAAGGAACACGCGTTCATGCCGATCGTCGTGCGCGTGGTGTCCGACGCCGACTACACCAAGTGGGTCGA
CGGCAAGAAGAAGGAAATGGCCGCCAAGGCCGATGATCCGAACAAGACCTGGACGCTCGACGAAATGAAGGCGCGCGGCG
AGAAGGTCTACACCGCCAACTGCGCGGTCTGCCACCAGCCGAACGGCAAGGGCGGCGGCGCGTTCCCGGCGCTGGACGGC
TCGAAGATCGTGAATGGCCCGAAGGCCGGCCAGATGCACATCATGCTGGAAGGCAAGAACGCCATGCCGTCGTGGAAGCA
GCTGTCCGATACGGAGCTGGCTGCAGCGATGACCTATGTGCGCAACAGCTGGAGCAACAAGACCGGCGAAGTGATCCAGC
CCAGCGATTTCGTGAATGCCCGCGCCGGCAAGTTCCCCGAGGGCGGCGGCGCTGCAGGCGGCGACGCACCGAAGGCGGAC
GCGAAGCCCGCCAAAGACCAGGGCAGCAAGCAGGCCAGCATCGCGGGCGACCGCACCGCAGGCTGA

Upstream 100 bases:

>100_bases
AAGTTCGCCCAGGAGCTCGCAGCGGCCCTGCGCCGCCTCTGAGAGGTGGCGGGGGCGGATGCGGGGACAGATTTGGATCT
GTAAATTGGGTAGATAACAA

Downstream 100 bases:

>100_bases
CCGGCTGAAGACAGGACAGGATTAGAGGAGCATTTGCGATGAGTACTGCTACCCCCGACGCAATCGGCCATCCGCACGAT
CACGCGCACGACCACGCGCA

Product: cytochrome c oxidase, subunit II:cytochrome c, class I:cytochrome C oxidase subunit II, transmembrane region

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II; Oxidase aa(3) subunit 2 [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MKMWKKASAVCLASASLLASQAALAVSDMPGGPAVRQLNLTEPVTKIAEQIHWLNWMMLIICTVIFVAVFGVMFYSVFTH
RKAKGAKPASFHESITVEVVWTIVPFLIVIAMALPATKTVVAMKDTTNSDVTIKATGYQWKWGYDYLKGEGEGISFVSTL
TTPREQINNEAPKSNTYLMEVDNELVVPVNKKVRIVTTANDVIHAWMIPAFGVKQDAIPGFVRDTWFKAEKIGVYRGQCA
ELCGKEHAFMPIVVRVVSDADYTKWVDGKKKEMAAKADDPNKTWTLDEMKARGEKVYTANCAVCHQPNGKGGGAFPALDG
SKIVNGPKAGQMHIMLEGKNAMPSWKQLSDTELAAAMTYVRNSWSNKTGEVIQPSDFVNARAGKFPEGGGAAGGDAPKAD
AKPAKDQGSKQASIAGDRTAG

Sequences:

>Translated_421_residues
MKMWKKASAVCLASASLLASQAALAVSDMPGGPAVRQLNLTEPVTKIAEQIHWLNWMMLIICTVIFVAVFGVMFYSVFTH
RKAKGAKPASFHESITVEVVWTIVPFLIVIAMALPATKTVVAMKDTTNSDVTIKATGYQWKWGYDYLKGEGEGISFVSTL
TTPREQINNEAPKSNTYLMEVDNELVVPVNKKVRIVTTANDVIHAWMIPAFGVKQDAIPGFVRDTWFKAEKIGVYRGQCA
ELCGKEHAFMPIVVRVVSDADYTKWVDGKKKEMAAKADDPNKTWTLDEMKARGEKVYTANCAVCHQPNGKGGGAFPALDG
SKIVNGPKAGQMHIMLEGKNAMPSWKQLSDTELAAAMTYVRNSWSNKTGEVIQPSDFVNARAGKFPEGGGAAGGDAPKAD
AKPAKDQGSKQASIAGDRTAG
>Mature_421_residues
MKMWKKASAVCLASASLLASQAALAVSDMPGGPAVRQLNLTEPVTKIAEQIHWLNWMMLIICTVIFVAVFGVMFYSVFTH
RKAKGAKPASFHESITVEVVWTIVPFLIVIAMALPATKTVVAMKDTTNSDVTIKATGYQWKWGYDYLKGEGEGISFVSTL
TTPREQINNEAPKSNTYLMEVDNELVVPVNKKVRIVTTANDVIHAWMIPAFGVKQDAIPGFVRDTWFKAEKIGVYRGQCA
ELCGKEHAFMPIVVRVVSDADYTKWVDGKKKEMAAKADDPNKTWTLDEMKARGEKVYTANCAVCHQPNGKGGGAFPALDG
SKIVNGPKAGQMHIMLEGKNAMPSWKQLSDTELAAAMTYVRNSWSNKTGEVIQPSDFVNARAGKFPEGGGAAGGDAPKAD
AKPAKDQGSKQASIAGDRTAG

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=161, Percent_Identity=37.888198757764, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6226540, Length=210, Percent_Identity=32.3809523809524, Blast_Score=127, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 45637; Mature: 45637

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA ; PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMWKKASAVCLASASLLASQAALAVSDMPGGPAVRQLNLTEPVTKIAEQIHWLNWMMLI
CCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHH
ICTVIFVAVFGVMFYSVFTHRKAKGAKPASFHESITVEVVWTIVPFLIVIAMALPATKTV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEE
VAMKDTTNSDVTIKATGYQWKWGYDYLKGEGEGISFVSTLTTPREQINNEAPKSNTYLME
EEEECCCCCCEEEEECCEEEECCCHHHCCCCCCEEEEEHHCCCHHHHCCCCCCCCEEEEE
VDNELVVPVNKKVRIVTTANDVIHAWMIPAFGVKQDAIPGFVRDTWFKAEKIGVYRGQCA
ECCEEEEECCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
ELCGKEHAFMPIVVRVVSDADYTKWVDGKKKEMAAKADDPNKTWTLDEMKARGEKVYTAN
HHCCCCCCHHHHHHHHHCCCCHHHHCCCCHHHHHCCCCCCCCEEEHHHHHHCCCEEEEEC
CAVCHQPNGKGGGAFPALDGSKIVNGPKAGQMHIMLEGKNAMPSWKQLSDTELAAAMTYV
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHCCHHHHHHHHHHH
RNSWSNKTGEVIQPSDFVNARAGKFPEGGGAAGGDAPKADAKPAKDQGSKQASIAGDRTA
HHCCCCCCCCEECCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCC
G
C
>Mature Secondary Structure
MKMWKKASAVCLASASLLASQAALAVSDMPGGPAVRQLNLTEPVTKIAEQIHWLNWMMLI
CCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHH
ICTVIFVAVFGVMFYSVFTHRKAKGAKPASFHESITVEVVWTIVPFLIVIAMALPATKTV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEE
VAMKDTTNSDVTIKATGYQWKWGYDYLKGEGEGISFVSTLTTPREQINNEAPKSNTYLME
EEEECCCCCCEEEEECCEEEECCCHHHCCCCCCEEEEEHHCCCHHHHCCCCCCCCEEEEE
VDNELVVPVNKKVRIVTTANDVIHAWMIPAFGVKQDAIPGFVRDTWFKAEKIGVYRGQCA
ECCEEEEECCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
ELCGKEHAFMPIVVRVVSDADYTKWVDGKKKEMAAKADDPNKTWTLDEMKARGEKVYTAN
HHCCCCCCHHHHHHHHHCCCCHHHHCCCCHHHHHCCCCCCCCEEEHHHHHHCCCEEEEEC
CAVCHQPNGKGGGAFPALDGSKIVNGPKAGQMHIMLEGKNAMPSWKQLSDTELAAAMTYV
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHCCHHHHHHHHHHH
RNSWSNKTGEVIQPSDFVNARAGKFPEGGGAAGGDAPKADAKPAKDQGSKQASIAGDRTA
HHCCCCCCCCEECCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2820725; 7651515; 9380672 [H]