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The map label for this gene is bioA [C]

Identifier: 73539954

GI number: 73539954

Start: 273870

End: 275201

Strand: Direct

Name: bioA [C]

Synonym: Reut_A0248

Alternate gene names: 73539954

Gene position: 273870-275201 (Clockwise)

Preceding gene: 73539951

Following gene: 73539955

Centisome position: 7.19

GC content: 67.72

Gene sequence:

>1332_bases
ATGGACGCCGCGAAGACCGTGATTCCCGATCTCGATGCCCTGTGGATGCCCTTTACCGCGAACCGCCAGTACAAGGCGGC
GCCGCGCCTGCTGGCCTCGGCCAGCGGCATGTACTACACCACCCACGACGGACGCCAGATCCTCGACGGTTGCGCGGGCC
TCTGGTGCGTAGCGGCCGGCCACTGCCGCAAGGAGATTGCCGAGGCCGTGGCCCGCCAGGCCGCCACGCTCGACTACGCG
CCGCCGTTCCAGATGGGCCATCCGCTGTCGTTCGAAGCCGCCACCAAGGTGGCCGCGATCATGCCGCAGGGACTGGACCG
CATCTTCTTCACGAATTCCGGTTCGGAATCGGTGGACACCGCGCTGAAGATTGCGCTGGCCTACCACCGTGCGCGCGGCG
AGGGCCAGCGCACCCGCTTCATCGGGCGCGAACGCGGTTACCACGGCGTGGGCTTTGGCGGCATGGCTGTCGGTGGCATC
GGGCCGAACCGCAAGGCGTTCTCGGCCAACCTGATGCCGGGCACCGACCATCTGCCGGCGACGCTGAATATCGCCGAAGC
GGCGTTCTCCAAGGGTCAGCCGACATGGGGCGCGCACCTTGCCGACGAACTCGAGCGCATCGTCGCGCTGCATGATCCGT
CCACGATTGCCGCCGTCATCGTGGAACCGCTGGCGGGCTCCGCCGGGGTGCTGGTGCCGCCGGTCGGCTACCTCGACAAG
CTGCGCGAGATCACGACCAAGCACGGCATCCTGCTGATCTTCGACGAGGTCATCACGGCCTTTGGTCGCCTGGGTACCGC
CACCGCGGCGGAACGCTTCAAGGTCACGCCGGACCTGATCACCATGGCCAAGGCCATCAACAACGCCGCCGTGCCGATGG
GTGCCGTGGCCGTGCGCCGCGAAGTCCATGACACCGTGGTCAACTCGGCCGCGCCGGGCGCGATCGAACTCGCGCATGGC
TACACCTACTCGGGCCACCCGCTGGCCGCCGCCGCTGCCATCGCCACGCTGGACCTGTATCAGCGCGAGAACCTGTTCGG
CCGTGCCGCGGAGCTGTCGCCGGTGTTCGAAGCGGCCGTTCACAGCGTACGCAGCGCGCCGCATGTGAAGGACATCCGCA
ACCTCGGCATGGTGGCCGGCATCGAGCTGGAGCCGCGTCCGGGCCAGCCCGGCGCACGCGCCTACGAAGCCTTCCTCAAA
TGCCTTGAGCGTGGCGTGCTGGTGCGCTACACCGGCGATATCCTCGCGTTCTCGCCGCCGCTGATCATCAGCGAGGCGCA
GATTGCCGAGCTGTTCGATACGGTCAAGCAGGCCTTGCAGGAAGTGCAGTAA

Upstream 100 bases:

>100_bases
GGCGCCGCCGGTAGAGTGGCCGACATCCCTGCCGCTGCACACGTTTCGCCGTGACAGCGCGCGCCAACCCGAATCGCCCA
GATTGCCCAGAGGAGGACGT

Downstream 100 bases:

>100_bases
AGAGGGATTCCAAAGTGAATATTGCTGAGAACCGGCAGATCGCCGAAATCCACCACTACATCGGTGGCACCGTCCGGCCA
GGCGCGTCCGCGCGCTTTGC

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MDAAKTVIPDLDALWMPFTANRQYKAAPRLLASASGMYYTTHDGRQILDGCAGLWCVAAGHCRKEIAEAVARQAATLDYA
PPFQMGHPLSFEAATKVAAIMPQGLDRIFFTNSGSESVDTALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGMAVGGI
GPNRKAFSANLMPGTDHLPATLNIAEAAFSKGQPTWGAHLADELERIVALHDPSTIAAVIVEPLAGSAGVLVPPVGYLDK
LREITTKHGILLIFDEVITAFGRLGTATAAERFKVTPDLITMAKAINNAAVPMGAVAVRREVHDTVVNSAAPGAIELAHG
YTYSGHPLAAAAAIATLDLYQRENLFGRAAELSPVFEAAVHSVRSAPHVKDIRNLGMVAGIELEPRPGQPGARAYEAFLK
CLERGVLVRYTGDILAFSPPLIISEAQIAELFDTVKQALQEVQ

Sequences:

>Translated_443_residues
MDAAKTVIPDLDALWMPFTANRQYKAAPRLLASASGMYYTTHDGRQILDGCAGLWCVAAGHCRKEIAEAVARQAATLDYA
PPFQMGHPLSFEAATKVAAIMPQGLDRIFFTNSGSESVDTALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGMAVGGI
GPNRKAFSANLMPGTDHLPATLNIAEAAFSKGQPTWGAHLADELERIVALHDPSTIAAVIVEPLAGSAGVLVPPVGYLDK
LREITTKHGILLIFDEVITAFGRLGTATAAERFKVTPDLITMAKAINNAAVPMGAVAVRREVHDTVVNSAAPGAIELAHG
YTYSGHPLAAAAAIATLDLYQRENLFGRAAELSPVFEAAVHSVRSAPHVKDIRNLGMVAGIELEPRPGQPGARAYEAFLK
CLERGVLVRYTGDILAFSPPLIISEAQIAELFDTVKQALQEVQ
>Mature_443_residues
MDAAKTVIPDLDALWMPFTANRQYKAAPRLLASASGMYYTTHDGRQILDGCAGLWCVAAGHCRKEIAEAVARQAATLDYA
PPFQMGHPLSFEAATKVAAIMPQGLDRIFFTNSGSESVDTALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGMAVGGI
GPNRKAFSANLMPGTDHLPATLNIAEAAFSKGQPTWGAHLADELERIVALHDPSTIAAVIVEPLAGSAGVLVPPVGYLDK
LREITTKHGILLIFDEVITAFGRLGTATAAERFKVTPDLITMAKAINNAAVPMGAVAVRREVHDTVVNSAAPGAIELAHG
YTYSGHPLAAAAAIATLDLYQRENLFGRAAELSPVFEAAVHSVRSAPHVKDIRNLGMVAGIELEPRPGQPGARAYEAFLK
CLERGVLVRYTGDILAFSPPLIISEAQIAELFDTVKQALQEVQ

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=428, Percent_Identity=27.803738317757, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI37574042, Length=431, Percent_Identity=26.4501160092807, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI226442709, Length=395, Percent_Identity=26.8354430379747, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI284507298, Length=240, Percent_Identity=33.75, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI226442705, Length=431, Percent_Identity=26.4501160092807, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI13994255, Length=450, Percent_Identity=26, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI24119277, Length=414, Percent_Identity=24.8792270531401, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1786991, Length=435, Percent_Identity=31.4942528735632, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI145693181, Length=344, Percent_Identity=31.1046511627907, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1789016, Length=420, Percent_Identity=29.0476190476191, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1789759, Length=423, Percent_Identity=28.3687943262411, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788044, Length=422, Percent_Identity=28.6729857819905, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1787560, Length=412, Percent_Identity=28.6407766990291, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786349, Length=348, Percent_Identity=29.5977011494253, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=445, Percent_Identity=27.8651685393258, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=438, Percent_Identity=27.6255707762557, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25144271, Length=424, Percent_Identity=25.9433962264151, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=231, Percent_Identity=31.6017316017316, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323470, Length=434, Percent_Identity=26.9585253456221, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324386, Length=476, Percent_Identity=23.3193277310924, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324432, Length=417, Percent_Identity=25.4196642685851, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357415, Length=427, Percent_Identity=28.3372365339578, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI161085790, Length=443, Percent_Identity=26.86230248307, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28574759, Length=445, Percent_Identity=27.1910112359551, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21356575, Length=434, Percent_Identity=28.5714285714286, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 47233; Mature: 47233

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAAKTVIPDLDALWMPFTANRQYKAAPRLLASASGMYYTTHDGRQILDGCAGLWCVAAG
CCCCHHHCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHH
HCRKEIAEAVARQAATLDYAPPFQMGHPLSFEAATKVAAIMPQGLDRIFFTNSGSESVDT
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
ALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGMAVGGIGPNRKAFSANLMPGTDHLPA
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEECCCCCCCCCCCC
TLNIAEAAFSKGQPTWGAHLADELERIVALHDPSTIAAVIVEPLAGSAGVLVPPVGYLDK
EEHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCEEECCHHHHHH
LREITTKHGILLIFDEVITAFGRLGTATAAERFKVTPDLITMAKAINNAAVPMGAVAVRR
HHHHHHHCCEEEEHHHHHHHHHCCCCHHHHHHEECCHHHHHHHHHHCCCCCCHHHHHHHH
EVHDTVVNSAAPGAIELAHGYTYSGHPLAAAAAIATLDLYQRENLFGRAAELSPVFEAAV
HHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHH
HSVRSAPHVKDIRNLGMVAGIELEPRPGQPGARAYEAFLKCLERGVLVRYTGDILAFSPP
HHHHCCCCHHHHHHCCCEECEEECCCCCCCCHHHHHHHHHHHHCCEEEEEECCEEEECCC
LIISEAQIAELFDTVKQALQEVQ
CEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDAAKTVIPDLDALWMPFTANRQYKAAPRLLASASGMYYTTHDGRQILDGCAGLWCVAAG
CCCCHHHCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHH
HCRKEIAEAVARQAATLDYAPPFQMGHPLSFEAATKVAAIMPQGLDRIFFTNSGSESVDT
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
ALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGMAVGGIGPNRKAFSANLMPGTDHLPA
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEECCCCCCCCCCCC
TLNIAEAAFSKGQPTWGAHLADELERIVALHDPSTIAAVIVEPLAGSAGVLVPPVGYLDK
EEHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCEEECCHHHHHH
LREITTKHGILLIFDEVITAFGRLGTATAAERFKVTPDLITMAKAINNAAVPMGAVAVRR
HHHHHHHCCEEEEHHHHHHHHHCCCCHHHHHHEECCHHHHHHHHHHCCCCCCHHHHHHHH
EVHDTVVNSAAPGAIELAHGYTYSGHPLAAAAAIATLDLYQRENLFGRAAELSPVFEAAV
HHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHH
HSVRSAPHVKDIRNLGMVAGIELEPRPGQPGARAYEAFLKCLERGVLVRYTGDILAFSPP
HHHHCCCCHHHHHHCCCEECEEECCCCCCCCHHHHHHHHHHHHCCEEEEEECCEEEECCC
LIISEAQIAELFDTVKQALQEVQ
CEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]