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The map label for this gene is fadD [C]

Identifier: 73539966

GI number: 73539966

Start: 288733

End: 290691

Strand: Direct

Name: fadD [C]

Synonym: Reut_A0260

Alternate gene names: 73539966

Gene position: 288733-290691 (Clockwise)

Preceding gene: 73539962

Following gene: 73539967

Centisome position: 7.59

GC content: 64.17

Gene sequence:

>1959_bases
ATGCAGGAATCGTCGGCGACGACCTTCCCGCGATTGCTGCTGGAGCACGCCCGGCAGCGGCCGGCGCATCCGGCATATCG
CGAAAAGGATCTCGGCATCTGGCAAACATACAGCTGGTCACAGGCGGCGCAGGAGGTCAGGGCGCTTGCTTGCGGGCTTG
CGGCATTGGGATTCACGCGCGGCATGAACCTGGCGGTGGTGGGCGACAACCGCCCGCGCCTGTACTGGGCCATGACCGCC
GCACAGGCCCTGGGCGGCGTGCCGGTGCCCTTGTACCAGGACGCCATTGCGAATGAAATGGTCTACGTGCTCAACGACGC
GGAGATCGACTTCGCGATCGTCGAGGACCAGGAGCAGGTGGACAAGCTGCTGGAAGTCGAAGAGCAGCTTGCCGCTTCCG
GCCGCAGCGTGCGCCACGTGATCTACGAAGATCCGCGCGGCCTGCGCGACTACGATCATCCGTCGCTGATGTCGTACGAG
CGCCTGCAGGAAATCGGGCGCGAGTTCGACCAGGCGCATCCCGGCTTCTATGACGCATCGATTGCCGCGGGATCGCCCGA
GGACACGGCCATTATCCTCTATACATCGGGTACCACCGGCAAGCCCAAGGGCGTTTGCCACGCGCATCGGGGCCTGATCG
GCTCGGCGCAGAACGGTTGCGGCTTCGACGGCCTGACGGCGAAGGACGACGTGCTGTCCTACCTGCCGATGGCGTGGGTT
GGCGACAACCTGTTCTCGTATGCGCAGGCCATGGTGGCCGGCTTCACGGTGAACTGCCCCGAATCGCGCGAGACCGTGAT
GACGGACTTGCGCGAGATCGGCCCAACCTATTACTTCGCGCCGCCGCGCATCTATGAAGGGTTGCTCACGCAGGTGATGA
TCCGCATGGAAGACGCAGGCTGGATCAAGCGCAAGCTGTTCCATTGGGCCATGGACGTCGCGCGCCGCTGCGGCGCCGAC
ATCCTCGACGGCAAGCACGTCGGACTGGCCGAACGCATGCGTTACGCCGCCGGCGAGTTCCTCGTCTACGGGCCGCTGCG
CAACGTGCTCGGCATGAGCCGCATCCGCGTGGGCTATACCGCTGGCGAGGCGATCGGCCCGGACCTGTTCCGCTTCTATC
GTTCGATCGGCGTGAACCTCAAGCAGTTCTATGGCCAGACCGAAACCTGCGCCTATGTCTGCCTGCAGCCCGATGGTCAG
GTGAAGTTCGATTCCGTGGGGCCCGCGGCACCGGGCATGGAAATCCGCATCGCCGACAACGGCGAAGTGCTCGTGCGTGG
CGTAGGTCTGCTGAAGTCCTACTACAAGCGCGACGATGCCACGCGCGAGGCCATCAACGACGAGGGCTACTTCATGACCG
GCGATGCCGGCGTGATCGATGCCGACGGCCATCTCAAGATCATCGACCGCGCCAAGGACGTGGGCAAGCTTGCCGACGGC
TCGATGTTCGCGCCCAAGTACATCGAGAACAAGCTCAAGTTCTTTCCGTACATCAAGGAAGCGGTGGCTTTCGGCACGGG
CCGCGACAAGGTGTGCGCGTTCATCAATATCGATTTCGACGCGGTGGGCAACTGGGCCGAGCGCCGTCACCTGCCGTACG
CCGGCTATGTGGATCTCGCGGGCCAGCCTGACGTGATCGCGATGATCGGCGAATGCGTCGAACAGGTGAATGCCGACCTC
GTCAACGACGGCATGCTGGCCGGCTCGCAGATCGCGCGCTTCCTGATTTTGCACAAGGAGCTTGATCCGGATGACGACGA
ACTGACCCGCACGCGCAAGGTGCGGCGCGGCTTTATCGCAGAGAAGTACGCGGTGCTGGTCGATGCGCTGTATGCGGGCA
AGACCGAGCAGTTCATCGAGACGCGCGTCAAGTTCGAGGACGGGCGCGAGGGCAGCGTGTCGGCCACGCTGAGGCTGATG
GATGCCAAACGCCTGCCGCCGGCGGCACGCGCGGCATGA

Upstream 100 bases:

>100_bases
GCGGCATGACTGCCGCCAGGCAAAACAGGCCAAGTATAACGACCGGACCGGCGCTTGACACCGCGAGTGGATCCCCACCG
CGGAGGGACAGGAGACAGCG

Downstream 100 bases:

>100_bases
GCAGGGGAGCGAAAGCATGACGCAAGTGGCCTGGCAAGGAACAGACCGCATGCCCGCGGCGCGTACGGACGCGAGCGGTG
CAATGCCTGGTGGCGGCGCC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 652; Mature: 652

Protein sequence:

>652_residues
MQESSATTFPRLLLEHARQRPAHPAYREKDLGIWQTYSWSQAAQEVRALACGLAALGFTRGMNLAVVGDNRPRLYWAMTA
AQALGGVPVPLYQDAIANEMVYVLNDAEIDFAIVEDQEQVDKLLEVEEQLAASGRSVRHVIYEDPRGLRDYDHPSLMSYE
RLQEIGREFDQAHPGFYDASIAAGSPEDTAIILYTSGTTGKPKGVCHAHRGLIGSAQNGCGFDGLTAKDDVLSYLPMAWV
GDNLFSYAQAMVAGFTVNCPESRETVMTDLREIGPTYYFAPPRIYEGLLTQVMIRMEDAGWIKRKLFHWAMDVARRCGAD
ILDGKHVGLAERMRYAAGEFLVYGPLRNVLGMSRIRVGYTAGEAIGPDLFRFYRSIGVNLKQFYGQTETCAYVCLQPDGQ
VKFDSVGPAAPGMEIRIADNGEVLVRGVGLLKSYYKRDDATREAINDEGYFMTGDAGVIDADGHLKIIDRAKDVGKLADG
SMFAPKYIENKLKFFPYIKEAVAFGTGRDKVCAFINIDFDAVGNWAERRHLPYAGYVDLAGQPDVIAMIGECVEQVNADL
VNDGMLAGSQIARFLILHKELDPDDDELTRTRKVRRGFIAEKYAVLVDALYAGKTEQFIETRVKFEDGREGSVSATLRLM
DAKRLPPAARAA

Sequences:

>Translated_652_residues
MQESSATTFPRLLLEHARQRPAHPAYREKDLGIWQTYSWSQAAQEVRALACGLAALGFTRGMNLAVVGDNRPRLYWAMTA
AQALGGVPVPLYQDAIANEMVYVLNDAEIDFAIVEDQEQVDKLLEVEEQLAASGRSVRHVIYEDPRGLRDYDHPSLMSYE
RLQEIGREFDQAHPGFYDASIAAGSPEDTAIILYTSGTTGKPKGVCHAHRGLIGSAQNGCGFDGLTAKDDVLSYLPMAWV
GDNLFSYAQAMVAGFTVNCPESRETVMTDLREIGPTYYFAPPRIYEGLLTQVMIRMEDAGWIKRKLFHWAMDVARRCGAD
ILDGKHVGLAERMRYAAGEFLVYGPLRNVLGMSRIRVGYTAGEAIGPDLFRFYRSIGVNLKQFYGQTETCAYVCLQPDGQ
VKFDSVGPAAPGMEIRIADNGEVLVRGVGLLKSYYKRDDATREAINDEGYFMTGDAGVIDADGHLKIIDRAKDVGKLADG
SMFAPKYIENKLKFFPYIKEAVAFGTGRDKVCAFINIDFDAVGNWAERRHLPYAGYVDLAGQPDVIAMIGECVEQVNADL
VNDGMLAGSQIARFLILHKELDPDDDELTRTRKVRRGFIAEKYAVLVDALYAGKTEQFIETRVKFEDGREGSVSATLRLM
DAKRLPPAARAA
>Mature_652_residues
MQESSATTFPRLLLEHARQRPAHPAYREKDLGIWQTYSWSQAAQEVRALACGLAALGFTRGMNLAVVGDNRPRLYWAMTA
AQALGGVPVPLYQDAIANEMVYVLNDAEIDFAIVEDQEQVDKLLEVEEQLAASGRSVRHVIYEDPRGLRDYDHPSLMSYE
RLQEIGREFDQAHPGFYDASIAAGSPEDTAIILYTSGTTGKPKGVCHAHRGLIGSAQNGCGFDGLTAKDDVLSYLPMAWV
GDNLFSYAQAMVAGFTVNCPESRETVMTDLREIGPTYYFAPPRIYEGLLTQVMIRMEDAGWIKRKLFHWAMDVARRCGAD
ILDGKHVGLAERMRYAAGEFLVYGPLRNVLGMSRIRVGYTAGEAIGPDLFRFYRSIGVNLKQFYGQTETCAYVCLQPDGQ
VKFDSVGPAAPGMEIRIADNGEVLVRGVGLLKSYYKRDDATREAINDEGYFMTGDAGVIDADGHLKIIDRAKDVGKLADG
SMFAPKYIENKLKFFPYIKEAVAFGTGRDKVCAFINIDFDAVGNWAERRHLPYAGYVDLAGQPDVIAMIGECVEQVNADL
VNDGMLAGSQIARFLILHKELDPDDDELTRTRKVRRGFIAEKYAVLVDALYAGKTEQFIETRVKFEDGREGSVSATLRLM
DAKRLPPAARAA

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI27477105, Length=606, Percent_Identity=24.4224422442244, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI83745141, Length=634, Percent_Identity=23.0283911671924, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI40807491, Length=620, Percent_Identity=26.1290322580645, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI12669909, Length=646, Percent_Identity=24.922600619195, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI4758332, Length=646, Percent_Identity=24.922600619195, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI57165412, Length=610, Percent_Identity=25.5737704918033, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI57165410, Length=613, Percent_Identity=24.9592169657423, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI42794756, Length=611, Percent_Identity=24.0589198036007, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI42794760, Length=611, Percent_Identity=24.0589198036007, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI42794758, Length=611, Percent_Identity=24.0589198036007, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI42794754, Length=548, Percent_Identity=23.9051094890511, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI42794752, Length=548, Percent_Identity=23.9051094890511, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1788107, Length=512, Percent_Identity=23.6328125, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693145, Length=501, Percent_Identity=21.9560878243513, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17510401, Length=607, Percent_Identity=25.0411861614498, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17541856, Length=632, Percent_Identity=24.5253164556962, Blast_Score=151, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17564090, Length=633, Percent_Identity=23.696682464455, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI193204819, Length=513, Percent_Identity=24.1715399610136, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17556552, Length=492, Percent_Identity=23.3739837398374, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI25147511, Length=646, Percent_Identity=22.6006191950464, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17553312, Length=659, Percent_Identity=24.5827010622155, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17558820, Length=135, Percent_Identity=31.8518518518519, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32563687, Length=135, Percent_Identity=32.5925925925926, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI133901848, Length=209, Percent_Identity=25.8373205741627, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71985884, Length=138, Percent_Identity=29.7101449275362, Blast_Score=66, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320852, Length=645, Percent_Identity=24.4961240310078, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324893, Length=461, Percent_Identity=24.5119305856833, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323903, Length=452, Percent_Identity=25, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322182, Length=543, Percent_Identity=23.0202578268877, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17933690, Length=643, Percent_Identity=22.5505443234837, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI19921316, Length=626, Percent_Identity=23.1629392971246, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24666501, Length=609, Percent_Identity=23.8095238095238, Blast_Score=152, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24666497, Length=609, Percent_Identity=23.8095238095238, Blast_Score=152, Evalue=1e-36,
Organism=Drosophila melanogaster, GI281366413, Length=610, Percent_Identity=23.7704918032787, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI62471681, Length=477, Percent_Identity=23.0607966457023, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI62471687, Length=477, Percent_Identity=23.0607966457023, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24586634, Length=477, Percent_Identity=23.0607966457023, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI22026970, Length=477, Percent_Identity=23.0607966457023, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI62471689, Length=477, Percent_Identity=23.0607966457023, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI62471679, Length=477, Percent_Identity=23.0607966457023, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI62471683, Length=477, Percent_Identity=23.0607966457023, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI62471685, Length=477, Percent_Identity=23.0607966457023, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24586636, Length=477, Percent_Identity=23.0607966457023, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24581924, Length=510, Percent_Identity=21.7647058823529, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281365686, Length=132, Percent_Identity=34.0909090909091, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 72226; Mature: 72226

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQESSATTFPRLLLEHARQRPAHPAYREKDLGIWQTYSWSQAAQEVRALACGLAALGFTR
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHC
GMNLAVVGDNRPRLYWAMTAAQALGGVPVPLYQDAIANEMVYVLNDAEIDFAIVEDQEQV
CCEEEEEECCCCEEEEEEEHHHHHCCCCCHHHHHHHHCCEEEEEECCCEEEEEECCHHHH
DKLLEVEEQLAASGRSVRHVIYEDPRGLRDYDHPSLMSYERLQEIGREFDQAHPGFYDAS
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECC
IAAGSPEDTAIILYTSGTTGKPKGVCHAHRGLIGSAQNGCGFDGLTAKDDVLSYLPMAWV
CCCCCCCCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHH
GDNLFSYAQAMVAGFTVNCPESRETVMTDLREIGPTYYFAPPRIYEGLLTQVMIRMEDAG
CHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCH
WIKRKLFHWAMDVARRCGADILDGKHVGLAERMRYAAGEFLVYGPLRNVLGMSRIRVGYT
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHEEEEEC
AGEAIGPDLFRFYRSIGVNLKQFYGQTETCAYVCLQPDGQVKFDSVGPAAPGMEIRIADN
CCCCCCHHHHHHHHHHCCCHHHHCCCCCCEEEEEECCCCCEEECCCCCCCCCCEEEECCC
GEVLVRGVGLLKSYYKRDDATREAINDEGYFMTGDAGVIDADGHLKIIDRAKDVGKLADG
CCEEEHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCCEEECCCCEEEEHHHHHHHHCCCC
SMFAPKYIENKLKFFPYIKEAVAFGTGRDKVCAFINIDFDAVGNWAERRHLPYAGYVDLA
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHCCHHHHCCCCCCCEEECC
GQPDVIAMIGECVEQVNADLVNDGMLAGSQIARFLILHKELDPDDDELTRTRKVRRGFIA
CCCHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EKYAVLVDALYAGKTEQFIETRVKFEDGREGSVSATLRLMDAKRLPPAARAA
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHEEEEEHHHCCCCHHCCC
>Mature Secondary Structure
MQESSATTFPRLLLEHARQRPAHPAYREKDLGIWQTYSWSQAAQEVRALACGLAALGFTR
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHC
GMNLAVVGDNRPRLYWAMTAAQALGGVPVPLYQDAIANEMVYVLNDAEIDFAIVEDQEQV
CCEEEEEECCCCEEEEEEEHHHHHCCCCCHHHHHHHHCCEEEEEECCCEEEEEECCHHHH
DKLLEVEEQLAASGRSVRHVIYEDPRGLRDYDHPSLMSYERLQEIGREFDQAHPGFYDAS
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECC
IAAGSPEDTAIILYTSGTTGKPKGVCHAHRGLIGSAQNGCGFDGLTAKDDVLSYLPMAWV
CCCCCCCCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHH
GDNLFSYAQAMVAGFTVNCPESRETVMTDLREIGPTYYFAPPRIYEGLLTQVMIRMEDAG
CHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCH
WIKRKLFHWAMDVARRCGADILDGKHVGLAERMRYAAGEFLVYGPLRNVLGMSRIRVGYT
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHEEEEEC
AGEAIGPDLFRFYRSIGVNLKQFYGQTETCAYVCLQPDGQVKFDSVGPAAPGMEIRIADN
CCCCCCHHHHHHHHHHCCCHHHHCCCCCCEEEEEECCCCCEEECCCCCCCCCCEEEECCC
GEVLVRGVGLLKSYYKRDDATREAINDEGYFMTGDAGVIDADGHLKIIDRAKDVGKLADG
CCEEEHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCCEEECCCCEEEEHHHHHHHHCCCC
SMFAPKYIENKLKFFPYIKEAVAFGTGRDKVCAFINIDFDAVGNWAERRHLPYAGYVDLA
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHCCHHHHCCCCCCCEEECC
GQPDVIAMIGECVEQVNADLVNDGMLAGSQIARFLILHKELDPDDDELTRTRKVRRGFIA
CCCHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EKYAVLVDALYAGKTEQFIETRVKFEDGREGSVSATLRLMDAKRLPPAARAA
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHEEEEEHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]